Motif ID: NKX2-4

Z-value: 0.651


Transcription factors associated with NKX2-4:

Gene SymbolEntrez IDGene Name
NKX2-4 ENSG00000125816.4 NKX2-4



Activity profile for motif NKX2-4.

activity profile for motif NKX2-4


Sorted Z-values histogram for motif NKX2-4

Sorted Z-values for motif NKX2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_19759228 0.755 ENST00000520959.1
LPL
lipoprotein lipase
chr2_+_36923830 0.680 ENST00000379242.3
ENST00000389975.3
VIT

vitrin

chr2_+_36923901 0.608 ENST00000457137.2
VIT
vitrin
chr2_+_36923933 0.551 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
VIT



vitrin



chr12_-_71182695 0.543 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_-_89591749 0.492 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr19_-_49843539 0.483 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4

CTC-301O7.4

chr11_+_73675873 0.444 ENST00000537753.1
ENST00000542350.1
DNAJB13

DnaJ (Hsp40) homolog, subfamily B, member 13

chr4_-_187517928 0.346 ENST00000512772.1
FAT1
FAT atypical cadherin 1
chr2_-_183291741 0.332 ENST00000351439.5
ENST00000409365.1
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr11_-_106889250 0.306 ENST00000526355.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr18_-_33702078 0.289 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr6_+_101846664 0.288 ENST00000421544.1
ENST00000413795.1
ENST00000369138.1
ENST00000358361.3
GRIK2



glutamate receptor, ionotropic, kainate 2



chr6_+_27925019 0.283 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr6_+_26158343 0.282 ENST00000377777.4
ENST00000289316.2
HIST1H2BD

histone cluster 1, H2bd

chr2_+_205410723 0.279 ENST00000358768.2
ENST00000351153.1
ENST00000349953.3
PARD3B


par-3 family cell polarity regulator beta


chr7_+_106810165 0.272 ENST00000468401.1
ENST00000497535.1
ENST00000485846.1
HBP1


HMG-box transcription factor 1


chr4_+_129349188 0.269 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr3_+_4535155 0.267 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr9_-_3469181 0.266 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr12_-_113658892 0.266 ENST00000299732.2
ENST00000416617.2
IQCD

IQ motif containing D

chr12_-_54778244 0.261 ENST00000549937.1
ZNF385A
zinc finger protein 385A
chr2_-_225434538 0.250 ENST00000409096.1
CUL3
cullin 3
chr5_+_147582387 0.249 ENST00000325630.2
SPINK6
serine peptidase inhibitor, Kazal type 6
chr14_-_34420259 0.248 ENST00000250457.3
ENST00000547327.2
EGLN3

egl-9 family hypoxia-inducible factor 3

chr18_+_11851383 0.227 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr12_-_71533055 0.226 ENST00000552128.1
TSPAN8
tetraspanin 8
chr13_-_96705624 0.225 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
UGGT2



UDP-glucose glycoprotein glucosyltransferase 2



chr1_-_205419053 0.223 ENST00000367154.1
LEMD1
LEM domain containing 1
chr6_-_30043539 0.212 ENST00000376751.3
ENST00000244360.6
RNF39

ring finger protein 39

chr5_+_147582348 0.207 ENST00000514389.1
SPINK6
serine peptidase inhibitor, Kazal type 6
chr12_-_102591604 0.206 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr5_+_139505520 0.206 ENST00000333305.3
IGIP
IgA-inducing protein
chr14_+_39703112 0.199 ENST00000555143.1
ENST00000280082.3
MIA2

melanoma inhibitory activity 2

chr10_-_61900762 0.197 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_11141925 0.196 ENST00000221086.3
MTMR9
myotubularin related protein 9
chr8_+_103876528 0.193 ENST00000522939.1
ENST00000524007.1
KB-1507C5.2

HCG15011, isoform CRA_a; Protein LOC100996457

chr3_+_118905564 0.192 ENST00000460625.1
UPK1B
uroplakin 1B
chr5_-_94417339 0.192 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1


multiple C2 domains, transmembrane 1


chr11_-_106889157 0.185 ENST00000282249.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr4_+_110834033 0.182 ENST00000509793.1
ENST00000265171.5
EGF

epidermal growth factor

chr17_-_41050716 0.181 ENST00000417193.1
ENST00000301683.3
ENST00000436546.1
ENST00000431109.2
LINC00671



long intergenic non-protein coding RNA 671



chr8_-_74206673 0.181 ENST00000396465.1
RPL7
ribosomal protein L7
chr13_+_53216565 0.180 ENST00000357495.2
HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr8_+_26247878 0.179 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_-_224624730 0.178 ENST00000445239.1
WDR26
WD repeat domain 26
chr3_-_125802765 0.178 ENST00000514891.1
ENST00000512470.1
ENST00000504035.1
ENST00000360370.4
ENST00000513723.1
ENST00000510651.1
ENST00000514333.1
SLC41A3






solute carrier family 41, member 3






chr11_+_107992518 0.178 ENST00000527942.1
ACAT1
acetyl-CoA acetyltransferase 1
chr13_-_52026730 0.175 ENST00000420668.2
INTS6
integrator complex subunit 6
chr3_+_186158169 0.172 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1

RP11-78H24.1

chr16_+_58010339 0.171 ENST00000290871.5
ENST00000441824.2
TEPP

testis, prostate and placenta expressed

chr9_+_128510454 0.169 ENST00000491787.3
ENST00000447726.2
PBX3

pre-B-cell leukemia homeobox 3

chr16_+_12059091 0.169 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_+_196788887 0.169 ENST00000367421.3
ENST00000320493.5
ENST00000367424.4
CFHR2
CFHR1

complement factor H-related 2
complement factor H-related 1

chr6_-_134861089 0.169 ENST00000606039.1
RP11-557H15.4
RP11-557H15.4
chr20_-_23402028 0.168 ENST00000398425.3
ENST00000432543.2
ENST00000377026.4
NAPB


N-ethylmaleimide-sensitive factor attachment protein, beta


chr10_+_99332529 0.168 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr12_-_54778471 0.168 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A


zinc finger protein 385A


chr20_-_43280325 0.167 ENST00000537820.1
ADA
adenosine deaminase
chr15_-_83474806 0.164 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2


fibronectin type III and SPRY domain containing 2


chr17_-_29641104 0.163 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr12_-_113658826 0.162 ENST00000546692.1
IQCD
IQ motif containing D
chr15_+_63354769 0.159 ENST00000558910.1
TPM1
tropomyosin 1 (alpha)
chr9_-_88874519 0.157 ENST00000376001.3
ENST00000339137.3
C9orf153

chromosome 9 open reading frame 153

chrX_+_102883620 0.156 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr8_+_128426535 0.155 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr8_-_18711866 0.154 ENST00000519851.1
PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_55920952 0.154 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr8_-_141774467 0.154 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2


protein tyrosine kinase 2


chr15_+_74466744 0.152 ENST00000560862.1
ENST00000395118.1
ISLR

immunoglobulin superfamily containing leucine-rich repeat

chr12_-_104532062 0.152 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr12_+_123011776 0.150 ENST00000450485.2
ENST00000333479.7
KNTC1

kinetochore associated 1

chr3_-_49066811 0.149 ENST00000442157.1
ENST00000326739.4
IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

chr7_-_96339167 0.148 ENST00000444799.1
ENST00000417009.1
ENST00000248566.2
SHFM1


split hand/foot malformation (ectrodactyly) type 1


chr5_+_43602750 0.148 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT


nicotinamide nucleotide transhydrogenase


chr2_-_36779411 0.147 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr1_+_46769303 0.147 ENST00000311672.5
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr2_-_188419200 0.146 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI



tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)



chr15_+_67430339 0.144 ENST00000439724.3
SMAD3
SMAD family member 3
chr10_-_91102410 0.144 ENST00000282673.4
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr7_-_96339132 0.143 ENST00000413065.1
SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr17_-_38574169 0.142 ENST00000423485.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr6_-_149806105 0.142 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D



zinc finger CCCH-type containing 12D



chrX_-_74376108 0.139 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ABCB7




ATP-binding cassette, sub-family B (MDR/TAP), member 7




chr13_-_43566301 0.137 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1


epithelial stromal interaction 1 (breast)


chr5_-_94417186 0.137 ENST00000312216.8
ENST00000512425.1
MCTP1

multiple C2 domains, transmembrane 1

chr17_-_62493131 0.137 ENST00000539111.2
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr2_-_37501692 0.137 ENST00000443977.1
PRKD3
protein kinase D3
chr2_-_188419078 0.136 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI



tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)



chr11_-_108438847 0.135 ENST00000531386.1
EXPH5
exophilin 5
chr1_-_212588157 0.134 ENST00000261455.4
ENST00000535273.1
TMEM206

transmembrane protein 206

chr12_-_54778444 0.133 ENST00000551771.1
ZNF385A
zinc finger protein 385A
chr2_-_179315786 0.132 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA


protein kinase, interferon-inducible double stranded RNA dependent activator


chr15_+_63334831 0.131 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
TPM1








tropomyosin 1 (alpha)








chr15_-_31523036 0.129 ENST00000559094.1
ENST00000558388.2
RP11-16E12.2

RP11-16E12.2

chr7_+_116139424 0.128 ENST00000222693.4
CAV2
caveolin 2
chr14_-_96830207 0.127 ENST00000359933.4
ATG2B
autophagy related 2B
chr17_-_29641084 0.127 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr4_-_185726906 0.127 ENST00000513317.1
ACSL1
acyl-CoA synthetase long-chain family member 1
chr1_-_161059380 0.127 ENST00000368012.3
PVRL4
poliovirus receptor-related 4
chr12_+_75874460 0.124 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chrX_-_133792480 0.123 ENST00000359237.4
PLAC1
placenta-specific 1
chr17_+_42923686 0.123 ENST00000591513.1
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr6_+_158733692 0.121 ENST00000367094.2
ENST00000367097.3
TULP4

tubby like protein 4

chr6_-_149969829 0.121 ENST00000367411.2
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr5_+_159436120 0.120 ENST00000522793.1
ENST00000231238.5
TTC1

tetratricopeptide repeat domain 1

chr14_+_24702073 0.118 ENST00000399440.2
GMPR2
guanosine monophosphate reductase 2
chr1_+_202431859 0.118 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr6_-_39282221 0.118 ENST00000453413.2
KCNK17
potassium channel, subfamily K, member 17
chr14_-_24701539 0.117 ENST00000524927.1
ENST00000250495.5
ENST00000534348.1
NEDD8

NEDD8-MDP1
neural precursor cell expressed, developmentally down-regulated 8

NEDD8-MDP1 readthrough
chr1_+_144989309 0.117 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr2_-_175462934 0.115 ENST00000392546.2
ENST00000436221.1
WIPF1

WAS/WASL interacting protein family, member 1

chr19_+_37998031 0.115 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
ZNF793


zinc finger protein 793


chr11_-_102826434 0.114 ENST00000340273.4
ENST00000260302.3
MMP13

matrix metallopeptidase 13 (collagenase 3)

chr12_+_12878829 0.114 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr7_+_6071007 0.113 ENST00000409061.1
ANKRD61
ankyrin repeat domain 61
chr1_+_61869748 0.113 ENST00000357977.5
NFIA
nuclear factor I/A
chr2_+_37571845 0.113 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr7_-_17980091 0.112 ENST00000409389.1
ENST00000409604.1
ENST00000428135.3
SNX13


sorting nexin 13


chr1_+_204485571 0.111 ENST00000454264.2
ENST00000367183.3
MDM4

Mdm4 p53 binding protein homolog (mouse)

chr5_-_94417314 0.111 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_-_78808617 0.111 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1


homer homolog 1 (Drosophila)


chr14_+_24701870 0.109 ENST00000561035.1
ENST00000559409.1
ENST00000558865.1
ENST00000558279.1
GMPR2



guanosine monophosphate reductase 2



chr14_+_24701628 0.109 ENST00000355299.4
ENST00000559836.1
GMPR2

guanosine monophosphate reductase 2

chr6_-_149969871 0.109 ENST00000335643.8
ENST00000444282.1
KATNA1

katanin p60 (ATPase containing) subunit A 1

chr4_-_682769 0.107 ENST00000507165.1
MFSD7
major facilitator superfamily domain containing 7
chr2_-_37544209 0.106 ENST00000234179.2
PRKD3
protein kinase D3
chrX_+_56644819 0.106 ENST00000446028.1
RP11-431N15.2
RP11-431N15.2
chr14_+_24702127 0.106 ENST00000557854.1
ENST00000348719.7
ENST00000559104.1
ENST00000456667.3
GMPR2



guanosine monophosphate reductase 2



chr14_+_24702099 0.105 ENST00000420554.2
GMPR2
guanosine monophosphate reductase 2
chr19_+_46531127 0.105 ENST00000601033.1
CTC-344H19.4
CTC-344H19.4
chr12_+_58176525 0.105 ENST00000543727.1
ENST00000540550.1
ENST00000323833.8
ENST00000350762.5
ENST00000550559.1
ENST00000548851.1
ENST00000434359.1
ENST00000457189.1
TSFM







Ts translation elongation factor, mitochondrial







chr1_-_12908578 0.104 ENST00000317869.6
HNRNPCL1
heterogeneous nuclear ribonucleoprotein C-like 1
chr11_+_12766583 0.104 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr14_+_24701819 0.104 ENST00000560139.1
ENST00000559910.1
GMPR2

guanosine monophosphate reductase 2

chr3_+_159706537 0.103 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A


interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)


chr1_-_249153059 0.102 ENST00000451251.1
ENST00000366469.5
ZNF692

zinc finger protein 692

chr10_-_48055018 0.102 ENST00000426610.2
ASAH2C
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr2_+_183982255 0.101 ENST00000455063.1
NUP35
nucleoporin 35kDa
chr8_+_22844995 0.100 ENST00000524077.1
RHOBTB2
Rho-related BTB domain containing 2
chr1_+_205225319 0.099 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr7_-_92463210 0.099 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr17_-_38074842 0.099 ENST00000309481.7
GSDMB
gasdermin B
chr2_-_219925189 0.099 ENST00000295731.6
IHH
indian hedgehog
chrX_+_48542168 0.099 ENST00000376701.4
WAS
Wiskott-Aldrich syndrome
chr12_+_54674482 0.098 ENST00000547708.1
ENST00000340913.6
ENST00000551702.1
ENST00000330752.8
ENST00000547276.1
HNRNPA1




heterogeneous nuclear ribonucleoprotein A1




chr12_+_21590549 0.098 ENST00000545178.1
ENST00000240651.9
PYROXD1

pyridine nucleotide-disulphide oxidoreductase domain 1

chr12_-_39837192 0.097 ENST00000361961.3
ENST00000395670.3
KIF21A

kinesin family member 21A

chr4_+_109541772 0.095 ENST00000506397.1
ENST00000394668.2
RPL34

ribosomal protein L34

chr2_-_105953912 0.095 ENST00000610036.1
RP11-332H14.2
RP11-332H14.2
chr10_+_116524547 0.095 ENST00000436932.1
RP11-106M7.1
RP11-106M7.1
chr3_+_141596371 0.094 ENST00000495216.1
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr5_+_118788433 0.094 ENST00000414835.2
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr19_+_4769117 0.093 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3HG








MIR7-3 host gene (non-protein coding)








chr11_-_85780086 0.093 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM


phosphatidylinositol binding clathrin assembly protein


chr12_-_57113333 0.093 ENST00000550920.1
NACA
nascent polypeptide-associated complex alpha subunit
chr1_+_188874798 0.092 ENST00000445072.1
LINC01035
long intergenic non-protein coding RNA 1035
chr10_-_28571015 0.092 ENST00000375719.3
ENST00000375732.1
MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr11_-_85780853 0.091 ENST00000531930.1
ENST00000528398.1
PICALM

phosphatidylinositol binding clathrin assembly protein

chr20_+_4702548 0.091 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr8_+_22844913 0.091 ENST00000519685.1
RHOBTB2
Rho-related BTB domain containing 2
chr4_+_90033968 0.090 ENST00000317005.2
TIGD2
tigger transposable element derived 2
chr10_-_52000307 0.090 ENST00000443575.1
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr11_-_83436446 0.090 ENST00000529399.1
DLG2
discs, large homolog 2 (Drosophila)
chr18_-_21852143 0.090 ENST00000399443.3
OSBPL1A
oxysterol binding protein-like 1A
chr7_+_129932974 0.090 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4





carboxypeptidase A4





chrX_+_41583408 0.089 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr1_-_249153266 0.088 ENST00000496231.1
ENST00000306601.4
ENST00000427146.1
ENST00000391820.3
ENST00000366471.3
ZNF692




zinc finger protein 692




chr7_-_47579188 0.088 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3



tensin 3



chr2_+_183982238 0.088 ENST00000442895.2
ENST00000446612.1
ENST00000409798.1
NUP35


nucleoporin 35kDa


chrX_-_44402231 0.087 ENST00000378045.4
FUNDC1
FUN14 domain containing 1
chr11_+_33037652 0.084 ENST00000311388.3
DEPDC7
DEP domain containing 7
chrX_-_138914394 0.084 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATP11C



ATPase, class VI, type 11C



chr3_-_125802998 0.084 ENST00000514677.1
SLC41A3
solute carrier family 41, member 3
chr6_+_153552455 0.084 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr14_-_104028595 0.084 ENST00000337322.4
ENST00000445922.2
BAG5

BCL2-associated athanogene 5

chr4_-_69434245 0.083 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_-_115301235 0.083 ENST00000525878.1
CSDE1
cold shock domain containing E1, RNA-binding
chr2_+_47799601 0.083 ENST00000601243.1
AC138655.1
CDNA: FLJ23120 fis, clone LNG07989; HCG1987724; Uncharacterized protein
chr11_-_4719072 0.082 ENST00000396950.3
ENST00000532598.1
OR51E2

olfactory receptor, family 51, subfamily E, member 2

chr15_-_34394008 0.081 ENST00000527822.1
ENST00000528949.1
EMC7

ER membrane protein complex subunit 7

chr10_-_131909071 0.080 ENST00000456581.1
LINC00959
long intergenic non-protein coding RNA 959
chr1_+_158901329 0.079 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1




pyrin and HIN domain family, member 1




chr9_+_46390277 0.079 ENST00000426006.1
FAM27D1
family with sequence similarity 27, member D1
chr12_-_57119106 0.079 ENST00000546392.1
NACA
nascent polypeptide-associated complex alpha subunit
chrX_-_30993201 0.079 ENST00000288422.2
ENST00000378932.2
TAB3

TGF-beta activated kinase 1/MAP3K7 binding protein 3

chr1_+_56046710 0.078 ENST00000422374.1
RP11-466L17.1
RP11-466L17.1
chr14_+_56078695 0.078 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chr6_-_143832793 0.078 ENST00000438118.2
FUCA2
fucosidase, alpha-L- 2, plasma
chr1_-_197744763 0.077 ENST00000422998.1
DENND1B
DENN/MADD domain containing 1B
chr2_-_166651152 0.077 ENST00000431484.1
ENST00000412248.1
GALNT3

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)

chr2_+_109065634 0.077 ENST00000409821.1
GCC2
GRIP and coiled-coil domain containing 2
chr12_+_48516357 0.077 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
PFKM


phosphofructokinase, muscle


chr1_-_89458287 0.077 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr18_+_21032781 0.077 ENST00000339486.3
RIOK3
RIO kinase 3
chr7_+_133812052 0.076 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr1_+_70671363 0.076 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11



serine/arginine-rich splicing factor 11



chr16_+_76343743 0.075 ENST00000478060.1
CNTNAP4
contactin associated protein-like 4
chr15_+_101256294 0.075 ENST00000559755.1
RP11-66B24.5
RP11-66B24.5
chr9_-_86432547 0.075 ENST00000376365.3
ENST00000376371.2
GKAP1

G kinase anchoring protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890) chylomicron remodeling(GO:0034371)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.6 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 0.2 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.1 0.2 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 0.2 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 0.2 GO:2000625 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.1 0.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.3 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.5 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.0 0.1 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.0 0.7 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.1 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.0 0.1 GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.0 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.0 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.2 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.0 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.1 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.0 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.8 GO:0042627 chylomicron(GO:0042627)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.0 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.7 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.1 GO:0019808 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.1 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle