Motif ID: SOX5
Z-value: 1.452
Transcription factors associated with SOX5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX5 | ENSG00000134532.11 | SOX5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX5 | hg19_v2_chr12_-_24103954_24103972 | 0.36 | 3.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.4 | GO:0060437 | lung growth(GO:0060437) regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.5 | 7.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.5 | 2.4 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.4 | 1.1 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.3 | 1.1 | GO:0045209 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.3 | 1.1 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.2 | 2.1 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.2 | 1.6 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.2 | 0.7 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.2 | 1.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 0.9 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.2 | 0.8 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.1 | 0.3 | GO:0003263 | cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264) |
| 0.1 | 7.4 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 1.0 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.1 | 0.5 | GO:0061324 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
| 0.1 | 0.4 | GO:0019082 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.1 | 2.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.4 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.1 | 1.0 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 4.2 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 1.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.4 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.2 | GO:0038169 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 0.5 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.1 | 0.3 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.1 | 0.6 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.1 | 0.5 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564) |
| 0.1 | 0.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 0.7 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 0.3 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.0 | 1.4 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.0 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 0.4 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.1 | GO:1904647 | response to rotenone(GO:1904647) |
| 0.0 | 0.1 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
| 0.0 | 0.1 | GO:0071503 | response to heparin(GO:0071503) |
| 0.0 | 0.2 | GO:0003415 | chondrocyte hypertrophy(GO:0003415) |
| 0.0 | 0.5 | GO:1901223 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.0 | 0.6 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.0 | 2.0 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 1.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.2 | GO:0030047 | actin modification(GO:0030047) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.9 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.2 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.0 | 0.1 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 0.1 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 0.0 | 0.2 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.0 | 0.1 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.0 | 0.5 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.4 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.1 | GO:0010693 | negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.0 | 0.1 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 0.3 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
| 0.0 | 0.2 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.0 | 0.1 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.0 | 0.1 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.0 | 0.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.1 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 0.3 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.4 | 7.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 0.6 | GO:0097134 | Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134) |
| 0.1 | 0.6 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.1 | 0.7 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 0.9 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 2.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 0.3 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.1 | 0.5 | GO:0070369 | Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 0.5 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.1 | 1.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.3 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.3 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 5.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.6 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.1 | GO:0005587 | collagen type IV trimer(GO:0005587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 1.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 5.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 1.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.1 | 7.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 0.2 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 0.3 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 2.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:1903763 | gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
| 0.0 | 1.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.2 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.0 | 0.2 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 6.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.1 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.0 | 0.1 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.0 | 0.9 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.1 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.1 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.2 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.1 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.0 | 0.4 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.2 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.0 | 0.6 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 1.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.6 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 0.2 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.0 | 0.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.1 | GO:0035473 | lipase binding(GO:0035473) |
| 0.0 | 0.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.2 | GO:0045159 | myosin II binding(GO:0045159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.4 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.0 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 7.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 5.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.5 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 1.9 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 2.4 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.4 | REACTOME_GAP_JUNCTION_TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.0 | 0.4 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
