Motif ID: PAX1_PAX9

Z-value: 0.361

Transcription factors associated with PAX1_PAX9:

Gene SymbolEntrez IDGene Name
PAX1 ENSG00000125813.9 PAX1
PAX9 ENSG00000198807.8 PAX9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37131058_37131139-0.646.4e-02Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.551.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_123747979 0.847 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr4_+_123747834 0.758 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr18_-_47813940 0.480 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC1


CXXC finger protein 1


chr18_-_47814032 0.372 ENST00000589548.1
ENST00000591474.1
CXXC1

CXXC finger protein 1

chr8_-_23282797 0.296 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr8_-_23282820 0.265 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr20_-_17641097 0.253 ENST00000246043.4
RRBP1
ribosome binding protein 1
chr11_-_67397371 0.179 ENST00000376693.2
ENST00000301490.4
NUDT8

nudix (nucleoside diphosphate linked moiety X)-type motif 8

chr14_-_69261310 0.175 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr4_+_75230853 0.151 ENST00000244869.2
EREG
epiregulin
chr17_+_39968926 0.134 ENST00000585664.1
ENST00000585922.1
ENST00000429461.1
FKBP10


FK506 binding protein 10, 65 kDa


chr8_-_121825088 0.128 ENST00000520717.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chrX_-_153707246 0.114 ENST00000407062.1
LAGE3
L antigen family, member 3
chrX_-_153707545 0.110 ENST00000357360.4
LAGE3
L antigen family, member 3
chr10_-_43904608 0.105 ENST00000337970.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr21_-_33104367 0.101 ENST00000286835.7
ENST00000399804.1
SCAF4

SR-related CTD-associated factor 4

chr7_-_2349579 0.095 ENST00000435060.1
SNX8
sorting nexin 8
chr22_-_41940404 0.093 ENST00000355209.4
ENST00000337566.5
ENST00000396504.2
ENST00000407461.1
POLR3H



polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)



chr19_-_18995029 0.081 ENST00000596048.1
CERS1
ceramide synthase 1
chr8_-_121824374 0.080 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr17_+_76374714 0.069 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1




phosphatidylglycerophosphate synthase 1




chr17_+_39969183 0.065 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr18_-_33077556 0.064 ENST00000589273.1
ENST00000586489.1
INO80C

INO80 complex subunit C

chr14_-_91884115 0.064 ENST00000389857.6
CCDC88C
coiled-coil domain containing 88C
chr6_+_34857019 0.063 ENST00000360359.3
ENST00000535627.1
ANKS1A

ankyrin repeat and sterile alpha motif domain containing 1A

chr6_-_170893268 0.060 ENST00000538195.1
PDCD2
programmed cell death 2
chr19_-_40791302 0.057 ENST00000392038.2
ENST00000578123.1
AKT2

v-akt murine thymoma viral oncogene homolog 2

chr17_-_7137582 0.052 ENST00000575756.1
ENST00000575458.1
DVL2

dishevelled segment polarity protein 2

chr9_-_131418944 0.049 ENST00000419989.1
ENST00000451652.1
ENST00000372715.2
WDR34


WD repeat domain 34


chr3_+_127771212 0.046 ENST00000243253.3
ENST00000481210.1
SEC61A1

Sec61 alpha 1 subunit (S. cerevisiae)

chr2_-_207629997 0.044 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr6_+_159290917 0.041 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr16_-_20566616 0.040 ENST00000569163.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr17_-_39968406 0.040 ENST00000393928.1
LEPREL4
leprecan-like 4
chr2_-_207630033 0.037 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr17_-_39968855 0.036 ENST00000355468.3
ENST00000590496.1
LEPREL4

leprecan-like 4

chr8_-_23261589 0.031 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2



lysyl oxidase-like 2



chr17_+_37356528 0.030 ENST00000225430.4
RPL19
ribosomal protein L19
chrX_+_148622513 0.029 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
CXorf40A




chromosome X open reading frame 40A




chr6_+_159291090 0.029 ENST00000367073.4
ENST00000608817.1
C6orf99

chromosome 6 open reading frame 99

chr17_+_37356555 0.028 ENST00000579374.1
RPL19
ribosomal protein L19
chr5_+_72251857 0.028 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2


FCH domain only 2


chr8_-_101965104 0.027 ENST00000437293.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr1_+_26758790 0.026 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
DHDDS





dehydrodolichyl diphosphate synthase





chr17_+_15848231 0.026 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr11_+_63870660 0.024 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr17_+_37356586 0.022 ENST00000579260.1
ENST00000582193.1
RPL19

ribosomal protein L19

chr6_-_170893669 0.017 ENST00000392090.2
ENST00000542896.1
ENST00000453163.2
ENST00000537445.1
PDCD2



programmed cell death 2



chr1_+_26759295 0.016 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr1_+_213031570 0.016 ENST00000366971.4
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr2_+_207630081 0.015 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2



FAST kinase domains 2



chr19_-_40791211 0.012 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr4_-_163085141 0.008 ENST00000427802.2
ENST00000306100.5
FSTL5

follistatin-like 5

chr1_-_204165610 0.008 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr11_-_126138808 0.006 ENST00000332118.6
ENST00000532259.1
SRPR

signal recognition particle receptor (docking protein)

chr10_+_30723105 0.006 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr6_-_137494775 0.004 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
IL22RA2


interleukin 22 receptor, alpha 2


chr6_+_74104471 0.003 ENST00000370336.4
DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr1_+_160121356 0.003 ENST00000368081.4
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr4_-_171011323 0.002 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
AADAT



aminoadipate aminotransferase



chr11_+_61522844 0.001 ENST00000265460.5
MYRF
myelin regulatory factor

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0042660 positive regulation of cell fate specification(GO:0042660)
0.1 0.6 GO:0018277 protein deamination(GO:0018277)
0.1 0.2 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.0 0.2 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.0 0.2 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 0.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation