Motif ID: SOX1

Z-value: 0.430


Transcription factors associated with SOX1:

Gene SymbolEntrez IDGene Name
SOX1 ENSG00000182968.3 SOX1



Activity profile for motif SOX1.

activity profile for motif SOX1


Sorted Z-values histogram for motif SOX1

Sorted Z-values for motif SOX1



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_65613340 0.564 ENST00000546702.1
 AK4
adenylate kinase 4
chr10_-_92681033 0.511 ENST00000371697.3
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_65613217 0.456 ENST00000545314.1
 AK4
adenylate kinase 4
chr18_+_6834472 0.238 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
 ARHGAP28


Rho GTPase activating protein 28


chr4_+_172734548 0.224 ENST00000506823.1
 GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr13_-_22178284 0.195 ENST00000468222.2
ENST00000382374.4
 MICU2

mitochondrial calcium uptake 2

chr6_+_26183958 0.188 ENST00000356530.3
 HIST1H2BE
histone cluster 1, H2be
chr5_+_135383008 0.180 ENST00000508767.1
ENST00000604555.1
 TGFBI

transforming growth factor, beta-induced, 68kDa

chr16_+_12059091 0.178 ENST00000562385.1
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_+_240255166 0.164 ENST00000319653.9
 FMN2
formin 2
chr7_+_36450169 0.159 ENST00000428612.1
 ANLN
anillin, actin binding protein
chr12_+_57810198 0.154 ENST00000598001.1
 AC126614.1
HCG1818482; Uncharacterized protein
chr16_+_12058961 0.150 ENST00000053243.1
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_+_138327542 0.142 ENST00000360570.3
ENST00000393035.2
 FAIM

Fas apoptotic inhibitory molecule

chrX_+_11129388 0.130 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
 HCCS


holocytochrome c synthase


chr3_+_158362299 0.121 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
 GFM1


G elongation factor, mitochondrial 1


chr3_-_189840223 0.113 ENST00000427335.2
 LEPREL1
leprecan-like 1
chr16_-_11876408 0.111 ENST00000396516.2
 ZC3H7A
zinc finger CCCH-type containing 7A
chr12_+_75874460 0.109 ENST00000266659.3
 GLIPR1
GLI pathogenesis-related 1
chr3_+_138327417 0.108 ENST00000338446.4
 FAIM
Fas apoptotic inhibitory molecule
chr7_-_110174754 0.103 ENST00000435466.1
 AC003088.1
AC003088.1
chr20_-_49575081 0.098 ENST00000371588.5
ENST00000371582.4
 DPM1

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

chr8_-_134501937 0.097 ENST00000519924.1
 ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr3_-_107596910 0.096 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
 LINC00635












long intergenic non-protein coding RNA 635












chr18_+_21719018 0.094 ENST00000585037.1
ENST00000415309.2
ENST00000399481.2
ENST00000577705.1
ENST00000327201.6
 CABYR




calcium binding tyrosine-(Y)-phosphorylation regulated




chr20_-_49575058 0.093 ENST00000371584.4
ENST00000371583.5
ENST00000413082.1
 DPM1


dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit


chr8_-_102181718 0.092 ENST00000565617.1
 KB-1460A1.5
KB-1460A1.5
chr16_+_12059050 0.089 ENST00000396495.3
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_+_11864458 0.088 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
 LPIN1


lipin 1


chr8_-_134501873 0.084 ENST00000523634.1
 ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr18_-_51751132 0.083 ENST00000256429.3
 MBD2
methyl-CpG binding domain protein 2
chr12_+_100594557 0.083 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
 ACTR6


ARP6 actin-related protein 6 homolog (yeast)


chr1_-_169455169 0.073 ENST00000367804.4
ENST00000236137.5
 SLC19A2

solute carrier family 19 (thiamine transporter), member 2

chr8_-_110620284 0.072 ENST00000529690.1
 SYBU
syntabulin (syntaxin-interacting)
chr9_-_123638633 0.069 ENST00000456291.1
 PHF19
PHD finger protein 19
chr16_-_18937072 0.066 ENST00000569122.1
 SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr13_+_53602894 0.064 ENST00000219022.2
 OLFM4
olfactomedin 4
chr5_-_16916624 0.063 ENST00000513882.1
 MYO10
myosin X
chr14_+_74417192 0.059 ENST00000554320.1
 COQ6
coenzyme Q6 monooxygenase
chr11_-_76381781 0.059 ENST00000260061.5
ENST00000404995.1
 LRRC32

leucine rich repeat containing 32

chr6_+_148593425 0.058 ENST00000367469.1
 SASH1
SAM and SH3 domain containing 1
chr10_+_15085895 0.057 ENST00000378228.3
 OLAH
oleoyl-ACP hydrolase
chr17_+_75181292 0.055 ENST00000431431.2
 SEC14L1
SEC14-like 1 (S. cerevisiae)
chr14_+_62164340 0.055 ENST00000557538.1
ENST00000539097.1
 HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr5_+_175740083 0.054 ENST00000332772.4
 SIMC1
SUMO-interacting motifs containing 1
chr12_-_120763739 0.053 ENST00000549767.1
 PLA2G1B
phospholipase A2, group IB (pancreas)
chr21_-_16126181 0.048 ENST00000455253.2
 AF127936.3
AF127936.3
chr1_-_212004090 0.047 ENST00000366997.4
 LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr6_-_130543958 0.046 ENST00000437477.2
ENST00000439090.2
 SAMD3

sterile alpha motif domain containing 3

chr9_-_13165457 0.046 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
 MPDZ


multiple PDZ domain protein


chr3_-_58200398 0.046 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
 DNASE1L3


deoxyribonuclease I-like 3


chr11_-_18062872 0.045 ENST00000250018.2
 TPH1
tryptophan hydroxylase 1
chrX_-_57021943 0.045 ENST00000374919.3
 SPIN3
spindlin family, member 3
chr11_-_76381029 0.045 ENST00000407242.2
ENST00000421973.1
 LRRC32

leucine rich repeat containing 32

chr1_+_206516200 0.045 ENST00000295713.5
 SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr22_+_20692438 0.042 ENST00000434783.3
 FAM230A
family with sequence similarity 230, member A
chr8_-_99955042 0.042 ENST00000519420.1
 STK3
serine/threonine kinase 3
chr10_-_73976884 0.041 ENST00000317126.4
ENST00000545550.1
 ASCC1

activating signal cointegrator 1 complex subunit 1

chr1_+_24646263 0.038 ENST00000524724.1
 GRHL3
grainyhead-like 3 (Drosophila)
chr17_+_80816395 0.037 ENST00000576160.2
ENST00000571712.1
 TBCD

tubulin folding cofactor D

chr11_-_111649074 0.036 ENST00000534218.1
 RP11-108O10.2
RP11-108O10.2
chr10_-_73976025 0.035 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
 ASCC1






activating signal cointegrator 1 complex subunit 1






chr1_+_12806141 0.035 ENST00000288048.5
 C1orf158
chromosome 1 open reading frame 158
chr1_+_19578033 0.034 ENST00000330263.4
 MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr9_-_2844058 0.034 ENST00000397885.2
 KIAA0020
KIAA0020
chr11_+_102980126 0.034 ENST00000375735.2
 DYNC2H1
dynein, cytoplasmic 2, heavy chain 1
chrX_+_114874727 0.034 ENST00000543070.1
 PLS3
plastin 3
chrX_-_115594160 0.033 ENST00000371894.4
 CXorf61
cancer/testis antigen 83
chr2_+_24232918 0.032 ENST00000406420.3
ENST00000338315.4
 MFSD2B

major facilitator superfamily domain containing 2B

chr14_-_20801427 0.031 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
 CCNB1IP1


cyclin B1 interacting protein 1, E3 ubiquitin protein ligase


chr22_-_17302589 0.031 ENST00000331428.5
 XKR3
XK, Kell blood group complex subunit-related family, member 3
chr19_+_38880252 0.031 ENST00000586301.1
 SPRED3
sprouty-related, EVH1 domain containing 3
chr2_-_200320768 0.030 ENST00000428695.1
 SATB2
SATB homeobox 2
chr3_+_174577070 0.030 ENST00000454872.1
 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr5_-_96209315 0.029 ENST00000504056.1
 CTD-2260A17.2
Uncharacterized protein
chr10_-_75401500 0.027 ENST00000359322.4
 MYOZ1
myozenin 1
chr16_-_1538765 0.027 ENST00000447419.2
ENST00000440447.2
 PTX4

pentraxin 4, long

chr11_-_113577052 0.027 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
 TMPRSS5



transmembrane protease, serine 5



chr5_-_95158644 0.026 ENST00000237858.6
 GLRX
glutaredoxin (thioltransferase)
chr11_-_47399942 0.026 ENST00000227163.4
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_-_5849134 0.026 ENST00000545860.1
 ANO2
anoctamin 2
chr19_+_3762703 0.026 ENST00000589174.1
 MRPL54
mitochondrial ribosomal protein L54
chr11_-_47400078 0.026 ENST00000378538.3
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_149539767 0.026 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
 TAB2

RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2

RP1-111D6.3
chr4_-_142134031 0.024 ENST00000420921.2
 RNF150
ring finger protein 150
chr17_+_75316336 0.024 ENST00000591934.1
 SEPT9
septin 9
chr11_-_47400062 0.021 ENST00000533030.1
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr22_-_30662828 0.021 ENST00000403463.1
ENST00000215781.2
 OSM

oncostatin M

chr9_-_85882145 0.020 ENST00000328788.1
 FRMD3
FERM domain containing 3
chr5_+_158654712 0.019 ENST00000520323.1
 CTB-11I22.2
CTB-11I22.2
chr1_+_202789394 0.018 ENST00000330493.5
 RP11-480I12.4
Putative inactive alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515
chr10_-_43892668 0.018 ENST00000544000.1
 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr3_+_126113734 0.017 ENST00000352312.1
ENST00000393425.1
 CCDC37

coiled-coil domain containing 37

chr12_+_7456880 0.017 ENST00000399422.4
 ACSM4
acyl-CoA synthetase medium-chain family member 4
chr1_+_184020811 0.017 ENST00000361641.1
 TSEN15
TSEN15 tRNA splicing endonuclease subunit
chr19_+_49588677 0.017 ENST00000598984.1
ENST00000598441.1
 SNRNP70

small nuclear ribonucleoprotein 70kDa (U1)

chr13_+_49280951 0.016 ENST00000282018.3
 CYSLTR2
cysteinyl leukotriene receptor 2
chr12_-_110434096 0.016 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
 GIT2



G protein-coupled receptor kinase interacting ArfGAP 2



chr9_-_95166841 0.016 ENST00000262551.4
 OGN
osteoglycin
chr1_-_43638168 0.015 ENST00000431635.2
 EBNA1BP2
EBNA1 binding protein 2
chr13_+_109248500 0.015 ENST00000356711.2
 MYO16
myosin XVI
chr11_-_6790286 0.014 ENST00000338569.2
 OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr3_-_58613323 0.014 ENST00000474531.1
ENST00000465970.1
 FAM107A

family with sequence similarity 107, member A

chr1_+_144811943 0.014 ENST00000281815.8
 NBPF9
neuroblastoma breakpoint family, member 9
chr7_+_142457315 0.013 ENST00000486171.1
ENST00000311737.7
 PRSS1

protease, serine, 1 (trypsin 1)

chr18_-_67629015 0.012 ENST00000579496.1
 CD226
CD226 molecule
chr4_+_154622652 0.011 ENST00000260010.6
 TLR2
toll-like receptor 2
chr1_+_148560843 0.010 ENST00000442702.2
ENST00000369187.3
 NBPF15

neuroblastoma breakpoint family, member 15

chr2_+_87808725 0.009 ENST00000413202.1
 LINC00152
long intergenic non-protein coding RNA 152
chr18_-_56985776 0.009 ENST00000587244.1
 CPLX4
complexin 4
chr1_-_13698405 0.009 ENST00000540591.1
 PRAMEF19
PRAME family member 19
chr10_+_23384435 0.008 ENST00000376510.3
 MSRB2
methionine sulfoxide reductase B2
chr17_-_15168624 0.008 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
 PMP22


peripheral myelin protein 22


chr12_-_7848364 0.007 ENST00000329913.3
 GDF3
growth differentiation factor 3
chr4_-_74486109 0.007 ENST00000395777.2
 RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_+_184020830 0.007 ENST00000533373.1
ENST00000423085.2
 TSEN15

TSEN15 tRNA splicing endonuclease subunit

chr20_-_14318248 0.007 ENST00000378053.3
ENST00000341420.4
 FLRT3

fibronectin leucine rich transmembrane protein 3

chr8_+_110551925 0.006 ENST00000395785.2
 EBAG9
estrogen receptor binding site associated, antigen, 9
chrX_+_106163626 0.006 ENST00000336803.1
 CLDN2
claudin 2
chr2_+_171036635 0.006 ENST00000484338.2
ENST00000334231.6
 MYO3B

myosin IIIB

chr19_-_50990785 0.005 ENST00000595005.1
 CTD-2545M3.8
CTD-2545M3.8
chr4_+_156680153 0.005 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
 GUCY1B3




guanylate cyclase 1, soluble, beta 3




chr5_-_173043591 0.004 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
 BOD1


biorientation of chromosomes in cell division 1


chr9_-_95166884 0.004 ENST00000375561.5
 OGN
osteoglycin
chr11_+_29181503 0.004 ENST00000530960.1
 RP11-466I1.1
RP11-466I1.1
chr11_-_26593649 0.002 ENST00000455601.2
 MUC15
mucin 15, cell surface associated
chr19_-_44388116 0.002 ENST00000587539.1
 ZNF404
zinc finger protein 404
chr1_-_19578003 0.002 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
 EMC1



ER membrane protein complex subunit 1



chr9_-_95166976 0.002 ENST00000447356.1
 OGN
osteoglycin
chr10_-_45802907 0.001 ENST00000374401.2
 OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr5_+_140743859 0.000 ENST00000518069.1
 PCDHGA5
protocadherin gamma subfamily A, 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.2 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 0.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.2 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.2 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0044026 DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027)
0.0 0.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.0 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.0 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0016296 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.0 0.0 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis