Motif ID: SOX21

Z-value: 0.233


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21



Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_43343886 0.192 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr5_-_147286065 0.154 ENST00000318315.4
ENST00000515291.1
 C5orf46

chromosome 5 open reading frame 46

chr4_-_39034542 0.118 ENST00000344606.6
 TMEM156
transmembrane protein 156
chr16_-_15982440 0.097 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
 FOPNL






FGFR1OP N-terminal like






chr11_-_8285405 0.092 ENST00000335790.3
ENST00000534484.1
 LMO1

LIM domain only 1 (rhombotin 1)

chr3_+_154741907 0.082 ENST00000492661.1
 MME
membrane metallo-endopeptidase
chr12_-_10588539 0.069 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
 KLRC2

NKG2-E
killer cell lectin-like receptor subfamily C, member 2

Uncharacterized protein
chr3_-_155524049 0.063 ENST00000534941.1
ENST00000340171.2
 C3orf33

chromosome 3 open reading frame 33

chr8_+_101170563 0.059 ENST00000520508.1
ENST00000388798.2
 SPAG1

sperm associated antigen 1

chr14_+_64565442 0.057 ENST00000553308.1
 SYNE2
spectrin repeat containing, nuclear envelope 2
chr8_-_94029882 0.052 ENST00000520686.1
 TRIQK
triple QxxK/R motif containing
chr22_+_39353527 0.047 ENST00000249116.2
 APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr18_-_47018897 0.047 ENST00000418495.1
 RPL17
ribosomal protein L17
chr3_+_38537763 0.044 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
 EXOG


endo/exonuclease (5'-3'), endonuclease G-like


chr1_-_169455169 0.043 ENST00000367804.4
ENST00000236137.5
 SLC19A2

solute carrier family 19 (thiamine transporter), member 2

chr18_-_47018869 0.042 ENST00000583036.1
ENST00000580261.1
 RPL17

ribosomal protein L17

chr14_-_92588013 0.042 ENST00000553514.1
ENST00000605997.1
 NDUFB1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa

chr5_-_179045199 0.042 ENST00000523921.1
 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr7_+_2394445 0.038 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
 EIF3B


eukaryotic translation initiation factor 3, subunit B


chr3_+_38537960 0.037 ENST00000453767.1
 EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr10_-_71169031 0.035 ENST00000373307.1
 TACR2
tachykinin receptor 2
chrX_-_138724677 0.035 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2


MCF.2 cell line derived transforming sequence


chr10_-_18944123 0.034 ENST00000606425.1
 RP11-139J15.7
Uncharacterized protein
chr15_-_80263506 0.033 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr8_+_26150628 0.033 ENST00000523925.1
ENST00000315985.7
 PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr6_+_31371337 0.032 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr12_+_101673872 0.031 ENST00000261637.4
 UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr5_+_134181755 0.030 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
 C5orf24


chromosome 5 open reading frame 24


chr3_+_141103634 0.029 ENST00000507722.1
 ZBTB38
zinc finger and BTB domain containing 38
chr10_-_17243579 0.029 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
 TRDMT1






tRNA aspartic acid methyltransferase 1






chr3_-_141747459 0.029 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chrX_-_131353461 0.028 ENST00000370874.1
 RAP2C
RAP2C, member of RAS oncogene family
chr18_-_47018769 0.027 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
 RPL17





ribosomal protein L17





chr14_-_92588246 0.025 ENST00000329559.3
 NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr20_-_22665932 0.025 ENST00000437696.1
 RP11-359G22.2
RP11-359G22.2
chr3_-_45957534 0.025 ENST00000536047.1
 LZTFL1
leucine zipper transcription factor-like 1
chr1_+_151171012 0.024 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
 PIP5K1A





phosphatidylinositol-4-phosphate 5-kinase, type I, alpha





chr1_+_146714291 0.023 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
 CHD1L



chromodomain helicase DNA binding protein 1-like



chr9_+_99690592 0.023 ENST00000354649.3
 NUTM2G
NUT family member 2G
chr6_-_3195981 0.021 ENST00000425384.2
ENST00000435043.2
 RP1-40E16.9

RP1-40E16.9

chr5_+_140579162 0.020 ENST00000536699.1
ENST00000354757.3
 PCDHB11

protocadherin beta 11

chr10_-_12084770 0.019 ENST00000357604.5
 UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr9_-_70465758 0.019 ENST00000489273.1
 CBWD5
COBW domain containing 5
chr12_-_89746173 0.019 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr1_+_203764742 0.018 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
 ZC3H11A




zinc finger CCCH-type containing 11A




chr22_-_40929812 0.018 ENST00000422851.1
 MKL1
megakaryoblastic leukemia (translocation) 1
chr3_-_141747439 0.017 ENST00000467667.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_158901329 0.017 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
 PYHIN1




pyrin and HIN domain family, member 1




chr2_+_102759199 0.017 ENST00000409288.1
ENST00000410023.1
 IL1R1

interleukin 1 receptor, type I

chr11_+_5775923 0.017 ENST00000317254.3
 OR52N4
olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)
chr6_-_121655593 0.017 ENST00000398212.2
 TBC1D32
TBC1 domain family, member 32
chr3_-_37034702 0.016 ENST00000322716.5
 EPM2AIP1
EPM2A (laforin) interacting protein 1
chr2_+_217363559 0.015 ENST00000600880.1
ENST00000446558.1
 RPL37A

ribosomal protein L37a

chr3_-_45957088 0.015 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr4_-_103747011 0.015 ENST00000350435.7
 UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrY_+_16634483 0.015 ENST00000382872.1
 NLGN4Y
neuroligin 4, Y-linked
chr19_+_42381173 0.015 ENST00000221972.3
 CD79A
CD79a molecule, immunoglobulin-associated alpha
chr7_-_37382683 0.014 ENST00000455879.1
 ELMO1
engulfment and cell motility 1
chrX_+_52927576 0.014 ENST00000416841.2
 FAM156B
family with sequence similarity 156, member B
chr19_+_18682531 0.014 ENST00000596304.1
ENST00000430157.2
 UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr3_-_155572164 0.014 ENST00000392845.3
ENST00000359479.3
 SLC33A1

solute carrier family 33 (acetyl-CoA transporter), member 1

chrX_-_110507098 0.013 ENST00000541758.1
 CAPN6
calpain 6
chr2_-_106013207 0.013 ENST00000447958.1
 FHL2
four and a half LIM domains 2
chr8_-_143961236 0.013 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
 CYP11B1


cytochrome P450, family 11, subfamily B, polypeptide 1


chr12_+_123011776 0.013 ENST00000450485.2
ENST00000333479.7
 KNTC1

kinetochore associated 1

chr4_-_103746924 0.013 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
 UBE2D3


ubiquitin-conjugating enzyme E2D 3


chr8_-_142377367 0.013 ENST00000377741.3
 GPR20
G protein-coupled receptor 20
chr1_-_202776392 0.013 ENST00000235790.4
 KDM5B
lysine (K)-specific demethylase 5B
chr12_+_59194154 0.013 ENST00000548969.1
 RP11-362K2.2
Protein LOC100506869
chr5_-_55529115 0.012 ENST00000513241.2
ENST00000341048.4
 ANKRD55

ankyrin repeat domain 55

chr4_-_103746683 0.012 ENST00000504211.1
ENST00000508476.1
 UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr17_-_18266660 0.012 ENST00000582653.1
ENST00000352886.6
 SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr4_+_81951957 0.010 ENST00000282701.2
 BMP3
bone morphogenetic protein 3
chr6_+_131958436 0.009 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
 ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr1_-_26394114 0.008 ENST00000374272.3
 TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chrX_-_153210107 0.008 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
 RENBP


renin binding protein


chr5_-_95158375 0.008 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX



glutaredoxin (thioltransferase)



chr5_-_95158644 0.008 ENST00000237858.6
 GLRX
glutaredoxin (thioltransferase)
chr1_+_2487631 0.008 ENST00000409119.1
 TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr2_+_3705785 0.008 ENST00000252505.3
 ALLC
allantoicase
chr1_-_151148492 0.008 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr7_+_6713376 0.008 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
 AC073343.1


Uncharacterized protein


chr3_+_155838337 0.008 ENST00000490337.1
ENST00000389636.5
 KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr14_+_60712463 0.007 ENST00000325642.3
ENST00000529574.1
 PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr19_-_54784937 0.007 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
 LILRB2


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2


chr14_+_92588281 0.007 ENST00000298875.4
ENST00000553427.1
 CPSF2

cleavage and polyadenylation specific factor 2, 100kDa

chr21_+_30672433 0.006 ENST00000451655.1
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr11_-_57479673 0.005 ENST00000337672.2
ENST00000431606.2
 MED19

mediator complex subunit 19

chr17_+_60457914 0.005 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
 EFCAB3


EF-hand calcium binding domain 3


chr1_-_112032284 0.005 ENST00000414219.1
 ADORA3
adenosine A3 receptor
chr19_-_2783255 0.005 ENST00000589251.1
 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr8_-_66750978 0.005 ENST00000523253.1
 PDE7A
phosphodiesterase 7A
chr11_+_2482661 0.005 ENST00000335475.5
 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr17_+_66245341 0.004 ENST00000577985.1
 AMZ2
archaelysin family metallopeptidase 2
chrX_-_71792477 0.004 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
 HDAC8








histone deacetylase 8








chrY_+_14813160 0.003 ENST00000338981.3
 USP9Y
ubiquitin specific peptidase 9, Y-linked
chr5_+_67588312 0.003 ENST00000519025.1
 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_248524883 0.003 ENST00000366475.1
 OR2T4
olfactory receptor, family 2, subfamily T, member 4
chr6_-_154568551 0.002 ENST00000519190.1
 IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_-_54303934 0.002 ENST00000537333.1
 NDC1
NDC1 transmembrane nucleoporin
chr5_+_175875349 0.002 ENST00000261942.6
 FAF2
Fas associated factor family member 2
chr6_-_52926539 0.002 ENST00000350082.5
ENST00000356971.3
 ICK

intestinal cell (MAK-like) kinase

chr10_-_13276329 0.002 ENST00000378681.3
ENST00000463405.2
 UCMA

upper zone of growth plate and cartilage matrix associated

chr6_-_154567984 0.002 ENST00000517438.1
 IPCEF1
interaction protein for cytohesin exchange factors 1
chr8_-_50466973 0.001 ENST00000520800.1
 RP11-738G5.2
Uncharacterized protein
chr15_+_58702742 0.000 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.0 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.0 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.0 0.0 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)