Motif ID: RELA
Z-value: 2.978
Transcription factors associated with RELA:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RELA | ENSG00000173039.14 | RELA |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | 0.95 | 1.0e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 24.6 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 5.5 | 16.5 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 4.4 | 21.8 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 4.2 | 16.8 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 3.9 | 11.8 | GO:2000364 | regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 3.7 | 14.7 | GO:2000503 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 3.1 | 37.7 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 2.0 | 6.1 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 1.5 | 3.0 | GO:2001183 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 1.5 | 4.4 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 1.3 | 15.2 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 1.1 | 3.4 | GO:0045083 | negative regulation of interleukin-12 biosynthetic process(GO:0045083) |
| 0.9 | 4.7 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.8 | 4.2 | GO:1901545 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.8 | 2.4 | GO:1990619 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619) |
| 0.8 | 2.4 | GO:0072616 | interleukin-18 secretion(GO:0072616) |
| 0.7 | 4.8 | GO:2000669 | negative regulation of dendritic cell apoptotic process(GO:2000669) |
| 0.6 | 1.7 | GO:0071790 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 0.5 | 1.0 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.5 | 8.2 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.4 | 0.9 | GO:0090291 | negative regulation of osteoclast proliferation(GO:0090291) |
| 0.4 | 2.9 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.4 | 7.1 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.4 | 2.7 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.4 | 2.3 | GO:0097368 | membrane to membrane docking(GO:0022614) establishment of Sertoli cell barrier(GO:0097368) |
| 0.3 | 1.0 | GO:0031394 | positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of fibroblast growth factor production(GO:0090271) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.3 | 3.0 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.3 | 1.6 | GO:1902534 | single-organism membrane invagination(GO:1902534) |
| 0.3 | 1.9 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.3 | 1.7 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.3 | 2.8 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.3 | 0.8 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.2 | 1.9 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.2 | 1.4 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.2 | 0.7 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.2 | 1.5 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.2 | 0.6 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.2 | 1.3 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.2 | 0.7 | GO:2000697 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 0.2 | 1.8 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.2 | 0.9 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.2 | 0.5 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.2 | 1.2 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 0.2 | 2.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.2 | 1.0 | GO:0045350 | interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.2 | 0.5 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.2 | 1.3 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 1.1 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 0.2 | 1.1 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.1 | 0.6 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.1 | 0.4 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.1 | 1.6 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 1.8 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.1 | 3.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 0.8 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.1 | 0.7 | GO:0097056 | selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056) |
| 0.1 | 1.0 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.1 | 1.0 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.1 | 0.5 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 0.8 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 1.6 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 3.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.5 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.9 | GO:2000544 | cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544) |
| 0.1 | 0.5 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.1 | 1.5 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.1 | 0.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.5 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.1 | 2.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 1.3 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.1 | 0.6 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.1 | 0.8 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.5 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.1 | 3.5 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 2.2 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.6 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.0 | 2.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 1.5 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.0 | 3.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.3 | GO:0021590 | cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699) |
| 0.0 | 1.0 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.0 | 0.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 1.6 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.3 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 0.1 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.0 | 0.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.1 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.0 | 2.0 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.0 | 0.5 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.3 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.0 | 0.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.4 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.0 | 0.6 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 1.0 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.6 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.0 | 0.1 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.0 | 0.2 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 0.0 | 2.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.1 | GO:1900169 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 0.4 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 1.6 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.0 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.0 | 0.9 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 2.6 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.3 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 0.1 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.0 | 0.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.1 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.1 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.0 | GO:0001828 | inner cell mass cellular morphogenesis(GO:0001828) |
| 0.0 | 0.0 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.0 | 0.3 | GO:1903672 | positive regulation of sprouting angiogenesis(GO:1903672) |
| 0.0 | 0.5 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 0.4 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.1 | GO:1901970 | positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) |
| 0.0 | 0.1 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 16.8 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 2.9 | 14.7 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 1.7 | 17.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.6 | 2.4 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.6 | 1.7 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.5 | 6.6 | GO:0060091 | kinocilium(GO:0060091) |
| 0.4 | 1.1 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.3 | 1.5 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.3 | 3.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 2.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 4.8 | GO:0033643 | host cell part(GO:0033643) |
| 0.2 | 1.4 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 1.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 0.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 2.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 0.5 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 1.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 8.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 3.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 15.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 24.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 3.5 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 0.2 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.1 | 0.2 | GO:1990423 | Dsl1p complex(GO:0070939) RZZ complex(GO:1990423) |
| 0.1 | 0.7 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 1.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.4 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.4 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 1.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.8 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.6 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.0 | 0.6 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 1.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.7 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 5.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.9 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.3 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 11.1 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 3.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.6 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 1.0 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.8 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 14.6 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 22.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.3 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.4 | 37.7 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.9 | 15.1 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 1.5 | 14.7 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 1.1 | 20.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.9 | 7.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.8 | 2.4 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.5 | 1.6 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.3 | 21.8 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.3 | 4.7 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.3 | 2.1 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.3 | 4.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.3 | 13.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 7.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 1.8 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.2 | 1.0 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.2 | 0.8 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.2 | 0.6 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.2 | 0.7 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.2 | 25.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.2 | 0.7 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.2 | 6.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 1.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.2 | 0.8 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.2 | 1.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 1.0 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.1 | 0.4 | GO:0086039 | lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039) |
| 0.1 | 1.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 2.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 1.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.6 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 0.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 0.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 0.7 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.4 | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223) |
| 0.1 | 0.9 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.1 | 1.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.8 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.1 | 0.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 1.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.6 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 3.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 0.4 | GO:0097677 | STAT family protein binding(GO:0097677) |
| 0.1 | 5.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 0.7 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 0.6 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 1.2 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 2.2 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 3.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 0.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 2.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.9 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.5 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.8 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.6 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.4 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 33.4 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 0.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.0 | 1.0 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 1.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.7 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 1.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 2.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.2 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 0.2 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 0.9 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 1.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.5 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.4 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.1 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 1.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.7 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.3 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 59.1 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 16.5 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.4 | 37.0 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 19.5 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 9.5 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 3.1 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.8 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 5.1 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.9 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 3.1 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.2 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 2.2 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 1.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 4.7 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.4 | PID_TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 3.2 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.8 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 0.8 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 4.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.9 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.3 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.4 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.3 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 0.3 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.2 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.8 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 50.4 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 1.0 | 60.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.8 | 15.8 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.6 | 36.0 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.3 | 2.8 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 1.0 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 7.1 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 2.0 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 4.7 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 1.0 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 2.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 2.5 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 3.7 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.0 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 0.8 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 1.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.6 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.2 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.0 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 1.1 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 2.1 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.5 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.1 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 1.6 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.9 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.7 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.5 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.0 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.5 | REACTOME_PI_METABOLISM | Genes involved in PI Metabolism |
| 0.0 | 0.1 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.7 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 1.0 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
