Motif ID: NFATC4

Z-value: 0.622


Transcription factors associated with NFATC4:

Gene SymbolEntrez IDGene Name
NFATC4 ENSG00000100968.9 NFATC4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC4hg19_v2_chr14_+_24837226_248375470.872.1e-03Click!


Activity profile for motif NFATC4.

activity profile for motif NFATC4


Sorted Z-values histogram for motif NFATC4

Sorted Z-values for motif NFATC4



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_51318513 0.773 ENST00000332160.4
METTL7A
methyltransferase like 7A
chrX_-_13835147 0.762 ENST00000493677.1
ENST00000355135.2
GPM6B

glycoprotein M6B

chr1_+_186265399 0.687 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4






proteoglycan 4






chr2_-_190044480 0.579 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr15_+_43985084 0.555 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr15_+_43885252 0.549 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr1_-_151826173 0.547 ENST00000368817.5
THEM5
thioesterase superfamily member 5
chr3_+_154797428 0.530 ENST00000460393.1
MME
membrane metallo-endopeptidase
chr10_+_81838792 0.505 ENST00000372273.3
TMEM254
transmembrane protein 254
chr20_+_12989596 0.496 ENST00000434210.1
ENST00000399002.2
SPTLC3

serine palmitoyltransferase, long chain base subunit 3

chr8_-_22089845 0.495 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr17_+_76311791 0.490 ENST00000586321.1
AC061992.2
AC061992.2
chr14_-_74551096 0.465 ENST00000350259.4
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr3_-_98241760 0.448 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1










claudin domain containing 1










chr1_+_45274154 0.429 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19


BTB (POZ) domain containing 19


chr5_+_43603229 0.427 ENST00000344920.4
ENST00000512996.2
NNT

nicotinamide nucleotide transhydrogenase

chr18_-_3220106 0.421 ENST00000356443.4
ENST00000400569.3
MYOM1

myomesin 1

chr17_-_1613663 0.420 ENST00000330676.6
TLCD2
TLC domain containing 2
chr14_-_74551172 0.415 ENST00000553458.1
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr3_+_154797636 0.407 ENST00000481828.1
MME
membrane metallo-endopeptidase
chr8_+_101349823 0.400 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr14_+_21156915 0.399 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr18_-_3247084 0.386 ENST00000609924.1
RP13-270P17.3
RP13-270P17.3
chr10_+_81838411 0.386 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
TMEM254



transmembrane protein 254



chr12_-_68845417 0.380 ENST00000542875.1
RP11-81H14.2
RP11-81H14.2
chr11_-_83984231 0.378 ENST00000330014.6
ENST00000537455.1
ENST00000376106.3
ENST00000418306.2
ENST00000531015.1
DLG2




discs, large homolog 2 (Drosophila)




chr3_+_140981456 0.377 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr17_-_17740325 0.371 ENST00000338854.5
SREBF1
sterol regulatory element binding transcription factor 1
chr5_+_43602750 0.371 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT


nicotinamide nucleotide transhydrogenase


chr1_-_161337662 0.369 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr3_-_49837254 0.363 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4


cadherin-related family member 4


chr14_-_92413353 0.360 ENST00000556154.1
FBLN5
fibulin 5
chr3_-_98241598 0.352 ENST00000513287.1
ENST00000514537.1
ENST00000508071.1
ENST00000507944.1
CLDND1



claudin domain containing 1



chr10_-_62704005 0.350 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr17_-_17740287 0.349 ENST00000355815.4
ENST00000261646.5
SREBF1

sterol regulatory element binding transcription factor 1

chr16_+_53412368 0.345 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr11_+_65190245 0.342 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1


nuclear paraspeckle assembly transcript 1 (non-protein coding)


chr20_+_57466357 0.342 ENST00000371095.3
ENST00000371085.3
ENST00000354359.7
ENST00000265620.7
GNAS



GNAS complex locus



chrX_+_100663243 0.341 ENST00000316594.5
HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr22_-_39548627 0.325 ENST00000216133.5
CBX7
chromobox homolog 7
chr16_-_85969774 0.312 ENST00000598933.1
RP11-542M13.3
RP11-542M13.3
chr1_-_155881156 0.309 ENST00000539040.1
ENST00000368323.3
RIT1

Ras-like without CAAX 1

chr14_-_92588246 0.309 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr16_+_29690358 0.305 ENST00000395384.4
ENST00000562473.1
QPRT

quinolinate phosphoribosyltransferase

chr15_-_52587945 0.303 ENST00000443683.2
ENST00000558479.1
ENST00000261839.7
MYO5C


myosin VC


chr6_-_26056695 0.302 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr6_+_106534192 0.299 ENST00000369091.2
ENST00000369096.4
PRDM1

PR domain containing 1, with ZNF domain

chr1_+_162602244 0.299 ENST00000367922.3
ENST00000367921.3
DDR2

discoidin domain receptor tyrosine kinase 2

chr12_-_7244469 0.298 ENST00000538050.1
ENST00000536053.2
C1R

complement component 1, r subcomponent

chr17_+_7792101 0.293 ENST00000358181.4
ENST00000330494.7
CHD3

chromodomain helicase DNA binding protein 3

chr5_-_112630598 0.287 ENST00000302475.4
MCC
mutated in colorectal cancers
chr20_+_33292068 0.285 ENST00000374810.3
ENST00000374809.2
ENST00000451665.1
TP53INP2


tumor protein p53 inducible nuclear protein 2


chr2_+_189839046 0.284 ENST00000304636.3
ENST00000317840.5
COL3A1

collagen, type III, alpha 1

chr12_-_54653313 0.284 ENST00000550411.1
ENST00000439541.2
CBX5

chromobox homolog 5

chr7_-_111202511 0.283 ENST00000452895.1
ENST00000452753.1
ENST00000331762.3
IMMP2L


IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)


chr9_-_113342160 0.281 ENST00000401783.2
ENST00000374461.1
SVEP1

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

chr4_-_186682716 0.280 ENST00000445343.1
SORBS2
sorbin and SH3 domain containing 2
chr6_+_26087646 0.278 ENST00000309234.6
HFE
hemochromatosis
chr4_+_89300158 0.274 ENST00000502870.1
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr6_-_134495992 0.272 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1


serum/glucocorticoid regulated kinase 1


chr20_+_12989822 0.271 ENST00000378194.4
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr2_-_179343226 0.269 ENST00000434643.2
FKBP7
FK506 binding protein 7
chr17_-_44657017 0.265 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A





ADP-ribosylation factor-like 17A





chr4_-_186733119 0.265 ENST00000419063.1
SORBS2
sorbin and SH3 domain containing 2
chr16_+_2039946 0.264 ENST00000248121.2
ENST00000568896.1
SYNGR3

synaptogyrin 3

chr11_-_62474803 0.263 ENST00000533982.1
ENST00000360796.5
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr20_+_57466461 0.257 ENST00000306090.10
GNAS
GNAS complex locus
chr11_-_88070920 0.256 ENST00000524463.1
ENST00000227266.5
CTSC

cathepsin C

chr3_-_98241713 0.256 ENST00000502288.1
ENST00000512147.1
ENST00000510541.1
ENST00000503621.1
ENST00000511081.1
CLDND1




claudin domain containing 1




chr2_-_179343268 0.247 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr3_+_154797781 0.246 ENST00000382989.3
MME
membrane metallo-endopeptidase
chr11_-_46142948 0.246 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr8_-_18541603 0.245 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_145470383 0.242 ENST00000369314.1
ENST00000369313.3
POLR3GL

polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like

chr19_-_46146946 0.242 ENST00000536630.1
EML2
echinoderm microtubule associated protein like 2
chr6_-_112081113 0.240 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chrX_+_22056165 0.237 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr4_-_84255935 0.235 ENST00000513463.1
HPSE
heparanase
chr1_-_155177677 0.227 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3


thrombospondin 3


chr22_-_39548443 0.225 ENST00000401405.3
CBX7
chromobox homolog 7
chr5_-_149535190 0.219 ENST00000517488.1
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr11_-_88070896 0.216 ENST00000529974.1
ENST00000527018.1
CTSC

cathepsin C

chr12_-_89918982 0.215 ENST00000549504.1
POC1B
POC1 centriolar protein B
chr4_+_175204818 0.213 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr8_-_95449155 0.213 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr17_+_6900201 0.213 ENST00000480801.1
ALOX12
arachidonate 12-lipoxygenase
chr19_+_39759154 0.212 ENST00000331982.5
IFNL2
interferon, lambda 2
chr8_-_95274536 0.211 ENST00000297596.2
ENST00000396194.2
GEM

GTP binding protein overexpressed in skeletal muscle

chrX_+_102631844 0.210 ENST00000372634.1
ENST00000299872.7
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr12_+_12938541 0.204 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr4_-_174254823 0.204 ENST00000438704.2
HMGB2
high mobility group box 2
chr2_+_191208196 0.203 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1



inositol polyphosphate-1-phosphatase



chr2_+_86668464 0.203 ENST00000409064.1
KDM3A
lysine (K)-specific demethylase 3A
chr6_-_110736742 0.200 ENST00000368924.3
ENST00000368923.3
DDO

D-aspartate oxidase

chr2_+_128458514 0.200 ENST00000310981.4
SFT2D3
SFT2 domain containing 3
chr8_+_17434689 0.199 ENST00000398074.3
PDGFRL
platelet-derived growth factor receptor-like
chr3_+_108321623 0.197 ENST00000497905.1
ENST00000463306.1
DZIP3

DAZ interacting zinc finger protein 3

chr4_-_84256024 0.193 ENST00000311412.5
HPSE
heparanase
chr1_+_150266256 0.193 ENST00000309092.7
ENST00000369084.5
MRPS21

mitochondrial ribosomal protein S21

chr1_+_174846570 0.186 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr11_+_62475130 0.185 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr8_-_49833978 0.185 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr6_+_122720681 0.184 ENST00000368455.4
ENST00000452194.1
HSF2

heat shock transcription factor 2

chr2_-_84686552 0.184 ENST00000393868.2
SUCLG1
succinate-CoA ligase, alpha subunit
chr6_+_106546808 0.183 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr4_+_175204865 0.183 ENST00000505124.1
CEP44
centrosomal protein 44kDa
chr12_-_71551652 0.182 ENST00000546561.1
TSPAN8
tetraspanin 8
chr4_-_89744365 0.180 ENST00000513837.1
ENST00000503556.1
FAM13A

family with sequence similarity 13, member A

chr4_+_175205038 0.180 ENST00000457424.2
ENST00000514712.1
CEP44

centrosomal protein 44kDa

chr14_+_58754751 0.177 ENST00000598233.1
AL132989.1
AL132989.1
chr15_+_59665194 0.177 ENST00000560394.1
FAM81A
family with sequence similarity 81, member A
chr18_-_60987220 0.177 ENST00000398117.1
BCL2
B-cell CLL/lymphoma 2
chr9_+_71394945 0.173 ENST00000394264.3
FAM122A
family with sequence similarity 122A
chr14_+_32546274 0.172 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr1_-_155880672 0.172 ENST00000609492.1
ENST00000368322.3
RIT1

Ras-like without CAAX 1

chr6_+_87865262 0.170 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
ZNF292



zinc finger protein 292



chr4_-_89744457 0.170 ENST00000395002.2
FAM13A
family with sequence similarity 13, member A
chr15_+_32933866 0.168 ENST00000300175.4
ENST00000413748.2
ENST00000494364.1
ENST00000497208.1
SCG5



secretogranin V (7B2 protein)



chr11_+_123986069 0.167 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
VWA5A





von Willebrand factor A domain containing 5A





chr1_-_219615984 0.167 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr1_-_205744205 0.166 ENST00000446390.2
RAB7L1
RAB7, member RAS oncogene family-like 1
chr11_-_46113756 0.165 ENST00000531959.1
PHF21A
PHD finger protein 21A
chr11_+_77532233 0.162 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr11_-_69867159 0.162 ENST00000528507.1
RP11-626H12.2
RP11-626H12.2
chr11_+_77532155 0.160 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
AAMDC




adipogenesis associated, Mth938 domain containing




chr8_-_73793975 0.158 ENST00000523881.1
RP11-1145L24.1
RP11-1145L24.1
chr11_-_10315741 0.155 ENST00000256190.8
SBF2
SET binding factor 2
chr9_-_23779367 0.152 ENST00000440102.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr19_-_49137790 0.151 ENST00000599385.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr17_-_44439084 0.149 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B





ADP-ribosylation factor-like 17B





chr14_+_54863682 0.148 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3



cyclin-dependent kinase inhibitor 3



chr1_+_104068312 0.147 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3



RNA-binding region (RNP1, RRM) containing 3



chr20_-_14318248 0.146 ENST00000378053.3
ENST00000341420.4
FLRT3

fibronectin leucine rich transmembrane protein 3

chr17_+_40996590 0.146 ENST00000253799.3
ENST00000452774.2
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr1_-_205744574 0.145 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1



RAB7, member RAS oncogene family-like 1



chr4_+_175205100 0.145 ENST00000515299.1
CEP44
centrosomal protein 44kDa
chr8_+_86157699 0.145 ENST00000321764.3
CA13
carbonic anhydrase XIII
chr4_-_89744314 0.145 ENST00000508369.1
FAM13A
family with sequence similarity 13, member A
chr16_-_54963026 0.144 ENST00000560208.1
ENST00000557792.1
CRNDE

colorectal neoplasia differentially expressed (non-protein coding)

chr3_-_114035026 0.144 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr14_+_54863667 0.144 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr8_-_57123815 0.143 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1


pleiomorphic adenoma gene 1


chr20_+_35201993 0.141 ENST00000373872.4
TGIF2
TGFB-induced factor homeobox 2
chr1_+_61547894 0.141 ENST00000403491.3
NFIA
nuclear factor I/A
chr3_-_119379719 0.141 ENST00000493094.1
POPDC2
popeye domain containing 2
chr17_-_7120525 0.141 ENST00000447163.1
ENST00000399506.2
ENST00000302955.6
DLG4


discs, large homolog 4 (Drosophila)


chr5_+_118812237 0.138 ENST00000513628.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr11_-_8892464 0.138 ENST00000527347.1
ENST00000526241.1
ENST00000526126.1
ENST00000530938.1
ENST00000526057.1
ST5




suppression of tumorigenicity 5




chr11_-_87908600 0.137 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38


RAB38, member RAS oncogene family


chr14_-_75593708 0.136 ENST00000557673.1
ENST00000238616.5
NEK9

NIMA-related kinase 9

chr17_+_52978185 0.136 ENST00000572405.1
ENST00000572158.1
ENST00000540336.1
ENST00000572298.1
ENST00000536554.1
ENST00000575333.1
ENST00000570499.1
ENST00000572576.1
TOM1L1







target of myb1 (chicken)-like 1







chr5_-_149465990 0.136 ENST00000543093.1
CSF1R
colony stimulating factor 1 receptor
chr17_-_39093672 0.135 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23


keratin 23 (histone deacetylase inducible)


chr5_+_137722255 0.134 ENST00000542866.1
KDM3B
lysine (K)-specific demethylase 3B
chr7_+_132937820 0.134 ENST00000393161.2
ENST00000253861.4
EXOC4

exocyst complex component 4

chr19_-_49137762 0.133 ENST00000593500.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chrX_+_115567767 0.132 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr12_-_100378006 0.131 ENST00000547776.2
ENST00000329257.7
ENST00000547010.1
ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr5_+_118812294 0.130 ENST00000509514.1
HSD17B4
hydroxysteroid (17-beta) dehydrogenase 4
chr11_-_33757950 0.129 ENST00000533403.1
ENST00000528700.1
ENST00000527577.1
ENST00000395850.3
ENST00000351554.3
CD59




CD59 molecule, complement regulatory protein




chr4_+_39046615 0.129 ENST00000261425.3
ENST00000508137.2
KLHL5

kelch-like family member 5

chr12_-_9268707 0.128 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr19_-_10697895 0.128 ENST00000591240.1
ENST00000589684.1
ENST00000591676.1
ENST00000250244.6
ENST00000590923.1
AP1M2




adaptor-related protein complex 1, mu 2 subunit




chr11_+_19799327 0.127 ENST00000540292.1
NAV2
neuron navigator 2
chr3_+_15643476 0.127 ENST00000436193.1
ENST00000383778.4
BTD

biotinidase

chr11_+_66824276 0.126 ENST00000308831.2
RHOD
ras homolog family member D
chr1_-_161039647 0.126 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr17_-_7120498 0.126 ENST00000485100.1
DLG4
discs, large homolog 4 (Drosophila)
chr6_-_159065741 0.125 ENST00000367085.3
ENST00000367089.3
DYNLT1

dynein, light chain, Tctex-type 1

chr16_-_2260834 0.125 ENST00000562360.1
ENST00000566018.1
BRICD5

BRICHOS domain containing 5

chr10_-_16563870 0.124 ENST00000298943.3
C1QL3
complement component 1, q subcomponent-like 3
chr3_+_178866199 0.123 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr1_+_104068562 0.122 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr12_-_95467267 0.122 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr19_-_39735646 0.122 ENST00000413851.2
IFNL3
interferon, lambda 3
chr9_+_123906331 0.122 ENST00000431571.1
CNTRL
centriolin
chr1_-_161039753 0.120 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr11_-_96076334 0.120 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr2_+_204192942 0.119 ENST00000295851.5
ENST00000261017.5
ABI2

abl-interactor 2

chr12_-_21910775 0.118 ENST00000539782.1
LDHB
lactate dehydrogenase B
chr1_+_164528437 0.118 ENST00000485769.1
PBX1
pre-B-cell leukemia homeobox 1
chr17_+_73452545 0.117 ENST00000314256.7
KIAA0195
KIAA0195
chr2_+_191208601 0.116 ENST00000413239.1
ENST00000431594.1
ENST00000444194.1
INPP1


inositol polyphosphate-1-phosphatase


chr1_+_149553003 0.116 ENST00000369222.3
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr4_+_41540160 0.116 ENST00000503057.1
ENST00000511496.1
LIMCH1

LIM and calponin homology domains 1

chr12_+_41086297 0.115 ENST00000551295.2
CNTN1
contactin 1
chr21_-_28215332 0.115 ENST00000517777.1
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_+_118905564 0.114 ENST00000460625.1
UPK1B
uroplakin 1B
chr11_-_64570624 0.112 ENST00000439069.1
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr1_+_10292308 0.110 ENST00000377081.1
KIF1B
kinesin family member 1B
chr2_+_173600514 0.110 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_149375783 0.109 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1


WW domain containing transcription regulator 1


chr1_+_164528866 0.109 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr15_+_91416092 0.108 ENST00000559353.1
FURIN
furin (paired basic amino acid cleaving enzyme)
chr14_+_54863739 0.107 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr14_+_100531615 0.105 ENST00000392920.3
EVL
Enah/Vasp-like
chr6_+_7590413 0.105 ENST00000342415.5
SNRNP48
small nuclear ribonucleoprotein 48kDa (U11/U12)
chr3_+_155838337 0.105 ENST00000490337.1
ENST00000389636.5
KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr10_+_114710516 0.103 ENST00000542695.1
ENST00000346198.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr8_+_75736761 0.103 ENST00000260113.2
PI15
peptidase inhibitor 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.8 GO:0006740 NADPH regeneration(GO:0006740)
0.1 1.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.3 GO:1903989 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.2 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.1 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.3 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.2 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.5 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.1 0.2 GO:2001301 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.0 0.1 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.0 0.7 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.3 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 0.1 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 0.3 GO:0046874 quinolinate metabolic process(GO:0046874) pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.6 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.1 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.3 GO:0060346 bone trabecula formation(GO:0060346)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.1 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.0 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.0 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.5 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0042701 progesterone secretion(GO:0042701)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.0 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) cellular response to iron(III) ion(GO:0071283) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.0 0.0 GO:0030167 proteoglycan catabolic process(GO:0030167)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.0 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.1 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.0 GO:0043366 beta selection(GO:0043366)
0.0 0.0 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0002027 regulation of heart rate(GO:0002027)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.8 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.0 GO:0043159 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 1.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.8 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.4 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.1 0.4 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.1 0.4 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.4 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 0.3 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.7 GO:0032810 sterol response element binding(GO:0032810)
0.1 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.3 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.2 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.1 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.3 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.6 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.2 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.1 GO:0019959 interleukin-8 binding(GO:0019959)
0.0 0.2 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.5 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.1 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.1 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.0 0.5 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.8 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide