Motif ID: REST

Z-value: 0.227


Transcription factors associated with REST:

Gene SymbolEntrez IDGene Name
REST ENSG00000084093.11 REST

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.452.2e-01Click!


Activity profile for motif REST.

activity profile for motif REST


Sorted Z-values histogram for motif REST

Sorted Z-values for motif REST



Network of associatons between targets according to the STRING database.



First level regulatory network of REST

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_57567180 0.140 ENST00000316660.6
ENST00000269518.9
 PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

chr19_-_3971050 0.097 ENST00000545797.2
ENST00000596311.1
 DAPK3

death-associated protein kinase 3

chr10_+_99609996 0.091 ENST00000370602.1
 GOLGA7B
golgin A7 family, member B
chr16_+_3019309 0.087 ENST00000576565.1
 PAQR4
progestin and adipoQ receptor family member IV
chr15_-_79576156 0.076 ENST00000560452.1
ENST00000560872.1
ENST00000560732.1
ENST00000559979.1
ENST00000560533.1
ENST00000559225.1
 RP11-17L5.4





RP11-17L5.4





chr22_+_31199037 0.068 ENST00000424224.1
 OSBP2
oxysterol binding protein 2
chr11_-_75141206 0.064 ENST00000376292.4
 KLHL35
kelch-like family member 35
chr3_+_193853927 0.055 ENST00000232424.3
 HES1
hes family bHLH transcription factor 1
chr8_-_145559943 0.053 ENST00000332135.4
 SCRT1
scratch family zinc finger 1
chr1_-_241520385 0.052 ENST00000366564.1
 RGS7
regulator of G-protein signaling 7
chr20_+_30555805 0.051 ENST00000562532.2
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr6_+_35773070 0.048 ENST00000373853.1
ENST00000360215.1
 LHFPL5

lipoma HMGIC fusion partner-like 5

chr11_-_72492878 0.045 ENST00000535054.1
ENST00000545082.1
 STARD10

StAR-related lipid transfer (START) domain containing 10

chr7_-_100808394 0.045 ENST00000445482.2
 VGF
VGF nerve growth factor inducible
chr15_+_75287861 0.044 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5







secretory carrier membrane protein 5







chr12_-_29936731 0.041 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
 TMTC1


transmembrane and tetratricopeptide repeat containing 1


chr9_+_140033862 0.038 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
 GRIN1






glutamate receptor, ionotropic, N-methyl D-aspartate 1






chr8_-_91095099 0.035 ENST00000265431.3
 CALB1
calbindin 1, 28kDa
chr8_-_145752390 0.035 ENST00000529415.2
ENST00000533758.1
 LRRC24

leucine rich repeat containing 24

chr19_-_45927622 0.034 ENST00000300853.3
ENST00000589165.1
 ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr7_-_100808843 0.033 ENST00000249330.2
 VGF
VGF nerve growth factor inducible
chr11_-_6677018 0.031 ENST00000299441.3
 DCHS1
dachsous cadherin-related 1
chr19_-_11639910 0.030 ENST00000588998.1
ENST00000586149.1
 ECSIT

ECSIT signalling integrator

chr16_+_3019246 0.029 ENST00000318782.8
ENST00000293978.8
 PAQR4

progestin and adipoQ receptor family member IV

chr12_+_71833550 0.028 ENST00000266674.5
 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr5_-_176037105 0.028 ENST00000303991.4
 GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr14_+_93389425 0.027 ENST00000216492.5
ENST00000334654.4
 CHGA

chromogranin A (parathyroid secretory protein 1)

chr19_-_11639931 0.027 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
 ECSIT





ECSIT signalling integrator





chr3_+_9745487 0.025 ENST00000383832.3
 CPNE9
copine family member IX
chr12_+_119419294 0.023 ENST00000267260.4
 SRRM4
serine/arginine repetitive matrix 4
chr15_-_72612470 0.023 ENST00000287202.5
 CELF6
CUGBP, Elav-like family member 6
chr15_-_83378611 0.022 ENST00000542200.1
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_175930 0.021 ENST00000538872.1
ENST00000326261.4
 IQSEC3

IQ motif and Sec7 domain 3

chr3_+_120626919 0.020 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
 STXBP5L




syntaxin binding protein 5-like




chr5_+_63802109 0.020 ENST00000334025.2
 RGS7BP
regulator of G-protein signaling 7 binding protein
chr18_-_40857493 0.018 ENST00000255224.3
 SYT4
synaptotagmin IV
chr17_+_42385927 0.017 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
 RUNDC3A


RUN domain containing 3A


chr11_-_66115032 0.017 ENST00000311181.4
 B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr4_+_96012585 0.017 ENST00000502683.1
 BMPR1B
bone morphogenetic protein receptor, type IB
chr2_-_51259528 0.017 ENST00000404971.1
 NRXN1
neurexin 1
chr19_-_40724246 0.017 ENST00000311308.6
 TTC9B
tetratricopeptide repeat domain 9B
chr15_-_83378526 0.017 ENST00000535348.1
ENST00000535359.1
 AP3B2

adaptor-related protein complex 3, beta 2 subunit

chr14_+_93897199 0.017 ENST00000553484.1
 UNC79
unc-79 homolog (C. elegans)
chr18_-_5197501 0.016 ENST00000580650.1
 C18orf42
chromosome 18 open reading frame 42
chr9_-_104357277 0.016 ENST00000374806.1
 PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr2_-_51259292 0.015 ENST00000401669.2
 NRXN1
neurexin 1
chr19_-_45926739 0.015 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
 ERCC1



excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)



chr2_-_51259229 0.015 ENST00000405472.3
 NRXN1
neurexin 1
chr1_-_151689259 0.015 ENST00000420342.1
ENST00000290583.4
 CELF3

CUGBP, Elav-like family member 3

chrX_-_47479246 0.015 ENST00000295987.7
ENST00000340666.4
 SYN1

synapsin I

chr14_+_93897272 0.015 ENST00000393151.2
 UNC79
unc-79 homolog (C. elegans)
chr12_-_24737089 0.015 ENST00000483544.1
 LINC00477
long intergenic non-protein coding RNA 477
chrX_-_153141302 0.014 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM




L1 cell adhesion molecule




chr7_+_145813453 0.014 ENST00000361727.3
 CNTNAP2
contactin associated protein-like 2
chr17_-_7218403 0.014 ENST00000570780.1
 GPS2
G protein pathway suppressor 2
chr3_+_75955817 0.013 ENST00000487694.3
ENST00000602589.1
 ROBO2

roundabout, axon guidance receptor, homolog 2 (Drosophila)

chr17_-_27333163 0.013 ENST00000360295.9
 SEZ6
seizure related 6 homolog (mouse)
chr15_-_83378638 0.013 ENST00000261722.3
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chrX_+_153238220 0.013 ENST00000425274.1
 TMEM187
transmembrane protein 187
chrX_-_153237258 0.013 ENST00000310441.7
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_51259641 0.013 ENST00000406316.2
ENST00000405581.1
 NRXN1

neurexin 1

chr17_-_3301704 0.012 ENST00000322608.2
 OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr5_+_167956121 0.012 ENST00000338333.4
 FBLL1
fibrillarin-like 1
chr18_-_5197224 0.012 ENST00000434239.3
 C18orf42
chromosome 18 open reading frame 42
chr20_+_5892147 0.011 ENST00000455042.1
 CHGB
chromogranin B (secretogranin 1)
chrX_-_153141434 0.011 ENST00000407935.2
ENST00000439496.1
 L1CAM

L1 cell adhesion molecule

chr12_+_113229737 0.011 ENST00000551052.1
ENST00000415485.3
 RPH3A

rabphilin 3A homolog (mouse)

chr19_-_45927097 0.010 ENST00000340192.7
 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr11_+_45907177 0.010 ENST00000241014.2
 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr5_-_151304337 0.010 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
 GLRA1


glycine receptor, alpha 1


chr20_+_5892037 0.009 ENST00000378961.4
 CHGB
chromogranin B (secretogranin 1)
chr15_+_68117872 0.009 ENST00000380035.2
ENST00000389002.1
 SKOR1

SKI family transcriptional corepressor 1

chr9_+_93921855 0.009 ENST00000423719.2
ENST00000609752.1
 LINC00484

long intergenic non-protein coding RNA 484

chr19_+_41036371 0.009 ENST00000392023.1
 SPTBN4
spectrin, beta, non-erythrocytic 4
chr20_-_62284766 0.009 ENST00000370053.1
 STMN3
stathmin-like 3
chr15_+_68117844 0.009 ENST00000554054.1
 SKOR1
SKI family transcriptional corepressor 1
chr8_-_57358432 0.009 ENST00000517415.1
ENST00000314922.3
 PENK

proenkephalin

chr1_+_171750776 0.009 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
 METTL13



methyltransferase like 13



chr11_+_64808675 0.008 ENST00000529996.1
 SAC3D1
SAC3 domain containing 1
chr7_+_150748288 0.008 ENST00000490540.1
 ASIC3
acid-sensing (proton-gated) ion channel 3
chr3_+_149531607 0.008 ENST00000468648.1
ENST00000459632.1
 RNF13

ring finger protein 13

chr17_-_27332931 0.008 ENST00000442608.3
ENST00000335960.6
 SEZ6

seizure related 6 homolog (mouse)

chr2_+_46524537 0.008 ENST00000263734.3
 EPAS1
endothelial PAS domain protein 1
chr11_-_125773085 0.008 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
 PUS3


pseudouridylate synthase 3


chr6_+_25652432 0.008 ENST00000377961.2
 SCGN
secretagogin, EF-hand calcium binding protein
chr1_-_175712665 0.007 ENST00000263525.2
 TNR
tenascin R
chr3_+_9745510 0.007 ENST00000383831.3
 CPNE9
copine family member IX
chr12_-_57871853 0.007 ENST00000549602.1
ENST00000430041.2
 ARHGAP9

Rho GTPase activating protein 9

chr10_-_79398127 0.007 ENST00000372443.1
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr15_-_27018884 0.006 ENST00000299267.4
 GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr18_-_40857447 0.006 ENST00000590752.1
ENST00000596867.1
 SYT4

synaptotagmin IV

chr17_-_27333311 0.006 ENST00000317338.12
ENST00000585644.1
 SEZ6

seizure related 6 homolog (mouse)

chr7_-_65113280 0.005 ENST00000593865.1
 AC104057.1
Protein LOC100996407
chr1_+_212606219 0.004 ENST00000366988.3
 NENF
neudesin neurotrophic factor
chr4_+_96012614 0.004 ENST00000264568.4
 BMPR1B
bone morphogenetic protein receptor, type IB
chr14_-_51561784 0.004 ENST00000360392.4
 TRIM9
tripartite motif containing 9
chr10_-_79398250 0.003 ENST00000286627.5
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr19_-_55691377 0.003 ENST00000589172.1
 SYT5
synaptotagmin V
chr9_-_74061751 0.003 ENST00000357533.2
ENST00000423814.3
 TRPM3

transient receptor potential cation channel, subfamily M, member 3

chr12_+_113229543 0.003 ENST00000447659.2
 RPH3A
rabphilin 3A homolog (mouse)
chr1_+_33352036 0.002 ENST00000373467.3
 HPCA
hippocalcin
chr9_-_139096955 0.002 ENST00000371748.5
 LHX3
LIM homeobox 3
chr14_-_51562037 0.002 ENST00000338969.5
 TRIM9
tripartite motif containing 9
chr6_+_43603552 0.002 ENST00000372171.4
 MAD2L1BP
MAD2L1 binding protein
chr11_+_637246 0.002 ENST00000176183.5
 DRD4
dopamine receptor D4
chr12_+_113229452 0.001 ENST00000389385.4
 RPH3A
rabphilin 3A homolog (mouse)
chr19_-_55691472 0.001 ENST00000537500.1
 SYT5
synaptotagmin V

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2000974 trochlear nerve development(GO:0021558) negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.0 GO:0043449 cellular alkene metabolic process(GO:0043449) olefin metabolic process(GO:1900673)