• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: SIX4

Z-value: 0.317

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr13_-_78492927	0.421	ENST00000334286.5	EDNRB	endothelin receptor type B
chr3_-_52488048	0.340	ENST00000232975.3	TNNC1	troponin C type 1 (slow)
chr13_-_78492955	0.327	ENST00000446573.1	EDNRB	endothelin receptor type B
chr8_+_144798429	0.185	ENST00000338033.4 ENST00000395107.4 ENST00000395108.2	MAPK15	mitogen-activated protein kinase 15
chr1_+_226250379	0.184	ENST00000366815.3 ENST00000366814.3	H3F3A	H3 histone, family 3A
chr3_-_93692681	0.163	ENST00000348974.4	PROS1	protein S (alpha)
chr11_-_2906979	0.145	ENST00000380725.1 ENST00000313407.6 ENST00000430149.2 ENST00000440480.2 ENST00000414822.3	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr2_+_85811525	0.136	ENST00000306384.4	VAMP5	vesicle-associated membrane protein 5
chr10_-_75255724	0.134	ENST00000342558.3 ENST00000360663.5 ENST00000394829.2 ENST00000394828.2 ENST00000394822.2	PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme
chr5_+_85913721	0.127	ENST00000247655.3 ENST00000509578.1 ENST00000515763.1	COX7C	cytochrome c oxidase subunit VIIc
chr3_+_32147997	0.121	ENST00000282541.5	GPD1L	glycerol-3-phosphate dehydrogenase 1-like
chr11_+_117049910	0.115	ENST00000431081.2 ENST00000524842.1	SIDT2	SID1 transmembrane family, member 2
chr11_+_117049854	0.107	ENST00000278951.7	SIDT2	SID1 transmembrane family, member 2
chr12_+_43086018	0.104	ENST00000550177.1	RP11-25I15.3	RP11-25I15.3
chr19_+_11466167	0.103	ENST00000591608.1	DKFZP761J1410	Lipid phosphate phosphatase-related protein type 2
chr2_+_128458514	0.099	ENST00000310981.4	SFT2D3	SFT2 domain containing 3
chr11_-_96076334	0.099	ENST00000524717.1	MAML2	mastermind-like 2 (Drosophila)
chr7_-_99063769	0.094	ENST00000430982.1 ENST00000555673.1 ENST00000394186.3 ENST00000359832.4 ENST00000449683.1 ENST00000488775.1 ENST00000523680.1 ENST00000292475.3 ENST00000413834.1	PTCD1 ATP5J2 ATP5J2-PTCD1	pentatricopeptide repeat domain 1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 ATP5J2-PTCD1 readthrough
chr11_+_117049445	0.083	ENST00000324225.4 ENST00000532960.1	SIDT2	SID1 transmembrane family, member 2
chrX_-_19504642	0.080	ENST00000469203.2	MAP3K15	mitogen-activated protein kinase kinase kinase 15
chr19_+_30414551	0.078	ENST00000360605.4 ENST00000570564.1 ENST00000574233.1 ENST00000585655.1	URI1	URI1, prefoldin-like chaperone
chr4_+_11470867	0.078	ENST00000515343.1	RP11-281P23.1	RP11-281P23.1
chr19_+_19174795	0.073	ENST00000318596.7	SLC25A42	solute carrier family 25, member 42
chrX_-_119763835	0.068	ENST00000371313.2 ENST00000304661.5	C1GALT1C1	C1GALT1-specific chaperone 1
chr19_+_11466062	0.066	ENST00000251473.5 ENST00000591329.1 ENST00000586380.1	DKFZP761J1410	Lipid phosphate phosphatase-related protein type 2
chr1_-_207119738	0.065	ENST00000356495.4	PIGR	polymeric immunoglobulin receptor
chr2_+_120687335	0.063	ENST00000544261.1	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_-_224624730	0.062	ENST00000445239.1	WDR26	WD repeat domain 26
chr6_+_160693591	0.060	ENST00000419196.1	RP1-276N6.2	RP1-276N6.2
chr2_+_219135115	0.058	ENST00000248451.3 ENST00000273077.4	PNKD	paroxysmal nonkinesigenic dyskinesia
chr12_+_133757995	0.053	ENST00000536435.2 ENST00000228289.5 ENST00000541211.2 ENST00000500625.3 ENST00000539248.2 ENST00000542711.2 ENST00000536899.2 ENST00000542986.2 ENST00000537565.1 ENST00000541975.2	ZNF268	zinc finger protein 268
chr12_+_133758115	0.051	ENST00000541009.2 ENST00000592241.1	ZNF268	zinc finger protein 268
chr7_+_69064566	0.051	ENST00000403018.2	AUTS2	autism susceptibility candidate 2
chr4_-_84255935	0.049	ENST00000513463.1	HPSE	heparanase
chr11_-_130184555	0.047	ENST00000525842.1	ZBTB44	zinc finger and BTB domain containing 44
chrX_+_56100757	0.046	ENST00000433279.1	AL353698.1	Uncharacterized protein
chr10_-_131762105	0.045	ENST00000368648.3 ENST00000355311.5	EBF3	early B-cell factor 3
chr1_+_231473743	0.044	ENST00000295050.7	SPRTN	SprT-like N-terminal domain
chr14_-_67981870	0.044	ENST00000555994.1	TMEM229B	transmembrane protein 229B
chr15_-_73661605	0.043	ENST00000261917.3	HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr17_+_15635561	0.040	ENST00000584301.1 ENST00000580596.1 ENST00000464963.1 ENST00000437605.2 ENST00000579428.1	TBC1D26	TBC1 domain family, member 26
chr10_+_89622870	0.040	ENST00000371953.3	PTEN	phosphatase and tensin homolog
chr1_+_26737253	0.038	ENST00000326279.6	LIN28A	lin-28 homolog A (C. elegans)
chr19_-_474880	0.037	ENST00000382696.3 ENST00000315489.4	ODF3L2	outer dense fiber of sperm tails 3-like 2
chr5_+_78365536	0.037	ENST00000255192.3	BHMT2	betaine--homocysteine S-methyltransferase 2
chr14_-_67981916	0.037	ENST00000357461.2	TMEM229B	transmembrane protein 229B
chr11_-_130184470	0.037	ENST00000357899.4 ENST00000397753.1	ZBTB44	zinc finger and BTB domain containing 44
chr14_-_70038032	0.037	ENST00000543986.1	CCDC177	coiled-coil domain containing 177
chr1_+_116915855	0.034	ENST00000295598.5	ATP1A1	ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr12_-_4488872	0.033	ENST00000237837.1	FGF23	fibroblast growth factor 23
chrX_+_70503037	0.033	ENST00000535149.1	NONO	non-POU domain containing, octamer-binding
chr16_-_15180257	0.033	ENST00000540462.1	RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chrX_+_48687283	0.032	ENST00000338270.1	ERAS	ES cell expressed Ras
chr22_+_37318082	0.031	ENST00000406230.1	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr11_+_117947782	0.031	ENST00000522307.1 ENST00000523251.1 ENST00000437212.3 ENST00000522824.1 ENST00000522151.1	TMPRSS4	transmembrane protease, serine 4
chr14_+_38065052	0.030	ENST00000556845.1	TTC6	tetratricopeptide repeat domain 6
chr20_-_43150601	0.027	ENST00000541235.1 ENST00000255175.1 ENST00000342374.4	SERINC3	serine incorporator 3
chr4_-_2420335	0.027	ENST00000503000.1	ZFYVE28	zinc finger, FYVE domain containing 28
chr22_-_30960876	0.026	ENST00000401975.1 ENST00000428682.1 ENST00000423299.1	GAL3ST1	galactose-3-O-sulfotransferase 1
chr17_-_72527605	0.026	ENST00000392621.1 ENST00000314401.3	CD300LB	CD300 molecule-like family member b
chr22_-_39268308	0.025	ENST00000407418.3	CBX6	chromobox homolog 6
chr11_+_33279850	0.023	ENST00000531504.1 ENST00000456517.1	HIPK3	homeodomain interacting protein kinase 3
chr1_+_8378140	0.022	ENST00000377479.2	SLC45A1	solute carrier family 45, member 1
chr5_-_175788758	0.022	ENST00000510164.1 ENST00000533553.1 ENST00000504688.1 ENST00000393725.2 ENST00000503082.1 ENST00000506983.1	KIAA1191	KIAA1191
chr3_+_72200408	0.021	ENST00000473713.1	LINC00870	long intergenic non-protein coding RNA 870
chr1_+_26737292	0.021	ENST00000254231.4	LIN28A	lin-28 homolog A (C. elegans)
chr19_-_47128294	0.021	ENST00000596260.1 ENST00000597185.1 ENST00000598865.1 ENST00000594275.1 ENST00000291294.2	PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)
chr20_+_816695	0.021	ENST00000246100.3	FAM110A	family with sequence similarity 110, member A
chr8_-_6115044	0.018	ENST00000519555.1	RP11-124B13.1	RP11-124B13.1
chr1_-_42800860	0.018	ENST00000445886.1 ENST00000361346.1 ENST00000361776.1	FOXJ3	forkhead box J3
chr1_+_38022572	0.018	ENST00000541606.1	DNALI1	dynein, axonemal, light intermediate chain 1
chr1_-_247335269	0.017	ENST00000543802.2 ENST00000491356.1 ENST00000472531.1 ENST00000340684.6	ZNF124	zinc finger protein 124
chr21_-_31874435	0.017	ENST00000334151.2	KRTAP19-5	keratin associated protein 19-5
chr1_-_151778630	0.017	ENST00000368820.3	LINGO4	leucine rich repeat and Ig domain containing 4
chr8_+_144295067	0.017	ENST00000330824.2	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr7_-_14880892	0.016	ENST00000406247.3 ENST00000399322.3 ENST00000258767.5	DGKB	diacylglycerol kinase, beta 90kDa
chr12_-_10282836	0.016	ENST00000304084.8 ENST00000353231.5 ENST00000525605.1	CLEC7A	C-type lectin domain family 7, member A
chr10_+_71444655	0.015	ENST00000434931.2	RP11-242G20.1	Uncharacterized protein
chr6_+_53794780	0.015	ENST00000505762.1 ENST00000511369.1 ENST00000431554.2	MLIP RP11-411K7.1	muscular LMNA-interacting protein RP11-411K7.1
chr20_+_57875457	0.014	ENST00000337938.2 ENST00000311585.7 ENST00000371028.2	EDN3	endothelin 3
chr12_+_8975061	0.014	ENST00000299698.7	A2ML1	alpha-2-macroglobulin-like 1
chrY_+_22737604	0.014	ENST00000361365.2	EIF1AY	eukaryotic translation initiation factor 1A, Y-linked
chr1_+_160097462	0.014	ENST00000447527.1	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr11_-_35547572	0.014	ENST00000378880.2	PAMR1	peptidase domain containing associated with muscle regeneration 1
chr1_-_109849612	0.014	ENST00000357155.1	MYBPHL	myosin binding protein H-like
chr17_-_61523622	0.013	ENST00000448884.2 ENST00000582297.1 ENST00000582034.1 ENST00000578072.1 ENST00000360793.3	CYB561	cytochrome b561
chr4_-_176828307	0.011	ENST00000513365.1 ENST00000513667.1 ENST00000503563.1	GPM6A	glycoprotein M6A
chr4_+_2420659	0.010	ENST00000382849.2	RP11-503N18.1	RP11-503N18.1
chr1_-_42800614	0.010	ENST00000372572.1	FOXJ3	forkhead box J3
chr1_+_161123536	0.009	ENST00000368003.5	UFC1	ubiquitin-fold modifier conjugating enzyme 1
chrX_+_135388147	0.009	ENST00000394141.1	GPR112	G protein-coupled receptor 112
chr19_+_55235969	0.008	ENST00000402254.2 ENST00000538269.1 ENST00000541392.1 ENST00000396284.2 ENST00000291860.1	KIR3DL1 KIR2DL4 KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
chr12_-_58135903	0.008	ENST00000257897.3	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_114414316	0.007	ENST00000528414.1 ENST00000538253.1 ENST00000460620.1 ENST00000420377.2 ENST00000525799.1 ENST00000359785.5	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr3_-_122712079	0.006	ENST00000393583.2	SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr20_+_57875658	0.006	ENST00000371025.3	EDN3	endothelin 3
chrX_+_41583408	0.006	ENST00000302548.4	GPR82	G protein-coupled receptor 82
chrX_-_152160740	0.006	ENST00000361887.5 ENST00000439251.1 ENST00000452693.1	PNMA5	paraneoplastic Ma antigen family member 5
chr14_-_92413353	0.006	ENST00000556154.1	FBLN5	fibulin 5
chr10_+_26505179	0.005	ENST00000376261.3	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr5_+_78365577	0.004	ENST00000518666.1 ENST00000521567.1	BHMT2	betaine--homocysteine S-methyltransferase 2
chr1_-_38061522	0.004	ENST00000373062.3	GNL2	guanine nucleotide binding protein-like 2 (nucleolar)
chr11_+_117947724	0.004	ENST00000534111.1	TMPRSS4	transmembrane protease, serine 4
chr6_+_1080164	0.004	ENST00000314040.1	AL033381.1	Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr2_-_113999260	0.004	ENST00000468980.2	PAX8	paired box 8
chr12_+_4829507	0.003	ENST00000252318.2	GALNT8	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr14_-_107211459	0.002	ENST00000390636.2	IGHV3-73	immunoglobulin heavy variable 3-73
chrY_+_22737678	0.002	ENST00000382772.3	EIF1AY	eukaryotic translation initiation factor 1A, Y-linked
chr6_+_52051171	0.002	ENST00000340057.1	IL17A	interleukin 17A
chr2_+_74710194	0.001	ENST00000410003.1 ENST00000442235.2 ENST00000233623.5	TTC31	tetratricopeptide repeat domain 31
chr6_-_41040049	0.001	ENST00000471367.1	OARD1	O-acyl-ADP-ribose deacylase 1
chr10_+_50507232	0.001	ENST00000374144.3	C10orf71	chromosome 10 open reading frame 71
chr1_+_17559776	0.001	ENST00000537499.1 ENST00000413717.2 ENST00000536552.1	PADI1	peptidyl arginine deiminase, type I
chr1_-_42801540	0.000	ENST00000372573.1	FOXJ3	forkhead box J3
chr3_-_87325612	0.000	ENST00000561167.1 ENST00000560656.1 ENST00000344265.3	POU1F1	POU class 1 homeobox 1

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0007497	posterior midgut development(GO:0007497) positive regulation of penile erection(GO:0060406) endothelin receptor signaling pathway(GO:0086100)
0.1	0.3	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
0.0	0.2	GO:0031508	pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0	0.1	GO:0046168	glycerol-3-phosphate catabolic process(GO:0046168)
0.0	0.1	GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0071106	coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0	0.3	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.1	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:0016267	O-glycan processing, core 1(GO:0016267)
0.0	0.1	GO:0002415	immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0	0.1	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.0	0.1	GO:1902746	regulation of lens fiber cell differentiation(GO:1902746)
0.0	0.0	GO:0038043	interleukin-5-mediated signaling pathway(GO:0038043)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1990584	cardiac Troponin complex(GO:1990584)
0.0	0.2	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0005955	calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0004962	endothelin receptor activity(GO:0004962)
0.1	0.3	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.3	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0015228	coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0	0.0	GO:0047150	betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0	0.0	GO:0030305	beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0	0.0	GO:0001181	transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0	0.0	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.0	GO:0004914	interleukin-5 receptor activity(GO:0004914)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	REACTOME_COMMON_PATHWAY	Genes involved in Common Pathway

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