Motif ID: NKX6-3

Z-value: 0.204


Transcription factors associated with NKX6-3:

Gene SymbolEntrez IDGene Name
NKX6-3 ENSG00000165066.11 NKX6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41508855_415088550.422.6e-01Click!


Activity profile for motif NKX6-3.

activity profile for motif NKX6-3


Sorted Z-values histogram for motif NKX6-3

Sorted Z-values for motif NKX6-3



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_208417620 0.169 ENST00000367033.3
 PLXNA2
plexin A2
chr1_+_66820058 0.117 ENST00000480109.2
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr18_+_32558208 0.116 ENST00000436190.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr9_+_125132803 0.108 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125133315 0.108 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_+_160370344 0.107 ENST00000368061.2
 VANGL2
VANGL planar cell polarity protein 2
chr18_+_32558380 0.107 ENST00000588349.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr5_-_142780280 0.065 ENST00000424646.2
 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_139726181 0.063 ENST00000507104.1
ENST00000230990.6
 HBEGF

heparin-binding EGF-like growth factor

chr9_+_125133467 0.060 ENST00000426608.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_124329336 0.060 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
 DAB2IP


DAB2 interacting protein


chrX_+_47696275 0.055 ENST00000376954.1
ENST00000338637.7
 ZNF81

zinc finger protein 81

chr14_+_67831576 0.051 ENST00000555876.1
 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrX_+_47696337 0.051 ENST00000334937.4
ENST00000376950.4
 ZNF81

zinc finger protein 81

chr6_-_9933500 0.039 ENST00000492169.1
 OFCC1
orofacial cleft 1 candidate 1
chr18_+_20494078 0.036 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
 RBBP8



retinoblastoma binding protein 8



chr1_-_151431647 0.035 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
 POGZ




pogo transposable element with ZNF domain




chr14_-_51027838 0.034 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr19_+_4402659 0.034 ENST00000301280.5
ENST00000585854.1
 CHAF1A

chromatin assembly factor 1, subunit A (p150)

chr20_+_30697298 0.032 ENST00000398022.2
 TM9SF4
transmembrane 9 superfamily protein member 4
chr1_-_151431674 0.031 ENST00000531094.1
 POGZ
pogo transposable element with ZNF domain
chr1_-_232651312 0.030 ENST00000262861.4
 SIPA1L2
signal-induced proliferation-associated 1 like 2
chr14_+_88851874 0.029 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
 SPATA7



spermatogenesis associated 7



chr14_+_88852059 0.029 ENST00000045347.7
 SPATA7
spermatogenesis associated 7
chr10_-_27529486 0.028 ENST00000375888.1
 ACBD5
acyl-CoA binding domain containing 5
chr15_+_48051920 0.024 ENST00000559196.1
 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr21_-_35796241 0.024 ENST00000450895.1
 AP000322.53
AP000322.53
chr3_-_191000172 0.020 ENST00000427544.2
 UTS2B
urotensin 2B
chrX_-_110655306 0.019 ENST00000371993.2
 DCX
doublecortin
chr17_-_64225508 0.019 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr15_+_90735145 0.018 ENST00000559792.1
 SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr12_-_52761262 0.013 ENST00000257901.3
 KRT85
keratin 85
chr1_-_151431909 0.012 ENST00000361398.3
ENST00000271715.2
 POGZ

pogo transposable element with ZNF domain

chrX_+_43515467 0.011 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chr8_+_92261516 0.011 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr15_+_48483736 0.007 ENST00000559641.1
ENST00000417307.2
 SLC12A1
CTXN2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
cortexin 2
chr12_-_94673956 0.007 ENST00000551941.1
 RP11-1105G2.3
Uncharacterized protein
chr5_-_58295712 0.007 ENST00000317118.8
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_-_6057282 0.005 ENST00000592281.1
 RFX2
regulatory factor X, 2 (influences HLA class II expression)
chrX_+_107288239 0.004 ENST00000217957.5
 VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_107288197 0.003 ENST00000415430.3
 VSIG1
V-set and immunoglobulin domain containing 1
chr6_+_78400375 0.003 ENST00000602452.2
 MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr17_-_10372875 0.003 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chr4_+_71384300 0.003 ENST00000504451.1
 AMTN
amelotin
chr4_+_26324474 0.001 ENST00000514675.1
 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_+_77593474 0.000 ENST00000455469.2
ENST00000050961.6
 ZFHX4

zinc finger homeobox 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0097451 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)