Motif ID: NFKB1
Z-value: 1.082
Transcription factors associated with NFKB1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NFKB1 | ENSG00000109320.7 | NFKB1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103423055_103423112 | 0.93 | 2.8e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 7.2 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 1.3 | 3.8 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 1.0 | 3.9 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.8 | 9.0 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.6 | 2.2 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.5 | 1.0 | GO:2001183 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.5 | 1.5 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.5 | 1.4 | GO:0007497 | posterior midgut development(GO:0007497) positive regulation of penile erection(GO:0060406) endothelin receptor signaling pathway(GO:0086100) |
| 0.3 | 3.8 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.3 | 0.9 | GO:1990619 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619) |
| 0.3 | 0.9 | GO:0045083 | negative regulation of interleukin-12 biosynthetic process(GO:0045083) |
| 0.3 | 0.9 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.3 | 0.8 | GO:0043449 | insecticide metabolic process(GO:0017143) cellular alkene metabolic process(GO:0043449) olefin metabolic process(GO:1900673) |
| 0.2 | 3.2 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.2 | 1.1 | GO:1901545 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.2 | 0.4 | GO:0090291 | negative regulation of osteoclast proliferation(GO:0090291) |
| 0.2 | 1.3 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.2 | 0.8 | GO:0032218 | riboflavin transport(GO:0032218) |
| 0.2 | 1.1 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.2 | 0.5 | GO:0031394 | positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of fibroblast growth factor production(GO:0090271) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.1 | 0.9 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.1 | 0.4 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.4 | GO:0071790 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 0.1 | 2.5 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.1 | 1.0 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 0.5 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 2.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.6 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.1 | 0.3 | GO:2000625 | response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627) |
| 0.1 | 1.0 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 0.3 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.6 | GO:0043652 | engulfment of apoptotic cell(GO:0043652) |
| 0.1 | 0.5 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.1 | 2.2 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) |
| 0.1 | 0.7 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.1 | 0.2 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 0.5 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.4 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 0.1 | 0.3 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.1 | 0.2 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.1 | 0.3 | GO:0045350 | interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.1 | 0.6 | GO:0042940 | D-amino acid transport(GO:0042940) |
| 0.0 | 1.0 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.4 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.0 | 0.2 | GO:2000697 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 0.0 | 0.3 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.0 | 0.7 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.0 | 0.3 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.0 | 0.4 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 0.4 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.0 | 0.2 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.0 | 0.4 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 0.4 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.4 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.4 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 1.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.5 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.0 | 0.2 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 0.6 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.0 | 0.2 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.0 | 0.8 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 0.3 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.4 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.2 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.0 | 2.8 | GO:0007004 | telomere maintenance via telomerase(GO:0007004) |
| 0.0 | 1.6 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 0.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.0 | 0.4 | GO:0048535 | lymph node development(GO:0048535) |
| 0.0 | 0.1 | GO:1900169 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 0.1 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.0 | 0.1 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.0 | 0.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.2 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.0 | 0.1 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.1 | GO:0001828 | inner cell mass cellular morphogenesis(GO:0001828) |
| 0.0 | 0.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.7 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 0.0 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.0 | 0.4 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 1.0 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.0 | 0.3 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.0 | 0.0 | GO:0090222 | centrosome-templated microtubule nucleation(GO:0090222) |
| 0.0 | 0.0 | GO:0035397 | helper T cell enhancement of adaptive immune response(GO:0035397) |
| 0.0 | 1.4 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 0.4 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.0 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.0 | 0.4 | GO:0051930 | regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931) |
| 0.0 | 0.2 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.1 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.5 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.4 | 4.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.3 | 1.0 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.2 | 0.9 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.2 | 1.7 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.2 | 0.7 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.2 | 2.0 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.4 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.1 | 0.7 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.1 | 1.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.4 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.1 | 0.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.4 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.1 | 0.5 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 2.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 0.2 | GO:0070993 | translation preinitiation complex(GO:0070993) |
| 0.0 | 0.2 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.6 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 1.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.4 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 0.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 1.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.3 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 5.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 2.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 9.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.8 | 3.2 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.5 | 1.4 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.3 | 0.9 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.3 | 2.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.3 | 5.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.2 | 1.0 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981) |
| 0.2 | 1.4 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.2 | 0.8 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
| 0.2 | 0.8 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.2 | 1.7 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 0.5 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.1 | 0.4 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 7.2 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 0.4 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.1 | 0.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.1 | 0.4 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.1 | 0.7 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.3 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.1 | 1.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 0.2 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 0.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 3.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.1 | 0.4 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.4 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.0 | 0.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.0 | 1.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 1.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.3 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 0.3 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.0 | 0.4 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.0 | 0.7 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.2 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.0 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.4 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 1.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 2.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 1.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 0.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 1.0 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.0 | 0.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 1.0 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 2.4 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.1 | GO:0046997 | oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.0 | 0.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 0.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.8 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.1 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 4.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.4 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 8.7 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 3.0 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.2 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.6 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.7 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.9 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.6 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.1 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 1.7 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.2 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.5 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 0.2 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.4 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.4 | PID_REELIN_PATHWAY | Reelin signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 7.6 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 9.0 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.0 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 2.9 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.7 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 0.3 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 2.2 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 1.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 0.4 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 1.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.1 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 0.7 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 1.5 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.9 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 1.4 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.2 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.7 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 2.6 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.1 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.3 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
