Motif ID: LEF1

Z-value: 1.590


Transcription factors associated with LEF1:

Gene SymbolEntrez IDGene Name
LEF1 ENSG00000138795.5 LEF1



Activity profile for motif LEF1.

activity profile for motif LEF1


Sorted Z-values histogram for motif LEF1

Sorted Z-values for motif LEF1



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_80457442 2.691 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr11_-_8285405 2.435 ENST00000335790.3
ENST00000534484.1
LMO1

LIM domain only 1 (rhombotin 1)

chr6_-_64029879 2.315 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN


lengsin, lens protein with glutamine synthetase domain


chr2_-_183387430 1.283 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387064 1.274 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A



phosphodiesterase 1A, calmodulin-dependent



chr8_-_124553437 1.214 ENST00000517956.1
ENST00000443022.2
FBXO32

F-box protein 32

chr2_-_86564776 1.152 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1


receptor accessory protein 1


chr9_-_23826298 1.112 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr11_-_8290263 1.046 ENST00000428101.2
LMO1
LIM domain only 1 (rhombotin 1)
chr7_+_116312411 1.035 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET


met proto-oncogene


chr1_+_196621002 1.019 ENST00000367429.4
ENST00000439155.2
CFH

complement factor H

chr10_-_61900762 0.995 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_-_23825956 0.991 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr1_+_6845578 0.982 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1

chr2_+_181845843 0.974 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr15_+_43885252 0.950 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr1_+_6845497 0.946 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr2_+_196440692 0.928 ENST00000458054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr15_+_101402041 0.921 ENST00000558475.1
ENST00000558641.1
ENST00000559673.1
RP11-66B24.1


RP11-66B24.1


chr2_-_183387283 0.899 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr5_+_137514687 0.890 ENST00000394894.3
KIF20A
kinesin family member 20A
chrX_-_80457385 0.882 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5


high mobility group nucleosome binding domain 5


chr15_+_43985084 0.878 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr5_+_147258266 0.872 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr4_-_140477928 0.865 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_-_109935819 0.860 ENST00000538502.1
SORT1
sortilin 1
chr11_+_77184416 0.852 ENST00000598970.1
DKFZP434E1119
DKFZP434E1119
chr4_+_78078304 0.850 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2


cyclin G2


chr2_+_181845763 0.849 ENST00000602499.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr13_+_30002846 0.823 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr5_+_137514834 0.803 ENST00000508792.1
ENST00000504621.1
KIF20A

kinesin family member 20A

chr1_-_32801825 0.797 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr10_-_69597915 0.793 ENST00000225171.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr15_+_43985725 0.790 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr10_+_114710211 0.780 ENST00000349937.2
ENST00000369397.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr17_-_41738931 0.769 ENST00000329168.3
ENST00000549132.1
MEOX1

mesenchyme homeobox 1

chr14_+_54863682 0.760 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
CDKN3



cyclin-dependent kinase inhibitor 3



chr15_-_74495188 0.758 ENST00000563965.1
ENST00000395105.4
STRA6

stimulated by retinoic acid 6

chr14_+_54863667 0.753 ENST00000335183.6
CDKN3
cyclin-dependent kinase inhibitor 3
chr5_+_137514403 0.745 ENST00000513276.1
KIF20A
kinesin family member 20A
chr17_-_41739283 0.738 ENST00000393661.2
ENST00000318579.4
MEOX1

mesenchyme homeobox 1

chr10_+_54074033 0.731 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr5_+_172068232 0.724 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B


neuralized E3 ubiquitin protein ligase 1B


chr4_+_78079450 0.724 ENST00000395640.1
ENST00000512918.1
CCNG2

cyclin G2

chr10_-_69597828 0.719 ENST00000339758.7
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr1_+_36348790 0.719 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr6_+_37137939 0.718 ENST00000373509.5
PIM1
pim-1 oncogene
chr10_-_69597810 0.702 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr2_-_86564740 0.688 ENST00000540790.1
ENST00000428491.1
REEP1

receptor accessory protein 1

chr2_-_1748214 0.679 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
PXDN


peroxidasin homolog (Drosophila)


chr4_+_78079570 0.665 ENST00000509972.1
CCNG2
cyclin G2
chr1_+_196621156 0.657 ENST00000359637.2
CFH
complement factor H
chr10_+_123970670 0.646 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_78383813 0.641 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr14_+_54863739 0.622 ENST00000541304.1
CDKN3
cyclin-dependent kinase inhibitor 3
chr2_-_166060552 0.619 ENST00000283254.7
ENST00000453007.1
SCN3A

sodium channel, voltage-gated, type III, alpha subunit

chr13_+_30002741 0.612 ENST00000380808.2
MTUS2
microtubule associated tumor suppressor candidate 2
chr3_-_149375783 0.612 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1


WW domain containing transcription regulator 1


chr10_+_114710425 0.601 ENST00000352065.5
ENST00000369395.1
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr18_+_32073253 0.599 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA


dystrobrevin, alpha


chr1_+_100111479 0.597 ENST00000263174.4
PALMD
palmdelphin
chr4_-_140477910 0.594 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chrX_+_135229600 0.584 ENST00000370690.3
FHL1
four and a half LIM domains 1
chr11_+_130184888 0.582 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1


RP11-121M22.1


chr1_+_100111580 0.578 ENST00000605497.1
PALMD
palmdelphin
chr11_-_111794446 0.568 ENST00000527950.1
CRYAB
crystallin, alpha B
chr12_+_70760056 0.567 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr4_-_111119804 0.564 ENST00000394607.3
ENST00000302274.3
ELOVL6

ELOVL fatty acid elongase 6

chr3_-_141747459 0.563 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chr6_+_64282447 0.560 ENST00000370650.2
ENST00000578299.1
PTP4A1

protein tyrosine phosphatase type IVA, member 1

chrX_+_135229559 0.560 ENST00000394155.2
FHL1
four and a half LIM domains 1
chr1_-_12677714 0.557 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_-_134639235 0.555 ENST00000533224.1
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_114178512 0.547 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr4_-_23891693 0.537 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_-_140477353 0.532 ENST00000406354.1
ENST00000506866.2
SETD7

SET domain containing (lysine methyltransferase) 7

chr5_-_58571935 0.530 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_52043722 0.519 ENST00000454181.2
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr22_-_31688431 0.502 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1



phosphoinositide-3-kinase interacting protein 1



chr7_+_30185406 0.497 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr1_+_23037323 0.496 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
EPHB2



EPH receptor B2



chr10_+_114709999 0.490 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2






transcription factor 7-like 2 (T-cell specific, HMG-box)






chr14_-_35182994 0.485 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr6_+_27925019 0.483 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr10_-_32345305 0.480 ENST00000302418.4
KIF5B
kinesin family member 5B
chr3_+_20081515 0.476 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr12_-_31477072 0.474 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr6_+_13925318 0.472 ENST00000423553.2
ENST00000537388.1
RNF182

ring finger protein 182

chrX_-_138724677 0.468 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2


MCF.2 cell line derived transforming sequence


chr15_+_67358163 0.468 ENST00000327367.4
SMAD3
SMAD family member 3
chr9_+_124088860 0.463 ENST00000373806.1
GSN
gelsolin
chr4_-_111120132 0.457 ENST00000506625.1
ELOVL6
ELOVL fatty acid elongase 6
chr3_-_148804275 0.456 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF



helicase-like transcription factor



chr19_-_3029011 0.454 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
TLE2



transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)



chr1_-_115292591 0.454 ENST00000438362.2
CSDE1
cold shock domain containing E1, RNA-binding
chr5_+_95066823 0.453 ENST00000506817.1
ENST00000379982.3
RHOBTB3

Rho-related BTB domain containing 3

chr9_+_71819927 0.452 ENST00000535702.1
TJP2
tight junction protein 2
chr1_+_6845384 0.452 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr2_-_211341411 0.452 ENST00000233714.4
ENST00000443314.1
ENST00000441020.3
ENST00000450366.2
ENST00000431941.2
LANCL1




LanC lantibiotic synthetase component C-like 1 (bacterial)




chr11_-_76155700 0.452 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr16_+_57673430 0.439 ENST00000540164.2
ENST00000568531.1
GPR56

G protein-coupled receptor 56

chr12_-_118498958 0.432 ENST00000315436.3
WSB2
WD repeat and SOCS box containing 2
chr9_+_133971909 0.430 ENST00000247291.3
ENST00000372302.1
ENST00000372300.1
ENST00000372298.1
AIF1L



allograft inflammatory factor 1-like



chr3_-_141747439 0.429 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_-_141747950 0.429 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_16793160 0.427 ENST00000262067.4
TSPAN13
tetraspanin 13
chrX_-_109683446 0.426 ENST00000372057.1
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr7_-_102985035 0.423 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr2_-_166060382 0.421 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr7_+_151791074 0.416 ENST00000447796.1
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr11_-_76155618 0.415 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr7_-_137028534 0.415 ENST00000348225.2
PTN
pleiotrophin
chr17_-_26697304 0.413 ENST00000536498.1
VTN
vitronectin
chr5_-_137674000 0.410 ENST00000510119.1
ENST00000513970.1
CDC25C

cell division cycle 25C

chr5_-_68665084 0.410 ENST00000509462.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr4_-_111120334 0.403 ENST00000503885.1
ELOVL6
ELOVL fatty acid elongase 6
chr15_-_41120896 0.403 ENST00000299174.5
ENST00000427255.2
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr7_+_151791037 0.401 ENST00000419245.1
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr11_+_126081662 0.398 ENST00000528985.1
ENST00000529731.1
ENST00000360194.4
ENST00000530043.1
FAM118B



family with sequence similarity 118, member B



chr17_+_26369865 0.397 ENST00000582037.1
NLK
nemo-like kinase
chr8_+_39770803 0.395 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr2_-_67442409 0.392 ENST00000414404.1
ENST00000433133.1
AC078941.1

AC078941.1

chr9_+_133971863 0.388 ENST00000372309.3
AIF1L
allograft inflammatory factor 1-like
chr6_+_135502501 0.387 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB






v-myb avian myeloblastosis viral oncogene homolog






chr4_-_170192185 0.386 ENST00000284637.9
SH3RF1
SH3 domain containing ring finger 1
chr5_-_146435501 0.385 ENST00000336640.6
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_-_104359475 0.385 ENST00000553183.1
C12orf73
chromosome 12 open reading frame 73
chr7_-_137028498 0.384 ENST00000393083.2
PTN
pleiotrophin
chr8_-_17104356 0.383 ENST00000361272.4
ENST00000523917.1
CNOT7

CCR4-NOT transcription complex, subunit 7

chr11_-_94965667 0.382 ENST00000542176.1
ENST00000278499.2
SESN3

sestrin 3

chr1_-_153522562 0.382 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr3_-_171528227 0.379 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
PLD1



phospholipase D1, phosphatidylcholine-specific



chr7_-_27224842 0.378 ENST00000517402.1
HOXA11
homeobox A11
chr12_-_118498911 0.377 ENST00000544233.1
WSB2
WD repeat and SOCS box containing 2
chr12_+_7167980 0.375 ENST00000360817.5
ENST00000402681.3
C1S

complement component 1, s subcomponent

chrX_-_131623982 0.373 ENST00000370844.1
MBNL3
muscleblind-like splicing regulator 3
chr2_+_172864490 0.373 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr14_-_35099315 0.373 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
SNX6



sorting nexin 6



chr5_+_65018017 0.369 ENST00000380985.5
ENST00000502464.1
NLN

neurolysin (metallopeptidase M3 family)

