Motif ID: RAD21_SMC3

Z-value: 1.399

Transcription factors associated with RAD21_SMC3:

Gene SymbolEntrez IDGene Name
RAD21 ENSG00000164754.8 RAD21
SMC3 ENSG00000108055.9 SMC3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RAD21hg19_v2_chr8_-_117886955_117887105-0.722.8e-02Click!
SMC3hg19_v2_chr10_+_112327425_112327516-0.245.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of RAD21_SMC3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_138188551 2.384 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr5_-_136834982 2.182 ENST00000510689.1
ENST00000394945.1
SPOCK1

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

chr10_+_104154229 2.182 ENST00000428099.1
ENST00000369966.3
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr6_+_138188378 1.966 ENST00000420009.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr9_+_116917807 1.956 ENST00000356083.3
COL27A1
collagen, type XXVII, alpha 1
chr9_+_100174232 1.889 ENST00000355295.4
TDRD7
tudor domain containing 7
chr9_+_100174344 1.708 ENST00000422139.2
TDRD7
tudor domain containing 7
chr20_-_30311703 1.625 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1



BCL2-like 1



chr1_-_186344802 1.495 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr12_-_51663728 1.340 ENST00000603864.1
ENST00000605426.1
SMAGP

small cell adhesion glycoprotein

chr12_-_51663959 1.327 ENST00000604188.1
ENST00000398453.3
SMAGP

small cell adhesion glycoprotein

chr1_-_94374946 1.321 ENST00000370238.3
GCLM
glutamate-cysteine ligase, modifier subunit
chr1_-_156675535 1.319 ENST00000368221.1
CRABP2
cellular retinoic acid binding protein 2
chr10_+_17272608 1.251 ENST00000421459.2
VIM
vimentin
chr5_-_139726181 1.224 ENST00000507104.1
ENST00000230990.6
HBEGF

heparin-binding EGF-like growth factor

chr16_+_30996502 1.214 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7




hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7




chr14_+_52118576 1.163 ENST00000395718.2
ENST00000344768.5
FRMD6

FERM domain containing 6

chr1_-_156675564 1.147 ENST00000368220.1
CRABP2
cellular retinoic acid binding protein 2
chr12_+_111843749 1.126 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr2_-_166060552 1.126 ENST00000283254.7
ENST00000453007.1
SCN3A

sodium channel, voltage-gated, type III, alpha subunit

chr3_+_50192457 1.074 ENST00000414301.1
ENST00000450338.1
SEMA3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

chr12_+_82752283 1.020 ENST00000548200.1
METTL25
methyltransferase like 25
chr8_+_67341239 1.011 ENST00000320270.2
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr12_+_82752647 1.002 ENST00000550058.1
METTL25
methyltransferase like 25
chr15_-_58358607 0.965 ENST00000249750.4
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr8_+_22446763 0.953 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4


Uncharacterized protein


chr3_+_50192499 0.951 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr8_-_90996459 0.945 ENST00000517337.1
ENST00000409330.1
NBN

nibrin

chr2_-_166060571 0.924 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_66104237 0.911 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr2_-_166060382 0.897 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr9_+_103189536 0.872 ENST00000374885.1
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr5_+_35617940 0.866 ENST00000282469.6
ENST00000509059.1
ENST00000356031.3
ENST00000510777.1
SPEF2



sperm flagellar 2



chr10_+_81107216 0.865 ENST00000394579.3
ENST00000225174.3
PPIF

peptidylprolyl isomerase F

chr11_+_2421718 0.853 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
TSSC4




tumor suppressing subtransferable candidate 4




chr6_+_31105426 0.827 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr1_-_212208842 0.822 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7



integrator complex subunit 7



chr1_-_159915386 0.822 ENST00000361509.3
ENST00000368094.1
IGSF9

immunoglobulin superfamily, member 9

chr19_+_7445850 0.812 ENST00000593531.1
CTD-2207O23.3
Rho guanine nucleotide exchange factor 18
chr9_+_103189405 0.812 ENST00000395067.2
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr9_+_103189458 0.808 ENST00000398977.2
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr9_-_38069208 0.800 ENST00000377707.3
ENST00000377700.4
SHB

Src homology 2 domain containing adaptor protein B

chr1_-_146989697 0.784 ENST00000437831.1
LINC00624
long intergenic non-protein coding RNA 624
chr10_-_47151341 0.767 ENST00000422732.2
LINC00842
long intergenic non-protein coding RNA 842
chr12_-_120703523 0.754 ENST00000267257.7
ENST00000228307.7
ENST00000424649.2
PXN


paxillin


chr8_-_90996837 0.753 ENST00000519426.1
ENST00000265433.3
NBN

nibrin

chr2_-_220025263 0.750 ENST00000457600.1
NHEJ1
nonhomologous end-joining factor 1
chr16_+_30406721 0.748 ENST00000320159.2
ZNF48
zinc finger protein 48
chr1_-_113249678 0.723 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
RHOC



ras homolog family member C



chr3_-_64009658 0.718 ENST00000394431.2
PSMD6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr1_-_113249734 0.718 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
RHOC




ras homolog family member C




chr11_-_118436606 0.712 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr10_-_96122682 0.705 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr15_+_75074410 0.703 ENST00000439220.2
CSK
c-src tyrosine kinase
chr9_-_139258235 0.699 ENST00000371738.3
DNLZ
DNL-type zinc finger
chr11_-_66103932 0.694 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr18_+_43753500 0.685 ENST00000587591.1
ENST00000588730.1
C18orf25

chromosome 18 open reading frame 25

chr6_+_155054459 0.682 ENST00000367178.3
ENST00000417268.1
ENST00000367186.4
SCAF8


SR-related CTD-associated factor 8


chr3_-_64009102 0.680 ENST00000478185.1
ENST00000482510.1
ENST00000497323.1
ENST00000492933.1
ENST00000295901.4
PSMD6




proteasome (prosome, macropain) 26S subunit, non-ATPase, 6




chr20_+_30102231 0.675 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
HM13




histocompatibility (minor) 13




chr19_-_19051993 0.670 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3



homer homolog 3 (Drosophila)



chr16_+_69345243 0.669 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_+_151129135 0.658 ENST00000602841.1
SCNM1
sodium channel modifier 1
chr15_+_75074385 0.656 ENST00000220003.9
CSK
c-src tyrosine kinase
chr19_+_47852538 0.648 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr6_+_35310312 0.645 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD



peroxisome proliferator-activated receptor delta



chr1_-_6614565 0.642 ENST00000377705.5
NOL9
nucleolar protein 9
chr16_-_69788816 0.640 ENST00000268802.5
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr1_+_112298514 0.640 ENST00000536167.1
DDX20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
chr11_-_72504681 0.634 ENST00000538536.1
ENST00000543304.1
ENST00000540587.1
ENST00000334805.6
STARD10



StAR-related lipid transfer (START) domain containing 10



chr19_+_4791722 0.633 ENST00000269856.3
FEM1A
fem-1 homolog a (C. elegans)
chr7_-_27219849 0.630 ENST00000396344.4
HOXA10
homeobox A10
chr19_-_1848451 0.626 ENST00000170168.4
REXO1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr17_-_79827808 0.624 ENST00000580685.1
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr10_-_30024716 0.619 ENST00000375398.2
ENST00000375400.3
SVIL

supervillin

chr11_-_798305 0.616 ENST00000531514.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr13_+_31774073 0.614 ENST00000343307.4
B3GALTL
beta 1,3-galactosyltransferase-like
chr7_-_5569588 0.611 ENST00000417101.1
ACTB
actin, beta
chr11_-_66103867 0.601 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr19_-_19051927 0.600 ENST00000600077.1
HOMER3
homer homolog 3 (Drosophila)
chr6_+_35310391 0.594 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD


peroxisome proliferator-activated receptor delta


chr12_+_110338323 0.592 ENST00000312777.5
ENST00000536408.2
TCHP

trichoplein, keratin filament binding

chr3_+_58291965 0.591 ENST00000445193.3
ENST00000295959.5
ENST00000466547.1
RPP14


ribonuclease P/MRP 14kDa subunit


chr2_+_102972363 0.590 ENST00000409599.1
IL18R1
interleukin 18 receptor 1
chr16_-_19897455 0.590 ENST00000568214.1
ENST00000569479.1
GPRC5B

G protein-coupled receptor, family C, group 5, member B

chr7_+_1126461 0.581 ENST00000297469.3
GPER1
G protein-coupled estrogen receptor 1
chr7_+_6629701 0.569 ENST00000359073.5
C7orf26
chromosome 7 open reading frame 26
chr14_+_24630465 0.567 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9


interferon regulatory factor 9


chr22_-_22292934 0.558 ENST00000538191.1
ENST00000424647.1
ENST00000407142.1
PPM1F


protein phosphatase, Mg2+/Mn2+ dependent, 1F


chr12_-_102224457 0.556 ENST00000549165.1
ENST00000549940.1
ENST00000392919.4
GNPTAB


N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits


chr22_+_31160239 0.556 ENST00000445781.1
ENST00000401475.1
OSBP2

oxysterol binding protein 2

chr12_-_82752159 0.554 ENST00000552377.1
CCDC59
coiled-coil domain containing 59
chr1_+_237205476 0.550 ENST00000366574.2
RYR2
ryanodine receptor 2 (cardiac)
chr16_+_4674814 0.548 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
MGRN1




mahogunin ring finger 1, E3 ubiquitin protein ligase




chr17_+_28804380 0.545 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
GOSR1




golgi SNAP receptor complex member 1




chr22_-_19132154 0.544 ENST00000252137.6
DGCR14
DiGeorge syndrome critical region gene 14
chr3_+_172468749 0.540 ENST00000366254.2
ENST00000415665.1
ENST00000438041.1
ECT2


epithelial cell transforming sequence 2 oncogene


chr11_-_119599794 0.539 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr6_-_34216766 0.536 ENST00000481533.1
ENST00000468145.1
ENST00000413013.2
ENST00000394990.4
ENST00000335352.3
C6orf1




chromosome 6 open reading frame 1




chr22_+_42834029 0.536 ENST00000428765.1
CTA-126B4.7
CTA-126B4.7
chr4_+_56815102 0.533 ENST00000257287.4
CEP135
centrosomal protein 135kDa
chr4_+_7045042 0.528 ENST00000310074.7
ENST00000512388.1
TADA2B

transcriptional adaptor 2B

chr2_-_72375167 0.522 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr1_+_186344945 0.511 ENST00000419367.3
ENST00000287859.6
C1orf27

chromosome 1 open reading frame 27

chrX_-_153279697 0.507 ENST00000444254.1
IRAK1
interleukin-1 receptor-associated kinase 1
chr12_+_110338063 0.505 ENST00000405876.4
TCHP
trichoplein, keratin filament binding
chr3_+_172468505 0.501 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2




epithelial cell transforming sequence 2 oncogene




chr15_+_45722727 0.501 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
C15orf48


chromosome 15 open reading frame 48


chr20_-_1447467 0.499 ENST00000353088.2
ENST00000350991.4
NSFL1C

NSFL1 (p97) cofactor (p47)

chr12_+_13197218 0.498 ENST00000197268.8
KIAA1467
KIAA1467
chr16_+_4674787 0.498 ENST00000262370.7
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr6_-_139309378 0.489 ENST00000450536.2
ENST00000258062.5
REPS1

RALBP1 associated Eps domain containing 1

chr6_-_139308777 0.488 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
REPS1



RALBP1 associated Eps domain containing 1



chr12_-_102224704 0.487 ENST00000299314.7
GNPTAB
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr8_+_42948641 0.484 ENST00000518991.1
ENST00000331373.5
POMK

protein-O-mannose kinase

chr11_+_66025938 0.484 ENST00000394066.2
KLC2
kinesin light chain 2
chr22_-_22901477 0.481 ENST00000420709.1
ENST00000398741.1
ENST00000405655.3
PRAME


preferentially expressed antigen in melanoma


chr19_-_41859814 0.474 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr18_-_21166841 0.470 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr1_+_186344883 0.469 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr9_-_22009241 0.468 ENST00000380142.4
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr9_+_91003271 0.466 ENST00000375859.3
ENST00000541629.1
SPIN1

spindlin 1

chr1_+_64239657 0.465 ENST00000371080.1
ENST00000371079.1
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr3_+_172468472 0.464 ENST00000232458.5
ENST00000392692.3
ECT2

epithelial cell transforming sequence 2 oncogene

chr13_-_88323218 0.462 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG


MIR4500 host gene (non-protein coding)


chr7_+_1126437 0.451 ENST00000413368.1
ENST00000397092.1
GPER1

G protein-coupled estrogen receptor 1

chr15_+_92396920 0.449 ENST00000318445.6
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr9_+_33617760 0.443 ENST00000379435.3
TRBV20OR9-2
T cell receptor beta variable 20/OR9-2 (non-functional)
chr20_-_1447547 0.443 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr2_+_69240511 0.442 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr20_+_48807351 0.435 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr14_+_52118694 0.432 ENST00000554778.1
FRMD6
FERM domain containing 6
chr8_+_74206829 0.426 ENST00000240285.5
RDH10
retinol dehydrogenase 10 (all-trans)
chr9_+_71650645 0.425 ENST00000396366.2
FXN
frataxin
chr9_+_103189660 0.420 ENST00000374886.3
MSANTD3
Myb/SANT-like DNA-binding domain containing 3
chr22_-_22901636 0.419 ENST00000406503.1
ENST00000439106.1
ENST00000402697.1
ENST00000543184.1
ENST00000398743.2
PRAME




preferentially expressed antigen in melanoma




chr16_+_29827285 0.416 ENST00000320330.6
PAGR1
PAXIP1 associated glutamate-rich protein 1
chr4_-_7044657 0.411 ENST00000310085.4
CCDC96
coiled-coil domain containing 96
chr19_+_5690207 0.411 ENST00000347512.3
RPL36
ribosomal protein L36
chr1_+_15480197 0.408 ENST00000400796.3
ENST00000434578.2
ENST00000376008.2
TMEM51


transmembrane protein 51


chr13_-_88323514 0.408 ENST00000441617.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr6_+_127588020 0.405 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146




ring finger protein 146




chr19_+_41313017 0.405 ENST00000595621.1
ENST00000595051.1
EGLN2

egl-9 family hypoxia-inducible factor 2

chr10_+_103892787 0.404 ENST00000278070.2
ENST00000413464.2
PPRC1

peroxisome proliferator-activated receptor gamma, coactivator-related 1

chr7_+_148844516 0.402 ENST00000420008.2
ENST00000475153.1
ZNF398

zinc finger protein 398

chr21_-_36262032 0.402 ENST00000325074.5
ENST00000399237.2
RUNX1

runt-related transcription factor 1

chr3_-_190040223 0.401 ENST00000295522.3
CLDN1
claudin 1
chr16_+_75032901 0.401 ENST00000335325.4
ENST00000320619.6
ZNRF1

zinc and ring finger 1, E3 ubiquitin protein ligase

chr16_+_29827832 0.400 ENST00000609618.1
PAGR1
PAXIP1-associated glutamate-rich protein 1
chr17_+_38137050 0.400 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr7_-_100425112 0.399 ENST00000358173.3
EPHB4
EPH receptor B4
chr1_-_114447683 0.399 ENST00000256658.4
ENST00000369564.1
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr22_-_22307199 0.399 ENST00000397495.4
ENST00000263212.5
PPM1F

protein phosphatase, Mg2+/Mn2+ dependent, 1F

chr1_+_145525015 0.397 ENST00000539363.1
ENST00000538811.1
ITGA10

integrin, alpha 10

chr11_-_68611721 0.396 ENST00000561996.1
CPT1A
carnitine palmitoyltransferase 1A (liver)
chr19_+_16222439 0.394 ENST00000300935.3
RAB8A
RAB8A, member RAS oncogene family
chr16_+_2255841 0.393 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr16_-_66907139 0.390 ENST00000561579.2
NAE1
NEDD8 activating enzyme E1 subunit 1
chr15_-_34502278 0.390 ENST00000559515.1
ENST00000256544.3
ENST00000560108.1
ENST00000559462.1
KATNBL1



katanin p80 subunit B-like 1



chr3_-_49967292 0.388 ENST00000455683.2
MON1A
MON1 secretory trafficking family member A
chr8_-_11325047 0.388 ENST00000531804.1
FAM167A
family with sequence similarity 167, member A
chr9_-_132404374 0.388 ENST00000277459.4
ENST00000450050.2
ENST00000277458.4
ASB6


ankyrin repeat and SOCS box containing 6


chr17_+_38137073 0.387 ENST00000541736.1
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr17_-_73901494 0.386 ENST00000309352.3
MRPL38
mitochondrial ribosomal protein L38
chr2_+_33701707 0.383 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3


RAS guanyl releasing protein 3 (calcium and DAG-regulated)


chr12_+_7033616 0.383 ENST00000356654.4
ATN1
atrophin 1
chr16_-_70713928 0.380 ENST00000576338.1
MTSS1L
metastasis suppressor 1-like
chr1_-_114447412 0.376 ENST00000369567.1
ENST00000369566.3
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr1_-_114447620 0.368 ENST00000369569.1
ENST00000432415.1
ENST00000369571.2
AP4B1


adaptor-related protein complex 4, beta 1 subunit


chr16_+_2255710 0.365 ENST00000397124.1
ENST00000565250.1
MLST8

MTOR associated protein, LST8 homolog (S. cerevisiae)

chr19_+_5690297 0.362 ENST00000582463.1
ENST00000579446.1
ENST00000394580.2
RPL36


ribosomal protein L36


chr16_+_1756162 0.361 ENST00000250894.4
ENST00000356010.5
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr8_-_101571933 0.361 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chr17_-_33469299 0.356 ENST00000586869.1
ENST00000360831.5
ENST00000442241.4
NLE1


notchless homolog 1 (Drosophila)


chr19_+_16222678 0.354 ENST00000586682.1
RAB8A
RAB8A, member RAS oncogene family
chr12_-_58159361 0.352 ENST00000546567.1
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_+_16767195 0.351 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2



NECAP endocytosis associated 2



chr3_-_183735731 0.349 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr7_+_6629621 0.348 ENST00000344417.5
C7orf26
chromosome 7 open reading frame 26
chr1_+_29063119 0.348 ENST00000474884.1
ENST00000542507.1
YTHDF2

YTH domain family, member 2

chr16_+_2255447 0.347 ENST00000562352.1
ENST00000562479.1
ENST00000301724.10
MLST8


MTOR associated protein, LST8 homolog (S. cerevisiae)


chr6_+_138188351 0.346 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr7_+_156742399 0.345 ENST00000275820.3
NOM1
nucleolar protein with MIF4G domain 1
chr1_+_28844778 0.345 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr12_-_95510743 0.345 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr1_+_16767167 0.343 ENST00000337132.5
NECAP2
NECAP endocytosis associated 2
chr15_-_34502197 0.342 ENST00000557877.1
KATNBL1
katanin p80 subunit B-like 1
chr3_+_156799587 0.341 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr12_+_50898881 0.340 ENST00000301180.5
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr4_+_1003742 0.338 ENST00000398484.2
FGFRL1
fibroblast growth factor receptor-like 1
chr17_-_45908875 0.333 ENST00000351111.2
ENST00000414011.1
MRPL10

mitochondrial ribosomal protein L10

chr14_-_75079026 0.330 ENST00000261978.4
LTBP2
latent transforming growth factor beta binding protein 2
chr12_+_49208234 0.330 ENST00000540990.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr11_-_36531774 0.328 ENST00000348124.5
ENST00000526995.1
TRAF6

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

chr19_+_49496782 0.328 ENST00000601968.1
ENST00000596837.1
RUVBL2

RuvB-like AAA ATPase 2

chr6_+_127587755 0.327 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146





ring finger protein 146





chr1_-_113249948 0.326 ENST00000339083.7
ENST00000369642.3
RHOC

ras homolog family member C

chr10_-_79789291 0.324 ENST00000372371.3
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr8_+_101170563 0.323 ENST00000520508.1
ENST00000388798.2
SPAG1

sperm associated antigen 1

chr19_+_49496705 0.321 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.6 1.7 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.5 2.2 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.4 2.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 1.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.3 1.0 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.3 1.3 GO:0097069 response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.3 1.0 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 1.9 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 1.8 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 0.9 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.3 2.0 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 0.7 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 0.7 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 1.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.2 1.6 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.2 1.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.2 1.2 GO:0051541 elastin metabolic process(GO:0051541)
0.2 3.9 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.2 0.5 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.2 1.6 GO:0003383 apical constriction(GO:0003383)
0.2 0.5 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.2 2.0 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.2 0.6 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 0.5 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.1 0.4 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 1.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.4 GO:0071284 cellular response to lead ion(GO:0071284) positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 0.8 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:1904690 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.1 0.4 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.1 0.4 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) proprioception(GO:0019230)
0.1 1.7 GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.1 3.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.3 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 1.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 1.0 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.1 0.2 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 1.0 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 0.3 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.1 0.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.6 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.1 0.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 1.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.2 GO:0032203 telomere formation via telomerase(GO:0032203)
0.1 1.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 3.2 GO:0019228 neuronal action potential(GO:0019228)
0.1 1.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.2 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.1 0.7 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.2 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.2 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 1.1 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.8 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.6 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.0 0.3 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.0 0.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:2000625 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.0 2.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.3 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 1.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.3 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.0 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.8 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.4 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.2 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.0 0.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.4 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.6 GO:0060065 uterus development(GO:0060065)
0.0 2.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124) regulation of GTP binding(GO:1904424)
0.0 0.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.1 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.0 0.1 GO:0060455 positive regulation of norepinephrine secretion(GO:0010701) response to anoxia(GO:0034059) positive regulation of penile erection(GO:0060406) negative regulation of gastric acid secretion(GO:0060455)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.6 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.1 GO:1990834 response to odorant(GO:1990834)
0.0 2.6 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.0 GO:0070781 response to biotin(GO:0070781)
0.0 0.1 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.6 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 1.0 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 0.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.3 GO:0048820 hair follicle maturation(GO:0048820)
0.0 0.5 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.1 GO:0060702 negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702)
0.0 0.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.0 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:1904526 regulation of microtubule binding(GO:1904526)
0.0 0.5 GO:0048536 spleen development(GO:0048536)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.3 1.3 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.3 1.5 GO:0097149 centralspindlin complex(GO:0097149)
0.2 3.6 GO:0033391 chromatoid body(GO:0033391)
0.2 3.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 0.7 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.2 0.9 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 0.4 GO:0034455 t-UTP complex(GO:0034455)
0.1 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.8 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.5 GO:0016938 kinesin I complex(GO:0016938)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.3 GO:0034515 proteasome storage granule(GO:0034515)
0.1 0.5 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 2.2 GO:0033268 node of Ranvier(GO:0033268)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 1.1 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.0 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0097255 R2TP complex(GO:0097255)
0.1 1.1 GO:0032059 bleb(GO:0032059)
0.1 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.8 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 1.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.6 GO:0097433 dense body(GO:0097433)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0030681 multimeric ribonuclease P complex(GO:0030681)
0.0 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.1 GO:0035101 FACT complex(GO:0035101)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.0 0.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.7 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.0 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.3 GO:0031904 endosome lumen(GO:0031904)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.2 GO:0045178 basal part of cell(GO:0045178)
0.0 0.3 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.3 1.3 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.3 1.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.2 4.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 0.2 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 0.6 GO:0031862 prostanoid receptor binding(GO:0031862)
0.2 0.6 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.2 1.3 GO:1990254 keratin filament binding(GO:1990254)
0.2 1.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.0 GO:0008097 5S rRNA binding(GO:0008097)
0.2 3.4 GO:0016918 retinal binding(GO:0016918)
0.1 0.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 1.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.4 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.1 0.6 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 3.0 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 2.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 2.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.2 GO:0019808 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.1 0.6 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.8 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.7 GO:0043495 protein anchor(GO:0043495)
0.1 1.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 0.4 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.0 1.2 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 1.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.6 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.6 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.7 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.1 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 0.3 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.9 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.3 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.0 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 2.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.0 0.4 GO:0043566 structure-specific DNA binding(GO:0043566)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0005003 ephrin receptor activity(GO:0005003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 4.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.1 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.1 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.1 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.4 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 0.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 5.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.4 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.5 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.1 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.2 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 1.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 2.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.4 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.4 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions