Motif ID: IRF9
Z-value: 3.440
Transcription factors associated with IRF9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF9 | ENSG00000213928.4 | IRF9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.97 | 9.2e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.2 | 64.8 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 3.2 | 19.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 3.2 | 19.0 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 3.1 | 37.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.2 | 31.4 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.3 | 15.3 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 1.2 | 3.7 | GO:0050823 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.2 | 9.8 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.9 | 93.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.7 | 2.7 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.5 | 9.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.5 | 2.3 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
| 0.4 | 1.3 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) |
| 0.4 | 2.9 | GO:0030578 | PML body organization(GO:0030578) |
| 0.4 | 4.0 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.4 | 2.8 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.3 | 1.5 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.2 | 6.4 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 3.3 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 4.9 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 0.8 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.1 | 0.7 | GO:0051891 | negative regulation of transforming growth factor beta1 production(GO:0032911) negative regulation of transforming growth factor beta2 production(GO:0032912) positive regulation of cardioblast differentiation(GO:0051891) |
| 0.1 | 1.7 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 1.9 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.1 | 2.4 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.1 | 4.4 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.1 | 0.5 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.1 | 1.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.1 | 3.6 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.0 | 0.7 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.0 | 0.4 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.0 | 0.7 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.0 | 0.7 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 8.7 | GO:0009615 | response to virus(GO:0009615) |
| 0.0 | 0.6 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.3 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.7 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.7 | 5.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.7 | 2.8 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.4 | 2.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.3 | 58.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 19.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.7 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 0.5 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.1 | 1.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.6 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 1.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 75.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 9.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 1.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 13.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 3.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.7 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 2.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.7 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 2.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 86.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 3.8 | 15.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 2.3 | 30.2 | GO:0031386 | protein tag(GO:0031386) |
| 1.0 | 5.0 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.9 | 5.5 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.7 | 7.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.6 | 84.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.4 | 3.3 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.3 | 19.0 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.3 | 7.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.3 | 2.8 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 7.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.2 | 1.2 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 6.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 2.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.2 | 5.1 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.1 | 0.8 | GO:0004534 | G-quadruplex RNA binding(GO:0002151) 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 0.7 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 3.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 1.5 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 1.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 0.7 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 1.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.0 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 2.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 2.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 4.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 2.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.6 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 2.7 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 3.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.6 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.7 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 6.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.3 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.7 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 60.0 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 1.6 | 6.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.4 | 128.8 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 9.9 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
| 0.3 | 2.7 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.3 | 15.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 16.8 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 3.3 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 2.9 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.3 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.7 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.5 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 7.3 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.6 | REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |
| 0.0 | 1.2 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
