Motif ID: KLF13
Z-value: 0.684
Transcription factors associated with KLF13:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| KLF13 | ENSG00000169926.5 | KLF13 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF13 | hg19_v2_chr15_+_31619013_31619095 | 0.63 | 7.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.4 | 1.2 | GO:0043095 | regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105) |
| 0.3 | 1.1 | GO:0061289 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.2 | 0.7 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 2.1 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.1 | 0.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.1 | 1.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.5 | GO:0071284 | cellular response to lead ion(GO:0071284) |
| 0.1 | 0.5 | GO:0046203 | spermidine catabolic process(GO:0046203) |
| 0.1 | 0.3 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
| 0.1 | 0.3 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.1 | 0.2 | GO:0015729 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.1 | 1.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.1 | 0.3 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.0 | 0.1 | GO:1904784 | NLRP1 inflammasome complex assembly(GO:1904784) |
| 0.0 | 0.3 | GO:0002155 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.0 | 0.3 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.0 | 0.6 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 0.3 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 0.0 | 0.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 1.5 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.2 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.0 | 0.1 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.0 | 0.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 0.1 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.0 | 0.1 | GO:0098502 | DNA dephosphorylation(GO:0098502) |
| 0.0 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.7 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.1 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.0 | 0.4 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.0 | 0.1 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.0 | 0.1 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.0 | 0.1 | GO:0034146 | toll-like receptor 5 signaling pathway(GO:0034146) |
| 0.0 | 0.0 | GO:0033488 | cholesterol biosynthetic process via 24,25-dihydrolanosterol(GO:0033488) |
| 0.0 | 0.6 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.0 | 0.1 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 0.2 | GO:0032310 | prostaglandin secretion(GO:0032310) |
| 0.0 | 0.1 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.0 | 0.1 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.3 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.3 | GO:0070977 | bone maturation(GO:0070977) |
| 0.0 | 0.2 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.0 | 0.3 | GO:1900120 | regulation of receptor binding(GO:1900120) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 1.8 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 1.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 0.8 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.2 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.3 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 0.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 0.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.0 | 0.1 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) |
| 0.0 | 0.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 2.2 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 0.2 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 0.2 | GO:0071014 | post-mRNA release spliceosomal complex(GO:0071014) |
| 0.0 | 0.5 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.1 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.1 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 0.1 | GO:0033165 | interphotoreceptor matrix(GO:0033165) |
| 0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0044549 | GTP cyclohydrolase binding(GO:0044549) |
| 0.2 | 0.6 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.2 | 1.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.2 | 0.5 | GO:0034038 | deoxyhypusine synthase activity(GO:0034038) |
| 0.2 | 0.5 | GO:1904854 | proteasome core complex binding(GO:1904854) |
| 0.1 | 0.4 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.1 | 0.3 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.1 | 0.2 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 0.2 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.1 | 0.3 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 0.6 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 1.1 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.7 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 0.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.1 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.0 | 0.1 | GO:0035539 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539) |
| 0.0 | 0.3 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.0 | 0.0 | GO:0008398 | sterol 14-demethylase activity(GO:0008398) |
| 0.0 | 0.1 | GO:1902444 | riboflavin binding(GO:1902444) |
| 0.0 | 0.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.1 | GO:0032408 | MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408) |
| 0.0 | 0.1 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.0 | 0.1 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) |
| 0.0 | 0.1 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.1 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.1 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 1.3 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.7 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.3 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.3 | REACTOME_SIGNALING_BY_FGFR3_MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.3 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.4 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.3 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.5 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
