ISMARA results: PITX2

Motif ID: PITX2

Z-value: 0.216

Transcription factors associated with PITX2:

Gene Symbol	Entrez ID	Gene Name
PITX2	ENSG00000164093.11	PITX2

View svg image
View png image

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_+_103986085	0.348	ENST00000370005.3	ELOVL3	ELOVL fatty acid elongase 3
chr3_-_69249863	0.170	ENST00000478263.1 ENST00000462512.1	FRMD4B	FERM domain containing 4B
chr19_-_46142362	0.147	ENST00000586770.1 ENST00000591721.1	EML2	echinoderm microtubule associated protein like 2
chr17_-_4643114	0.081	ENST00000293778.6	CXCL16	chemokine (C-X-C motif) ligand 16
chr8_+_123875624	0.076	ENST00000534247.1	ZHX2	zinc fingers and homeoboxes 2
chr17_-_4643161	0.073	ENST00000574412.1	CXCL16	chemokine (C-X-C motif) ligand 16
chr6_+_46661575	0.072	ENST00000450697.1	TDRD6	tudor domain containing 6
chr17_-_10633535	0.070	ENST00000341871.3	TMEM220	transmembrane protein 220
chr10_-_61900762	0.070	ENST00000355288.2	ANK3	ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_79495397	0.062	ENST00000417245.2 ENST00000334850.7	FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr3_-_49837254	0.056	ENST00000412678.2 ENST00000343366.4 ENST00000487256.1	CDHR4	cadherin-related family member 4
chr9_-_131486367	0.053	ENST00000372663.4 ENST00000406904.2 ENST00000452105.1 ENST00000372672.2 ENST00000372667.5	ZDHHC12	zinc finger, DHHC-type containing 12
chr10_+_18240834	0.042	ENST00000377371.3 ENST00000539911.1	SLC39A12	solute carrier family 39 (zinc transporter), member 12
chr12_+_7941989	0.040	ENST00000229307.4	NANOG	Nanog homeobox
chr22_-_39096661	0.037	ENST00000216039.5	JOSD1	Josephin domain containing 1
chr17_+_4643300	0.034	ENST00000433935.1	ZMYND15	zinc finger, MYND-type containing 15
chr17_+_4643337	0.033	ENST00000592813.1	ZMYND15	zinc finger, MYND-type containing 15
chr13_-_36429763	0.032	ENST00000379893.1	DCLK1	doublecortin-like kinase 1
chr6_-_111804905	0.032	ENST00000358835.3 ENST00000435970.1	REV3L	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr18_-_47017956	0.031	ENST00000584895.1 ENST00000332968.6 ENST00000580210.1 ENST00000579408.1	RPL17-C18orf32 RPL17	RPL17-C18orf32 readthrough ribosomal protein L17
chr4_+_126237554	0.031	ENST00000394329.3	FAT4	FAT atypical cadherin 4
chr3_-_50388522	0.030	ENST00000232501.3	NPRL2	nitrogen permease regulator-like 2 (S. cerevisiae)
chr4_+_70916119	0.030	ENST00000246896.3 ENST00000511674.1	HTN1	histatin 1
chr10_+_18240753	0.029	ENST00000377369.2	SLC39A12	solute carrier family 39 (zinc transporter), member 12
chr9_+_8858102	0.026	ENST00000447950.1 ENST00000430766.1	RP11-75C9.1	RP11-75C9.1
chr10_+_18240814	0.025	ENST00000377374.4	SLC39A12	solute carrier family 39 (zinc transporter), member 12
chr16_-_15736345	0.023	ENST00000549219.1	KIAA0430	KIAA0430
chr2_+_3622893	0.021	ENST00000407445.3 ENST00000403564.1	RPS7	ribosomal protein S7
chr21_-_19775973	0.021	ENST00000284885.3	TMPRSS15	transmembrane protease, serine 15
chr1_+_201979645	0.018	ENST00000367284.5 ENST00000367283.3	ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr3_-_191000172	0.018	ENST00000427544.2	UTS2B	urotensin 2B
chr11_+_61522844	0.018	ENST00000265460.5	MYRF	myelin regulatory factor
chr7_+_73868439	0.017	ENST00000424337.2	GTF2IRD1	GTF2I repeat domain containing 1
chr7_+_73868220	0.017	ENST00000455841.2	GTF2IRD1	GTF2I repeat domain containing 1
chr2_+_120770645	0.017	ENST00000443902.2	EPB41L5	erythrocyte membrane protein band 4.1 like 5
chr4_+_146560245	0.017	ENST00000541599.1	MMAA	methylmalonic aciduria (cobalamin deficiency) cblA type
chrM_+_9207	0.017	ENST00000362079.2	MT-CO3	mitochondrially encoded cytochrome c oxidase III
chrX_-_6146876	0.017	ENST00000381095.3	NLGN4X	neuroligin 4, X-linked
chr16_-_5116025	0.012	ENST00000472572.3 ENST00000315997.5 ENST00000422873.1 ENST00000350219.4	C16orf89	chromosome 16 open reading frame 89
chr9_-_95166841	0.011	ENST00000262551.4	OGN	osteoglycin
chr5_-_64920115	0.011	ENST00000381018.3 ENST00000274327.7	TRIM23	tripartite motif containing 23
chr11_-_96076334	0.009	ENST00000524717.1	MAML2	mastermind-like 2 (Drosophila)
chr9_-_98268883	0.009	ENST00000551630.1 ENST00000548420.1	PTCH1	patched 1
chr13_+_73632897	0.008	ENST00000377687.4	KLF5	Kruppel-like factor 5 (intestinal)
chr3_+_139062838	0.008	ENST00000310776.4 ENST00000465056.1 ENST00000465373.1	MRPS22	mitochondrial ribosomal protein S22
chr9_+_34458851	0.007	ENST00000545019.1	DNAI1	dynein, axonemal, intermediate chain 1
chr8_-_27462822	0.006	ENST00000522098.1	CLU	clusterin
chr18_-_3880051	0.005	ENST00000584874.1	DLGAP1	discs, large (Drosophila) homolog-associated protein 1
chr2_+_120770581	0.005	ENST00000263713.5	EPB41L5	erythrocyte membrane protein band 4.1 like 5
chr4_-_68620053	0.004	ENST00000420975.2 ENST00000226413.4	GNRHR	gonadotropin-releasing hormone receptor
chr2_+_120770686	0.003	ENST00000331393.4 ENST00000443124.1	EPB41L5	erythrocyte membrane protein band 4.1 like 5
chr14_+_75988768	0.003	ENST00000286639.6	BATF	basic leucine zipper transcription factor, ATF-like
chr2_+_201994569	0.003	ENST00000457277.1	CFLAR	CASP8 and FADD-like apoptosis regulator
chr12_+_6949964	0.002	ENST00000541978.1 ENST00000435982.2	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3
chr16_-_68014732	0.001	ENST00000268793.4	DPEP3	dipeptidase 3
chr22_-_30234218	0.001	ENST00000307790.3 ENST00000542393.1 ENST00000397771.2	ASCC2	activating signal cointegrator 1 complex subunit 2
chrX_+_107069063	0.000	ENST00000262843.6	MID2	midline 2
chr17_-_40021656	0.000	ENST00000319121.3	KLHL11	kelch-like family member 11
chr11_-_119217365	0.000	ENST00000445041.2 ENST00000360167.4 ENST00000555262.1 ENST00000449574.2	C1QTNF5 MFRP	C1q and tumor necrosis factor related protein 5 membrane frizzled-related protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0072658	maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)