Motif ID: PKNOX1_TGIF2

Z-value: 0.956

Transcription factors associated with PKNOX1_TGIF2:

Gene SymbolEntrez IDGene Name
PKNOX1 ENSG00000160199.10 PKNOX1
TGIF2 ENSG00000118707.5 TGIF2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PKNOX1hg19_v2_chr21_+_44394620_44394737-0.694.2e-02Click!
TGIF2hg19_v2_chr20_+_35202909_352030750.343.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_138188551 1.449 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr12_-_15114191 0.878 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr15_+_59908633 0.690 ENST00000559626.1
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr18_-_52626622 0.680 ENST00000591504.1
CCDC68
coiled-coil domain containing 68
chr17_-_39661849 0.660 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13



keratin 13



chr5_+_125758865 0.633 ENST00000542322.1
ENST00000544396.1
GRAMD3

GRAM domain containing 3

chr1_+_181057638 0.624 ENST00000367577.4
IER5
immediate early response 5
chr12_+_13044787 0.611 ENST00000534831.1
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr5_+_125758813 0.595 ENST00000285689.3
ENST00000515200.1
GRAMD3

GRAM domain containing 3

chr18_+_54318893 0.591 ENST00000593058.1
WDR7
WD repeat domain 7
chr14_-_100842588 0.587 ENST00000556645.1
ENST00000556209.1
ENST00000556504.1
ENST00000556435.1
ENST00000554772.1
ENST00000553581.1
ENST00000553769.2
ENST00000554605.1
ENST00000557722.1
ENST00000553413.1
ENST00000553524.1
ENST00000358655.4
WARS











tryptophanyl-tRNA synthetase











chr5_+_125759140 0.584 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr8_-_99837856 0.575 ENST00000518165.1
ENST00000419617.2
STK3

serine/threonine kinase 3

chr18_-_54318353 0.542 ENST00000590954.1
ENST00000540155.1
TXNL1

thioredoxin-like 1

chr18_+_54318566 0.532 ENST00000589935.1
ENST00000357574.3
WDR7

WD repeat domain 7

chr17_+_39868577 0.528 ENST00000329402.3
GAST
gastrin
chr19_+_49375649 0.527 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr18_+_54318616 0.509 ENST00000254442.3
WDR7
WD repeat domain 7
chr1_-_208417620 0.489 ENST00000367033.3
PLXNA2
plexin A2
chr11_-_107729504 0.476 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr1_+_207262627 0.472 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr11_-_107729287 0.453 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr16_-_69418649 0.450 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr1_+_207262540 0.438 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr1_+_207262170 0.434 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr12_+_72148614 0.421 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr11_-_71810258 0.418 ENST00000544594.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_+_207262578 0.416 ENST00000243611.5
ENST00000367076.3
C4BPB

complement component 4 binding protein, beta

chr1_+_66258846 0.404 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr11_-_107729887 0.403 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr1_-_179198702 0.390 ENST00000502732.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr1_-_53163992 0.382 ENST00000371538.3
SELRC1
cytochrome c oxidase assembly factor 7
chr14_-_50474238 0.376 ENST00000399206.1
C14orf182
chromosome 14 open reading frame 182
chr1_-_179198806 0.370 ENST00000392043.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr16_-_69418553 0.367 ENST00000569542.2
TERF2
telomeric repeat binding factor 2
chr1_+_207262881 0.355 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr10_+_28966271 0.354 ENST00000375533.3
BAMBI
BMP and activin membrane-bound inhibitor
chr3_+_150804676 0.353 ENST00000474524.1
ENST00000273432.4
MED12L

mediator complex subunit 12-like

chr16_+_50776021 0.352 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD


cylindromatosis (turban tumor syndrome)


chr7_-_148580563 0.350 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_-_29151686 0.349 ENST00000544695.1
CRLF3
cytokine receptor-like factor 3
chr5_-_132073111 0.344 ENST00000403231.1
KIF3A
kinesin family member 3A
chr2_+_113321939 0.342 ENST00000458012.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr9_-_132805430 0.330 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
FNBP1


formin binding protein 1


chrX_-_148713440 0.321 ENST00000536359.1
ENST00000316916.8
TMEM185A

transmembrane protein 185A

chr18_-_54305658 0.315 ENST00000586262.1
ENST00000217515.6
TXNL1

thioredoxin-like 1

chr9_-_123639445 0.313 ENST00000312189.6
PHF19
PHD finger protein 19
chrX_+_101380642 0.307 ENST00000372780.1
ENST00000329035.2
TCEAL2

transcription elongation factor A (SII)-like 2

chr16_-_89556942 0.302 ENST00000301030.4
ANKRD11
ankyrin repeat domain 11
chr22_+_36044411 0.294 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr2_+_29353520 0.292 ENST00000438819.1
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr16_-_30457048 0.291 ENST00000500504.2
ENST00000542752.1
SEPHS2

selenophosphate synthetase 2

chr1_+_22778337 0.291 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
ZBTB40



zinc finger and BTB domain containing 40



chr9_-_123639304 0.287 ENST00000436309.1
PHF19
PHD finger protein 19
chr6_-_37225391 0.277 ENST00000356757.2
TMEM217
transmembrane protein 217
chr3_-_52719888 0.277 ENST00000458294.1
PBRM1
polybromo 1
chr3_+_67048721 0.276 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8



kelch repeat and BTB (POZ) domain containing 8



chr2_+_33661382 0.275 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_66205712 0.274 ENST00000442563.1
ENST00000450873.2
ENST00000284957.5
ENST00000451741.2
RABGEF1


KCTD7
RAB guanine nucleotide exchange factor (GEF) 1


potassium channel tetramerization domain containing 7
chr14_+_100842735 0.272 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WDR25



WD repeat domain 25



chr15_+_51200871 0.271 ENST00000560508.1
AP4E1
adaptor-related protein complex 4, epsilon 1 subunit
chr2_-_3504587 0.269 ENST00000415131.1
ADI1
acireductone dioxygenase 1
chr6_-_86099898 0.268 ENST00000455071.1
RP11-30P6.6
RP11-30P6.6
chr22_+_44761431 0.268 ENST00000406912.1
RP1-32I10.10
Uncharacterized protein
chr7_+_23210760 0.267 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr2_-_74780176 0.260 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr1_-_186649543 0.260 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_114682224 0.259 ENST00000342666.5
ENST00000515496.1
ENST00000514328.1
ENST00000508738.1
ENST00000379773.2
CAMK2D




calcium/calmodulin-dependent protein kinase II delta




chr12_+_95611569 0.258 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
VEZT


vezatin, adherens junctions transmembrane protein


chr5_-_94620239 0.253 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr2_+_62900986 0.250 ENST00000405015.3
ENST00000413434.1
ENST00000426940.1
ENST00000449820.1
EHBP1



EH domain binding protein 1



chr12_+_95611516 0.250 ENST00000436874.1
VEZT
vezatin, adherens junctions transmembrane protein
chr12_+_62654155 0.249 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15


ubiquitin specific peptidase 15


chr11_-_46867780 0.247 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
CKAP5


cytoskeleton associated protein 5


chr17_-_29151794 0.245 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr19_+_2867325 0.244 ENST00000307635.2
ENST00000586426.1
ZNF556

zinc finger protein 556

chr16_-_3030407 0.241 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1






protein kinase, membrane associated tyrosine/threonine 1






chr12_+_69201923 0.240 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2





MDM2 oncogene, E3 ubiquitin protein ligase





chr2_-_207078154 0.237 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr16_+_16484691 0.237 ENST00000344087.4
NPIPA7
nuclear pore complex interacting protein family, member A7
chr10_+_94608245 0.237 ENST00000443748.2
ENST00000260762.6
EXOC6

exocyst complex component 6

chr16_-_57831676 0.235 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3


kinesin family member C3


chr5_+_95187934 0.232 ENST00000357880.3
ENST00000436592.1
C5orf27

chromosome 5 open reading frame 27

chr4_+_84457250 0.230 ENST00000395226.2
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr3_-_52719810 0.230 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1



polybromo 1



chr15_+_36871983 0.218 ENST00000437989.2
ENST00000569302.1
C15orf41

chromosome 15 open reading frame 41

chr18_+_3449695 0.215 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr6_-_160209471 0.212 ENST00000539948.1
TCP1
t-complex 1
chr18_+_3449330 0.211 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr9_+_98637954 0.209 ENST00000288985.7
ERCC6L2
excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2
chr9_-_123638633 0.209 ENST00000456291.1
PHF19
PHD finger protein 19
chr13_+_76413852 0.208 ENST00000533809.2
LMO7
LIM domain 7
chr12_+_95611536 0.206 ENST00000549002.1
VEZT
vezatin, adherens junctions transmembrane protein
chrX_-_153583257 0.205 ENST00000438732.1
FLNA
filamin A, alpha
chr17_-_30228678 0.203 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr9_-_100459639 0.202 ENST00000375128.4
XPA
xeroderma pigmentosum, complementation group A
chr9_-_123639600 0.201 ENST00000373896.3
PHF19
PHD finger protein 19
chr5_+_150406527 0.200 ENST00000520059.1
GPX3
glutathione peroxidase 3 (plasma)
chr5_+_125798031 0.199 ENST00000502348.1
GRAMD3
GRAM domain containing 3
chr2_+_238165734 0.199 ENST00000445534.2
AC112715.2
Uncharacterized protein
chr16_+_2588012 0.196 ENST00000354836.5
ENST00000389224.3
PDPK1

3-phosphoinositide dependent protein kinase-1

chr21_+_38792602 0.196 ENST00000398960.2
ENST00000398956.2
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr17_+_38296576 0.195 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr15_+_33010175 0.194 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1


gremlin 1, DAN family BMP antagonist


chr9_-_123605177 0.192 ENST00000373904.5
ENST00000210313.3
PSMD5

proteasome (prosome, macropain) 26S subunit, non-ATPase, 5

chr17_+_8316442 0.191 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr12_+_75784850 0.189 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2





GLI pathogenesis-related 1 like 2





chr5_+_40841276 0.189 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr8_+_72755367 0.187 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr16_+_31044812 0.186 ENST00000313843.3
STX4
syntaxin 4
chr11_+_64052294 0.179 ENST00000536667.1
GPR137
G protein-coupled receptor 137
chr10_+_49514698 0.178 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8


mitogen-activated protein kinase 8


chr7_-_156685841 0.178 ENST00000354505.4
ENST00000540390.1
LMBR1

limb development membrane protein 1

chr20_-_33872548 0.177 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr9_-_111696340 0.177 ENST00000374647.5
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr2_+_198380289 0.177 ENST00000233892.4
ENST00000409916.1
MOB4

MOB family member 4, phocein

chr3_-_33482002 0.172 ENST00000283628.5
ENST00000456378.1
UBP1

upstream binding protein 1 (LBP-1a)

chr18_+_3449821 0.172 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1


TGFB-induced factor homeobox 1


chr3_-_52719912 0.171 ENST00000420148.1
PBRM1
polybromo 1
chr4_+_110736659 0.169 ENST00000394631.3
ENST00000226796.6
GAR1

GAR1 ribonucleoprotein

chr15_-_31283798 0.168 ENST00000435680.1
ENST00000425768.1
MTMR10

myotubularin related protein 10

chrX_-_148713365 0.165 ENST00000511776.1
ENST00000507237.1
TMEM185A

transmembrane protein 185A

chr2_-_61765732 0.164 ENST00000443240.1
ENST00000436018.1
XPO1

exportin 1 (CRM1 homolog, yeast)

chr21_+_30502806 0.162 ENST00000399928.1
ENST00000399926.1
MAP3K7CL

MAP3K7 C-terminal like

chr19_-_13044494 0.162 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
FARSA



phenylalanyl-tRNA synthetase, alpha subunit



chr17_-_79827808 0.161 ENST00000580685.1
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr10_+_28822636 0.160 ENST00000442148.1
ENST00000448193.1
WAC

WW domain containing adaptor with coiled-coil

chr11_+_6411636 0.158 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1


sphingomyelin phosphodiesterase 1, acid lysosomal


chr1_-_179112173 0.158 ENST00000408940.3
ENST00000504405.1
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr20_-_33872518 0.157 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr14_-_105635090 0.155 ENST00000331782.3
ENST00000347004.2
JAG2

jagged 2

chr12_-_30887948 0.155 ENST00000433722.2
CAPRIN2
caprin family member 2
chr2_-_61765315 0.154 ENST00000406957.1
ENST00000401558.2
XPO1

exportin 1 (CRM1 homolog, yeast)

chr7_+_29234101 0.153 ENST00000435288.2
CHN2
chimerin 2
chr1_-_179112189 0.153 ENST00000512653.1
ENST00000344730.3
ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr22_+_17082732 0.151 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr13_+_24844857 0.151 ENST00000409126.1
ENST00000343003.6
SPATA13

spermatogenesis associated 13

chr19_-_10764509 0.150 ENST00000591501.1
ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr19_+_11877838 0.149 ENST00000357901.4
ENST00000454339.2
ZNF441

zinc finger protein 441

chr1_+_41448820 0.148 ENST00000372616.1
CTPS1
CTP synthase 1
chr22_-_37640277 0.147 ENST00000401529.3
ENST00000249071.6
RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr19_+_52800410 0.146 ENST00000595962.1
ENST00000598016.1
ENST00000334564.7
ENST00000490272.1
ZNF480



zinc finger protein 480



chr11_+_60552797 0.145 ENST00000308287.1
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr11_+_6411670 0.145 ENST00000530395.1
ENST00000527275.1
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr14_+_62164340 0.145 ENST00000557538.1
ENST00000539097.1
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr17_+_76374714 0.143 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1




phosphatidylglycerophosphate synthase 1




chr13_-_39564993 0.140 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr3_-_49967292 0.139 ENST00000455683.2
MON1A
MON1 secretory trafficking family member A
chr7_-_53879623 0.139 ENST00000380970.2
GS1-179L18.1
GS1-179L18.1
chr1_+_145549203 0.138 ENST00000355594.4
ENST00000544626.1
ANKRD35

ankyrin repeat domain 35

chr7_+_79765071 0.136 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr7_+_29234028 0.134 ENST00000222792.6
CHN2
chimerin 2
chr4_-_105416039 0.134 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr3_-_142166796 0.133 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chrX_+_16804544 0.132 ENST00000380122.5
ENST00000398155.4
TXLNG

taxilin gamma

chr20_-_36156293 0.132 ENST00000373537.2
ENST00000414542.2
BLCAP

bladder cancer associated protein

chr2_+_10560147 0.125 ENST00000422133.1
HPCAL1
hippocalcin-like 1
chr1_+_109756523 0.124 ENST00000234677.2
ENST00000369923.4
SARS

seryl-tRNA synthetase

chr16_+_81528948 0.124 ENST00000539778.2
CMIP
c-Maf inducing protein
chr1_+_28844648 0.124 ENST00000373832.1
ENST00000373831.3
RCC1

regulator of chromosome condensation 1

chr4_-_114682364 0.122 ENST00000511664.1
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr4_+_169418195 0.121 ENST00000261509.6
ENST00000335742.7
PALLD

palladin, cytoskeletal associated protein

chr6_+_111195973 0.121 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1



adenosylmethionine decarboxylase 1



chr3_+_57875711 0.118 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr19_+_36393422 0.116 ENST00000437550.2
HCST
hematopoietic cell signal transducer
chr20_+_60878005 0.115 ENST00000253003.2
ADRM1
adhesion regulating molecule 1
chr5_-_52405564 0.115 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2






molybdenum cofactor synthesis 2






chr16_+_81678957 0.114 ENST00000398040.4
CMIP
c-Maf inducing protein
chr11_+_129245796 0.114 ENST00000281437.4
BARX2
BARX homeobox 2
chr11_-_842509 0.114 ENST00000322028.4
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr3_+_12329397 0.114 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr10_-_73848764 0.112 ENST00000317376.4
ENST00000412663.1
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr1_-_247335269 0.112 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124



zinc finger protein 124



chr16_+_2587965 0.110 ENST00000342085.4
ENST00000566659.1
PDPK1

3-phosphoinositide dependent protein kinase-1

chr4_+_169418255 0.110 ENST00000505667.1
ENST00000511948.1
PALLD

palladin, cytoskeletal associated protein

chr14_+_61995722 0.109 ENST00000556347.1
RP11-47I22.4
RP11-47I22.4
chr10_-_16859442 0.108 ENST00000602389.1
ENST00000345264.5
RSU1

Ras suppressor protein 1

chr15_-_78538025 0.108 ENST00000560817.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr3_-_33481835 0.108 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr19_-_11849697 0.107 ENST00000586121.1
ENST00000431998.1
ENST00000341191.6
ENST00000545749.1
ENST00000440527.1
ZNF823




zinc finger protein 823




chr2_+_233925038 0.106 ENST00000451407.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr20_-_36156125 0.105 ENST00000397135.1
ENST00000397137.1
BLCAP

bladder cancer associated protein

chr9_+_4839762 0.104 ENST00000448872.2
ENST00000441844.1
RCL1

RNA terminal phosphate cyclase-like 1

chr5_-_65018834 0.104 ENST00000506816.1
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr17_-_39661947 0.103 ENST00000590425.1
KRT13
keratin 13
chr7_-_104909435 0.103 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr18_+_3451584 0.102 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr19_-_6424783 0.102 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr18_+_3451646 0.101 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1


TGFB-induced factor homeobox 1


chr1_-_32384693 0.100 ENST00000602683.1
ENST00000470404.1
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr17_+_8191815 0.100 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor



chr16_+_4896659 0.098 ENST00000592120.1
UBN1
ubinuclein 1
chr3_-_142166846 0.098 ENST00000463916.1
ENST00000544157.1
XRN1

5'-3' exoribonuclease 1

chr6_-_52926539 0.095 ENST00000350082.5
ENST00000356971.3
ICK

intestinal cell (MAK-like) kinase

chr10_+_121485588 0.095 ENST00000361976.2
ENST00000369083.3
INPP5F

inositol polyphosphate-5-phosphatase F

chr7_+_23637118 0.095 ENST00000448353.1
CCDC126
coiled-coil domain containing 126
chr3_+_57875738 0.094 ENST00000417128.1
ENST00000438794.1
SLMAP

sarcolemma associated protein

chr1_-_145715565 0.093 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160


CD160 molecule


chr4_-_114682326 0.091 ENST00000505990.1
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr13_+_73302047 0.090 ENST00000377814.2
ENST00000377815.3
ENST00000390667.5
BORA


bora, aurora kinase A activator



Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.2 2.1 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.2 0.8 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.2 0.5 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.2 0.7 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.4 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.4 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.4 GO:0060620 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.1 0.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.2 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.1 0.3 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.3 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.1 0.3 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of fibroblast growth factor production(GO:0090271) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.2 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.1 1.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.2 GO:0044053 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.8 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.1 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.2 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.3 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.1 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.5 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.5 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.2 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 0.1 GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol(GO:0033488)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:2000230 regulation of cholesterol transporter activity(GO:0060694) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.4 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 1.2 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.1 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:0021644 vagus nerve morphogenesis(GO:0021644) chemorepulsion of branchiomotor axon(GO:0021793)
0.0 0.4 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0048680 positive regulation of axon regeneration(GO:0048680) neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.0 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.0 GO:0006258 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.4 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.2 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.0 GO:0070839 divalent metal ion export(GO:0070839)
0.0 0.0 GO:0060126 somatotropin secreting cell differentiation(GO:0060126) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.8 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.2 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 2.1 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.1 0.4 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 1.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 1.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.3 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.1 0.2 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.1 0.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.8 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.0 0.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0008398 sterol 14-demethylase activity(GO:0008398)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.2 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.0 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 2.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 2.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_ATM_PATHWAY ATM pathway
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.4 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.9 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.8 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination