Motif ID: ISL2

Z-value: 0.280


Transcription factors associated with ISL2:

Gene SymbolEntrez IDGene Name
ISL2 ENSG00000159556.5 ISL2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_76629073-0.225.6e-01Click!


Activity profile for motif ISL2.

activity profile for motif ISL2


Sorted Z-values histogram for motif ISL2

Sorted Z-values for motif ISL2



Network of associatons between targets according to the STRING database.



First level regulatory network of ISL2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_131438496 0.317 ENST00000543826.1
 GPR133
G protein-coupled receptor 133
chr12_+_131438443 0.298 ENST00000261654.5
 GPR133
G protein-coupled receptor 133
chr7_-_16844611 0.198 ENST00000401412.1
ENST00000419304.2
 AGR2

anterior gradient 2

chr8_+_70404996 0.194 ENST00000402687.4
ENST00000419716.3
 SULF1

sulfatase 1

chr20_+_30102231 0.174 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
 HM13




histocompatibility (minor) 13




chr2_-_207078086 0.170 ENST00000442134.1
 GPR1
G protein-coupled receptor 1
chr1_+_149871171 0.159 ENST00000369150.1
 BOLA1
bolA family member 1
chr2_-_207078154 0.157 ENST00000447845.1
 GPR1
G protein-coupled receptor 1
chr12_+_104337515 0.156 ENST00000550595.1
 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr22_-_29107919 0.155 ENST00000434810.1
ENST00000456369.1
 CHEK2

checkpoint kinase 2

chr19_-_3557570 0.139 ENST00000355415.2
 MFSD12
major facilitator superfamily domain containing 12
chr11_-_327537 0.125 ENST00000602735.1
 IFITM3
interferon induced transmembrane protein 3
chr1_+_160370344 0.111 ENST00000368061.2
 VANGL2
VANGL planar cell polarity protein 2
chr13_+_49551020 0.110 ENST00000541916.1
 FNDC3A
fibronectin type III domain containing 3A
chr9_-_95298254 0.110 ENST00000444490.2
 ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr16_+_28565230 0.103 ENST00000317058.3
 CCDC101
coiled-coil domain containing 101
chr11_-_8892900 0.101 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
 ST5






suppression of tumorigenicity 5






chr1_+_151253991 0.101 ENST00000443959.1
 ZNF687
zinc finger protein 687
chr19_+_3185910 0.100 ENST00000588428.1
 NCLN
nicalin
chr14_+_61449076 0.095 ENST00000526105.1
 SLC38A6
solute carrier family 38, member 6
chr17_-_47786375 0.090 ENST00000511657.1
 SLC35B1
solute carrier family 35, member B1
chr1_+_149871135 0.087 ENST00000369152.5
 BOLA1
bolA family member 1
chr20_-_50722183 0.083 ENST00000371523.4
 ZFP64
ZFP64 zinc finger protein
chr14_+_61449197 0.080 ENST00000533744.2
 SLC38A6
solute carrier family 38, member 6
chr15_-_83378638 0.074 ENST00000261722.3
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr5_-_54988448 0.070 ENST00000503817.1
ENST00000512595.1
 SLC38A9

solute carrier family 38, member 9

chr11_-_63376013 0.060 ENST00000540943.1
 PLA2G16
phospholipase A2, group XVI
chr3_-_193096600 0.056 ENST00000446087.1
ENST00000342358.4
 ATP13A5

ATPase type 13A5

chr10_-_13350447 0.055 ENST00000429930.1
 AL138764.1
Uncharacterized protein
chr6_+_26440700 0.053 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3









butyrophilin, subfamily 3, member A3









chr20_-_33735070 0.053 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr2_-_85108363 0.052 ENST00000335459.5
 TRABD2A
TraB domain containing 2A
chr16_-_28937027 0.049 ENST00000358201.4
 RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr19_+_4402659 0.049 ENST00000301280.5
ENST00000585854.1
 CHAF1A

chromatin assembly factor 1, subunit A (p150)

chr4_-_120243545 0.049 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr1_-_178840157 0.048 ENST00000367629.1
ENST00000234816.2
 ANGPTL1

angiopoietin-like 1

chr10_-_29923893 0.045 ENST00000355867.4
 SVIL
supervillin
chr15_-_75748143 0.041 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
 SIN3A




SIN3 transcription regulator family member A




chr10_-_115904361 0.041 ENST00000428953.1
ENST00000543782.1
 C10orf118

chromosome 10 open reading frame 118

chr7_-_45151272 0.039 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
 TBRG4





transforming growth factor beta regulator 4





chr5_-_54988559 0.036 ENST00000502247.1
 SLC38A9
solute carrier family 38, member 9
chr6_+_31105426 0.035 ENST00000547221.1
 PSORS1C1
psoriasis susceptibility 1 candidate 1
chrX_-_48931648 0.035 ENST00000376386.3
ENST00000376390.4
 PRAF2

PRA1 domain family, member 2

chr10_+_35484793 0.034 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
 CREM




cAMP responsive element modulator




chr9_+_35042205 0.034 ENST00000312292.5
ENST00000378745.3
 C9orf131

chromosome 9 open reading frame 131

chr11_-_58378759 0.034 ENST00000601906.1
 AP001350.1
Uncharacterized protein
chr3_+_159943362 0.033 ENST00000326474.3
 C3orf80
chromosome 3 open reading frame 80
chr17_+_4710391 0.028 ENST00000263088.6
ENST00000572940.1
 PLD2

phospholipase D2

chr12_-_58212487 0.027 ENST00000549994.1
 AVIL
advillin
chr3_+_169629354 0.027 ENST00000428432.2
ENST00000335556.3
 SAMD7

sterile alpha motif domain containing 7

chr6_-_32095968 0.026 ENST00000375203.3
ENST00000375201.4
 ATF6B

activating transcription factor 6 beta

chr11_-_62521614 0.025 ENST00000527994.1
ENST00000394807.3
 ZBTB3

zinc finger and BTB domain containing 3

chr2_+_88047606 0.023 ENST00000359481.4
 PLGLB2
plasminogen-like B2
chr17_-_4710288 0.023 ENST00000571067.1
 RP11-81A22.5
RP11-81A22.5
chr5_+_102200948 0.021 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
 PAM


peptidylglycine alpha-amidating monooxygenase


chr1_+_15668240 0.021 ENST00000444385.1
 FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr5_-_130500922 0.020 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
 HINT1



histidine triad nucleotide binding protein 1



chr15_+_51669513 0.020 ENST00000558426.1
 GLDN
gliomedin
chr18_-_3845321 0.020 ENST00000539435.1
ENST00000400147.2
 DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr1_-_202897724 0.020 ENST00000435533.3
ENST00000367258.1
 KLHL12

kelch-like family member 12

chr17_-_64225508 0.020 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr18_-_3845293 0.019 ENST00000400145.2
 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr15_+_64680003 0.018 ENST00000261884.3
 TRIP4
thyroid hormone receptor interactor 4
chr10_-_74283694 0.018 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
 MICU1


mitochondrial calcium uptake 1


chr10_-_128359074 0.017 ENST00000544758.1
 C10orf90
chromosome 10 open reading frame 90
chr4_+_86525299 0.017 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr4_-_48116540 0.016 ENST00000506073.1
 TXK
TXK tyrosine kinase
chr2_-_209010874 0.016 ENST00000260988.4
 CRYGB
crystallin, gamma B
chrX_+_108779004 0.016 ENST00000218004.1
 NXT2
nuclear transport factor 2-like export factor 2
chrX_-_15332665 0.016 ENST00000537676.1
ENST00000344384.4
 ASB11

ankyrin repeat and SOCS box containing 11

chr4_+_95128748 0.016 ENST00000359052.4
 SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_191000172 0.015 ENST00000427544.2
 UTS2B
urotensin 2B
chr7_+_123241908 0.015 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
 ASB15


ankyrin repeat and SOCS box containing 15


chr17_+_7155819 0.015 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
 ELP5


elongator acetyltransferase complex subunit 5


chr15_-_42500351 0.015 ENST00000348544.4
ENST00000318006.5
 VPS39

vacuolar protein sorting 39 homolog (S. cerevisiae)

chr13_+_24144509 0.015 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr17_-_7307358 0.014 ENST00000535512.1
ENST00000576017.1
ENST00000302422.3
 TMEM256-PLSCR3
TMEM256

TMEM256-PLSCR3 readthrough (NMD candidate)
transmembrane protein 256

chr19_+_14693888 0.014 ENST00000547437.1
ENST00000397439.2
ENST00000417570.1
 CLEC17A


C-type lectin domain family 17, member A


chr3_-_157221380 0.014 ENST00000468233.1
 VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_53964336 0.014 ENST00000447836.2
ENST00000511678.1
 MLIP

muscular LMNA-interacting protein

chr12_+_122356488 0.014 ENST00000397454.2
 WDR66
WD repeat domain 66
chr12_-_12715266 0.014 ENST00000228862.2
 DUSP16
dual specificity phosphatase 16
chr7_+_13141010 0.014 ENST00000443947.1
 AC011288.2
AC011288.2
chr9_-_100854838 0.013 ENST00000538344.1
 TRIM14
tripartite motif containing 14
chr6_-_47445214 0.013 ENST00000604014.1
 RP11-385F7.1
RP11-385F7.1
chr2_-_87248975 0.013 ENST00000409310.2
ENST00000355705.3
 PLGLB1

plasminogen-like B1

chr8_-_116504448 0.013 ENST00000518018.1
 TRPS1
trichorhinophalangeal syndrome I
chr3_-_150421752 0.013 ENST00000498386.1
 FAM194A
family with sequence similarity 194, member A
chr12_-_49581152 0.013 ENST00000550811.1
 TUBA1A
tubulin, alpha 1a
chr11_+_73498898 0.012 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr15_+_48483736 0.012 ENST00000559641.1
ENST00000417307.2
 SLC12A1
CTXN2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
cortexin 2
chr2_-_136633940 0.012 ENST00000264156.2
 MCM6
minichromosome maintenance complex component 6
chr8_-_125577940 0.012 ENST00000519168.1
ENST00000395508.2
 MTSS1

metastasis suppressor 1

chr17_-_10372875 0.012 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chr1_-_95391315 0.011 ENST00000545882.1
ENST00000415017.1
 CNN3

calponin 3, acidic

chr3_+_136649311 0.011 ENST00000469404.1
ENST00000467911.1
 NCK1

NCK adaptor protein 1

chr4_+_88532028 0.011 ENST00000282478.7
 DSPP
dentin sialophosphoprotein
chr1_-_17766198 0.010 ENST00000375436.4
 RCC2
regulator of chromosome condensation 2
chr1_+_77333117 0.010 ENST00000477717.1
 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_-_62609281 0.010 ENST00000525239.1
ENST00000538098.2
 WDR74

WD repeat domain 74

chr7_-_115670792 0.009 ENST00000265440.7
ENST00000393485.1
 TFEC

transcription factor EC

chrX_+_65384182 0.009 ENST00000441993.2
ENST00000419594.1
 HEPH

hephaestin

chr14_-_23058063 0.009 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
 DAD1


defender against cell death 1


chrX_-_32173579 0.009 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD




dystrophin




chr7_-_115670804 0.009 ENST00000320239.7
 TFEC
transcription factor EC
chr12_+_4829507 0.009 ENST00000252318.2
 GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr5_+_140201183 0.009 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
 PCDHA5


protocadherin alpha 5


chr1_-_12946025 0.009 ENST00000235349.5
 PRAMEF4
PRAME family member 4
chr13_-_74993252 0.008 ENST00000325811.1
 AL355390.1
Uncharacterized protein
chr6_+_64345698 0.008 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
 PHF3




PHD finger protein 3




chr12_-_54689532 0.008 ENST00000540264.2
ENST00000312156.4
 NFE2

nuclear factor, erythroid 2

chr19_-_46234119 0.008 ENST00000317683.3
 FBXO46
F-box protein 46
chr6_+_42989344 0.007 ENST00000244496.5
 RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr1_-_232651312 0.007 ENST00000262861.4
 SIPA1L2
signal-induced proliferation-associated 1 like 2
chr16_-_3350614 0.007 ENST00000268674.2
 TIGD7
tigger transposable element derived 7
chr4_+_95128996 0.007 ENST00000457823.2
 SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr13_-_46716969 0.007 ENST00000435666.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_141811539 0.006 ENST00000550469.2
ENST00000477922.3
 RP11-1220K2.2

Putative inactive maltase-glucoamylase-like protein LOC93432

chr13_-_45768841 0.006 ENST00000379108.1
 KCTD4
potassium channel tetramerization domain containing 4
chr16_-_1538765 0.006 ENST00000447419.2
ENST00000440447.2
 PTX4

pentraxin 4, long

chr11_+_101983176 0.006 ENST00000524575.1
 YAP1
Yes-associated protein 1
chr17_-_10325261 0.006 ENST00000403437.2
 MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chrX_+_65382433 0.006 ENST00000374727.3
 HEPH
hephaestin
chr5_+_68860949 0.006 ENST00000507595.1
 GTF2H2C
general transcription factor IIH, polypeptide 2C
chr3_+_134514093 0.006 ENST00000398015.3
 EPHB1
EPH receptor B1
chr3_-_183145873 0.006 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
 MCF2L2


MCF.2 cell line derived transforming sequence-like 2


chr12_-_10282742 0.006 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chr8_+_38662960 0.005 ENST00000524193.1
 TACC1
transforming, acidic coiled-coil containing protein 1
chrM_+_9207 0.005 ENST00000362079.2
 MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr5_+_57787254 0.005 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
 GAPT


GRB2-binding adaptor protein, transmembrane


chr11_+_12132117 0.005 ENST00000256194.4
 MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr2_-_197675000 0.005 ENST00000342506.2
 C2orf66
chromosome 2 open reading frame 66
chr18_-_64271363 0.004 ENST00000262150.2
 CDH19
cadherin 19, type 2
chr8_-_124741451 0.004 ENST00000520519.1
 ANXA13
annexin A13
chr1_-_228613026 0.004 ENST00000366696.1
 HIST3H3
histone cluster 3, H3
chr8_+_92261516 0.004 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr2_-_169887827 0.004 ENST00000263817.6
 ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr10_-_5046042 0.003 ENST00000421196.3
ENST00000455190.1
 AKR1C2

aldo-keto reductase family 1, member C2

chr17_-_3496171 0.003 ENST00000399756.4
 TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr9_-_95166976 0.003 ENST00000447356.1
 OGN
osteoglycin
chr9_-_28670283 0.003 ENST00000379992.2
 LINGO2
leucine rich repeat and Ig domain containing 2
chr2_-_190446738 0.003 ENST00000427419.1
ENST00000455320.1
 SLC40A1

solute carrier family 40 (iron-regulated transporter), member 1

chrX_-_119077695 0.003 ENST00000371410.3
 NKAP
NFKB activating protein
chr2_-_159237472 0.003 ENST00000409187.1
 CCDC148
coiled-coil domain containing 148
chr3_-_164796269 0.002 ENST00000264382.3
 SI
sucrase-isomaltase (alpha-glucosidase)
chr15_-_72563585 0.002 ENST00000287196.9
ENST00000260376.7
 PARP6

poly (ADP-ribose) polymerase family, member 6

chr5_+_110427983 0.002 ENST00000513710.2
ENST00000505303.1
 WDR36

WD repeat domain 36

chr8_-_133772870 0.002 ENST00000522334.1
ENST00000519016.1
 TMEM71

transmembrane protein 71

chr18_-_64271316 0.002 ENST00000540086.1
ENST00000580157.1
 CDH19

cadherin 19, type 2

chr21_+_39644305 0.001 ENST00000398930.1
 KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr15_-_75748115 0.001 ENST00000360439.4
 SIN3A
SIN3 transcription regulator family member A
chr15_+_78370140 0.001 ENST00000409568.2
 SH2D7
SH2 domain containing 7
chrX_-_84634737 0.001 ENST00000262753.4
 POF1B
premature ovarian failure, 1B
chrX_-_77225135 0.001 ENST00000458128.1
 PGAM4
phosphoglycerate mutase family member 4
chr6_+_151561085 0.001 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_118628315 0.001 ENST00000540561.1
 TAOK3
TAO kinase 3
chr4_+_25162253 0.000 ENST00000512921.1
 PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chrX_-_84634708 0.000 ENST00000373145.3
 POF1B
premature ovarian failure, 1B
chrX_+_65382381 0.000 ENST00000519389.1
 HEPH
hephaestin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.2 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.1 GO:1904808 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.0 GO:0033186 CAF-1 complex(GO:0033186)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR