Motif ID: KLF7

Z-value: 0.669


Transcription factors associated with KLF7:

Gene SymbolEntrez IDGene Name
KLF7 ENSG00000118263.10 KLF7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030647_208030689-0.932.6e-04Click!


Activity profile for motif KLF7.

activity profile for motif KLF7


Sorted Z-values histogram for motif KLF7

Sorted Z-values for motif KLF7



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_92929192 1.706 ENST00000332647.4
 FAM133A
family with sequence similarity 133, member A
chr16_+_81772633 0.873 ENST00000565054.1
ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
 PLCG2
RP11-960L18.1


phospholipase C, gamma 2 (phosphatidylinositol-specific)
RP11-960L18.1


chr3_+_105085734 0.660 ENST00000306107.5
 ALCAM
activated leukocyte cell adhesion molecule
chr16_-_65268795 0.582 ENST00000565901.1
ENST00000567058.1
 RP11-256I9.2

RP11-256I9.2

chr14_+_38660185 0.507 ENST00000555655.1
 CTD-2142D14.1
CTD-2142D14.1
chr17_+_19282064 0.407 ENST00000603493.1
 MAPK7
mitogen-activated protein kinase 7
chr17_+_19281787 0.358 ENST00000482850.1
 MAPK7
mitogen-activated protein kinase 7
chr19_-_7694417 0.323 ENST00000358368.4
ENST00000534844.1
 XAB2

XPA binding protein 2

chr1_-_157108266 0.307 ENST00000326786.4
 ETV3
ets variant 3
chr1_-_6453399 0.298 ENST00000608083.1
 ACOT7
acyl-CoA thioesterase 7
chr8_+_115294296 0.292 ENST00000521523.1
ENST00000523682.1
ENST00000507929.2
ENST00000520543.1
ENST00000519248.1
 RP11-267L5.1




RP11-267L5.1




chr1_-_6453426 0.283 ENST00000545482.1
 ACOT7
acyl-CoA thioesterase 7
chr17_+_38375528 0.273 ENST00000583268.1
 WIPF2
WAS/WASL interacting protein family, member 2
chr18_+_72166564 0.242 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
 CNDP2


CNDP dipeptidase 2 (metallopeptidase M20 family)


chr12_-_49581152 0.212 ENST00000550811.1
 TUBA1A
tubulin, alpha 1a
chr12_+_1099675 0.192 ENST00000545318.2
 ERC1
ELKS/RAB6-interacting/CAST family member 1
chr19_-_40931891 0.187 ENST00000357949.4
 SERTAD1
SERTA domain containing 1
chr3_+_178865887 0.185 ENST00000477735.1
 PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr17_+_41476327 0.184 ENST00000320033.4
 ARL4D
ADP-ribosylation factor-like 4D
chr9_+_130565487 0.178 ENST00000373225.3
ENST00000431857.1
 FPGS

folylpolyglutamate synthase

chr17_+_18218587 0.170 ENST00000406438.3
 SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr3_+_183817967 0.169 ENST00000335304.2
ENST00000431041.1
ENST00000436361.2
ENST00000440596.2
 HTR3E



5-hydroxytryptamine (serotonin) receptor 3E, ionotropic



chr9_+_130565147 0.158 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
 FPGS



folylpolyglutamate synthase



chr6_-_30585009 0.154 ENST00000376511.2
 PPP1R10
protein phosphatase 1, regulatory subunit 10
chr8_+_17104401 0.146 ENST00000324815.3
ENST00000518038.1
 VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr12_-_49582837 0.137 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
 TUBA1A


tubulin, alpha 1a


chr15_+_96873921 0.136 ENST00000394166.3
 NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_+_38375574 0.130 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
 WIPF2



WAS/WASL interacting protein family, member 2



chr19_+_39390320 0.120 ENST00000576510.1
 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_-_161102367 0.119 ENST00000464113.1
 DEDD
death effector domain containing
chr17_-_18218237 0.119 ENST00000542570.1
 TOP3A
topoisomerase (DNA) III alpha
chr2_-_61765732 0.119 ENST00000443240.1
ENST00000436018.1
 XPO1

exportin 1 (CRM1 homolog, yeast)

chr12_-_49582593 0.113 ENST00000295766.5
 TUBA1A
tubulin, alpha 1a
chr22_-_30987849 0.109 ENST00000402284.3
ENST00000354694.7
 PES1

pescadillo ribosomal biogenesis factor 1

chr19_-_14629224 0.109 ENST00000254322.2
 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr3_-_105588231 0.104 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr2_-_74710078 0.103 ENST00000290418.4
 CCDC142
coiled-coil domain containing 142
chr22_-_30987837 0.089 ENST00000335214.6
 PES1
pescadillo ribosomal biogenesis factor 1
chr9_+_130565568 0.087 ENST00000423577.1
 FPGS
folylpolyglutamate synthase
chr6_+_43603552 0.085 ENST00000372171.4
 MAD2L1BP
MAD2L1 binding protein
chr1_-_19229014 0.084 ENST00000538839.1
ENST00000290597.5
 ALDH4A1

aldehyde dehydrogenase 4 family, member A1

chr17_-_18218270 0.081 ENST00000321105.5
 TOP3A
topoisomerase (DNA) III alpha
chr1_-_19229248 0.071 ENST00000375341.3
 ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr3_-_105587879 0.067 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr20_+_2821366 0.066 ENST00000453689.1
ENST00000417508.1
 VPS16

vacuolar protein sorting 16 homolog (S. cerevisiae)

chr1_-_19229218 0.063 ENST00000432718.1
 ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr17_+_73008755 0.061 ENST00000584208.1
ENST00000301585.5
 ICT1

immature colon carcinoma transcript 1

chr1_-_161102421 0.047 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
 DEDD



death effector domain containing



chr20_-_2821271 0.039 ENST00000448755.1
ENST00000360652.2
 PCED1A

PC-esterase domain containing 1A

chr17_-_46894576 0.030 ENST00000393382.3
 TTLL6
tubulin tyrosine ligase-like family, member 6
chr13_-_108867101 0.026 ENST00000356922.4
 LIG4
ligase IV, DNA, ATP-dependent
chr8_+_17104539 0.025 ENST00000521829.1
ENST00000521005.1
 VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr20_-_2821756 0.020 ENST00000356872.3
ENST00000439542.1
 PCED1A

PC-esterase domain containing 1A

chr16_+_20499024 0.012 ENST00000593357.1
 AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr20_+_2821340 0.012 ENST00000380445.3
ENST00000380469.3
 VPS16

vacuolar protein sorting 16 homolog (S. cerevisiae)

chr19_+_39390587 0.012 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
 NFKBIB



nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta



chr19_-_39390350 0.011 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
 SIRT2


sirtuin 2


chr19_-_39390212 0.011 ENST00000437828.1
 SIRT2
sirtuin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.2 0.9 GO:0002316 follicular B cell differentiation(GO:0002316)
0.1 0.6 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.4 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.3 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.3 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.7 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008841 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.1 0.2 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.8 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.2 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway