Motif ID: NHLH1

Z-value: 1.968


Transcription factors associated with NHLH1:

Gene SymbolEntrez IDGene Name
NHLH1 ENSG00000171786.5 NHLH1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH1hg19_v2_chr1_+_160336851_1603368680.551.3e-01Click!


Activity profile for motif NHLH1.

activity profile for motif NHLH1


Sorted Z-values histogram for motif NHLH1

Sorted Z-values for motif NHLH1



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_165555200 5.006 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE



butyrylcholinesterase



chr4_-_186696561 4.890 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
SORBS2





sorbin and SH3 domain containing 2





chr4_-_186696425 4.668 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2


sorbin and SH3 domain containing 2


chr4_-_186697044 3.301 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chrX_-_107018969 3.145 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr4_-_186696515 3.088 ENST00000456596.1
ENST00000414724.1
SORBS2

sorbin and SH3 domain containing 2

chr11_-_63933504 2.626 ENST00000255681.6
MACROD1
MACRO domain containing 1
chr16_+_11439286 2.525 ENST00000312499.5
ENST00000576027.1
RMI2

RecQ mediated genome instability 2

chr4_-_186696636 2.449 ENST00000444771.1
SORBS2
sorbin and SH3 domain containing 2
chrX_-_107019181 2.448 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3



TSC22 domain family, member 3



chr10_+_18689637 2.421 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_196521845 2.340 ENST00000359634.5
ENST00000412905.1
SLC39A10

solute carrier family 39 (zinc transporter), member 10

chr16_-_30107491 2.313 ENST00000566134.1
ENST00000565110.1
ENST00000398841.1
ENST00000398838.4
YPEL3



yippee-like 3 (Drosophila)



chr2_+_196521903 2.214 ENST00000541054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr2_-_86564776 2.191 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1


receptor accessory protein 1


chr10_+_18429671 2.112 ENST00000282343.8
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_196522032 2.111 ENST00000418005.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr11_-_66725837 2.074 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
PC



pyruvate carboxylase



chr1_-_47134085 1.947 ENST00000371937.4
ENST00000574428.1
ENST00000329231.4
ATPAF1


ATP synthase mitochondrial F1 complex assembly factor 1


chr2_-_233352531 1.940 ENST00000304546.1
ECEL1
endothelin converting enzyme-like 1
chr2_-_96811170 1.905 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr11_-_66336060 1.868 ENST00000310325.5
CTSF
cathepsin F
chr1_-_47134101 1.841 ENST00000576409.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr2_+_85981008 1.801 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr11_+_46299199 1.554 ENST00000529193.1
ENST00000288400.3
CREB3L1

cAMP responsive element binding protein 3-like 1

chr2_+_196521458 1.532 ENST00000409086.3
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr9_+_101569944 1.530 ENST00000375011.3
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr10_-_103347883 1.453 ENST00000339310.3
ENST00000370158.3
ENST00000299206.4
ENST00000456836.2
ENST00000413344.1
ENST00000429502.1
ENST00000430045.1
ENST00000370172.1
ENST00000436284.2
ENST00000370162.3
POLL









polymerase (DNA directed), lambda









chr19_+_14184370 1.449 ENST00000590772.1
hsa-mir-1199
hsa-mir-1199
chr8_+_97506033 1.439 ENST00000518385.1
SDC2
syndecan 2
chr17_+_74723031 1.408 ENST00000586200.1
METTL23
methyltransferase like 23
chr2_+_8822113 1.377 ENST00000396290.1
ENST00000331129.3
ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr11_-_74022658 1.359 ENST00000427714.2
ENST00000331597.4
P4HA3

prolyl 4-hydroxylase, alpha polypeptide III

chr6_+_72596604 1.347 ENST00000348717.5
ENST00000517960.1
ENST00000518273.1
ENST00000522291.1
ENST00000521978.1
ENST00000520567.1
ENST00000264839.7
RIMS1






regulating synaptic membrane exocytosis 1






chr5_+_139027877 1.345 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr17_+_40688190 1.330 ENST00000225927.2
NAGLU
N-acetylglucosaminidase, alpha
chr19_-_45996465 1.306 ENST00000430715.2
RTN2
reticulon 2
chr6_+_30848557 1.243 ENST00000460944.2
ENST00000324771.8
DDR1

discoidin domain receptor tyrosine kinase 1

chr1_-_84464780 1.238 ENST00000260505.8
TTLL7
tubulin tyrosine ligase-like family, member 7
chr3_+_167453026 1.225 ENST00000472941.1
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr1_+_89990431 1.224 ENST00000330947.2
ENST00000358200.4
LRRC8B

leucine rich repeat containing 8 family, member B

chr3_+_167453493 1.199 ENST00000295777.5
ENST00000472747.2
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr10_-_62704005 1.189 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr16_+_23847267 1.152 ENST00000321728.7
PRKCB
protein kinase C, beta
chr12_-_54779511 1.145 ENST00000551109.1
ENST00000546970.1
ZNF385A

zinc finger protein 385A

chr17_+_74722912 1.134 ENST00000589977.1
ENST00000591571.1
ENST00000592849.1
ENST00000586738.1
ENST00000588783.1
ENST00000588563.1
ENST00000586752.1
ENST00000588302.1
ENST00000590964.1
ENST00000341249.6
ENST00000588822.1
METTL23










methyltransferase like 23










chr9_-_112970436 1.110 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr5_-_22853429 1.028 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_+_130646999 1.015 ENST00000539839.1
ENST00000229030.4
FZD10

frizzled family receptor 10

chr11_-_63684316 1.010 ENST00000301459.4
RCOR2
REST corepressor 2
chr16_-_90085824 1.007 ENST00000002501.6
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr16_+_23847339 0.950 ENST00000303531.7
PRKCB
protein kinase C, beta
chrX_-_134049262 0.942 ENST00000370783.3
MOSPD1
motile sperm domain containing 1
chr2_-_86564740 0.920 ENST00000540790.1
ENST00000428491.1
REEP1

receptor accessory protein 1

chr9_-_139948468 0.920 ENST00000312665.5
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
chr10_+_12391481 0.918 ENST00000378847.3
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr20_+_57430162 0.905 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS


GNAS complex locus


chr2_-_178483694 0.901 ENST00000355689.5
TTC30A
tetratricopeptide repeat domain 30A
chr3_-_178789220 0.897 ENST00000414084.1
ZMAT3
zinc finger, matrin-type 3
chr5_+_52776228 0.885 ENST00000256759.3
FST
follistatin
chr10_-_43762329 0.873 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr1_-_53387352 0.858 ENST00000541281.1
ECHDC2
enoyl CoA hydratase domain containing 2
chr9_-_34376851 0.858 ENST00000297625.7
KIAA1161
KIAA1161
chr6_+_30848740 0.852 ENST00000505534.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr14_-_45603657 0.852 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr17_+_66255310 0.848 ENST00000448504.2
ARSG
arylsulfatase G
chr5_+_52776449 0.848 ENST00000396947.3
FST
follistatin
chr12_-_113658892 0.841 ENST00000299732.2
ENST00000416617.2
IQCD

IQ motif containing D

chr11_-_62494821 0.841 ENST00000301785.5
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr16_+_22217577 0.836 ENST00000263026.5
EEF2K
eukaryotic elongation factor-2 kinase
chr15_+_79603479 0.835 ENST00000424155.2
ENST00000536821.1
TMED3

transmembrane emp24 protein transport domain containing 3

chr7_+_7811992 0.833 ENST00000406829.1
RPA3-AS1
RPA3 antisense RNA 1
chr13_+_88324870 0.830 ENST00000325089.6
SLITRK5
SLIT and NTRK-like family, member 5
chr11_-_1606513 0.829 ENST00000382171.2
KRTAP5-1
keratin associated protein 5-1
chr17_+_74261277 0.828 ENST00000327490.6
UBALD2
UBA-like domain containing 2
chr3_-_32022733 0.827 ENST00000438237.2
ENST00000396556.2
OSBPL10

oxysterol binding protein-like 10

chr4_+_87856129 0.809 ENST00000395146.4
ENST00000507468.1
AFF1

AF4/FMR2 family, member 1

chr17_-_34122596 0.803 ENST00000250144.8
MMP28
matrix metallopeptidase 28
chr4_+_89300158 0.800 ENST00000502870.1
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr6_+_72596406 0.796 ENST00000491071.2
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_30848829 0.793 ENST00000508317.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr20_-_32274179 0.787 ENST00000343380.5
E2F1
E2F transcription factor 1
chr5_+_43603229 0.786 ENST00000344920.4
ENST00000512996.2
NNT

nicotinamide nucleotide transhydrogenase

chr5_-_59064458 0.777 ENST00000502575.1
ENST00000507116.1
PDE4D

phosphodiesterase 4D, cAMP-specific

chr2_+_172778952 0.771 ENST00000392584.1
ENST00000264108.4
HAT1

histone acetyltransferase 1

chr2_-_102003987 0.768 ENST00000324768.5
CREG2
cellular repressor of E1A-stimulated genes 2
chrX_-_134049233 0.764 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr17_-_79139817 0.761 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr6_+_149068464 0.761 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr8_+_142138711 0.754 ENST00000518347.1
ENST00000262585.2
ENST00000424248.1
ENST00000519811.1
ENST00000520986.1
ENST00000523058.1
DENND3





DENN/MADD domain containing 3





chr4_+_184826418 0.752 ENST00000308497.4
ENST00000438269.1
STOX2

storkhead box 2

chr7_+_99613195 0.740 ENST00000324306.6
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr22_-_21905120 0.715 ENST00000331505.5
RIMBP3C
RIMS binding protein 3C
chr3_+_49711391 0.712 ENST00000296456.5
ENST00000449966.1
APEH

acylaminoacyl-peptide hydrolase

chr13_+_88325498 0.695 ENST00000400028.3
SLITRK5
SLIT and NTRK-like family, member 5
chr11_+_67070919 0.694 ENST00000308127.4
ENST00000308298.7
SSH3

slingshot protein phosphatase 3

chr12_-_122241812 0.688 ENST00000538335.1
AC084018.1
AC084018.1
chr21_+_40752170 0.688 ENST00000333781.5
ENST00000541890.1
WRB

tryptophan rich basic protein

chr7_-_99869799 0.688 ENST00000436886.2
GATS
GATS, stromal antigen 3 opposite strand
chr11_-_27494309 0.671 ENST00000389858.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr11_+_7598239 0.658 ENST00000525597.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_27494279 0.654 ENST00000379214.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr3_+_49711777 0.654 ENST00000442186.1
ENST00000438011.1
ENST00000457042.1
APEH


acylaminoacyl-peptide hydrolase


chr6_-_82462425 0.646 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A


family with sequence similarity 46, member A


chr17_-_56595196 0.646 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4


myotubularin related protein 4


chr20_+_30193083 0.639 ENST00000376112.3
ENST00000376105.3
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr11_-_14913190 0.633 ENST00000532378.1
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr12_+_7055767 0.628 ENST00000447931.2
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr18_+_43914159 0.625 ENST00000588679.1
ENST00000269439.7
ENST00000543885.1
RNF165


ring finger protein 165


chr16_+_19222479 0.625 ENST00000568433.1
SYT17
synaptotagmin XVII
chr2_+_27274506 0.623 ENST00000451003.1
ENST00000323064.8
ENST00000360131.4
AGBL5


ATP/GTP binding protein-like 5


chr2_-_178417742 0.615 ENST00000408939.3
TTC30B
tetratricopeptide repeat domain 30B
chr15_+_79603404 0.612 ENST00000299705.5
TMED3
transmembrane emp24 protein transport domain containing 3
chr20_-_39317868 0.611 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr12_+_7055631 0.611 ENST00000543115.1
ENST00000399448.1
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr6_+_30848771 0.608 ENST00000503180.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr10_+_12391685 0.601 ENST00000378845.1
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr12_-_118541692 0.599 ENST00000538357.1
VSIG10
V-set and immunoglobulin domain containing 10
chr2_+_65663812 0.596 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1


AC074391.1


chr6_-_43596899 0.594 ENST00000307126.5
ENST00000452781.1
GTPBP2

GTP binding protein 2

chr17_-_66453562 0.591 ENST00000262139.5
ENST00000546360.1
WIPI1

WD repeat domain, phosphoinositide interacting 1

chr15_-_75199178 0.590 ENST00000563119.1
ENST00000457294.2
FAM219B

family with sequence similarity 219, member B

chr4_+_154074217 0.586 ENST00000437508.2
TRIM2
tripartite motif containing 2
chr2_-_7005785 0.584 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2


cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial


chr6_+_31730773 0.584 ENST00000415669.2
ENST00000425424.1
SAPCD1

suppressor APC domain containing 1

chr1_-_53387386 0.579 ENST00000467988.1
ENST00000358358.5
ENST00000371522.4
ECHDC2


enoyl CoA hydratase domain containing 2


chr8_+_142138799 0.575 ENST00000518668.1
DENND3
DENN/MADD domain containing 3
chrX_-_118826784 0.575 ENST00000394616.4
SEPT6
septin 6
chr15_-_75198954 0.573 ENST00000565772.1
FAM219B
family with sequence similarity 219, member B
chr19_-_17445613 0.570 ENST00000159087.4
ANO8
anoctamin 8
chr8_+_98788057 0.563 ENST00000517924.1
LAPTM4B
lysosomal protein transmembrane 4 beta
chr16_-_89043377 0.563 ENST00000436887.2
ENST00000448839.1
ENST00000360302.2
CBFA2T3


core-binding factor, runt domain, alpha subunit 2; translocated to, 3


chr2_-_96812751 0.563 ENST00000449242.1
AC012307.2
AC012307.2
chr11_-_14913765 0.558 ENST00000334636.5
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr4_+_86749045 0.556 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr9_+_114393634 0.546 ENST00000556107.1
ENST00000374294.3
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr17_+_74864476 0.545 ENST00000301618.4
ENST00000569840.2
MGAT5B

mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B

chr20_+_8112824 0.544 ENST00000378641.3
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
chr12_+_50017184 0.543 ENST00000548825.2
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr1_-_119683251 0.542 ENST00000369426.5
ENST00000235521.4
WARS2

tryptophanyl tRNA synthetase 2, mitochondrial

chr19_-_12889226 0.542 ENST00000589400.1
ENST00000590839.1
ENST00000592079.1
HOOK2


hook microtubule-tethering protein 2


chr12_+_50017327 0.541 ENST00000261897.1
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chrX_-_118827113 0.535 ENST00000394617.2
SEPT6
septin 6
chr2_-_230135937 0.531 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
PID1


phosphotyrosine interaction domain containing 1


chr2_+_65283506 0.527 ENST00000377990.2
CEP68
centrosomal protein 68kDa
chr5_-_138739739 0.521 ENST00000514983.1
ENST00000507779.2
ENST00000451821.2
ENST00000450845.2
ENST00000509959.1
ENST00000302091.5
SPATA24





spermatogenesis associated 24





chr4_+_86748898 0.520 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr14_-_23772032 0.519 ENST00000452015.4
PPP1R3E
protein phosphatase 1, regulatory subunit 3E
chr6_+_26156551 0.514 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr17_+_42248063 0.513 ENST00000293414.1
ASB16
ankyrin repeat and SOCS box containing 16
chr1_+_117910047 0.510 ENST00000356554.3
MAN1A2
mannosidase, alpha, class 1A, member 2
chr12_-_118541743 0.507 ENST00000359236.5
VSIG10
V-set and immunoglobulin domain containing 10
chr12_-_6579833 0.506 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr5_+_118788433 0.503 ENST00000414835.2
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr19_-_3061397 0.502 ENST00000586839.1
AES
amino-terminal enhancer of split
chr20_+_34043085 0.500 ENST00000397527.1
ENST00000342580.4
CEP250

centrosomal protein 250kDa

chr20_-_43438912 0.487 ENST00000541604.2
ENST00000372851.3
RIMS4

regulating synaptic membrane exocytosis 4

chr1_+_89990378 0.485 ENST00000449440.1
LRRC8B
leucine rich repeat containing 8 family, member B
chrX_-_47004437 0.484 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr6_+_30851840 0.481 ENST00000511510.1
ENST00000376569.3
ENST00000376575.3
ENST00000376570.4
ENST00000446312.1
ENST00000504927.1
DDR1





discoidin domain receptor tyrosine kinase 1





chr14_+_64971292 0.480 ENST00000358738.3
ENST00000394712.2
ZBTB1

zinc finger and BTB domain containing 1

chr15_-_52472078 0.478 ENST00000396335.4
ENST00000560116.1
ENST00000358784.7
GNB5


guanine nucleotide binding protein (G protein), beta 5


chr8_+_98788003 0.476 ENST00000521545.2
LAPTM4B
lysosomal protein transmembrane 4 beta
chr19_+_12949251 0.473 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr12_-_31744031 0.470 ENST00000389082.5
DENND5B
DENN/MADD domain containing 5B
chr12_-_6579808 0.467 ENST00000535180.1
ENST00000400911.3
VAMP1

vesicle-associated membrane protein 1 (synaptobrevin 1)

chr3_-_47619623 0.464 ENST00000456150.1
CSPG5
chondroitin sulfate proteoglycan 5 (neuroglycan C)
chr12_+_56137064 0.459 ENST00000257868.5
ENST00000546799.1
GDF11

growth differentiation factor 11

chr5_+_118788261 0.452 ENST00000504811.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr4_-_89744365 0.449 ENST00000513837.1
ENST00000503556.1
FAM13A

family with sequence similarity 13, member A

chr7_+_99613212 0.448 ENST00000426572.1
ENST00000535170.1
ZKSCAN1

zinc finger with KRAB and SCAN domains 1

chr15_-_75199213 0.448 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr11_+_394145 0.446 ENST00000528036.1
PKP3
plakophilin 3
chr10_+_102821551 0.444 ENST00000370200.5
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr2_+_65283529 0.443 ENST00000546106.1
ENST00000537589.1
ENST00000260569.4
CEP68


centrosomal protein 68kDa


chr12_-_113658826 0.443 ENST00000546692.1
IQCD
IQ motif containing D
chr5_+_118788138 0.441 ENST00000256216.6
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr1_+_113217345 0.441 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr14_+_24583836 0.437 ENST00000559115.1
ENST00000558215.1
ENST00000557810.1
ENST00000561375.1
ENST00000446197.3
ENST00000559796.1
ENST00000560713.1
ENST00000560901.1
ENST00000559382.1
DCAF11








DDB1 and CUL4 associated factor 11








chr8_+_90914757 0.437 ENST00000451899.2
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr12_-_6580094 0.437 ENST00000361716.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr3_+_99833755 0.433 ENST00000489081.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr17_+_36858694 0.433 ENST00000563897.1
CTB-58E17.1
CTB-58E17.1
chr5_+_118788182 0.431 ENST00000515320.1
ENST00000510025.1
HSD17B4

hydroxysteroid (17-beta) dehydrogenase 4

chr1_+_174846570 0.430 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr1_+_27114418 0.424 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr11_-_61124776 0.423 ENST00000542361.1
CYB561A3
cytochrome b561 family, member A3
chr4_-_89744457 0.422 ENST00000395002.2
FAM13A
family with sequence similarity 13, member A
chr1_-_119682812 0.421 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr17_-_55162360 0.420 ENST00000576871.1
ENST00000576313.1
RP11-166P13.3

RP11-166P13.3

chr18_+_9913977 0.419 ENST00000400000.2
ENST00000340541.4
VAPA

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

chr18_-_30050395 0.418 ENST00000269209.6
ENST00000399218.4
GAREM

GRB2 associated, regulator of MAPK1

chr14_+_24584372 0.416 ENST00000559396.1
ENST00000558638.1
ENST00000561041.1
ENST00000559288.1
ENST00000558408.1
DCAF11




DDB1 and CUL4 associated factor 11




chr11_-_61124711 0.415 ENST00000536915.1
CYB561A3
cytochrome b561 family, member A3
chr12_+_90102729 0.410 ENST00000605386.1
LINC00936
long intergenic non-protein coding RNA 936
chr10_-_81205373 0.409 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chrX_-_117250740 0.406 ENST00000371882.1
ENST00000540167.1
ENST00000545703.1
KLHL13


kelch-like family member 13


chr11_-_61197480 0.405 ENST00000439958.3
ENST00000394888.4
CPSF7

cleavage and polyadenylation specific factor 7, 59kDa

chr12_+_102091400 0.400 ENST00000229266.3
ENST00000549872.1
CHPT1

choline phosphotransferase 1

chr14_-_64971288 0.399 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.2 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.8 3.8 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.7 2.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.6 5.6 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.6 4.5 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of high voltage-gated calcium channel activity(GO:1901843) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.6 5.0 GO:0009820 alkaloid metabolic process(GO:0009820)
0.5 2.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.4 2.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.4 1.2 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.4 17.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 1.3 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.8 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.3 0.8 GO:0034059 response to anoxia(GO:0034059)
0.3 0.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 1.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 1.6 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.2 0.6 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.2 4.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 1.2 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.2 1.4 GO:0008218 bioluminescence(GO:0008218)
0.2 0.6 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.2 0.6 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.2 0.8 GO:0006740 NADPH regeneration(GO:0006740)
0.2 1.7 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 1.5 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 0.9 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.2 0.5 GO:0080154 regulation of fertilization(GO:0080154)
0.2 0.5 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.2 1.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 0.6 GO:1900046 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.2 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.2 0.5 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.2 0.9 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.1 0.6 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 0.9 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.1 3.1 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.4 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.5 GO:0002572 pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1 1.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.6 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 2.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.3 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.1 0.8 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.1 0.4 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.1 0.5 GO:2001170 positive regulation of fat cell proliferation(GO:0070346) negative regulation of ATP biosynthetic process(GO:2001170)
0.1 1.8 GO:0051450 myoblast proliferation(GO:0051450)
0.1 0.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.3 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 2.1 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 0.3 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 1.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.3 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.1 0.8 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.6 GO:0035608 protein deglutamylation(GO:0035608)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.4 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.9 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 0.6 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 0.5 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.8 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 1.3 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.5 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.4 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.2 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) positive regulation of mast cell cytokine production(GO:0032765) mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.3 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.1 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.1 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 1.5 GO:0021756 striatum development(GO:0021756)
0.1 0.8 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 0.9 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 1.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 1.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.8 GO:0006477 protein sulfation(GO:0006477)
0.1 0.2 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.1 0.5 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.1 GO:1903413 cellular response to bile acid(GO:1903413)
0.1 0.2 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 0.1 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.1 0.3 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.2 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.1 0.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 0.2 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 1.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 2.2 GO:0003016 respiratory system process(GO:0003016)
0.1 0.1 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 2.4 GO:0000732 strand displacement(GO:0000732)
0.0 0.4 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.7 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.5 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.2 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.5 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 1.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.1 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.5 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.4 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0019322 xylulose metabolic process(GO:0005997) pentose biosynthetic process(GO:0019322)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.7 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.9 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.5 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 1.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.3 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.8 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 1.4 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.0 0.5 GO:0021511 spinal cord patterning(GO:0021511)
0.0 0.2 GO:0042426 choline catabolic process(GO:0042426)
0.0 0.3 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:0030432 peristalsis(GO:0030432)
0.0 0.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 1.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 1.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.1 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.1 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.8 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 1.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 1.7 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.1 GO:1990253 cellular response to leucine(GO:0071233) cellular response to leucine starvation(GO:1990253)
0.0 0.0 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.0 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.0 1.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0002586 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.3 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0021772 olfactory bulb development(GO:0021772)
0.0 0.0 GO:1902309 regulation of peptidyl-serine dephosphorylation(GO:1902308) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.1 GO:2000334 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0021678 third ventricle development(GO:0021678)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 1.0 GO:0016266 O-glycan processing(GO:0016266)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0032173 septin ring(GO:0005940) septin collar(GO:0032173)
0.3 5.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 0.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 4.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 1.3 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.0 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 1.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.4 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 0.8 GO:0097165 nuclear stress granule(GO:0097165)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 3.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.6 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.5 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 0.3 GO:0070985 TFIIK complex(GO:0070985)
0.1 1.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 18.7 GO:0030018 Z disc(GO:0030018)
0.1 0.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 2.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 1.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 4.9 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 1.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.6 GO:0043204 perikaryon(GO:0043204)
0.0 1.7 GO:0034702 ion channel complex(GO:0034702)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.8 GO:0005605 basal lamina(GO:0005605)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 1.2 GO:0043235 receptor complex(GO:0043235)
0.0 0.1 GO:0032010 phagolysosome(GO:0032010)
0.0 0.0 GO:0032280 asymmetric synapse(GO:0032279) symmetric synapse(GO:0032280) neuron to neuron synapse(GO:0098984)
0.0 0.2 GO:0030914 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0 1.3 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.7 2.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.6 1.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.6 5.5 GO:0043426 MRF binding(GO:0043426)
0.6 4.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 3.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 18.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 1.0 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.3 1.8 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.3 1.2 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.3 4.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 0.8 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 2.1 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.2 8.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 1.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.6 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 1.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.9 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 1.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.4 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.1 0.5 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 0.3 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 1.4 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.5 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.1 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.5 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.3 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.3 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.9 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.3 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 1.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 1.3 GO:0015929 hexosaminidase activity(GO:0015929)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 1.4 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0046790 virion binding(GO:0046790)
0.0 0.9 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.8 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 2.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 3.5 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 3.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.7 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.0 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 6.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.2 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 8.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 0.2 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1 2.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 4.5 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 2.1 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 0.9 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 2.1 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.1 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.0 0.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.2 REACTOME_SIGNAL_AMPLIFICATION Genes involved in Signal amplification
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins