Motif ID: SMAD2

Z-value: 0.714


Transcription factors associated with SMAD2:

Gene SymbolEntrez IDGene Name
SMAD2 ENSG00000175387.11 SMAD2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457192_454572780.957.6e-05Click!


Activity profile for motif SMAD2.

activity profile for motif SMAD2


Sorted Z-values histogram for motif SMAD2

Sorted Z-values for motif SMAD2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_2198604 1.737 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chrX_-_107018969 1.293 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr20_+_43343517 1.025 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr2_-_228028829 0.996 ENST00000396625.3
ENST00000329662.7
COL4A4

collagen, type IV, alpha 4

chr20_+_43343476 0.976 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr20_+_43343886 0.962 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chrX_-_107019181 0.729 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3



TSC22 domain family, member 3



chr1_+_33722080 0.655 ENST00000483388.1
ENST00000539719.1
ZNF362

zinc finger protein 362

chr22_+_31518938 0.607 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J






inositol polyphosphate-5-phosphatase J






chr12_+_53443963 0.601 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1


tensin like C1 domain containing phosphatase (tensin 2)


chr3_-_15374659 0.527 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr9_+_101867359 0.500 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr16_+_57702099 0.490 ENST00000333493.4
ENST00000327655.6
GPR97

G protein-coupled receptor 97

chr9_+_101867387 0.489 ENST00000374990.2
ENST00000552516.1
TGFBR1

transforming growth factor, beta receptor 1

chr17_+_7792101 0.445 ENST00000358181.4
ENST00000330494.7
CHD3

chromodomain helicase DNA binding protein 3

chr19_+_10527449 0.391 ENST00000592685.1
ENST00000380702.2
PDE4A

phosphodiesterase 4A, cAMP-specific

chr16_+_57702210 0.382 ENST00000450388.3
GPR97
G protein-coupled receptor 97
chr11_+_7597639 0.374 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_30852738 0.371 ENST00000508312.1
ENST00000512336.1
DDR1

discoidin domain receptor tyrosine kinase 1

chr22_+_48027423 0.368 ENST00000423737.1
RP11-191L9.4
RP11-191L9.4
chr9_-_73029540 0.354 ENST00000377126.2
KLF9
Kruppel-like factor 9
chrX_-_99987088 0.336 ENST00000372981.1
ENST00000263033.5
SYTL4

synaptotagmin-like 4

chr12_-_57410304 0.333 ENST00000441881.1
ENST00000458521.2
TAC3

tachykinin 3

chr6_+_32132360 0.325 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8


EGF-like-domain, multiple 8


chr19_+_49977818 0.323 ENST00000594009.1
ENST00000595510.1
FLT3LG

fms-related tyrosine kinase 3 ligand

chr6_+_30853002 0.309 ENST00000421124.2
ENST00000512725.1
DDR1

discoidin domain receptor tyrosine kinase 1

chr19_-_6481776 0.309 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C


DENN/MADD domain containing 1C


chr3_-_88108192 0.309 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr11_-_46142948 0.306 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr12_+_47473369 0.303 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr6_+_31730773 0.293 ENST00000415669.2
ENST00000425424.1
SAPCD1

suppressor APC domain containing 1

chr12_+_53443680 0.280 ENST00000314250.6
ENST00000451358.1
TENC1

tensin like C1 domain containing phosphatase (tensin 2)

chr7_-_102257139 0.277 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4




RAS p21 protein activator 4




chr5_-_151066514 0.271 ENST00000538026.1
ENST00000522348.1
ENST00000521569.1
SPARC


secreted protein, acidic, cysteine-rich (osteonectin)


chr2_+_113033164 0.266 ENST00000409871.1
ENST00000343936.4
ZC3H6

zinc finger CCCH-type containing 6

chr19_+_11466062 0.264 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410


Lipid phosphate phosphatase-related protein type 2


chr17_-_10017864 0.263 ENST00000323816.4
GAS7
growth arrest-specific 7
chr20_+_34680620 0.260 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1


erythrocyte membrane protein band 4.1-like 1


chr6_+_99282570 0.255 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chrX_+_48660565 0.238 ENST00000413163.2
ENST00000441703.1
ENST00000426196.1
HDAC6


histone deacetylase 6


chr7_-_10979750 0.235 ENST00000339600.5
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr19_+_11466167 0.233 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr12_-_6740802 0.233 ENST00000431922.1
LPAR5
lysophosphatidic acid receptor 5
chr2_-_220173685 0.227 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN


protein tyrosine phosphatase, receptor type, N


chr1_+_93913665 0.225 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L


formin binding protein 1-like


chr19_-_3551043 0.221 ENST00000589995.1
MFSD12
major facilitator superfamily domain containing 12
chr5_-_74062867 0.220 ENST00000509097.1
GFM2
G elongation factor, mitochondrial 2
chr5_-_150521192 0.214 ENST00000523714.1
ENST00000521749.1
ANXA6

annexin A6

chrX_+_48660107 0.213 ENST00000376643.2
HDAC6
histone deacetylase 6
chr9_-_28670283 0.213 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr13_-_96705624 0.211 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
UGGT2



UDP-glucose glycoprotein glucosyltransferase 2



chr22_+_38035623 0.208 ENST00000336738.5
ENST00000442465.2
SH3BP1

SH3-domain binding protein 1

chr17_-_15165854 0.207 ENST00000395936.1
ENST00000395938.2
PMP22

peripheral myelin protein 22

chr1_+_100111479 0.204 ENST00000263174.4
PALMD
palmdelphin
chr11_+_2923423 0.198 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr16_+_28889801 0.193 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr16_+_28889703 0.193 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr4_-_39640700 0.192 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr17_+_68165657 0.192 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_-_201915590 0.188 ENST00000367288.4
LMOD1
leiomodin 1 (smooth muscle)
chr19_-_14224969 0.186 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr19_-_44285401 0.186 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_+_41010293 0.173 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2


translocator protein 2


chr1_+_100111580 0.173 ENST00000605497.1
PALMD
palmdelphin
chr12_-_71003568 0.169 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB




protein tyrosine phosphatase, receptor type, B




chr22_+_22676808 0.169 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr3_+_23847394 0.167 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr1_-_1243252 0.165 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr17_-_1389419 0.163 ENST00000575158.1
MYO1C
myosin IC
chr4_-_140477353 0.160 ENST00000406354.1
ENST00000506866.2
SETD7

SET domain containing (lysine methyltransferase) 7

chr1_-_207119738 0.157 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chrX_+_48660287 0.155 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6



histone deacetylase 6



chr22_+_29876197 0.151 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr9_-_136006496 0.149 ENST00000372062.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr3_-_79068138 0.149 ENST00000495273.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_15165825 0.148 ENST00000426385.3
PMP22
peripheral myelin protein 22
chr6_-_134861089 0.147 ENST00000606039.1
RP11-557H15.4
RP11-557H15.4
chr9_-_34523027 0.145 ENST00000399775.2
ENHO
energy homeostasis associated
chr10_+_102821551 0.140 ENST00000370200.5
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr3_+_23847432 0.138 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr16_+_58549378 0.138 ENST00000310682.2
ENST00000394266.4
ENST00000219315.4
SETD6


SET domain containing 6


chr9_-_140513231 0.137 ENST00000371417.3
C9orf37
chromosome 9 open reading frame 37
chr11_-_46142615 0.135 ENST00000529734.1
ENST00000323180.6
PHF21A

PHD finger protein 21A

chr5_+_33441053 0.135 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS


threonyl-tRNA synthetase


chr15_+_45879964 0.134 ENST00000565409.1
ENST00000564765.1
BLOC1S6

biogenesis of lysosomal organelles complex-1, subunit 6, pallidin

chr18_+_20715416 0.131 ENST00000580153.1
CABLES1
Cdk5 and Abl enzyme substrate 1
chr20_+_42143053 0.130 ENST00000373135.3
ENST00000444063.1
L3MBTL1

l(3)mbt-like 1 (Drosophila)

chr4_-_39640513 0.128 ENST00000511809.1
ENST00000505729.1
SMIM14

small integral membrane protein 14

chr19_-_54824344 0.124 ENST00000346508.3
ENST00000446712.3
ENST00000432233.3
ENST00000301219.3
LILRA5



leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5



chr8_-_117886732 0.123 ENST00000517485.1
RAD21
RAD21 homolog (S. pombe)
chr1_-_94586651 0.122 ENST00000535735.1
ENST00000370225.3
ABCA4

ATP-binding cassette, sub-family A (ABC1), member 4

chr7_-_100493744 0.121 ENST00000428317.1
ENST00000441605.1
ACHE

acetylcholinesterase (Yt blood group)

chr22_+_24891210 0.120 ENST00000382760.2
UPB1
ureidopropionase, beta
chrX_+_153029633 0.114 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3



plexin B3



chr3_-_150320937 0.112 ENST00000479209.1
SERP1
stress-associated endoplasmic reticulum protein 1
chr7_-_102158157 0.111 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B


RAS p21 protein activator 4B


chr1_+_174933899 0.110 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr20_-_56284816 0.110 ENST00000395819.3
ENST00000341744.3
PMEPA1

prostate transmembrane protein, androgen induced 1

chr9_+_140145713 0.108 ENST00000388931.3
ENST00000412566.1
C9orf173

chromosome 9 open reading frame 173

chr7_-_130080681 0.104 ENST00000469826.1
CEP41
centrosomal protein 41kDa
chr16_+_58059470 0.104 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chrY_+_16634483 0.101 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr11_-_117166201 0.101 ENST00000510915.1
BACE1
beta-site APP-cleaving enzyme 1
chr19_-_51587502 0.098 ENST00000156499.2
ENST00000391802.1
KLK14

kallikrein-related peptidase 14

chr19_-_46272462 0.097 ENST00000317578.6
SIX5
SIX homeobox 5
chr1_+_26872324 0.094 ENST00000531382.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_-_142377367 0.093 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr12_-_3982511 0.090 ENST00000427057.2
ENST00000228820.4
PARP11

poly (ADP-ribose) polymerase family, member 11

chr12_-_104531785 0.089 ENST00000551727.1
NFYB
nuclear transcription factor Y, beta
chr11_-_1619524 0.088 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr11_+_64808675 0.087 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr6_-_30523865 0.087 ENST00000433809.1
GNL1
guanine nucleotide binding protein-like 1
chr19_+_16999654 0.087 ENST00000248076.3
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr4_+_39640787 0.086 ENST00000532680.1
RP11-539G18.2
RP11-539G18.2
chr12_-_56583243 0.084 ENST00000550164.1
SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr11_-_74204692 0.084 ENST00000528085.1
LIPT2
lipoyl(octanoyl) transferase 2 (putative)
chrX_-_30595959 0.084 ENST00000378962.3
CXorf21
chromosome X open reading frame 21
chr12_-_89918522 0.083 ENST00000529983.2
GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
chr12_+_122516626 0.083 ENST00000319080.7
MLXIP
MLX interacting protein
chr16_-_11681316 0.083 ENST00000571688.1
LITAF
lipopolysaccharide-induced TNF factor
chr11_-_108464465 0.080 ENST00000525344.1
EXPH5
exophilin 5
chrX_-_100183894 0.080 ENST00000328526.5
ENST00000372956.2
XKRX

XK, Kell blood group complex subunit-related, X-linked

chrX_+_591524 0.080 ENST00000554971.1
ENST00000381575.1
SHOX

short stature homeobox

chr19_-_14606900 0.076 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1






GIPC PDZ domain containing family, member 1






chr5_+_64064748 0.076 ENST00000381070.3
ENST00000508024.1
CWC27

CWC27 spliceosome-associated protein homolog (S. cerevisiae)

chr3_+_195447738 0.076 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20


mucin 20, cell surface associated


chr11_-_65150103 0.073 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45




solute carrier family 25, member 45




chr10_-_14372870 0.071 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr9_+_5890802 0.070 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA


melan-A


chr8_-_123706338 0.070 ENST00000521608.1
RP11-973F15.1
long intergenic non-protein coding RNA 1151
chr6_+_6588902 0.068 ENST00000230568.4
LY86
lymphocyte antigen 86
chr7_-_130080818 0.067 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41


centrosomal protein 41kDa


chr7_+_39125365 0.065 ENST00000559001.1
ENST00000464276.2
POU6F2

POU class 6 homeobox 2

chr16_-_4987065 0.064 ENST00000590782.2
ENST00000345988.2
PPL

periplakin

chr22_+_19702069 0.063 ENST00000412544.1
SEPT5
septin 5
chr12_-_52604607 0.061 ENST00000551894.1
ENST00000553017.1
C12orf80

chromosome 12 open reading frame 80

chr5_-_145895753 0.056 ENST00000311104.2
GPR151
G protein-coupled receptor 151
chr7_-_130080977 0.056 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr7_+_69064566 0.056 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr1_-_151119087 0.055 ENST00000341697.3
ENST00000368914.3
SEMA6C

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr3_+_52529346 0.055 ENST00000321725.6
STAB1
stabilin 1
chr17_+_65375082 0.054 ENST00000584471.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_+_143772060 0.053 ENST00000367591.4
PEX3
peroxisomal biogenesis factor 3
chr10_-_102046098 0.052 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr20_+_36888551 0.052 ENST00000418004.1
ENST00000451435.1
BPI

bactericidal/permeability-increasing protein

chr8_-_96281419 0.051 ENST00000286688.5
C8orf37
chromosome 8 open reading frame 37
chr11_-_22647350 0.050 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr10_-_102046417 0.047 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr1_-_149908710 0.047 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11


myotubularin related protein 11


chr2_+_113735575 0.047 ENST00000376489.2
ENST00000259205.4
IL36G

interleukin 36, gamma

chr11_+_71238313 0.047 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr1_-_235813290 0.047 ENST00000391854.2
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chrX_+_24167828 0.047 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX



zinc finger protein, X-linked



chr6_+_143771934 0.046 ENST00000367592.1
PEX3
peroxisomal biogenesis factor 3
chr8_-_125384927 0.044 ENST00000297632.6
TMEM65
transmembrane protein 65
chr3_-_187694195 0.043 ENST00000446091.1
RP11-132N15.3
RP11-132N15.3
chr3_-_51937331 0.041 ENST00000310914.5
IQCF1
IQ motif containing F1
chr17_-_58469687 0.040 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr7_-_130418888 0.040 ENST00000310992.4
KLF14
Kruppel-like factor 14
chr8_+_106331769 0.039 ENST00000520492.1
ZFPM2
zinc finger protein, FOG family member 2
chr16_-_54320675 0.039 ENST00000329734.3
IRX3
iroquois homeobox 3
chrX_-_151143140 0.039 ENST00000393914.3
ENST00000370328.3
ENST00000370325.1
GABRE


gamma-aminobutyric acid (GABA) A receptor, epsilon


chr14_+_70078303 0.038 ENST00000342745.4
KIAA0247
KIAA0247
chr16_+_58549412 0.038 ENST00000447443.1
SETD6
SET domain containing 6
chr7_+_130020180 0.038 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1


carboxypeptidase A1 (pancreatic)


chr15_+_74610894 0.037 ENST00000558821.1
ENST00000268082.4
CCDC33

coiled-coil domain containing 33

chr6_+_108487245 0.037 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr12_+_1800179 0.036 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr9_+_33524240 0.036 ENST00000290943.6
ANKRD18B
ankyrin repeat domain 18B
chr12_-_8765446 0.036 ENST00000537228.1
ENST00000229335.6
AICDA

activation-induced cytidine deaminase

chr11_-_75379479 0.034 ENST00000434603.2
MAP6
microtubule-associated protein 6
chr1_+_226411319 0.034 ENST00000542034.1
ENST00000366810.5
MIXL1

Mix paired-like homeobox

chr14_+_81421355 0.034 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr22_-_44287875 0.033 ENST00000438734.1
ENST00000597664.1
ENST00000216177.4
ENST00000593866.1
ENST00000381198.2
PNPLA5




patatin-like phospholipase domain containing 5




chr12_-_108991778 0.032 ENST00000549447.1
TMEM119
transmembrane protein 119
chr19_-_18337240 0.032 ENST00000262805.12
PDE4C
phosphodiesterase 4C, cAMP-specific
chr11_-_75379612 0.030 ENST00000526740.1
MAP6
microtubule-associated protein 6
chr19_-_52150053 0.030 ENST00000222107.4
ENST00000360844.6
ENST00000599649.1
ENST00000429354.3
SIGLEC5
SIGLEC14
SIGLEC5

sialic acid binding Ig-like lectin 5
sialic acid binding Ig-like lectin 14
SIGLEC5

chr14_-_68159152 0.030 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr9_+_15422702 0.030 ENST00000380821.3
ENST00000421710.1
SNAPC3

small nuclear RNA activating complex, polypeptide 3, 50kDa

chr10_+_102729249 0.029 ENST00000519649.1
ENST00000518124.1
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr4_-_164534657 0.028 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr4_-_103748880 0.026 ENST00000453744.2
ENST00000349311.8
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr20_+_34020827 0.026 ENST00000374375.1
GDF5OS
growth differentiation factor 5 opposite strand
chr2_+_27237615 0.026 ENST00000458529.1
ENST00000402218.1
MAPRE3

microtubule-associated protein, RP/EB family, member 3

chr15_+_74509530 0.025 ENST00000321288.5
CCDC33
coiled-coil domain containing 33
chr16_+_2286726 0.023 ENST00000382437.4
ENST00000569184.1
DNASE1L2

deoxyribonuclease I-like 2

chr17_-_74533963 0.023 ENST00000293230.5
CYGB
cytoglobin
chr20_-_23066953 0.023 ENST00000246006.4
CD93
CD93 molecule
chrX_+_24167746 0.022 ENST00000428571.1
ENST00000539115.1
ZFX

zinc finger protein, X-linked

chr11_-_75380165 0.021 ENST00000304771.3
MAP6
microtubule-associated protein 6
chr4_+_39640754 0.021 ENST00000529094.1
ENST00000533736.1
RP11-539G18.2

RP11-539G18.2

chr20_-_25062767 0.019 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
VSX1


visual system homeobox 1


chr12_-_120241187 0.018 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr16_-_56459354 0.018 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr7_-_100493482 0.018 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE



acetylcholinesterase (Yt blood group)



chr6_-_30128657 0.017 ENST00000449742.2
ENST00000376704.3
TRIM10

tripartite motif containing 10

chr20_+_57226841 0.017 ENST00000358029.4
ENST00000361830.3
STX16

syntaxin 16

chr20_-_45976816 0.016 ENST00000441977.1
ZMYND8
zinc finger, MYND-type containing 8
chr21_-_38639813 0.016 ENST00000309117.6
ENST00000398998.1
DSCR3

Down syndrome critical region gene 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 1.0 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.2 0.6 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.4 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.1 0.2 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 0.3 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.4 GO:0051414 response to cortisol(GO:0051414)
0.1 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.3 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.1 0.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 1.0 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.1 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 0.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.2 GO:0002415 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 1.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0048867 ganglion mother cell fate determination(GO:0007402) stem cell fate determination(GO:0048867)
0.0 0.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.0 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.0 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0007320 insemination(GO:0007320)
0.0 0.4 GO:0032060 bleb assembly(GO:0032060)
0.0 0.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 1.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0045160 myosin I complex(GO:0045160)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0043426 MRF binding(GO:0043426)
0.1 0.6 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 1.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.6 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions