Motif ID: IRX6_IRX4

Z-value: 0.157

Transcription factors associated with IRX6_IRX4:

Gene SymbolEntrez IDGene Name
IRX4 ENSG00000113430.5 IRX4
IRX6 ENSG00000159387.7 IRX6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.646.3e-02Click!
IRX6hg19_v2_chr16_+_55357672_553576720.571.1e-01Click!


Activity profile for motif IRX6_IRX4.

activity profile for motif IRX6_IRX4


Sorted Z-values histogram for motif IRX6_IRX4

Sorted Z-values for motif IRX6_IRX4



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_38673270 0.193 ENST00000578280.1
 RP5-1028K7.2
RP5-1028K7.2
chr1_-_201438282 0.180 ENST00000367311.3
ENST00000367309.1
 PHLDA3

pleckstrin homology-like domain, family A, member 3

chr14_-_23623577 0.139 ENST00000422941.2
ENST00000453702.1
 SLC7A8

solute carrier family 7 (amino acid transporter light chain, L system), member 8

chr19_-_54974894 0.096 ENST00000333834.4
 LENG9
leukocyte receptor cluster (LRC) member 9
chr7_-_16844611 0.091 ENST00000401412.1
ENST00000419304.2
 AGR2

anterior gradient 2

chrX_-_135962923 0.090 ENST00000565438.1
 RBMX
RNA binding motif protein, X-linked
chr14_-_23624511 0.088 ENST00000529705.2
 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr5_+_36608280 0.072 ENST00000513646.1
 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_3566627 0.069 ENST00000419924.2
ENST00000270708.7
 WRAP73

WD repeat containing, antisense to TP73

chr6_+_149887377 0.058 ENST00000367419.5
 GINM1
glycoprotein integral membrane 1
chr1_-_3566590 0.047 ENST00000424367.1
ENST00000378322.3
 WRAP73

WD repeat containing, antisense to TP73

chr4_+_123653882 0.043 ENST00000433287.1
 BBS12
Bardet-Biedl syndrome 12
chr10_+_90660832 0.040 ENST00000371924.1
 STAMBPL1
STAM binding protein-like 1
chr17_-_29641104 0.036 ENST00000577894.1
ENST00000330927.4
 EVI2B

ecotropic viral integration site 2B

chr7_+_871559 0.035 ENST00000421580.1
 SUN1
Sad1 and UNC84 domain containing 1
chr7_-_55583740 0.034 ENST00000453256.1
 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chrX_-_19988382 0.033 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
 CXorf23


chromosome X open reading frame 23


chr11_+_61891445 0.032 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
 INCENP


inner centromere protein antigens 135/155kDa


chrX_+_15767971 0.030 ENST00000479740.1
ENST00000454127.2
 CA5B

carbonic anhydrase VB, mitochondrial

chr18_-_47376197 0.029 ENST00000592688.1
 MYO5B
myosin VB
chr19_-_22379753 0.028 ENST00000397121.2
 ZNF676
zinc finger protein 676
chr2_+_58655461 0.027 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
 AC007092.1


long intergenic non-protein coding RNA 1122


chr3_+_111630451 0.026 ENST00000495180.1
 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr10_-_115904361 0.024 ENST00000428953.1
ENST00000543782.1
 C10orf118

chromosome 10 open reading frame 118

chr20_+_43990576 0.023 ENST00000372727.1
ENST00000414310.1
 SYS1

SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr2_+_58655520 0.023 ENST00000455219.3
ENST00000449448.2
 AC007092.1

long intergenic non-protein coding RNA 1122

chr8_+_27631903 0.020 ENST00000305188.8
 ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr13_-_46716969 0.018 ENST00000435666.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_86184676 0.017 ENST00000543283.1
 CCSER2
coiled-coil serine-rich protein 2
chr18_-_46784778 0.017 ENST00000582399.1
 DYM
dymeclin
chr3_-_168865522 0.016 ENST00000464456.1
 MECOM
MDS1 and EVI1 complex locus
chr20_+_10199566 0.014 ENST00000430336.1
 SNAP25
synaptosomal-associated protein, 25kDa
chr17_-_29641084 0.013 ENST00000544462.1
 EVI2B
ecotropic viral integration site 2B
chr7_-_92855762 0.012 ENST00000453812.2
ENST00000394468.2
 HEPACAM2

HEPACAM family member 2

chr3_+_171561127 0.011 ENST00000334567.5
ENST00000450693.1
 TMEM212

transmembrane protein 212

chr21_-_48024986 0.011 ENST00000291700.4
ENST00000367071.4
 S100B

S100 calcium binding protein B

chr4_+_40194609 0.010 ENST00000508513.1
 RHOH
ras homolog family member H
chr17_-_47723943 0.009 ENST00000510476.1
ENST00000503676.1
 SPOP

speckle-type POZ protein

chr2_+_133874577 0.009 ENST00000596384.1
 AC011755.1
HCG2006742; Protein LOC100996685
chrX_-_15333736 0.009 ENST00000380470.3
 ASB11
ankyrin repeat and SOCS box containing 11
chr12_-_123728548 0.009 ENST00000545406.1
 MPHOSPH9
M-phase phosphoprotein 9
chr2_+_113670548 0.008 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
 IL37



interleukin 37



chr16_+_777739 0.007 ENST00000563792.1
 HAGHL
hydroxyacylglutathione hydrolase-like
chr17_-_3301704 0.006 ENST00000322608.2
 OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr4_-_153303658 0.006 ENST00000296555.5
 FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr2_+_160590469 0.005 ENST00000409591.1
 MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr6_-_117747015 0.005 ENST00000368508.3
ENST00000368507.3
 ROS1

c-ros oncogene 1 , receptor tyrosine kinase

chr6_+_140175987 0.005 ENST00000414038.1
ENST00000431609.1
 RP5-899B16.1

RP5-899B16.1

chr5_+_175490540 0.005 ENST00000515817.1
 FAM153B
family with sequence similarity 153, member B
chr1_+_26644441 0.005 ENST00000374213.2
 CD52
CD52 molecule
chr16_+_21689835 0.005 ENST00000286149.4
ENST00000388958.3
 OTOA

otoancorin

chr17_-_6524159 0.005 ENST00000589033.1
 KIAA0753
KIAA0753
chr4_+_40194570 0.004 ENST00000507851.1
 RHOH
ras homolog family member H
chr5_-_177207634 0.003 ENST00000513554.1
ENST00000440605.3
 FAM153A

family with sequence similarity 153, member A

chr4_+_113558612 0.003 ENST00000505034.1
ENST00000324052.6
 LARP7

La ribonucleoprotein domain family, member 7

chr12_+_32655110 0.003 ENST00000546442.1
ENST00000583694.1
 FGD4

FYVE, RhoGEF and PH domain containing 4

chr1_-_89641680 0.002 ENST00000294671.2
 GBP7
guanylate binding protein 7
chr3_+_68053359 0.002 ENST00000478136.1
 FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr14_-_106845789 0.002 ENST00000390617.2
 IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr3_-_9994021 0.002 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr7_-_80141328 0.001 ENST00000398291.3
 GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr4_+_144312659 0.001 ENST00000509992.1
 GAB1
GRB2-associated binding protein 1
chr14_-_104408032 0.001 ENST00000455348.2
 RD3L
retinal degeneration 3-like
chr21_-_34185944 0.001 ENST00000479548.1
 C21orf62
chromosome 21 open reading frame 62
chr4_-_177190364 0.001 ENST00000296525.3
 ASB5
ankyrin repeat and SOCS box containing 5
chr6_+_116691001 0.001 ENST00000537543.1
 DSE
dermatan sulfate epimerase
chr7_+_6121296 0.000 ENST00000428901.1
 AC004895.4
AC004895.4
chr21_-_34186006 0.000 ENST00000490358.1
 C21orf62
chromosome 21 open reading frame 62

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481) positive regulation of PERK-mediated unfolded protein response(GO:1903899)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)