Motif ID: RUNX1_RUNX2

Z-value: 0.623

Transcription factors associated with RUNX1_RUNX2:

Gene SymbolEntrez IDGene Name
RUNX1 ENSG00000159216.14 RUNX1
RUNX2 ENSG00000124813.16 RUNX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX2hg19_v2_chr6_+_45296391_452964640.561.1e-01Click!
RUNX1hg19_v2_chr21_-_36262032_362620870.472.1e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1_RUNX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_35856951 1.180 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R



interleukin 7 receptor



chr15_+_67390920 0.925 ENST00000559092.1
ENST00000560175.1
SMAD3

SMAD family member 3

chr17_-_29641104 0.902 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr10_+_91092241 0.686 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_-_39743139 0.645 ENST00000167586.6
KRT14
keratin 14
chr17_+_32582293 0.624 ENST00000580907.1
ENST00000225831.4
CCL2

chemokine (C-C motif) ligand 2

chrX_-_1331527 0.586 ENST00000381567.3
ENST00000381566.1
ENST00000400841.2
CRLF2


cytokine receptor-like factor 2


chr17_-_29641084 0.530 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr9_+_120466650 0.491 ENST00000355622.6
TLR4
toll-like receptor 4
chr10_-_5638048 0.488 ENST00000478294.1
RP13-463N16.6
RP13-463N16.6
chr2_+_102953608 0.460 ENST00000311734.2
ENST00000409584.1
IL1RL1

interleukin 1 receptor-like 1

chr9_+_120466610 0.455 ENST00000394487.4
TLR4
toll-like receptor 4
chr6_+_86159821 0.423 ENST00000369651.3
NT5E
5'-nucleotidase, ecto (CD73)
chr8_+_22435762 0.417 ENST00000456545.1
PDLIM2
PDZ and LIM domain 2 (mystique)
chr10_+_91152303 0.387 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr5_-_94417562 0.383 ENST00000505465.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_-_35938674 0.369 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL



calcyphosine-like



chr6_+_45296391 0.365 ENST00000371436.6
ENST00000576263.1
RUNX2

runt-related transcription factor 2

chr5_-_94417186 0.350 ENST00000312216.8
ENST00000512425.1
MCTP1

multiple C2 domains, transmembrane 1

chr5_-_94417314 0.337 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr8_+_22436248 0.333 ENST00000308354.7
PDLIM2
PDZ and LIM domain 2 (mystique)
chr8_+_22436635 0.319 ENST00000452226.1
ENST00000397760.4
ENST00000339162.7
ENST00000397761.2
PDLIM2



PDZ and LIM domain 2 (mystique)



chr5_-_138861926 0.318 ENST00000510817.1
TMEM173
transmembrane protein 173
chr9_-_32526299 0.292 ENST00000379882.1
ENST00000379883.2
DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

chr19_+_42580274 0.284 ENST00000359044.4
ZNF574
zinc finger protein 574
chr3_-_151034734 0.278 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr11_+_35198118 0.275 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44



CD44 molecule (Indian blood group)



chr11_-_66104237 0.269 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr11_-_796197 0.267 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22


solute carrier family 25 (mitochondrial carrier: glutamate), member 22


chr15_-_60695071 0.264 ENST00000557904.1
ANXA2
annexin A2
chr16_+_84801852 0.257 ENST00000569925.1
ENST00000567526.1
USP10

ubiquitin specific peptidase 10

chr12_-_49463753 0.250 ENST00000301068.6
RHEBL1
Ras homolog enriched in brain like 1
chr5_-_94417339 0.248 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1


multiple C2 domains, transmembrane 1


chr1_+_66796401 0.248 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_+_101591314 0.247 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr18_+_52385068 0.245 ENST00000586570.1
RAB27B
RAB27B, member RAS oncogene family
chr10_-_105845674 0.232 ENST00000353479.5
ENST00000369733.3
COL17A1

collagen, type XVII, alpha 1

chr17_+_78193443 0.226 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr2_-_207078154 0.224 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr22_+_42665742 0.221 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3


Z83851.3


chr11_-_64885111 0.221 ENST00000528598.1
ENST00000310597.4
ZNHIT2

zinc finger, HIT-type containing 2

chr11_-_66103932 0.217 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr2_-_217236750 0.215 ENST00000273067.4
MARCH4
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
chr12_-_48276710 0.214 ENST00000550314.1
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr11_+_35198243 0.210 ENST00000528455.1
CD44
CD44 molecule (Indian blood group)
chr17_-_73781567 0.208 ENST00000586607.1
H3F3B
H3 histone, family 3B (H3.3B)
chr9_+_115913222 0.208 ENST00000259392.3
SLC31A2
solute carrier family 31 (copper transporter), member 2
chr3_-_134093738 0.207 ENST00000506107.1
AMOTL2
angiomotin like 2
chr12_-_49581152 0.205 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr8_-_131399110 0.202 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr1_-_233431458 0.195 ENST00000258229.9
ENST00000430153.1
PCNXL2

pecanex-like 2 (Drosophila)

chr11_-_62323702 0.193 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr1_-_157014865 0.192 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr4_-_84035868 0.191 ENST00000426923.2
ENST00000509973.1
PLAC8

placenta-specific 8

chr17_-_79481666 0.191 ENST00000575659.1
ACTG1
actin, gamma 1
chr1_+_179051160 0.191 ENST00000367625.4
ENST00000352445.6
TOR3A

torsin family 3, member A

chr4_-_84035905 0.190 ENST00000311507.4
PLAC8
placenta-specific 8
chr2_-_75745823 0.189 ENST00000452003.1
EVA1A
eva-1 homolog A (C. elegans)
chr20_-_30311703 0.189 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1



BCL2-like 1



chr2_-_207078086 0.186 ENST00000442134.1
GPR1
G protein-coupled receptor 1
chr17_-_43025005 0.186 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
KIF18B


kinesin family member 18B


chr19_-_43969796 0.183 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr11_-_795286 0.182 ENST00000533385.1
ENST00000527723.1
SLC25A22

solute carrier family 25 (mitochondrial carrier: glutamate), member 22

chr3_-_134093275 0.180 ENST00000513145.1
ENST00000422605.2
AMOTL2

angiomotin like 2

chr22_+_21996549 0.180 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chrX_-_54209640 0.178 ENST00000375180.2
ENST00000328235.4
ENST00000477084.1
FAM120C


family with sequence similarity 120C


chr9_+_131902346 0.178 ENST00000432124.1
ENST00000435305.1
PPP2R4

protein phosphatase 2A activator, regulatory subunit 4

chr17_+_74372662 0.178 ENST00000591651.1
ENST00000545180.1
SPHK1

sphingosine kinase 1

chr14_-_50506589 0.176 ENST00000553914.2
RP11-58E21.3
RP11-58E21.3
chr11_-_128457446 0.175 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr11_-_66103867 0.175 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr15_+_73976715 0.174 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276




CD276 molecule




chrX_-_70331298 0.173 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
IL2RG



interleukin 2 receptor, gamma



chr1_+_206643806 0.173 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_+_65337901 0.171 ENST00000309328.3
ENST00000531405.1
ENST00000527920.1
ENST00000526877.1
ENST00000533115.1
ENST00000526433.1
SSSCA1





Sjogren syndrome/scleroderma autoantigen 1





chr22_-_30642728 0.169 ENST00000403987.3
LIF
leukemia inhibitory factor
chr12_-_49463620 0.167 ENST00000550675.1
RHEBL1
Ras homolog enriched in brain like 1
chr1_-_179112173 0.165 ENST00000408940.3
ENST00000504405.1
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr3_-_134093395 0.164 ENST00000249883.5
AMOTL2
angiomotin like 2
chr15_+_75080883 0.163 ENST00000567571.1
CSK
c-src tyrosine kinase
chr6_-_11382478 0.163 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9



neural precursor cell expressed, developmentally down-regulated 9



chr19_-_43032532 0.162 ENST00000403461.1
ENST00000352591.5
ENST00000358394.3
ENST00000403444.3
ENST00000308072.4
ENST00000599389.1
ENST00000351134.3
ENST00000161559.6
CEACAM1







carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)







chr12_+_93772326 0.162 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4



nudix (nucleoside diphosphate linked moiety X)-type motif 4



chrX_+_16185604 0.159 ENST00000400004.2
MAGEB17
melanoma antigen family B, 17
chr19_-_6415695 0.159 ENST00000594496.1
ENST00000594745.1
ENST00000600480.1
KHSRP


KH-type splicing regulatory protein


chr19_-_55767125 0.154 ENST00000592242.1
PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_-_98511756 0.154 ENST00000602984.1
ENST00000602852.1
MIR137HG

MIR137 host gene (non-protein coding)

chr1_-_179112189 0.153 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr10_+_104154229 0.153 ENST00000428099.1
ENST00000369966.3
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr16_-_18441131 0.152 ENST00000339303.5
NPIPA8
nuclear pore complex interacting protein family, member A8
chr17_+_76037081 0.149 ENST00000588549.1
TNRC6C
trinucleotide repeat containing 6C
chrX_-_19688475 0.141 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr5_-_142077569 0.141 ENST00000407758.1
ENST00000441680.2
ENST00000419524.2
FGF1


fibroblast growth factor 1 (acidic)


chr1_-_27480973 0.141 ENST00000545949.1
ENST00000374086.3
SLC9A1

solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

chr2_-_166060552 0.140 ENST00000283254.7
ENST00000453007.1
SCN3A

sodium channel, voltage-gated, type III, alpha subunit

chr15_+_59903975 0.140 ENST00000560585.1
ENST00000396065.1
GCNT3

glucosaminyl (N-acetyl) transferase 3, mucin type

chr19_-_15560730 0.139 ENST00000389282.4
ENST00000263381.7
WIZ

widely interspaced zinc finger motifs

chr6_-_152623231 0.139 ENST00000540663.1
ENST00000537033.1
SYNE1

spectrin repeat containing, nuclear envelope 1

chr15_+_73976545 0.138 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276


CD276 molecule


chr6_+_86159765 0.137 ENST00000369646.3
ENST00000257770.3
NT5E

5'-nucleotidase, ecto (CD73)

chr1_-_168464875 0.137 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr12_+_78359999 0.137 ENST00000550503.1
NAV3
neuron navigator 3
chr1_-_173174681 0.137 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr17_+_812872 0.133 ENST00000576252.1
RP11-676J12.7
Uncharacterized protein
chr17_+_79008940 0.133 ENST00000392411.3
ENST00000575989.1
ENST00000321280.7
ENST00000428708.2
ENST00000575712.1
ENST00000575245.1
ENST00000435091.3
ENST00000321300.6
BAIAP2







BAI1-associated protein 2







chr1_-_25291475 0.133 ENST00000338888.3
ENST00000399916.1
RUNX3

runt-related transcription factor 3

chr16_+_2255178 0.133 ENST00000564088.1
ENST00000382450.4
ENST00000569417.1
MLST8


MTOR associated protein, LST8 homolog (S. cerevisiae)


chr2_-_166060571 0.132 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_67141090 0.130 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr3_-_189840223 0.130 ENST00000427335.2
LEPREL1
leprecan-like 1
chr20_+_61299155 0.130 ENST00000451793.1
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr2_-_166060382 0.129 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_58345569 0.129 ENST00000528954.1
ENST00000528489.1
LPXN

leupaxin

chr1_+_206643787 0.129 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr18_-_49557 0.128 ENST00000308911.6
RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
chr1_-_115632035 0.128 ENST00000433172.1
ENST00000369514.2
ENST00000369516.2
ENST00000369515.2
TSPAN2



tetraspanin 2



chr1_-_6420737 0.127 ENST00000541130.1
ENST00000377845.3
ACOT7

acyl-CoA thioesterase 7

chr20_+_43992094 0.127 ENST00000453003.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr19_+_14063278 0.126 ENST00000254337.6
DCAF15
DDB1 and CUL4 associated factor 15
chr19_-_47291843 0.125 ENST00000542575.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr11_-_2950642 0.124 ENST00000314222.4
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr22_+_20119320 0.122 ENST00000334554.7
ENST00000320602.7
ENST00000405930.3
ZDHHC8


zinc finger, DHHC-type containing 8


chr11_-_10920838 0.122 ENST00000503469.2
CTD-2003C8.2
CTD-2003C8.2
chr1_-_32169920 0.122 ENST00000373672.3
ENST00000373668.3
COL16A1

collagen, type XVI, alpha 1

chr3_+_40518599 0.122 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
ZNF619



zinc finger protein 619



chr17_-_39780634 0.121 ENST00000577817.2
KRT17
keratin 17
chr1_+_155290677 0.121 ENST00000368354.3
ENST00000368352.5
RUSC1

RUN and SH3 domain containing 1

chr11_-_67141640 0.121 ENST00000533438.1
CLCF1
cardiotrophin-like cytokine factor 1
chr3_+_57541975 0.121 ENST00000487257.1
ENST00000311180.8
PDE12

phosphodiesterase 12

chrX_+_37639302 0.120 ENST00000545017.1
ENST00000536160.1
CYBB

cytochrome b-245, beta polypeptide

chr17_+_75316336 0.120 ENST00000591934.1
SEPT9
septin 9
chr1_-_94147385 0.120 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr22_-_30642782 0.119 ENST00000249075.3
LIF
leukemia inhibitory factor
chr1_-_207095324 0.119 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr18_+_61420169 0.119 ENST00000425392.1
ENST00000336429.2
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr10_+_104155450 0.117 ENST00000471698.1
ENST00000189444.6
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr3_+_51575596 0.117 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr1_+_149858461 0.116 ENST00000331380.2
HIST2H2AC
histone cluster 2, H2ac
chr18_-_50240 0.115 ENST00000573909.1
RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
chr1_-_147632428 0.115 ENST00000599640.1
BX842679.1
Uncharacterized protein FLJ46360
chr17_+_38599693 0.114 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr8_-_19540266 0.113 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr16_+_27226256 0.112 ENST00000567735.1
KDM8
lysine (K)-specific demethylase 8
chr17_+_42634844 0.111 ENST00000315323.3
FZD2
frizzled family receptor 2
chr12_-_58145889 0.111 ENST00000547853.1
CDK4
cyclin-dependent kinase 4
chr19_+_39647271 0.110 ENST00000599657.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr16_-_57837129 0.110 ENST00000562984.1
ENST00000564891.1
KIFC3

kinesin family member C3

chr17_+_40119801 0.108 ENST00000585452.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chrX_-_153599578 0.108 ENST00000360319.4
ENST00000344736.4
FLNA

filamin A, alpha

chrX_-_49121165 0.108 ENST00000376207.4
ENST00000376199.2
FOXP3

forkhead box P3

chr8_-_19540086 0.108 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr1_-_204329013 0.107 ENST00000272203.3
ENST00000414478.1
PLEKHA6

pleckstrin homology domain containing, family A member 6

chr17_+_1633755 0.107 ENST00000545662.1
WDR81
WD repeat domain 81
chr16_+_58033450 0.107 ENST00000561743.1
USB1
U6 snRNA biogenesis 1
chr6_+_42847649 0.107 ENST00000424341.2
ENST00000602561.1
RPL7L1

ribosomal protein L7-like 1

chr17_-_39728303 0.107 ENST00000588431.1
ENST00000246662.4
KRT9

keratin 9

chrX_+_47441712 0.106 ENST00000218388.4
ENST00000377018.2
ENST00000456754.2
ENST00000377017.1
ENST00000441738.1
TIMP1




TIMP metallopeptidase inhibitor 1




chr2_+_28618532 0.106 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr10_-_28623368 0.105 ENST00000441595.2
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_-_233792837 0.104 ENST00000373552.4
ENST00000409079.1
NGEF

neuronal guanine nucleotide exchange factor

chr19_+_17413663 0.104 ENST00000594999.1
MRPL34
mitochondrial ribosomal protein L34
chr5_-_180230830 0.104 ENST00000427865.2
ENST00000514283.1
MGAT1

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

chr17_+_79660798 0.104 ENST00000571237.1
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr16_-_31076273 0.104 ENST00000426488.2
ZNF668
zinc finger protein 668
chr17_-_1090599 0.104 ENST00000544583.2
ABR
active BCR-related
chr12_+_93772402 0.104 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr12_+_15125954 0.104 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr14_-_81425828 0.103 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128


centrosomal protein 128kDa


chr22_+_31488433 0.103 ENST00000455608.1
SMTN
smoothelin
chr1_+_110158726 0.103 ENST00000531734.1
AMPD2
adenosine monophosphate deaminase 2
chr19_-_45908292 0.102 ENST00000360957.5
ENST00000592134.1
PPP1R13L

protein phosphatase 1, regulatory subunit 13 like

chr6_-_26032288 0.102 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr11_+_117070904 0.102 ENST00000529792.1
TAGLN
transgelin
chr12_-_107487604 0.102 ENST00000008527.5
CRY1
cryptochrome 1 (photolyase-like)
chr17_-_42188598 0.102 ENST00000591714.1
HDAC5
histone deacetylase 5
chr19_+_36203830 0.102 ENST00000262630.3
ZBTB32
zinc finger and BTB domain containing 32
chr16_+_2255447 0.101 ENST00000562352.1
ENST00000562479.1
ENST00000301724.10
MLST8


MTOR associated protein, LST8 homolog (S. cerevisiae)


chr1_+_179050512 0.101 ENST00000367627.3
TOR3A
torsin family 3, member A
chr12_-_120687948 0.101 ENST00000458477.2
PXN
paxillin
chr19_+_49375649 0.100 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr21_+_30673091 0.098 ENST00000447177.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr12_-_49582837 0.098 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A


tubulin, alpha 1a


chr5_+_145316120 0.097 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr22_+_31031639 0.096 ENST00000343605.4
ENST00000300385.8
SLC35E4

solute carrier family 35, member E4

chr1_+_156095951 0.096 ENST00000448611.2
ENST00000368297.1
LMNA

lamin A/C

chr7_+_45067265 0.096 ENST00000474617.1
CCM2
cerebral cavernous malformation 2
chr17_-_15554940 0.095 ENST00000455584.2
RP11-385D13.1
Uncharacterized protein
chr11_-_102401469 0.095 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr2_+_242498135 0.094 ENST00000318407.3
BOK
BCL2-related ovarian killer
chrX_+_37639264 0.094 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr19_+_14017116 0.094 ENST00000589606.1
CC2D1A
coiled-coil and C2 domain containing 1A
chr5_+_667759 0.093 ENST00000594226.1
AC026740.1
Uncharacterized protein
chr17_+_72427477 0.093 ENST00000342648.5
ENST00000481232.1
GPRC5C

G protein-coupled receptor, family C, group 5, member C

chr16_+_67312049 0.093 ENST00000565899.1
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr6_-_42418999 0.092 ENST00000340840.2
ENST00000354325.2
TRERF1

transcriptional regulating factor 1

chr9_-_139581848 0.092 ENST00000538402.1
ENST00000371694.3
AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2

chr6_+_31895467 0.092 ENST00000556679.1
ENST00000456570.1
CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr16_+_30075463 0.092 ENST00000562168.1
ENST00000569545.1
ALDOA

aldolase A, fructose-bisphosphate

chr14_-_105767598 0.092 ENST00000548421.1
BRF1
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
chr3_+_101498074 0.092 ENST00000273347.5
ENST00000474165.1
NXPE3

neurexophilin and PC-esterase domain family, member 3


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.2 0.6 GO:0072683 T cell extravasation(GO:0072683)
0.1 1.0 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.5 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 0.6 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 1.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.4 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.3 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.1 GO:0010628 positive regulation of gene expression(GO:0010628)
0.1 0.3 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.1 0.3 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.1 0.3 GO:0052214 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.1 0.2 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 0.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.5 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.2 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.7 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.3 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.1 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.2 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.2 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887)
0.0 0.1 GO:0002652 regulation of tolerance induction dependent upon immune response(GO:0002652) positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.0 0.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432)
0.0 0.1 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.1 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.0 0.1 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 0.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.1 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.0 0.2 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0043324 eye pigment biosynthetic process(GO:0006726) synaptic vesicle recycling via endosome(GO:0036466) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.2 GO:0030578 PML body organization(GO:0030578)
0.0 0.2 GO:0038110 interleukin-4-mediated signaling pathway(GO:0035771) interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.0 GO:0048817 negative regulation of hair follicle maturation(GO:0048817) negative regulation of hair follicle development(GO:0051799)
0.0 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.1 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining(GO:2001033)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.1 GO:2000974 trochlear nerve development(GO:0021558) negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.0 0.1 GO:0035933 glucocorticoid secretion(GO:0035933) regulation of glucocorticoid secretion(GO:2000849)
0.0 0.1 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.3 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.1 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.1 GO:0060313 negative regulation of blood vessel remodeling(GO:0060313)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309)
0.0 0.0 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.0 GO:0060143 positive regulation of myotube differentiation(GO:0010831) regulation of syncytium formation by plasma membrane fusion(GO:0060142) positive regulation of syncytium formation by plasma membrane fusion(GO:0060143) regulation of myoblast fusion(GO:1901739) positive regulation of myoblast fusion(GO:1901741)
0.0 0.0 GO:2001038 regulation of cellular response to drug(GO:2001038)
0.0 0.1 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.0 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.0 0.0 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0030035 microspike assembly(GO:0030035)
0.0 0.1 GO:0032796 uropod organization(GO:0032796)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.0 GO:1902080 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:1905045 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.0 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0009233 menaquinone metabolic process(GO:0009233)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.0 0.0 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.2 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.0 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.0 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) notochord regression(GO:0060032)
0.0 0.1 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.0 0.0 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.0 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.2 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.0 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.2 GO:0015816 glycine transport(GO:0015816)
0.0 0.0 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0002133 polycystin complex(GO:0002133)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0033565 ESCRT-0 complex(GO:0033565)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.2 0.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 1.0 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.9 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.7 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.5 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.1 GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040)
0.0 0.1 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.7 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.0 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.8 ST_GA13_PATHWAY G alpha 13 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 1.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors