Motif ID: NKX1-1

Z-value: 0.244


Transcription factors associated with NKX1-1:

Gene SymbolEntrez IDGene Name
NKX1-1 ENSG00000235608.1 NKX1-1



Activity profile for motif NKX1-1.

activity profile for motif NKX1-1


Sorted Z-values histogram for motif NKX1-1

Sorted Z-values for motif NKX1-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX1-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_8822113 0.591 ENST00000396290.1
ENST00000331129.3
 ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr18_-_33709268 0.282 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr3_-_52567792 0.273 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
 NT5DC2


5'-nucleotidase domain containing 2


chr11_-_111741994 0.241 ENST00000398006.2
 ALG9
ALG9, alpha-1,2-mannosyltransferase
chr10_+_120789223 0.150 ENST00000425699.1
 NANOS1
nanos homolog 1 (Drosophila)
chr1_+_155278539 0.135 ENST00000447866.1
 FDPS
farnesyl diphosphate synthase
chr1_+_155278625 0.128 ENST00000368356.4
ENST00000356657.6
 FDPS

farnesyl diphosphate synthase

chr9_+_34646651 0.120 ENST00000378842.3
 GALT
galactose-1-phosphate uridylyltransferase
chr17_-_44657017 0.118 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
 ARL17A





ADP-ribosylation factor-like 17A





chr1_-_151762943 0.111 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
 TDRKH




tudor and KH domain containing




chr10_-_1095050 0.106 ENST00000381344.3
 IDI1
isopentenyl-diphosphate delta isomerase 1
chr19_-_14228541 0.106 ENST00000590853.1
ENST00000308677.4
 PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

chr9_+_34646624 0.102 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr1_+_46972668 0.094 ENST00000371956.4
ENST00000360032.3
 DMBX1

diencephalon/mesencephalon homeobox 1

chr10_-_1094819 0.093 ENST00000429642.1
 IDI1
isopentenyl-diphosphate delta isomerase 1
chr17_+_57233087 0.091 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
 PRR11


proline rich 11


chr3_-_105587879 0.090 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr17_-_44439084 0.090 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
 ARL17B





ADP-ribosylation factor-like 17B





chr17_-_57232596 0.088 ENST00000581068.1
ENST00000330137.7
 SKA2

spindle and kinetochore associated complex subunit 2

chr1_+_240255166 0.087 ENST00000319653.9
 FMN2
formin 2
chr11_+_134201768 0.085 ENST00000535456.2
ENST00000339772.7
 GLB1L2

galactosidase, beta 1-like 2

chr11_+_72983246 0.084 ENST00000393590.2
 P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_23851928 0.082 ENST00000467766.1
ENST00000424381.1
 UBE2E1

ubiquitin-conjugating enzyme E2E 1

chr12_+_102513950 0.081 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
 PARPBP



PARP1 binding protein



chr12_+_102514019 0.080 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
 PARPBP


PARP1 binding protein


chr4_-_103682145 0.080 ENST00000226578.4
 MANBA
mannosidase, beta A, lysosomal
chr17_+_57232690 0.080 ENST00000262293.4
 PRR11
proline rich 11
chr15_-_64386120 0.077 ENST00000300030.3
 FAM96A
family with sequence similarity 96, member A
chr15_-_64385981 0.077 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
 FAM96A


family with sequence similarity 96, member A


chr7_-_27239703 0.074 ENST00000222753.4
 HOXA13
homeobox A13
chr7_-_6048702 0.071 ENST00000265849.7
 PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr7_-_6048650 0.071 ENST00000382321.4
ENST00000406569.3
 PMS2

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

chr17_-_57232525 0.069 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
 SKA2



spindle and kinetochore associated complex subunit 2



chr3_+_158519654 0.069 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
 MFSD1


major facilitator superfamily domain containing 1


chr14_+_32798547 0.068 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6


A kinase (PRKA) anchor protein 6


chr19_+_32896697 0.064 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr3_-_105588231 0.063 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr7_-_86849883 0.062 ENST00000433078.1
 TMEM243
transmembrane protein 243, mitochondrial
chr7_+_99717230 0.061 ENST00000262932.3
 CNPY4
canopy FGF signaling regulator 4
chrX_-_153363188 0.059 ENST00000303391.6
 MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr1_-_159832438 0.058 ENST00000368100.1
 VSIG8
V-set and immunoglobulin domain containing 8
chr1_-_197115818 0.055 ENST00000367409.4
ENST00000294732.7
 ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr11_-_4629367 0.054 ENST00000533021.1
 TRIM68
tripartite motif containing 68
chrX_+_19362011 0.053 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
 PDHA1







pyruvate dehydrogenase (lipoamide) alpha 1







chr19_+_32897009 0.053 ENST00000342179.5
ENST00000586427.1
 DPY19L3

dpy-19-like 3 (C. elegans)

chr4_-_54232144 0.052 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
 SCFD2


sec1 family domain containing 2


chr5_-_22853429 0.052 ENST00000504376.2
 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_174843548 0.052 ENST00000478442.1
ENST00000465412.1
 RABGAP1L

RAB GTPase activating protein 1-like

chr1_-_108507631 0.051 ENST00000527011.1
ENST00000370056.4
 VAV3

vav 3 guanine nucleotide exchange factor

chr7_+_26331541 0.049 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
 SNX10


sorting nexin 10


chr4_-_19458597 0.048 ENST00000505347.1
 RP11-3J1.1
RP11-3J1.1
chr11_-_62494821 0.042 ENST00000301785.5
 HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr7_+_26331678 0.040 ENST00000446848.2
 SNX10
sorting nexin 10
chr1_-_28969517 0.039 ENST00000263974.4
ENST00000373824.4
 TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr7_-_99716914 0.038 ENST00000431404.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_80247105 0.037 ENST00000369846.4
 LCA5
Leber congenital amaurosis 5
chr1_-_51796987 0.037 ENST00000262676.5
 TTC39A
tetratricopeptide repeat domain 39A
chr8_+_26371763 0.036 ENST00000521913.1
 DPYSL2
dihydropyrimidinase-like 2
chr4_-_89442940 0.036 ENST00000527353.1
 PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr9_+_116225999 0.035 ENST00000317613.6
 RGS3
regulator of G-protein signaling 3
chr15_-_75199213 0.034 ENST00000562698.1
 FAM219B
family with sequence similarity 219, member B
chr17_-_45266542 0.033 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
 CDC27




cell division cycle 27




chr22_-_39151463 0.033 ENST00000405510.1
ENST00000433561.1
 SUN2

Sad1 and UNC84 domain containing 2

chr17_+_1666108 0.033 ENST00000570731.1
 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_+_7014126 0.032 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr11_-_4629388 0.031 ENST00000526337.1
ENST00000300747.5
 TRIM68

tripartite motif containing 68

chr8_+_98656693 0.030 ENST00000519934.1
 MTDH
metadherin
chr1_-_151762900 0.030 ENST00000440583.2
 TDRKH
tudor and KH domain containing
chr17_+_45286387 0.029 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
 MYL4



myosin, light chain 4, alkali; atrial, embryonic



chr3_+_57261743 0.027 ENST00000288266.3
 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr4_+_128554081 0.027 ENST00000335251.6
ENST00000296461.5
 INTU

inturned planar cell polarity protein

chr7_+_120628731 0.027 ENST00000310396.5
 CPED1
cadherin-like and PC-esterase domain containing 1
chr11_-_62521614 0.025 ENST00000527994.1
ENST00000394807.3
 ZBTB3

zinc finger and BTB domain containing 3

chr1_-_190446759 0.025 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr15_+_64386261 0.025 ENST00000560829.1
 SNX1
sorting nexin 1
chr4_-_87515202 0.019 ENST00000502302.1
ENST00000513186.1
 MAPK10

mitogen-activated protein kinase 10

chr8_+_98656336 0.019 ENST00000336273.3
 MTDH
metadherin
chr15_-_78526942 0.019 ENST00000258873.4
 ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr3_+_186560476 0.019 ENST00000320741.2
ENST00000444204.2
 ADIPOQ

adiponectin, C1Q and collagen domain containing

chr14_-_88200641 0.019 ENST00000556168.1
 RP11-1152H15.1
RP11-1152H15.1
chr1_-_51796226 0.017 ENST00000451380.1
ENST00000371747.3
ENST00000439482.1
 TTC39A


tetratricopeptide repeat domain 39A


chr17_-_27418537 0.016 ENST00000408971.2
 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr19_-_8070474 0.016 ENST00000407627.2
ENST00000593807.1
 ELAVL1

ELAV like RNA binding protein 1

chr2_+_105050794 0.015 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2


long intergenic non-protein coding RNA 1102


chr1_+_62439037 0.015 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr11_+_72983450 0.014 ENST00000536225.1
 P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr12_+_48499252 0.013 ENST00000549003.1
ENST00000550924.1
 PFKM

phosphofructokinase, muscle

chr6_-_167040731 0.011 ENST00000265678.4
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr5_+_150226085 0.011 ENST00000522154.1
 IRGM
immunity-related GTPase family, M
chr3_+_186560462 0.011 ENST00000412955.2
 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr11_-_71823715 0.009 ENST00000545944.1
ENST00000502597.2
 ANAPC15

anaphase promoting complex subunit 15

chr12_+_64798826 0.008 ENST00000540203.1
 XPOT
exportin, tRNA
chr1_-_231004220 0.007 ENST00000366663.5
 C1orf198
chromosome 1 open reading frame 198
chr11_-_124981475 0.005 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
 TMEM218











transmembrane protein 218











chr12_-_102513843 0.005 ENST00000551744.2
ENST00000552283.1
 NUP37

nucleoporin 37kDa

chr1_-_201140673 0.005 ENST00000367333.2
 TMEM9
transmembrane protein 9
chr17_+_45286706 0.005 ENST00000393450.1
ENST00000572303.1
 MYL4

myosin, light chain 4, alkali; atrial, embryonic

chr4_+_87515454 0.004 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
 PTPN13


protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)


chr10_-_99205607 0.003 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
 EXOSC1





exosome component 1





chr2_-_167232484 0.003 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
 SCN9A


sodium channel, voltage-gated, type IX, alpha subunit


chr12_+_7013897 0.003 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr10_-_50599907 0.002 ENST00000434016.1
 DRGX
dorsal root ganglia homeobox
chr12_+_16500571 0.002 ENST00000543076.1
ENST00000396210.3
 MGST1

microsomal glutathione S-transferase 1

chr14_+_32798462 0.002 ENST00000280979.4
 AKAP6
A kinase (PRKA) anchor protein 6
chr14_-_81425828 0.001 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
 CEP128


centrosomal protein 128kDa


chr1_+_222910625 0.001 ENST00000360827.2
 FAM177B
family with sequence similarity 177, member B
chr15_-_78526855 0.000 ENST00000541759.1
ENST00000558130.1
 ACSBG1

acyl-CoA synthetase bubblegum family member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.3 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.2 GO:0050993 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.0 GO:2000583 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.3 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.2 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis