Motif ID: PPARG
Z-value: 1.729
Transcription factors associated with PPARG:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PPARG | ENSG00000132170.15 | PPARG |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARG | hg19_v2_chr3_+_12329358_12329393 | 0.35 | 3.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 17.1 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 1.3 | 5.2 | GO:2000503 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.7 | 2.9 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.5 | 2.5 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.4 | 1.3 | GO:0045553 | TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556) |
| 0.4 | 1.6 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.3 | 1.3 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.3 | 1.2 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.3 | 0.8 | GO:0048320 | axial mesoderm formation(GO:0048320) |
| 0.2 | 1.7 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.2 | 1.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 1.2 | GO:0070221 | sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) |
| 0.2 | 0.6 | GO:1902463 | protein localization to cell leading edge(GO:1902463) |
| 0.2 | 0.5 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) |
| 0.2 | 0.5 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.2 | 0.7 | GO:0072287 | metanephric distal tubule morphogenesis(GO:0072287) |
| 0.2 | 0.6 | GO:1904199 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
| 0.1 | 3.8 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.1 | 5.0 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 1.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.6 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
| 0.1 | 0.5 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.1 | 1.1 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 0.4 | GO:0070781 | response to biotin(GO:0070781) |
| 0.1 | 0.5 | GO:1905224 | clathrin-coated pit assembly(GO:1905224) |
| 0.1 | 1.0 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.1 | 0.5 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.1 | 0.4 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 0.1 | 0.8 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.1 | 0.5 | GO:0050668 | cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668) |
| 0.1 | 1.5 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 0.4 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.1 | 0.5 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.1 | 0.7 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.1 | 1.8 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.1 | 0.4 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.1 | 0.4 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 1.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.3 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 0.1 | 0.5 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.1 | 0.4 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.1 | 0.2 | GO:2000395 | regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 0.1 | 0.6 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.1 | 0.3 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.1 | 0.3 | GO:1902045 | negative regulation of Fas signaling pathway(GO:1902045) |
| 0.1 | 0.4 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.1 | 0.4 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.0 | 0.4 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.0 | 0.5 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.0 | 0.6 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.0 | 0.3 | GO:1902019 | regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 0.0 | 0.5 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.0 | 0.6 | GO:0090261 | positive regulation of inclusion body assembly(GO:0090261) |
| 0.0 | 0.3 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.2 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.0 | 0.3 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.0 | 0.4 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 1.4 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.1 | GO:0019521 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
| 0.0 | 0.1 | GO:0001923 | B-1 B cell differentiation(GO:0001923) |
| 0.0 | 0.5 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.2 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.0 | 0.6 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
| 0.0 | 1.0 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.0 | 0.2 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 0.2 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.0 | 0.3 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 0.7 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 2.3 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.0 | 1.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.1 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.0 | 0.2 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.0 | 0.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.6 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 0.4 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.1 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.0 | 0.2 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.0 | 0.3 | GO:0060235 | embryonic retina morphogenesis in camera-type eye(GO:0060059) lens induction in camera-type eye(GO:0060235) |
| 0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 0.1 | GO:0014054 | positive regulation of gamma-aminobutyric acid secretion(GO:0014054) |
| 0.0 | 0.5 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 0.2 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.0 | 0.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.1 | GO:1904526 | regulation of microtubule binding(GO:1904526) |
| 0.0 | 4.1 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.0 | 0.0 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
| 0.0 | 0.8 | GO:0032402 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 0.0 | 0.2 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.0 | 0.2 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.0 | 0.5 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 0.3 | GO:0090344 | negative regulation of cell aging(GO:0090344) |
| 0.0 | 0.6 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.5 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.1 | GO:0034473 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 0.0 | 0.1 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.0 | 0.1 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.0 | 2.2 | GO:0045995 | regulation of embryonic development(GO:0045995) |
| 0.0 | 0.0 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.0 | 0.0 | GO:0052214 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.0 | 0.6 | GO:0042026 | protein refolding(GO:0042026) |
| 0.0 | 1.2 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.2 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.0 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.0 | 0.2 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.0 | 0.1 | GO:0050916 | sensory perception of sweet taste(GO:0050916) |
| 0.0 | 0.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.2 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.9 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.2 | 2.2 | GO:0098645 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.2 | 0.8 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.2 | 4.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 0.7 | GO:0002133 | polycystin complex(GO:0002133) |
| 0.1 | 4.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.5 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.1 | 1.2 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 0.4 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.1 | 0.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.5 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 1.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.2 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.0 | 3.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.9 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.3 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 0.6 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.3 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.4 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 0.7 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.2 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.9 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.6 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.6 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.0 | 0.1 | GO:0032449 | CBM complex(GO:0032449) |
| 0.0 | 0.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.3 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 0.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.1 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.0 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 17.1 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.6 | 5.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.6 | 1.7 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.3 | 1.3 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.3 | 1.0 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) |
| 0.3 | 2.9 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.3 | 1.2 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.3 | 4.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.3 | 0.8 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.2 | 1.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.2 | 0.5 | GO:0004423 | iduronate-2-sulfatase activity(GO:0004423) |
| 0.2 | 0.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.2 | 0.6 | GO:0050252 | retinol O-fatty-acyltransferase activity(GO:0050252) |
| 0.1 | 1.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 0.7 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.1 | 0.4 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.1 | 1.0 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.1 | 1.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 1.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 1.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 0.3 | GO:0010309 | acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309) |
| 0.1 | 3.8 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.3 | GO:0035539 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539) |
| 0.1 | 0.4 | GO:0050421 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026) nitrite reductase activity(GO:0098809) |
| 0.1 | 0.8 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 0.4 | GO:0004052 | arachidonate 12-lipoxygenase activity(GO:0004052) |
| 0.1 | 0.3 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.1 | 0.4 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 0.5 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.5 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.8 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.6 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.1 | 0.4 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.1 | 0.3 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.1 | 0.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.1 | 0.3 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 0.2 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.0 | 0.1 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.0 | 0.2 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.8 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.2 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.0 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.4 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 1.2 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 1.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.3 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 1.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 2.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.6 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.2 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 0.4 | GO:0022850 | serotonin-gated cation channel activity(GO:0022850) |
| 0.0 | 0.3 | GO:0009374 | biotin binding(GO:0009374) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 1.0 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 2.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.2 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.0 | 0.4 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 4.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 1.0 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 0.6 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.4 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 0.4 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 0.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549) |
| 0.0 | 0.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.8 | GO:0015485 | cholesterol binding(GO:0015485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 4.0 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 2.8 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.6 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 4.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.3 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.9 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.5 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 9.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.8 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 4.0 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.2 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.9 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.5 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.2 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.1 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 4.9 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 5.0 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.0 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 0.3 | REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 1.0 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 4.4 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.4 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.7 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.5 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 1.2 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 2.5 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 2.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.4 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.7 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.5 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.6 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.5 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.5 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.9 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.2 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.1 | REACTOME_DOWNSTREAM_TCR_SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 0.2 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
