Motif ID: NFATC1

Z-value: 0.724


Transcription factors associated with NFATC1:

Gene SymbolEntrez IDGene Name
NFATC1 ENSG00000131196.13 NFATC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v2_chr18_+_77155856_771559390.491.8e-01Click!


Activity profile for motif NFATC1.

activity profile for motif NFATC1


Sorted Z-values histogram for motif NFATC1

Sorted Z-values for motif NFATC1



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_948803 2.663 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr17_-_39780819 2.605 ENST00000311208.8
KRT17
keratin 17
chr17_-_39781054 2.595 ENST00000463128.1
KRT17
keratin 17
chr17_-_39780634 2.556 ENST00000577817.2
KRT17
keratin 17
chr1_+_79115503 2.168 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44


interferon-induced protein 44


chr17_-_34207295 1.686 ENST00000463941.1
ENST00000293272.3
CCL5

chemokine (C-C motif) ligand 5

chr17_-_39743139 1.042 ENST00000167586.6
KRT14
keratin 14
chr11_+_34642656 0.959 ENST00000257831.3
ENST00000450654.2
EHF

ets homologous factor

chr17_-_40264321 0.868 ENST00000430773.1
ENST00000413196.2
DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

chr7_+_28452130 0.831 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr21_-_35899113 0.816 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1


regulator of calcineurin 1


chr17_-_49124230 0.766 ENST00000510283.1
ENST00000510855.1
SPAG9

sperm associated antigen 9

chr1_+_86046433 0.691 ENST00000451137.2
CYR61
cysteine-rich, angiogenic inducer, 61
chr3_-_36986534 0.659 ENST00000429976.2
ENST00000301807.6
TRANK1

tetratricopeptide repeat and ankyrin repeat containing 1

chr1_+_100503643 0.583 ENST00000370152.3
HIAT1
hippocampus abundant transcript 1
chr7_+_1126437 0.570 ENST00000413368.1
ENST00000397092.1
GPER1

G protein-coupled estrogen receptor 1

chr8_+_70404996 0.548 ENST00000402687.4
ENST00000419716.3
SULF1

sulfatase 1

chr7_+_1126461 0.544 ENST00000297469.3
GPER1
G protein-coupled estrogen receptor 1
chr1_+_46640750 0.478 ENST00000372003.1
TSPAN1
tetraspanin 1
chr1_+_204042723 0.454 ENST00000367204.1
SOX13
SRY (sex determining region Y)-box 13
chr1_+_218519577 0.439 ENST00000366930.4
ENST00000366929.4
TGFB2

transforming growth factor, beta 2

chr15_+_73976545 0.437 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276


CD276 molecule


chr2_-_42160486 0.429 ENST00000427054.1
AC104654.2
AC104654.2
chr14_-_35873856 0.427 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA


nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha


chr13_-_49975632 0.421 ENST00000457041.1
ENST00000355854.4
CAB39L

calcium binding protein 39-like

chr16_+_15528332 0.401 ENST00000566490.1
C16orf45
chromosome 16 open reading frame 45
chr19_-_54692132 0.389 ENST00000449249.1
MBOAT7
membrane bound O-acyltransferase domain containing 7
chr9_-_16870704 0.371 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2



basonuclin 2



chr1_-_226926864 0.370 ENST00000429204.1
ENST00000366784.1
ITPKB

inositol-trisphosphate 3-kinase B

chr20_+_36149602 0.368 ENST00000062104.2
ENST00000346199.2
NNAT

neuronatin

chr3_-_71632894 0.367 ENST00000493089.1
FOXP1
forkhead box P1
chr3_-_192635943 0.366 ENST00000392452.2
MB21D2
Mab-21 domain containing 2
chrX_-_19905703 0.340 ENST00000397821.3
SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_52685312 0.327 ENST00000327741.5
KRT81
keratin 81
chr11_+_34654011 0.322 ENST00000531794.1
EHF
ets homologous factor
chr6_-_11232891 0.312 ENST00000379433.5
ENST00000379446.5
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr1_-_43638168 0.309 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr1_-_27226928 0.305 ENST00000361720.5
GPATCH3
G patch domain containing 3
chr19_-_30199516 0.304 ENST00000591243.1
C19orf12
chromosome 19 open reading frame 12
chr10_+_103825080 0.302 ENST00000299238.5
HPS6
Hermansky-Pudlak syndrome 6
chr3_-_107777208 0.294 ENST00000398258.3
CD47
CD47 molecule
chr5_+_50679506 0.288 ENST00000511384.1
ISL1
ISL LIM homeobox 1
chr17_+_32582293 0.283 ENST00000580907.1
ENST00000225831.4
CCL2

chemokine (C-C motif) ligand 2

chr8_-_81787006 0.281 ENST00000327835.3
ZNF704
zinc finger protein 704
chr12_+_34175398 0.278 ENST00000538927.1
ALG10
ALG10, alpha-1,2-glucosyltransferase
chr13_-_30160925 0.275 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr15_+_52155001 0.271 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chrX_-_19905577 0.263 ENST00000379697.3
SH3KBP1
SH3-domain kinase binding protein 1
chr18_+_55102917 0.260 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr5_-_73937244 0.246 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr7_-_80548493 0.238 ENST00000536800.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_122930121 0.236 ENST00000524552.1
HSPA8
heat shock 70kDa protein 8
chr1_+_235491714 0.234 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
GGPS1



geranylgeranyl diphosphate synthase 1



chr21_+_35445811 0.233 ENST00000399312.2
MRPS6
mitochondrial ribosomal protein S6
chr16_-_4323015 0.230 ENST00000204517.6
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr2_+_28618532 0.230 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr16_-_69418649 0.225 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr1_+_235492300 0.225 ENST00000476121.1
ENST00000497327.1
GGPS1

geranylgeranyl diphosphate synthase 1

chr6_-_15663198 0.220 ENST00000338950.5
ENST00000511762.2
ENST00000355917.3
ENST00000344537.5
DTNBP1



dystrobrevin binding protein 1



chr1_+_167298281 0.219 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr12_+_38710555 0.216 ENST00000551464.1
ALG10B
ALG10B, alpha-1,2-glucosyltransferase
chr11_-_122929699 0.212 ENST00000526686.1
HSPA8
heat shock 70kDa protein 8
chr1_-_168513229 0.202 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr11_-_13461790 0.202 ENST00000530907.1
BTBD10
BTB (POZ) domain containing 10
chr12_-_92536433 0.202 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79


chromosome 12 open reading frame 79


chr1_-_8000872 0.200 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr19_+_38779778 0.199 ENST00000590738.1
ENST00000587519.2
ENST00000591889.1
SPINT2
CTB-102L5.4

serine peptidase inhibitor, Kunitz type, 2
CTB-102L5.4

chr4_+_160203650 0.196 ENST00000514565.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr14_-_69261310 0.194 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chrX_+_102611373 0.186 ENST00000372661.3
ENST00000372656.3
WBP5

WW domain binding protein 5

chr1_-_154164534 0.183 ENST00000271850.7
ENST00000368530.2
TPM3

tropomyosin 3

chr17_+_36584662 0.182 ENST00000431231.2
ENST00000437668.3
ARHGAP23

Rho GTPase activating protein 23

chr21_+_17553910 0.180 ENST00000428669.2
LINC00478
long intergenic non-protein coding RNA 478
chr4_-_178363581 0.180 ENST00000264595.2
AGA
aspartylglucosaminidase
chr20_+_43990576 0.177 ENST00000372727.1
ENST00000414310.1
SYS1

SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr11_+_118754475 0.176 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr8_-_145754428 0.175 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82


chromosome 8 open reading frame 82


chr12_-_90103077 0.175 ENST00000551310.1
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr19_+_50094866 0.174 ENST00000418929.2
PRR12
proline rich 12
chr11_-_31832581 0.172 ENST00000379111.2
PAX6
paired box 6
chr1_-_27816556 0.167 ENST00000536657.1
WASF2
WAS protein family, member 2
chr1_+_15853308 0.166 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
DNAJC16


DnaJ (Hsp40) homolog, subfamily C, member 16


chr12_-_11214893 0.165 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chr7_-_105319536 0.164 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr20_-_50808236 0.163 ENST00000361387.2
ZFP64
ZFP64 zinc finger protein
chr19_+_56152361 0.161 ENST00000585995.1
ENST00000592996.1
ZNF581
CCDC106
zinc finger protein 581
coiled-coil domain containing 106
chr1_+_87595433 0.158 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1

long intergenic non-protein coding RNA 1140

chr3_+_152017924 0.156 ENST00000465907.2
ENST00000492948.1
ENST00000485509.1
ENST00000464596.1
MBNL1



muscleblind-like splicing regulator 1



chr5_+_38445641 0.155 ENST00000397210.3
ENST00000506135.1
ENST00000508131.1
EGFLAM


EGF-like, fibronectin type III and laminin G domains


chr6_-_138866823 0.154 ENST00000342260.5
NHSL1
NHS-like 1
chr1_+_36549676 0.153 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chrX_+_41193407 0.153 ENST00000457138.2
ENST00000441189.2
DDX3X

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

chr1_+_156254070 0.152 ENST00000405535.2
ENST00000456810.1
TMEM79

transmembrane protein 79

chr10_-_63995871 0.152 ENST00000315289.2
RTKN2
rhotekin 2
chr12_+_27396901 0.151 ENST00000541191.1
ENST00000389032.3
STK38L

serine/threonine kinase 38 like

chr20_-_50808290 0.151 ENST00000346617.4
ENST00000371515.4
ENST00000371518.2
ZFP64


ZFP64 zinc finger protein


chr19_+_16222678 0.151 ENST00000586682.1
RAB8A
RAB8A, member RAS oncogene family
chr7_+_76091775 0.150 ENST00000442516.1
DTX2
deltex homolog 2 (Drosophila)
chr1_+_22351977 0.148 ENST00000420503.1
ENST00000416769.1
ENST00000404210.2
LINC00339


long intergenic non-protein coding RNA 339


chr5_+_118691008 0.147 ENST00000504642.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr7_+_55177416 0.146 ENST00000450046.1
ENST00000454757.2
EGFR

epidermal growth factor receptor

chr11_-_31832207 0.146 ENST00000379109.2
PAX6
paired box 6
chr16_-_67694129 0.142 ENST00000602320.1
ACD
adrenocortical dysplasia homolog (mouse)
chr2_-_97535708 0.141 ENST00000305476.5
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr6_+_10528560 0.140 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_+_107364769 0.140 ENST00000449271.1
ENST00000425868.1
ENST00000449213.1
BBX


bobby sox homolog (Drosophila)


chr17_+_38444115 0.138 ENST00000580824.1
ENST00000577249.1
CDC6

cell division cycle 6

chr5_-_176836577 0.137 ENST00000253496.3
F12
coagulation factor XII (Hageman factor)
chr1_+_66820058 0.137 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_152011628 0.135 ENST00000404742.1
ENST00000440973.1
ESR1

estrogen receptor 1

chr19_+_10197463 0.134 ENST00000590378.1
ENST00000397881.3
C19orf66

chromosome 19 open reading frame 66

chr4_+_154387480 0.133 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922


KIAA0922


chr17_+_46189311 0.132 ENST00000582481.1
SNX11
sorting nexin 11
chr7_+_28725585 0.132 ENST00000396298.2
CREB5
cAMP responsive element binding protein 5
chr4_-_186732892 0.131 ENST00000451958.1
ENST00000439914.1
ENST00000428330.1
ENST00000429056.1
SORBS2



sorbin and SH3 domain containing 2



chr10_+_43932282 0.129 ENST00000431662.1
ENST00000315429.6
ZNF487

zinc finger protein 487

chr10_+_94590910 0.128 ENST00000371547.4
EXOC6
exocyst complex component 6
chr2_-_172087824 0.123 ENST00000521943.1
TLK1
tousled-like kinase 1
chr16_-_69418553 0.120 ENST00000569542.2
TERF2
telomeric repeat binding factor 2
chr21_-_16374688 0.119 ENST00000411932.1
NRIP1
nuclear receptor interacting protein 1
chr4_-_153274078 0.118 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr19_+_10216899 0.117 ENST00000253107.7
ENST00000556468.1
ENST00000393793.1
ENST00000428358.1
ENST00000393796.4
PPAN


PPAN-P2RY11

peter pan homolog (Drosophila)


PPAN-P2RY11 readthrough

chr3_+_178865887 0.116 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr3_+_177159695 0.116 ENST00000442937.1
LINC00578
long intergenic non-protein coding RNA 578
chr3_-_69370095 0.115 ENST00000473029.1
FRMD4B
FERM domain containing 4B
chr20_-_50808525 0.115 ENST00000216923.4
ZFP64
ZFP64 zinc finger protein
chr11_+_64950801 0.114 ENST00000526468.1
CAPN1
calpain 1, (mu/I) large subunit
chr1_+_66999799 0.114 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1


SH3-domain GRB2-like (endophilin) interacting protein 1


chr12_-_70093111 0.112 ENST00000548658.1
ENST00000476098.1
ENST00000331471.4
ENST00000393365.1
BEST3



bestrophin 3



chr16_-_67694597 0.111 ENST00000393919.4
ENST00000219251.8
ACD

adrenocortical dysplasia homolog (mouse)

chr14_+_35591509 0.110 ENST00000604073.1
KIAA0391
KIAA0391
chr12_+_109915179 0.109 ENST00000434735.2
UBE3B
ubiquitin protein ligase E3B
chr4_+_86749045 0.109 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr13_+_73629107 0.108 ENST00000539231.1
KLF5
Kruppel-like factor 5 (intestinal)
chr5_+_179125368 0.107 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
CANX


calnexin


chr8_-_122653630 0.105 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr9_-_14314518 0.104 ENST00000397581.2
NFIB
nuclear factor I/B
chr11_-_31832685 0.104 ENST00000438681.1
PAX6
paired box 6
chr16_-_29415350 0.104 ENST00000524087.1
NPIPB11
nuclear pore complex interacting protein family, member B11
chr19_+_17448348 0.104 ENST00000324894.8
ENST00000358792.7
ENST00000600625.1
GTPBP3


GTP binding protein 3 (mitochondrial)


chr1_+_150254936 0.103 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51


chromosome 1 open reading frame 51


chr3_+_107364683 0.102 ENST00000413213.1
BBX
bobby sox homolog (Drosophila)
chr3_-_71353892 0.102 ENST00000484350.1
FOXP1
forkhead box P1
chr16_+_30968615 0.102 ENST00000262519.8
SETD1A
SET domain containing 1A
chr12_-_48226897 0.102 ENST00000434070.1
HDAC7
histone deacetylase 7
chr8_-_57123815 0.100 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1


pleiomorphic adenoma gene 1


chr6_-_110736742 0.100 ENST00000368924.3
ENST00000368923.3
DDO

D-aspartate oxidase

chr12_+_11802753 0.100 ENST00000396373.4
ETV6
ets variant 6
chr2_-_157198860 0.100 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_+_42584847 0.098 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr19_-_4722780 0.097 ENST00000600621.1
DPP9
dipeptidyl-peptidase 9
chr10_+_13141441 0.096 ENST00000263036.5
OPTN
optineurin
chr2_-_239197238 0.096 ENST00000254657.3
PER2
period circadian clock 2
chr2_-_239197201 0.095 ENST00000254658.3
PER2
period circadian clock 2
chr2_+_46926326 0.095 ENST00000394861.2
SOCS5
suppressor of cytokine signaling 5
chr8_-_82443613 0.094 ENST00000360464.4
FABP12
fatty acid binding protein 12
chr1_+_44870866 0.093 ENST00000355387.2
ENST00000361799.2
RNF220

ring finger protein 220

chr3_-_50360165 0.092 ENST00000428028.1
HYAL2
hyaluronoglucosaminidase 2
chr2_+_46926048 0.092 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr5_+_7869217 0.090 ENST00000264668.2
ENST00000514220.1
ENST00000341013.6
ENST00000440940.2
ENST00000502550.1
ENST00000506877.1
MTRR





5-methyltetrahydrofolate-homocysteine methyltransferase reductase





chr1_-_55230165 0.089 ENST00000371279.3
PARS2
prolyl-tRNA synthetase 2, mitochondrial (putative)
chr12_-_13529642 0.087 ENST00000318426.2
C12orf36
chromosome 12 open reading frame 36
chr5_+_118690466 0.087 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr8_-_131399110 0.086 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr14_-_54418598 0.084 ENST00000609748.1
ENST00000558961.1
BMP4

bone morphogenetic protein 4

chr5_-_7869108 0.084 ENST00000264669.5
ENST00000507572.1
ENST00000504695.1
FASTKD3


FAST kinase domains 3


chr2_+_33701707 0.083 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3


RAS guanyl releasing protein 3 (calcium and DAG-regulated)


chr16_-_21868978 0.081 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
NPIPB4



nuclear pore complex interacting protein family, member B4



chr12_+_48225126 0.081 ENST00000550909.1
ENST00000550720.1
ENST00000548564.1
RP5-1057I20.2


RP5-1057I20.2


chr9_-_133769225 0.081 ENST00000343079.1
QRFP
pyroglutamylated RFamide peptide
chr9_-_35815013 0.079 ENST00000259667.5
HINT2
histidine triad nucleotide binding protein 2
chr13_+_49822041 0.079 ENST00000538056.1
ENST00000251108.6
ENST00000444959.1
ENST00000429346.1
CDADC1



cytidine and dCMP deaminase domain containing 1



chr4_+_26585686 0.078 ENST00000505206.1
ENST00000511789.1
TBC1D19

TBC1 domain family, member 19

chr1_+_155179012 0.077 ENST00000609421.1
MTX1
metaxin 1
chr14_+_22771851 0.076 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr17_+_12453278 0.075 ENST00000577679.1
LINC00670
long intergenic non-protein coding RNA 670
chr9_-_132597529 0.074 ENST00000372447.3
C9orf78
chromosome 9 open reading frame 78
chr6_-_128841503 0.073 ENST00000368215.3
ENST00000532331.1
ENST00000368213.5
ENST00000368207.3
ENST00000525459.1
ENST00000368210.3
ENST00000368226.4
ENST00000368227.3
PTPRK







protein tyrosine phosphatase, receptor type, K







chr10_+_104535994 0.073 ENST00000369889.4
WBP1L
WW domain binding protein 1-like
chr15_+_84841242 0.072 ENST00000558195.1
RP11-182J1.16
ubiquitin-conjugating enzyme E2Q family member 2-like
chrX_-_40506766 0.071 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
CXorf38




chromosome X open reading frame 38




chr18_-_52989525 0.069 ENST00000457482.3
TCF4
transcription factor 4
chr13_-_99174252 0.069 ENST00000376547.3
STK24
serine/threonine kinase 24
chr3_+_151986709 0.069 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1



muscleblind-like splicing regulator 1



chr2_-_122262593 0.068 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chr22_-_32022280 0.067 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr12_+_26205496 0.067 ENST00000537946.1
ENST00000541218.1
ENST00000282884.9
ENST00000545413.1
RASSF8



Ras association (RalGDS/AF-6) domain family (N-terminal) member 8



chr12_+_50144381 0.066 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr6_-_39082922 0.066 ENST00000229903.4
SAYSD1
SAYSVFN motif domain containing 1
chr2_-_214016314 0.066 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr11_+_392587 0.066 ENST00000534401.1
PKP3
plakophilin 3
chr17_-_70588936 0.065 ENST00000453722.2
LINC00511
long intergenic non-protein coding RNA 511
chr3_+_152017360 0.065 ENST00000485910.1
ENST00000463374.1
MBNL1

muscleblind-like splicing regulator 1

chr17_+_27573875 0.064 ENST00000225387.3
CRYBA1
crystallin, beta A1
chr9_+_22646189 0.064 ENST00000436786.1
RP11-399D6.2
RP11-399D6.2
chrX_-_10544942 0.064 ENST00000380779.1
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_204732487 0.063 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr4_+_146403912 0.062 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1


SMAD family member 1


chrX_-_48056199 0.062 ENST00000311798.1
ENST00000347757.1
SSX5

synovial sarcoma, X breakpoint 5

chr6_+_42989344 0.062 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.4 1.1 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264)
0.3 8.8 GO:0045109 intermediate filament organization(GO:0045109)
0.2 2.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 0.9 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 0.5 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.2 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.4 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) uterine wall breakdown(GO:0042704) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.8 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.1 0.3 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501) negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.1 0.3 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.1 0.3 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.5 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.4 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.1 0.5 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 0.4 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.1 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.2 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.2 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.2 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.3 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.2 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:1900920 lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.1 GO:0006433 prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.2 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0042335 cuticle development(GO:0042335)
0.0 0.1 GO:0002877 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.2 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.2 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 0.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.0 0.4 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.0 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.0 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0043418 S-adenosylmethionine cycle(GO:0033353) homocysteine catabolic process(GO:0043418)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.0 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.0 GO:0030879 mammary gland development(GO:0030879)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0036159 inner dynein arm assembly(GO:0036159)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.4 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.1 9.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.0 0.6 GO:0070187 telosome(GO:0070187)
0.0 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 1.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.3 0.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 1.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 2.7 GO:0031386 protein tag(GO:0031386)
0.1 1.0 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.5 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.1 GO:0004827 proline-tRNA ligase activity(GO:0004827)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.0 0.3 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.0 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 8.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 2.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.9 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation