Motif ID: MSX2

Z-value: 0.404


Transcription factors associated with MSX2:

Gene SymbolEntrez IDGene Name
MSX2 ENSG00000120149.7 MSX2



Activity profile for motif MSX2.

activity profile for motif MSX2


Sorted Z-values histogram for motif MSX2

Sorted Z-values for motif MSX2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_151034734 0.853 ENST00000260843.4
 GPR87
G protein-coupled receptor 87
chr1_-_151762943 0.309 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
 TDRKH




tudor and KH domain containing




chr9_+_74729511 0.188 ENST00000545168.1
 GDA
guanine deaminase
chr20_-_54967187 0.184 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A













chr17_+_74261277 0.173 ENST00000327490.6
 UBALD2
UBA-like domain containing 2
chr14_-_88200641 0.143 ENST00000556168.1
 RP11-1152H15.1
RP11-1152H15.1
chr6_-_116866773 0.141 ENST00000368602.3
 TRAPPC3L
trafficking protein particle complex 3-like
chr12_-_57039739 0.138 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B





ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide





chr10_-_28571015 0.130 ENST00000375719.3
ENST00000375732.1
 MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr22_-_30960876 0.113 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
 GAL3ST1


galactose-3-O-sulfotransferase 1


chr5_+_162864575 0.107 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
 CCNG1






cyclin G1






chr2_-_27603582 0.098 ENST00000323703.6
ENST00000436006.1
 ZNF513

zinc finger protein 513

chr11_+_108535752 0.095 ENST00000322536.3
 DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr11_+_108535849 0.093 ENST00000526794.1
 DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr3_-_11685345 0.088 ENST00000430365.2
 VGLL4
vestigial like 4 (Drosophila)
chr11_+_33061543 0.087 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1


t-complex 11, testis-specific-like 1


chr1_-_197115818 0.086 ENST00000367409.4
ENST00000294732.7
 ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr11_+_67250490 0.086 ENST00000528641.2
ENST00000279146.3
 AIP

aryl hydrocarbon receptor interacting protein

chr17_-_80250663 0.085 ENST00000581489.1
 RP13-516M14.4
RP13-516M14.4
chr3_-_180397256 0.085 ENST00000442201.2
 CCDC39
coiled-coil domain containing 39
chr10_-_105110831 0.083 ENST00000337211.4
 PCGF6
polycomb group ring finger 6
chr12_-_120315074 0.082 ENST00000261833.7
ENST00000392521.2
 CIT

citron (rho-interacting, serine/threonine kinase 21)

chr15_-_98417780 0.081 ENST00000503874.3
 LINC00923
long intergenic non-protein coding RNA 923
chr12_+_28410128 0.080 ENST00000381259.1
ENST00000381256.1
 CCDC91

coiled-coil domain containing 91

chr1_-_190446759 0.074 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr1_-_151762900 0.073 ENST00000440583.2
 TDRKH
tudor and KH domain containing
chr10_-_105110890 0.073 ENST00000369847.3
 PCGF6
polycomb group ring finger 6
chr9_+_80912059 0.072 ENST00000347159.2
ENST00000376588.3
 PSAT1

phosphoserine aminotransferase 1

chr17_-_38574169 0.069 ENST00000423485.1
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr19_+_42817527 0.067 ENST00000598766.1
 TMEM145
transmembrane protein 145
chr7_+_130794846 0.066 ENST00000421797.2
 MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr7_+_130794878 0.066 ENST00000416992.2
 MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr19_-_47137942 0.063 ENST00000300873.4
 GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr15_+_80351910 0.062 ENST00000261749.6
ENST00000561060.1
 ZFAND6

zinc finger, AN1-type domain 6

chr6_+_130339710 0.061 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr7_+_134331550 0.060 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
 BPGM


2,3-bisphosphoglycerate mutase


chr1_-_8877692 0.059 ENST00000400908.2
 RERE
arginine-glutamic acid dipeptide (RE) repeats
chr19_-_10121144 0.057 ENST00000264828.3
 COL5A3
collagen, type V, alpha 3
chr11_-_124190184 0.056 ENST00000357438.2
 OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_+_172864490 0.055 ENST00000315796.4
 METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr3_-_120400960 0.054 ENST00000476082.2
 HGD
homogentisate 1,2-dioxygenase
chr2_-_73460334 0.054 ENST00000258083.2
 PRADC1
protease-associated domain containing 1
chr14_-_51027838 0.053 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_-_55647057 0.052 ENST00000436346.1
 CCDC88A
coiled-coil domain containing 88A
chr2_-_55646957 0.052 ENST00000263630.8
 CCDC88A
coiled-coil domain containing 88A
chr1_-_21377383 0.052 ENST00000374935.3
 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr6_-_31830655 0.050 ENST00000375631.4
 NEU1
sialidase 1 (lysosomal sialidase)
chrX_+_77154935 0.050 ENST00000481445.1
 COX7B
cytochrome c oxidase subunit VIIb
chr7_-_2883650 0.048 ENST00000544127.1
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr4_-_19458597 0.048 ENST00000505347.1
 RP11-3J1.1
RP11-3J1.1
chr17_-_48785216 0.048 ENST00000285243.6
 ANKRD40
ankyrin repeat domain 40
chr16_-_29934558 0.048 ENST00000568995.1
ENST00000566413.1
 KCTD13

potassium channel tetramerization domain containing 13

chr12_+_64798826 0.045 ENST00000540203.1
 XPOT
exportin, tRNA
chr7_-_2883928 0.045 ENST00000275364.3
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr1_-_158173659 0.043 ENST00000415019.1
 RP11-404O13.5
RP11-404O13.5
chr5_+_150639360 0.043 ENST00000523004.1
 GM2A
GM2 ganglioside activator
chr1_-_151965048 0.043 ENST00000368809.1
 S100A10
S100 calcium binding protein A10
chr11_-_71823266 0.042 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15


anaphase promoting complex subunit 15


chr12_-_95397442 0.042 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
 NDUFA12


NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12


chr15_-_37393406 0.041 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
 MEIS2


Meis homeobox 2


chr8_-_117886612 0.041 ENST00000520992.1
 RAD21
RAD21 homolog (S. pombe)
chr2_+_187371440 0.040 ENST00000445547.1
 ZC3H15
zinc finger CCCH-type containing 15
chr12_-_10022735 0.039 ENST00000228438.2
 CLEC2B
C-type lectin domain family 2, member B
chr6_-_116833500 0.039 ENST00000356128.4
 TRAPPC3L
trafficking protein particle complex 3-like
chr1_-_36915880 0.039 ENST00000445843.3
 OSCP1
organic solute carrier partner 1
chr11_-_71823796 0.038 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15





anaphase promoting complex subunit 15





chr3_-_120003941 0.038 ENST00000464295.1
 GPR156
G protein-coupled receptor 156
chr5_-_132200477 0.038 ENST00000296875.2
 GDF9
growth differentiation factor 9
chr8_+_9413410 0.037 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
 TNKS


tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase


chr16_+_53133070 0.036 ENST00000565832.1
 CHD9
chromodomain helicase DNA binding protein 9
chr14_-_36990061 0.036 ENST00000546983.1
 NKX2-1
NK2 homeobox 1
chr11_-_102323740 0.035 ENST00000398136.2
 TMEM123
transmembrane protein 123
chr3_-_114866084 0.033 ENST00000357258.3
 ZBTB20
zinc finger and BTB domain containing 20
chr6_-_167040731 0.032 ENST00000265678.4
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_23694794 0.032 ENST00000374608.3
 ZNF436
zinc finger protein 436
chr11_+_101918153 0.032 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr12_-_9102224 0.032 ENST00000543845.1
ENST00000544245.1
 M6PR

mannose-6-phosphate receptor (cation dependent)

chr1_-_151431674 0.031 ENST00000531094.1
 POGZ
pogo transposable element with ZNF domain
chr12_-_9102549 0.031 ENST00000000412.3
 M6PR
mannose-6-phosphate receptor (cation dependent)
chr9_-_4666421 0.030 ENST00000381895.5
 SPATA6L
spermatogenesis associated 6-like
chr6_-_167040693 0.030 ENST00000366863.2
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_151431647 0.028 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
 POGZ




pogo transposable element with ZNF domain




chr11_-_71823715 0.028 ENST00000545944.1
ENST00000502597.2
 ANAPC15

anaphase promoting complex subunit 15

chr6_-_111927062 0.028 ENST00000359831.4
 TRAF3IP2
TRAF3 interacting protein 2
chr17_+_44679808 0.025 ENST00000571172.1
 NSF
N-ethylmaleimide-sensitive factor
chr20_+_30467600 0.025 ENST00000375934.4
ENST00000375922.4
 TTLL9

tubulin tyrosine ligase-like family, member 9

chr3_-_112127981 0.025 ENST00000486726.2
 RP11-231E6.1
RP11-231E6.1
chr19_+_41869894 0.024 ENST00000413014.2
 TMEM91
transmembrane protein 91
chr16_-_18923035 0.024 ENST00000563836.1
 SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr6_-_111927449 0.023 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2


TRAF3 interacting protein 2


chr8_-_117886563 0.022 ENST00000519837.1
ENST00000522699.1
 RAD21

RAD21 homolog (S. pombe)

chr7_+_91570165 0.022 ENST00000356239.3
ENST00000359028.2
ENST00000358100.2
 AKAP9


A kinase (PRKA) anchor protein 9


chr4_-_46126093 0.021 ENST00000295452.4
 GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr7_-_99716914 0.020 ENST00000431404.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr15_+_41245160 0.019 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr1_-_47779762 0.019 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
 STIL



SCL/TAL1 interrupting locus



chr9_-_95056010 0.019 ENST00000443024.2
 IARS
isoleucyl-tRNA synthetase
chr6_+_30687978 0.019 ENST00000327892.8
ENST00000435534.1
 TUBB

tubulin, beta class I

chr9_-_5339873 0.019 ENST00000223862.1
ENST00000223858.4
 RLN1

relaxin 1

chr4_-_69434245 0.018 ENST00000317746.2
 UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr12_+_54718904 0.018 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
 COPZ1








coatomer protein complex, subunit zeta 1








chr7_+_99717230 0.018 ENST00000262932.3
 CNPY4
canopy FGF signaling regulator 4
chr10_+_85954377 0.017 ENST00000332904.3
ENST00000372117.3
 CDHR1

cadherin-related family member 1

chr2_-_200335983 0.016 ENST00000457245.1
 SATB2
SATB homeobox 2
chr1_-_151431909 0.015 ENST00000361398.3
ENST00000271715.2
 POGZ

pogo transposable element with ZNF domain

chr1_+_211813019 0.015 ENST00000430123.1
 RP11-354K1.1
RP11-354K1.1
chr1_+_81001398 0.014 ENST00000418041.1
ENST00000443104.1
 RP5-887A10.1

RP5-887A10.1

chr3_+_113251143 0.014 ENST00000264852.4
ENST00000393830.3
 SIDT1

SID1 transmembrane family, member 1

chr12_+_117099342 0.013 ENST00000546835.1
 RP11-497G19.1
RP11-497G19.1
chr7_+_48211048 0.013 ENST00000435803.1
 ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr7_+_100183927 0.013 ENST00000241071.6
ENST00000360609.2
 FBXO24

F-box protein 24

chr17_+_12569306 0.013 ENST00000425538.1
 MYOCD
myocardin
chr10_+_99205894 0.013 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
 ZDHHC16



zinc finger, DHHC-type containing 16



chr19_-_46088068 0.013 ENST00000263275.4
ENST00000323060.3
 OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chrX_+_70752945 0.012 ENST00000373701.3
 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr10_-_99205607 0.012 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
 EXOSC1





exosome component 1





chr8_+_92261516 0.012 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr16_+_58783542 0.010 ENST00000500117.1
ENST00000565722.1
 RP11-410D17.2

RP11-410D17.2

chr14_+_32798547 0.010 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6


A kinase (PRKA) anchor protein 6


chr3_+_186353756 0.010 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
 FETUB


fetuin B


chr17_+_67759813 0.010 ENST00000587241.1
 AC003051.1
AC003051.1
chr1_+_202317815 0.010 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr17_-_12920907 0.009 ENST00000609757.1
ENST00000581499.2
ENST00000580504.1
 ELAC2


elaC ribonuclease Z 2


chrX_+_70752917 0.008 ENST00000373719.3
 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr19_+_42817450 0.008 ENST00000301204.3
 TMEM145
transmembrane protein 145
chr3_-_141747950 0.007 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_+_96904487 0.007 ENST00000600790.1
 AC087477.1
Uncharacterized protein
chr1_+_244515930 0.007 ENST00000366537.1
ENST00000308105.4
 C1orf100

chromosome 1 open reading frame 100

chr18_+_39535239 0.005 ENST00000585528.1
 PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr4_-_46996424 0.005 ENST00000264318.3
 GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr5_-_148758839 0.005 ENST00000261796.3
 IL17B
interleukin 17B
chr10_+_99205959 0.004 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
 ZDHHC16



zinc finger, DHHC-type containing 16



chr16_+_69345243 0.004 ENST00000254950.11
 VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_+_129247479 0.003 ENST00000296271.3
 RHO
rhodopsin
chr2_+_150187020 0.003 ENST00000334166.4
 LYPD6
LY6/PLAUR domain containing 6
chr6_+_78400375 0.002 ENST00000602452.2
 MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr20_+_49126881 0.002 ENST00000371621.3
ENST00000541713.1
 PTPN1

protein tyrosine phosphatase, non-receptor type 1

chr1_+_175036966 0.002 ENST00000239462.4
 TNN
tenascin N
chr1_-_94050668 0.001 ENST00000539242.1
 BCAR3
breast cancer anti-estrogen resistance 3
chr3_-_164796269 0.000 ENST00000264382.3
 SI
sucrase-isomaltase (alpha-glucosidase)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0006147 guanine catabolic process(GO:0006147)
0.1 0.2 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)