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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: MAFA

Z-value: 0.414

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_39781054	0.956	ENST00000463128.1	KRT17	keratin 17
chr17_-_39728303	0.462	ENST00000588431.1 ENST00000246662.4	KRT9	keratin 9
chr1_+_66458072	0.324	ENST00000423207.2	PDE4B	phosphodiesterase 4B, cAMP-specific
chr9_-_130712995	0.270	ENST00000373084.4	FAM102A	family with sequence similarity 102, member A
chr9_+_97488939	0.259	ENST00000277198.2 ENST00000297979.5	C9orf3	chromosome 9 open reading frame 3
chr11_-_66103932	0.251	ENST00000311320.4	RIN1	Ras and Rab interactor 1
chr2_+_191745535	0.240	ENST00000320717.3	GLS	glutaminase
chr4_+_15005391	0.237	ENST00000507071.1 ENST00000345451.3 ENST00000259997.5 ENST00000382395.3 ENST00000382401.3	CPEB2	cytoplasmic polyadenylation element binding protein 2
chr17_-_17109579	0.234	ENST00000321560.3	PLD6	phospholipase D family, member 6
chr11_-_66103867	0.225	ENST00000424433.2	RIN1	Ras and Rab interactor 1
chr1_-_38325256	0.222	ENST00000373036.4	MTF1	metal-regulatory transcription factor 1
chr1_-_57045228	0.220	ENST00000371250.3	PPAP2B	phosphatidic acid phosphatase type 2B
chr1_+_110754094	0.215	ENST00000369787.3 ENST00000413138.3 ENST00000438661.2	KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4
chr3_-_196439065	0.214	ENST00000399942.4 ENST00000409690.3	CEP19	centrosomal protein 19kDa
chr20_-_30795511	0.208	ENST00000246229.4	PLAGL2	pleiomorphic adenoma gene-like 2
chr10_-_29811456	0.205	ENST00000535393.1	SVIL	supervillin
chr12_+_79258444	0.195	ENST00000261205.4	SYT1	synaptotagmin I
chr12_+_79258547	0.186	ENST00000457153.2	SYT1	synaptotagmin I
chr16_-_67514982	0.183	ENST00000565835.1 ENST00000540149.1 ENST00000290949.3	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr2_+_191745560	0.181	ENST00000338435.4	GLS	glutaminase
chr17_-_41623009	0.175	ENST00000393664.2	ETV4	ets variant 4
chr10_+_120967072	0.168	ENST00000392870.2	GRK5	G protein-coupled receptor kinase 5
chr14_+_36295638	0.165	ENST00000543183.1	BRMS1L	breast cancer metastasis-suppressor 1-like
chrX_-_47509994	0.159	ENST00000343894.4	ELK1	ELK1, member of ETS oncogene family
chr16_+_67312049	0.155	ENST00000565899.1	PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr5_-_179285785	0.153	ENST00000520698.1 ENST00000518235.1 ENST00000376931.2 ENST00000518219.1 ENST00000521333.1 ENST00000523084.1	C5orf45	chromosome 5 open reading frame 45
chr7_-_73133959	0.149	ENST00000395155.3 ENST00000395154.3 ENST00000222812.3 ENST00000395156.3	STX1A	syntaxin 1A (brain)
chr5_-_179285848	0.146	ENST00000403396.2 ENST00000292586.6	C5orf45	chromosome 5 open reading frame 45
chr14_-_54317532	0.142	ENST00000418927.1	AL162759.1	AL162759.1
chr19_-_37958318	0.142	ENST00000316950.6 ENST00000591710.1	ZNF569	zinc finger protein 569
chr19_-_4124079	0.135	ENST00000394867.4 ENST00000262948.5	MAP2K2	mitogen-activated protein kinase kinase 2
chr11_-_104817919	0.133	ENST00000533252.1	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr19_+_54641444	0.132	ENST00000221232.5 ENST00000358389.3	CNOT3	CCR4-NOT transcription complex, subunit 3
chr16_-_21436459	0.129	ENST00000448012.2 ENST00000504841.2 ENST00000419180.2	NPIPB3	nuclear pore complex interacting protein family, member B3
chr1_+_90286562	0.129	ENST00000525774.1 ENST00000337338.5	LRRC8D	leucine rich repeat containing 8 family, member D
chr14_+_36295504	0.128	ENST00000216807.7	BRMS1L	breast cancer metastasis-suppressor 1-like
chr16_+_22524844	0.125	ENST00000538606.1 ENST00000424340.1 ENST00000517539.1 ENST00000528249.1	NPIPB5	nuclear pore complex interacting protein family, member B5
chr11_-_57177586	0.121	ENST00000529411.1	RP11-872D17.8	Uncharacterized protein
chr2_-_26205550	0.121	ENST00000405914.1	KIF3C	kinesin family member 3C
chr11_+_72929319	0.121	ENST00000393597.2 ENST00000311131.2	P2RY2	purinergic receptor P2Y, G-protein coupled, 2
chr19_+_39647271	0.120	ENST00000599657.1	PAK4	p21 protein (Cdc42/Rac)-activated kinase 4
chr15_+_80696666	0.115	ENST00000303329.4	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2
chr9_+_125133467	0.115	ENST00000426608.1	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr15_+_90744533	0.114	ENST00000411539.2	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr8_-_63998590	0.113	ENST00000260116.4	TTPA	tocopherol (alpha) transfer protein
chr9_+_131549610	0.113	ENST00000223865.8	TBC1D13	TBC1 domain family, member 13
chr15_+_98503922	0.111	ENST00000268042.6	ARRDC4	arrestin domain containing 4
chr17_+_38465441	0.111	ENST00000577646.1 ENST00000254066.5	RARA	retinoic acid receptor, alpha
chr15_+_90744745	0.109	ENST00000558051.1	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr6_-_74161977	0.109	ENST00000370318.1 ENST00000370315.3	MB21D1	Mab-21 domain containing 1
chrX_-_153141302	0.106	ENST00000361699.4 ENST00000543994.1 ENST00000370057.3 ENST00000538883.1 ENST00000361981.3	L1CAM	L1 cell adhesion molecule
chrX_-_153141434	0.103	ENST00000407935.2 ENST00000439496.1	L1CAM	L1 cell adhesion molecule
chr10_+_135122906	0.100	ENST00000368554.4	ZNF511	zinc finger protein 511
chr16_-_29415350	0.098	ENST00000524087.1	NPIPB11	nuclear pore complex interacting protein family, member B11
chr8_+_145438870	0.095	ENST00000527931.1	FAM203B	family with sequence similarity 203, member B
chrX_-_153141783	0.095	ENST00000458029.1	L1CAM	L1 cell adhesion molecule
chr11_+_72929402	0.094	ENST00000393596.2	P2RY2	purinergic receptor P2Y, G-protein coupled, 2
chr3_+_184016986	0.092	ENST00000417952.1	PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr16_-_29517141	0.090	ENST00000550665.1	RP11-231C14.4	Uncharacterized protein
chr16_+_28996572	0.090	ENST00000360872.5 ENST00000566177.1 ENST00000354453.4	LAT	linker for activation of T cells
chr13_-_28194541	0.090	ENST00000316334.3	LNX2	ligand of numb-protein X 2
chr1_+_206858328	0.089	ENST00000367103.3	MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2
chr10_-_79397391	0.083	ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr4_+_106067943	0.083	ENST00000380013.4 ENST00000394764.1 ENST00000413648.2	TET2	tet methylcytosine dioxygenase 2
chr16_-_21868739	0.083	ENST00000415645.2	NPIPB4	nuclear pore complex interacting protein family, member B4
chr4_+_2470664	0.081	ENST00000314289.8 ENST00000541204.1 ENST00000502316.1 ENST00000507247.1 ENST00000509258.1 ENST00000511859.1	RNF4	ring finger protein 4
chr15_-_66858298	0.079	ENST00000537670.1	LCTL	lactase-like
chr15_-_90456114	0.075	ENST00000398333.3	C15orf38-AP3S2	C15orf38-AP3S2 readthrough
chr15_-_23086259	0.075	ENST00000538684.1	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1
chr12_+_21654714	0.073	ENST00000542038.1 ENST00000540141.1 ENST00000229314.5	GOLT1B	golgi transport 1B
chrX_-_53310791	0.072	ENST00000375365.2	IQSEC2	IQ motif and Sec7 domain 2
chrX_+_74493896	0.070	ENST00000373383.4 ENST00000373379.1	UPRT	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr5_-_114505624	0.065	ENST00000513154.1	TRIM36	tripartite motif containing 36
chr4_-_10118348	0.063	ENST00000502702.1	WDR1	WD repeat domain 1
chr16_+_58074069	0.062	ENST00000570065.1	MMP15	matrix metallopeptidase 15 (membrane-inserted)
chr4_+_74606223	0.061	ENST00000307407.3 ENST00000401931.1	IL8	interleukin 8
chr13_+_53226963	0.059	ENST00000343788.6 ENST00000535397.1 ENST00000310528.8	SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr13_-_30951282	0.059	ENST00000420219.1	LINC00426	long intergenic non-protein coding RNA 426
chr5_+_176853702	0.055	ENST00000507633.1 ENST00000393576.3 ENST00000355958.5 ENST00000528793.1 ENST00000512684.1	GRK6	G protein-coupled receptor kinase 6
chr5_-_114505591	0.054	ENST00000508894.1	TRIM36	tripartite motif containing 36
chr7_-_30029574	0.049	ENST00000426154.1 ENST00000421434.1 ENST00000434476.2	SCRN1	secernin 1
chr17_-_10325261	0.049	ENST00000403437.2	MYH8	myosin, heavy chain 8, skeletal muscle, perinatal
chr14_+_24605389	0.048	ENST00000382708.3 ENST00000561435.1	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr9_+_100000717	0.048	ENST00000375205.2 ENST00000357054.1 ENST00000395220.1 ENST00000375202.2 ENST00000411667.2	CCDC180	coiled-coil domain containing 180
chr16_-_46865286	0.043	ENST00000285697.4	C16orf87	chromosome 16 open reading frame 87
chr8_-_9762871	0.043	ENST00000521242.1	LINC00599	long intergenic non-protein coding RNA 599
chr6_+_147525661	0.042	ENST00000321680.6 ENST00000367480.3	STXBP5	syntaxin binding protein 5 (tomosyn)
chr6_+_147525541	0.042	ENST00000367481.3 ENST00000546097.1	STXBP5	syntaxin binding protein 5 (tomosyn)
chr11_-_64660916	0.041	ENST00000413053.1	MIR194-2	microRNA 194-2
chr1_-_63782888	0.041	ENST00000436475.2	LINC00466	long intergenic non-protein coding RNA 466
chrX_-_47509887	0.040	ENST00000247161.3 ENST00000592066.1 ENST00000376983.3	ELK1	ELK1, member of ETS oncogene family
chr3_+_75955817	0.039	ENST00000487694.3 ENST00000602589.1	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr5_-_39270725	0.038	ENST00000512138.1 ENST00000512982.1 ENST00000540520.1	FYB	FYN binding protein
chr19_+_33182823	0.037	ENST00000397061.3	NUDT19	nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr3_-_49823941	0.037	ENST00000321599.4 ENST00000395238.1 ENST00000468463.1 ENST00000460540.1	IP6K1	inositol hexakisphosphate kinase 1
chr19_-_43099109	0.033	ENST00000599005.1	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8
chr10_-_70231639	0.028	ENST00000551118.2 ENST00000358410.3 ENST00000399180.2 ENST00000399179.2	DNA2	DNA replication helicase/nuclease 2
chr7_-_30029328	0.028	ENST00000425819.2 ENST00000409570.1	SCRN1	secernin 1
chr6_-_139613269	0.027	ENST00000358430.3	TXLNB	taxilin beta
chr19_+_6740888	0.027	ENST00000596673.1	TRIP10	thyroid hormone receptor interactor 10
chr3_+_196439170	0.026	ENST00000392391.3 ENST00000314118.4	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X
chrX_+_118892545	0.026	ENST00000343905.3	SOWAHD	sosondowah ankyrin repeat domain family member D
chrX_-_63425561	0.026	ENST00000374869.3 ENST00000330258.3	AMER1	APC membrane recruitment protein 1
chr17_+_7323634	0.024	ENST00000323675.3	SPEM1	spermatid maturation 1
chr3_+_107241882	0.022	ENST00000416476.2	BBX	bobby sox homolog (Drosophila)
chr3_+_196439275	0.022	ENST00000296333.5	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X
chr3_+_185304059	0.022	ENST00000427465.2	SENP2	SUMO1/sentrin/SMT3 specific peptidase 2
chr11_+_33563821	0.021	ENST00000321505.4 ENST00000265654.5 ENST00000389726.3	KIAA1549L	KIAA1549-like
chr6_+_97372734	0.021	ENST00000539200.1	KLHL32	kelch-like family member 32
chr19_-_33182616	0.020	ENST00000592431.1	CTD-2538C1.2	CTD-2538C1.2
chr6_+_97372645	0.019	ENST00000536676.1 ENST00000544166.1	KLHL32	kelch-like family member 32
chr6_+_97372596	0.019	ENST00000369261.4	KLHL32	kelch-like family member 32
chr17_+_18759612	0.019	ENST00000432893.2 ENST00000414602.1 ENST00000574522.1 ENST00000570450.1 ENST00000419071.2	PRPSAP2	phosphoribosyl pyrophosphate synthetase-associated protein 2
chr12_+_54943134	0.019	ENST00000243052.3	PDE1B	phosphodiesterase 1B, calmodulin-dependent
chr2_+_26915584	0.018	ENST00000302909.3	KCNK3	potassium channel, subfamily K, member 3
chr7_-_30029367	0.018	ENST00000242059.5	SCRN1	secernin 1
chr18_+_77623668	0.018	ENST00000316249.3	KCNG2	potassium voltage-gated channel, subfamily G, member 2
chr8_+_85095553	0.018	ENST00000521268.1	RALYL	RALY RNA binding protein-like
chr10_-_79397479	0.015	ENST00000404771.3	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr17_+_25936862	0.014	ENST00000582410.1	KSR1	kinase suppressor of ras 1
chr22_-_30662828	0.014	ENST00000403463.1 ENST00000215781.2	OSM	oncostatin M
chr7_-_135412925	0.014	ENST00000354042.4	SLC13A4	solute carrier family 13 (sodium/sulfate symporter), member 4
chr15_-_23086394	0.013	ENST00000337435.4	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1
chr5_+_139739772	0.012	ENST00000506757.2 ENST00000230993.6 ENST00000506545.1 ENST00000432095.2 ENST00000507527.1	SLC4A9	solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr1_+_163039143	0.011	ENST00000531057.1 ENST00000527809.1 ENST00000367908.4	RGS4	regulator of G-protein signaling 4
chr7_-_155160629	0.010	ENST00000378120.5	BLACE	B-cell acute lymphoblastic leukemia expressed
chr5_+_138629337	0.010	ENST00000394805.3 ENST00000512876.1 ENST00000513678.1	MATR3	matrin 3
chr16_+_70258261	0.009	ENST00000594734.1	FKSG63	FKSG63
chr7_-_150754935	0.008	ENST00000297518.4	CDK5	cyclin-dependent kinase 5
chr5_+_138629628	0.008	ENST00000508689.1 ENST00000514528.1	MATR3	matrin 3
chr8_+_85095769	0.008	ENST00000518566.1	RALYL	RALY RNA binding protein-like
chr8_-_89339705	0.008	ENST00000286614.6	MMP16	matrix metallopeptidase 16 (membrane-inserted)
chr6_+_22221010	0.006	ENST00000567753.1	RP11-524C21.2	RP11-524C21.2
chr7_-_86849836	0.006	ENST00000455575.1	TMEM243	transmembrane protein 243, mitochondrial
chr10_-_118897806	0.006	ENST00000277905.2	VAX1	ventral anterior homeobox 1
chr15_-_41047421	0.006	ENST00000560460.1 ENST00000338376.3 ENST00000560905.1	RMDN3	regulator of microtubule dynamics 3
chr14_+_81421861	0.005	ENST00000298171.2	TSHR	thyroid stimulating hormone receptor
chr19_+_21541777	0.004	ENST00000380870.4 ENST00000597810.1 ENST00000594245.1	ZNF738	zinc finger protein 738
chr12_+_108525517	0.002	ENST00000332082.4	WSCD2	WSC domain containing 2
chr5_+_138629389	0.002	ENST00000504045.1 ENST00000504311.1 ENST00000502499.1	MATR3	matrin 3
chr19_-_43099070	0.002	ENST00000244336.5	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8
chr1_-_203144941	0.002	ENST00000255416.4	MYBPH	myosin binding protein H
chr5_+_138629417	0.002	ENST00000510056.1 ENST00000511249.1 ENST00000503811.1 ENST00000511378.1	MATR3	matrin 3
chr11_+_111412053	0.001	ENST00000530962.1	LAYN	layilin
chr3_-_126277796	0.001	ENST00000318225.2	C3orf22	chromosome 3 open reading frame 22
chr14_+_81421921	0.001	ENST00000554263.1 ENST00000554435.1	TSHR	thyroid stimulating hormone receptor
chrX_+_3189861	0.001	ENST00000457435.1 ENST00000420429.2	CXorf28	chromosome X open reading frame 28

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.1	0.4	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1	0.4	GO:0006543	glutamine catabolic process(GO:0006543)
0.1	0.2	GO:1900248	cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0	0.1	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	1.4	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.2	GO:0010636	positive regulation of mitochondrial fusion(GO:0010636)
0.0	0.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	0.1	GO:0090212	vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.0	0.1	GO:0060010	Sertoli cell fate commitment(GO:0060010)
0.0	0.2	GO:0034378	chylomicron assembly(GO:0034378)
0.0	0.1	GO:0090170	regulation of Golgi inheritance(GO:0090170)
0.0	0.1	GO:0042247	morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.2	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.0	0.2	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.1	GO:0090234	regulation of kinetochore assembly(GO:0090234)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0034515	proteasome storage granule(GO:0034515)
0.0	0.1	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.1	GO:0042643	actomyosin, actin portion(GO:0042643)
0.0	0.2	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.2	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0030015	CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	0.2	GO:0047696	beta-adrenergic receptor kinase activity(GO:0047696)
0.1	0.4	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.4	GO:0030348	syntaxin-3 binding(GO:0030348)
0.0	0.1	GO:0008431	vitamin E binding(GO:0008431)
0.0	0.1	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0	0.2	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0008422	beta-glucosidase activity(GO:0008422)
0.0	0.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.1	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.0	0.1	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle

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