chrX_-_131623874 0.369 ENST00000436215.1
MBNL3
muscleblind-like splicing regulator 3
chr5_-_146435572 0.368 ENST00000394414.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_+_104359576 0.366 ENST00000392872.3
ENST00000436021.2
TDG

thymine-DNA glycosylase

chr7_-_27224795 0.366 ENST00000006015.3
HOXA11
homeobox A11
chr15_+_43885799 0.365 ENST00000449946.1
ENST00000417289.1
CKMT1B

creatine kinase, mitochondrial 1B

chr10_+_18948311 0.362 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chr7_+_114055052 0.362 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2







forkhead box P2







chr16_+_57673348 0.362 ENST00000567915.1
ENST00000564103.1
ENST00000562467.1
GPR56


G protein-coupled receptor 56


chr8_-_17579726 0.362 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr2_-_166060571 0.362 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr16_+_57673207 0.361 ENST00000564783.1
ENST00000564729.1
ENST00000565976.1
ENST00000566508.1
ENST00000544297.1
GPR56




G protein-coupled receptor 56




chr1_-_205419053 0.361 ENST00000367154.1
LEMD1
LEM domain containing 1
chr5_-_146435694 0.358 ENST00000356826.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr1_+_53793885 0.358 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr3_-_167813672 0.356 ENST00000470487.1
GOLIM4
golgi integral membrane protein 4
chr17_-_37382105 0.354 ENST00000333461.5
STAC2
SH3 and cysteine rich domain 2
chr15_-_43877062 0.351 ENST00000381885.1
ENST00000396923.3
PPIP5K1

diphosphoinositol pentakisphosphate kinase 1

chr9_+_101705893 0.347 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr5_+_93954039 0.342 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr15_-_52944231 0.342 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr4_+_170581213 0.341 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr1_-_156051789 0.339 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr16_-_22385901 0.337 ENST00000268383.2
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr9_+_128510454 0.337 ENST00000491787.3
ENST00000447726.2
PBX3

pre-B-cell leukemia homeobox 3

chr8_+_42873548 0.336 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr14_-_67981870 0.336 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr2_-_2334888 0.331 ENST00000428368.2
ENST00000399161.2
MYT1L

myelin transcription factor 1-like

chr6_+_32146131 0.327 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr9_+_71820057 0.326 ENST00000539225.1
TJP2
tight junction protein 2
chr3_-_167813132 0.326 ENST00000309027.4
GOLIM4
golgi integral membrane protein 4
chr17_+_38337491 0.325 ENST00000538981.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr6_+_135502408 0.324 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB


v-myb avian myeloblastosis viral oncogene homolog


chrX_+_12993202 0.322 ENST00000451311.2
ENST00000380636.1
TMSB4X

thymosin beta 4, X-linked

chr5_+_173930676 0.321 ENST00000504512.1
RP11-267A15.1
RP11-267A15.1
chr21_+_18811205 0.321 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr1_+_164528866 0.319 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr2_-_178129853 0.315 ENST00000397062.3
NFE2L2
nuclear factor, erythroid 2-like 2
chr12_+_104359614 0.314 ENST00000266775.9
ENST00000544861.1
TDG

thymine-DNA glycosylase

chr8_-_17104099 0.313 ENST00000524358.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr2_-_37501692 0.308 ENST00000443977.1
PRKD3
protein kinase D3
chr6_+_64281906 0.308 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_+_186501979 0.308 ENST00000498746.1
EIF4A2
eukaryotic translation initiation factor 4A2
chr1_-_219615984 0.307 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr16_-_4987065 0.305 ENST00000590782.2
ENST00000345988.2
PPL

periplakin

chr10_-_24911746 0.302 ENST00000320481.6
ARHGAP21
Rho GTPase activating protein 21
chr7_+_30185496 0.300 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr5_-_179047881 0.300 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr14_+_64971438 0.299 ENST00000555321.1
ZBTB1
zinc finger and BTB domain containing 1
chr19_-_3028354 0.296 ENST00000586422.1
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr5_-_175964366 0.296 ENST00000274811.4
RNF44
ring finger protein 44
chr5_-_137514288 0.295 ENST00000454473.1
ENST00000418329.1
ENST00000455658.2
ENST00000230901.5
ENST00000402931.1
BRD8




bromodomain containing 8




chr5_-_65018834 0.293 ENST00000506816.1
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr16_+_2820912 0.293 ENST00000570539.1
SRRM2
serine/arginine repetitive matrix 2
chr14_-_31676674 0.291 ENST00000399332.1
ENST00000556224.1
HECTD1

HECT domain containing E3 ubiquitin protein ligase 1

chr14_-_67981916 0.291 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr2_-_37551846 0.290 ENST00000443187.1
PRKD3
protein kinase D3
chr14_-_35099377 0.286 ENST00000362031.4
SNX6
sorting nexin 6
chr12_+_6309963 0.286 ENST00000382515.2
CD9
CD9 molecule
chr3_+_38495333 0.283 ENST00000352511.4
ACVR2B
activin A receptor, type IIB
chr15_-_43876702 0.283 ENST00000348806.6
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr7_+_151791095 0.283 ENST00000422997.2
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.6 2.3 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.3 1.5 GO:0061056 sclerotome development(GO:0061056)
0.3 0.8 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 0.8 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.3 2.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 0.7 GO:0100012 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.2 1.0 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.2 0.7 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.2 0.9 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.2 3.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.0 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.5 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.1 1.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 0.9 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 2.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.9 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.4 GO:0036269 swimming behavior(GO:0036269)
0.1 1.4 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.1 0.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.5 GO:0035948 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.1 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.1 0.3 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 0.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.7 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 1.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.5 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.5 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 0.3 GO:1903450 regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452)
0.1 1.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 2.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 2.1 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.7 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.1 0.3 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.1 0.3 GO:0044691 tooth eruption(GO:0044691)
0.1 0.4 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.8 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.5 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.1 0.5 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.7 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 0.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.3 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.2 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.5 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.1 0.3 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.7 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 0.2 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1 0.2 GO:1902823 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.1 0.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.7 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.6 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.9 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.9 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 2.3 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.5 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0061075 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 1.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.2 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.2 GO:0016246 RNA interference(GO:0016246)
0.0 0.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:1901297 regulation of Wnt signaling pathway involved in heart development(GO:0003307) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.3 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 1.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:1990697 protein depalmitoleylation(GO:1990697)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.0 0.2 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0090269 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 1.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.3 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0 0.4 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 1.2 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.8 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.1 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 0.3 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.1 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.0 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0060346 bone trabecula formation(GO:0060346)
0.0 0.6 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.0 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.4 GO:0006111 regulation of gluconeogenesis(GO:0006111)
0.0 0.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.0 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907)
0.2 0.7 GO:0075341 host cell PML body(GO:0075341)
0.1 0.5 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.9 GO:0000125 PCAF complex(GO:0000125)
0.1 0.3 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.7 GO:0097422 tubular endosome(GO:0097422)
0.1 0.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.2 GO:0008623 CHRAC(GO:0008623)
0.1 0.2 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1 2.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.6 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0044753 amphisome(GO:0044753)
0.0 0.8 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.9 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.2 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 0.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.0 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 2.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.5 3.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 2.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 1.0 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.2 0.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.2 0.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.9 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.2 1.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 1.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.5 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.4 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.6 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.2 GO:0030350 iron-responsive element binding(GO:0030350)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.7 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.2 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.2 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 1.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.8 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.9 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.5 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:1990175 EH domain binding(GO:1990175)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 2.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.4 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0019871 potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871)
0.0 0.0 GO:0031896 vasopressin receptor binding(GO:0031893) V2 vasopressin receptor binding(GO:0031896)
0.0 0.1 GO:0001225 RNA polymerase II transcription cofactor binding(GO:0001224) RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.1 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 2.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 2.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.0 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.6 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway