Motif ID: SIX6

Z-value: 0.636


Transcription factors associated with SIX6:

Gene SymbolEntrez IDGene Name
SIX6 ENSG00000184302.6 SIX6



Activity profile for motif SIX6.

activity profile for motif SIX6


Sorted Z-values histogram for motif SIX6

Sorted Z-values for motif SIX6



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_91061712 2.083 ENST00000371826.3
 IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_+_71104588 1.825 ENST00000418403.1
 RP11-462G2.1
RP11-462G2.1
chr12_-_121476959 1.821 ENST00000339275.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121477039 1.814 ENST00000257570.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121476750 1.449 ENST00000543677.1
 OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_67405438 1.143 ENST00000305454.3
 C8orf46
chromosome 8 open reading frame 46
chr5_-_66492562 0.960 ENST00000256447.4
 CD180
CD180 molecule
chr19_-_14628645 0.398 ENST00000598235.1
 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr8_+_101170257 0.372 ENST00000251809.3
 SPAG1
sperm associated antigen 1
chr15_+_63414760 0.344 ENST00000557972.1
 LACTB
lactamase, beta
chr1_-_157014865 0.297 ENST00000361409.2
 ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr19_+_3136115 0.274 ENST00000262958.3
 GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr8_-_82598067 0.263 ENST00000523942.1
ENST00000522997.1
 IMPA1

inositol(myo)-1(or 4)-monophosphatase 1

chr16_-_21436459 0.246 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3


nuclear pore complex interacting protein family, member B3


chr12_-_10601963 0.242 ENST00000543893.1
 KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr16_+_22524844 0.222 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
 NPIPB5



nuclear pore complex interacting protein family, member B5



chr22_+_24666763 0.221 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
 SPECC1L



sperm antigen with calponin homology and coiled-coil domains 1-like



chr14_+_20937538 0.220 ENST00000361505.5
ENST00000553591.1
 PNP

purine nucleoside phosphorylase

chr16_-_29517141 0.215 ENST00000550665.1
 RP11-231C14.4
Uncharacterized protein
chr2_+_21444025 0.209 ENST00000435237.1
ENST00000457901.1
 AC067959.1

AC067959.1

chr1_-_36235559 0.184 ENST00000251195.5
 CLSPN
claspin
chr12_-_71512027 0.182 ENST00000549357.1
 CTD-2021H9.3
Uncharacterized protein
chr1_+_179263308 0.175 ENST00000426956.1
 SOAT1
sterol O-acyltransferase 1
chr16_+_22524379 0.154 ENST00000536620.1
 NPIPB5
nuclear pore complex interacting protein family, member B5
chr1_-_150669604 0.152 ENST00000427665.1
ENST00000540514.1
 GOLPH3L

golgi phosphoprotein 3-like

chr16_-_21868978 0.149 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
 NPIPB4



nuclear pore complex interacting protein family, member B4



chr16_+_66410244 0.148 ENST00000562048.1
ENST00000568155.2
 CDH5

cadherin 5, type 2 (vascular endothelium)

chr12_+_119616447 0.146 ENST00000281938.2
 HSPB8
heat shock 22kDa protein 8
chr16_-_21868739 0.143 ENST00000415645.2
 NPIPB4
nuclear pore complex interacting protein family, member B4
chr3_-_111314230 0.134 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr6_-_8102279 0.122 ENST00000488226.2
 EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr12_-_122018859 0.117 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
 KDM2B


lysine (K)-specific demethylase 2B


chr17_-_67224812 0.113 ENST00000423818.2
 ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr12_-_122018346 0.113 ENST00000377069.4
 KDM2B
lysine (K)-specific demethylase 2B
chrX_-_20236970 0.109 ENST00000379548.4
 RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr12_-_46385811 0.107 ENST00000419565.2
 SCAF11
SR-related CTD-associated factor 11
chr8_-_110660975 0.107 ENST00000528045.1
 SYBU
syntabulin (syntaxin-interacting)
chr22_+_20877924 0.102 ENST00000445189.1
 MED15
mediator complex subunit 15
chr19_-_53426700 0.100 ENST00000596623.1
 ZNF888
zinc finger protein 888
chr3_-_196242233 0.099 ENST00000397537.2
 SMCO1
single-pass membrane protein with coiled-coil domains 1
chrX_-_118699325 0.098 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
 CXorf56


chromosome X open reading frame 56


chrX_+_38660704 0.093 ENST00000378474.3
 MID1IP1
MID1 interacting protein 1
chrX_-_53350522 0.089 ENST00000396435.3
ENST00000375368.5
 IQSEC2

IQ motif and Sec7 domain 2

chr16_-_87350970 0.088 ENST00000567970.1
 C16orf95
chromosome 16 open reading frame 95
chr4_-_71532668 0.087 ENST00000510437.1
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_53308398 0.085 ENST00000371528.1
 ZYG11A
zyg-11 family member A, cell cycle regulator
chr3_-_53916202 0.085 ENST00000335754.3
 ACTR8
ARP8 actin-related protein 8 homolog (yeast)
chr19_-_1650666 0.082 ENST00000588136.1
 TCF3
transcription factor 3
chr2_-_71222466 0.082 ENST00000606025.1
 AC007040.11
Uncharacterized protein
chr13_+_73629107 0.078 ENST00000539231.1
 KLF5
Kruppel-like factor 5 (intestinal)
chr3_-_107596910 0.072 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
 LINC00635












long intergenic non-protein coding RNA 635












chr16_-_1538765 0.070 ENST00000447419.2
ENST00000440447.2
 PTX4

pentraxin 4, long

chr17_+_60501228 0.065 ENST00000311506.5
 METTL2A
methyltransferase like 2A
chr5_+_171621176 0.064 ENST00000398186.4
 EFCAB9
EF-hand calcium binding domain 9
chr17_-_6524159 0.061 ENST00000589033.1
 KIAA0753
KIAA0753
chr9_-_135230336 0.060 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
 SETX


senataxin


chr12_+_10705960 0.059 ENST00000544591.1
 RP11-291B21.2
RP11-291B21.2
chrX_+_128674213 0.058 ENST00000371113.4
ENST00000357121.5
 OCRL

oculocerebrorenal syndrome of Lowe

chr13_+_42712178 0.057 ENST00000536612.1
 DGKH
diacylglycerol kinase, eta
chr9_-_67786624 0.055 ENST00000455764.2
 FAM27E3
family with sequence similarity 27, member E3
chr1_+_160709055 0.053 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7



SLAM family member 7



chr6_-_26043885 0.050 ENST00000357905.2
 HIST1H2BB
histone cluster 1, H2bb
chr1_-_67142710 0.050 ENST00000502413.2
 AL139147.1
Uncharacterized protein
chr20_-_4990931 0.050 ENST00000379333.1
 SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr3_+_151531859 0.049 ENST00000488869.1
 AADAC
arylacetamide deacetylase
chr19_+_46000479 0.048 ENST00000456399.2
 PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr12_-_11091862 0.046 ENST00000537503.1
 TAS2R14
taste receptor, type 2, member 14
chr9_-_99382065 0.045 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B


cell division cycle 14B


chr9_-_100684845 0.044 ENST00000375119.3
 C9orf156
chromosome 9 open reading frame 156
chr4_-_71532601 0.043 ENST00000510614.1
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr18_+_158327 0.043 ENST00000582707.1
 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chrX_+_142113704 0.041 ENST00000446864.1
ENST00000370504.3
 SPANXN4

SPANX family, member N4

chr4_+_74301880 0.039 ENST00000395792.2
ENST00000226359.2
 AFP

alpha-fetoprotein

chr4_-_71532339 0.038 ENST00000254801.4
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr12_-_498620 0.037 ENST00000399788.2
ENST00000382815.4
 KDM5A

lysine (K)-specific demethylase 5A

chrX_-_99665262 0.037 ENST00000373034.4
ENST00000255531.7
 PCDH19

protocadherin 19

chr12_-_28123206 0.036 ENST00000542963.1
ENST00000535992.1
 PTHLH

parathyroid hormone-like hormone

chr2_+_27760247 0.034 ENST00000447166.1
 AC109829.1
Uncharacterized protein
chr9_+_93759317 0.033 ENST00000563268.1
 RP11-367F23.2
RP11-367F23.2
chr10_-_79397479 0.032 ENST00000404771.3
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_77225135 0.031 ENST00000458128.1
 PGAM4
phosphoglycerate mutase family member 4
chr1_+_156119798 0.027 ENST00000355014.2
 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr12_-_28122980 0.027 ENST00000395868.3
ENST00000534890.1
 PTHLH

parathyroid hormone-like hormone

chr7_+_117251671 0.027 ENST00000468795.1
 CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr11_+_74699942 0.027 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
 NEU3




sialidase 3 (membrane sialidase)




chr10_-_14614311 0.027 ENST00000479731.1
ENST00000468492.1
 FAM107B

family with sequence similarity 107, member B

chr15_+_69857515 0.026 ENST00000559477.1
 RP11-279F6.1
RP11-279F6.1
chr1_+_145413268 0.025 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
 HFE2



hemochromatosis type 2 (juvenile)



chr11_-_45307817 0.023 ENST00000020926.3
 SYT13
synaptotagmin XIII
chr1_+_63063152 0.022 ENST00000371129.3
 ANGPTL3
angiopoietin-like 3
chrY_+_16168097 0.022 ENST00000250823.4
 VCY1B
variable charge, Y-linked 1B
chr7_-_92855762 0.021 ENST00000453812.2
ENST00000394468.2
 HEPACAM2

HEPACAM family member 2

chr17_-_5342380 0.021 ENST00000225698.4
 C1QBP
complement component 1, q subcomponent binding protein
chr10_-_75008620 0.020 ENST00000372950.4
 DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr5_+_161277603 0.020 ENST00000519621.1
 GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_+_31885963 0.018 ENST00000373709.3
 SERINC2
serine incorporator 2
chr22_-_19137796 0.017 ENST00000086933.2
 GSC2
goosecoid homeobox 2
chr4_-_184241927 0.017 ENST00000323319.5
 CLDN22
claudin 22
chr6_-_26189304 0.016 ENST00000340756.2
 HIST1H4D
histone cluster 1, H4d
chr2_-_77749387 0.016 ENST00000409884.1
 LRRTM4
leucine rich repeat transmembrane neuronal 4
chr3_+_40141502 0.015 ENST00000539167.1
 MYRIP
myosin VIIA and Rab interacting protein
chr3_+_151531810 0.015 ENST00000232892.7
 AADAC
arylacetamide deacetylase
chr1_-_161015663 0.015 ENST00000534633.1
 USF1
upstream transcription factor 1
chr11_-_102496063 0.014 ENST00000260228.2
 MMP20
matrix metallopeptidase 20
chrY_-_16098393 0.013 ENST00000250825.4
 VCY
variable charge, Y-linked
chrX_-_55020511 0.013 ENST00000375006.3
ENST00000374992.2
 PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

chr20_+_54987168 0.013 ENST00000360314.3
 CASS4
Cas scaffolding protein family member 4
chr19_+_9203855 0.011 ENST00000429566.3
 OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr1_-_20446020 0.010 ENST00000375105.3
 PLA2G2D
phospholipase A2, group IID
chr6_+_146348810 0.010 ENST00000492807.2
 GRM1
glutamate receptor, metabotropic 1
chr8_+_32579341 0.010 ENST00000519240.1
ENST00000539990.1
 NRG1

neuregulin 1

chr2_-_77749474 0.007 ENST00000409093.1
ENST00000409088.3
 LRRTM4

leucine rich repeat transmembrane neuronal 4

chr6_+_146348782 0.006 ENST00000361719.2
ENST00000392299.2
 GRM1

glutamate receptor, metabotropic 1

chr12_+_133614062 0.005 ENST00000540031.1
ENST00000536123.1
 ZNF84

zinc finger protein 84

chr1_-_10003372 0.005 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
 LZIC


leucine zipper and CTNNBIP1 domain containing


chr2_-_77749336 0.004 ENST00000409282.1
 LRRTM4
leucine rich repeat transmembrane neuronal 4
chrX_-_18238999 0.004 ENST00000380033.4
ENST00000380030.3
 BEND2

BEN domain containing 2

chr3_-_9994021 0.004 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr2_-_238305397 0.004 ENST00000409809.1
 COL6A3
collagen, type VI, alpha 3
chr5_-_117897751 0.003 ENST00000515704.1
ENST00000506769.1
 CTD-2281M20.1

CTD-2281M20.1

chr13_-_46679185 0.002 ENST00000439329.3
 CPB2
carboxypeptidase B2 (plasma)
chr6_+_127898312 0.001 ENST00000329722.7
 C6orf58
chromosome 6 open reading frame 58
chr13_+_34392200 0.001 ENST00000434425.1
 RFC3
replication factor C (activator 1) 3, 38kDa
chr5_+_175490540 0.001 ENST00000515817.1
 FAM153B
family with sequence similarity 153, member B
chr8_+_32579321 0.001 ENST00000522402.1
 NRG1
neuregulin 1
chr6_+_52051171 0.000 ENST00000340057.1
 IL17A
interleukin 17A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 1.0 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.2 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 5.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.3 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.3 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.0 GO:0015993 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.2 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.3 GO:0031403 lithium ion binding(GO:0031403)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.0 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.0 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism