Motif ID: IRF3
Z-value: 6.652
Transcription factors associated with IRF3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF3 | ENSG00000126456.11 | IRF3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50168861_50168873 | 0.89 | 1.4e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.6 | 98.4 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 20.2 | 121.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 11.7 | 163.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 9.8 | 58.8 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 8.3 | 90.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 7.3 | 87.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 4.6 | 55.5 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 2.2 | 32.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 2.1 | 6.2 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 2.0 | 7.9 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 1.8 | 7.3 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 1.5 | 4.5 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 1.4 | 5.8 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.2 | 14.4 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.1 | 50.2 | GO:0019835 | cytolysis(GO:0019835) |
| 0.7 | 16.6 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.6 | 2.8 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.6 | 1.7 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.5 | 1.5 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.5 | 1.4 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.5 | 2.3 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 0.4 | 8.0 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.4 | 12.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.4 | 3.4 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.4 | 2.9 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.4 | 1.2 | GO:0032242 | regulation of nucleoside transport(GO:0032242) |
| 0.4 | 2.0 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.4 | 2.5 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.4 | 1.8 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.3 | 1.9 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.3 | 1.8 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.3 | 3.6 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.3 | 21.4 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.2 | 4.8 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.2 | 5.6 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.2 | 4.1 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.2 | 9.0 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.2 | 0.7 | GO:1902990 | DNA replication, removal of RNA primer(GO:0043137) mitochondrial DNA repair(GO:0043504) mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.2 | 18.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 2.3 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.1 | 2.0 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.1 | 32.9 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.1 | 0.7 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.1 | 1.3 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.1 | 0.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 2.3 | GO:0033151 | V(D)J recombination(GO:0033151) |
| 0.1 | 2.2 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.1 | 0.3 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 1.2 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.1 | 4.2 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 2.0 | GO:0019054 | modulation by virus of host process(GO:0019054) |
| 0.1 | 5.8 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.4 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.7 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 1.1 | GO:2000404 | regulation of T cell migration(GO:2000404) |
| 0.0 | 0.6 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.8 | GO:0048714 | positive regulation of oligodendrocyte differentiation(GO:0048714) |
| 0.0 | 0.9 | GO:0002456 | T cell mediated immunity(GO:0002456) |
| 0.0 | 2.0 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.0 | 0.5 | GO:0090129 | positive regulation of synaptic plasticity(GO:0031915) positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 5.8 | GO:0009615 | response to virus(GO:0009615) |
| 0.0 | 0.2 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 1.1 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 0.0 | GO:1900369 | regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 0.0 | 1.1 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 0.7 | GO:0006693 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.0 | 0.5 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.0 | 0.4 | GO:0015695 | organic cation transport(GO:0015695) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 50.2 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 1.3 | 11.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.1 | 10.2 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 1.1 | 6.8 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.9 | 3.6 | GO:0031213 | RSF complex(GO:0031213) |
| 0.6 | 1.7 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.4 | 2.3 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.4 | 2.9 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.3 | 2.0 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.3 | 1.8 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.3 | 63.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 5.8 | GO:0032059 | bleb(GO:0032059) |
| 0.3 | 2.5 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 4.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 40.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 2.3 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 8.0 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 1.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 2.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 7.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 91.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 29.7 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 5.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 0.7 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 102.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 1.2 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 11.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 40.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 26.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 134.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 3.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 113.9 | GO:0005737 | cytoplasm(GO:0005737) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 58.8 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 8.8 | 105.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 5.7 | 73.8 | GO:0031386 | protein tag(GO:0031386) |
| 2.1 | 12.5 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 1.8 | 55.5 | GO:0070403 | NAD+ binding(GO:0070403) |
| 1.6 | 17.8 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 1.6 | 211.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 1.3 | 13.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 1.0 | 4.1 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 1.0 | 5.8 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.9 | 21.4 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.9 | 7.9 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978) |
| 0.9 | 6.8 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.7 | 2.2 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.6 | 5.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.5 | 1.5 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.4 | 50.2 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.4 | 11.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 2.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 2.3 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.2 | 0.9 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.2 | 1.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 2.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.2 | 2.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.2 | 1.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.7 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.1 | 1.8 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.1 | 5.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.7 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.1 | 0.6 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.1 | 1.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 19.2 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.1 | 5.8 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 1.2 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 0.7 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 2.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 1.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 0.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 12.4 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 1.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 113.7 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.0 | 0.3 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.0 | 11.0 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 4.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 4.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.2 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.0 | 1.0 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 6.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 4.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 33.6 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 0.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.4 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 1.7 | GO:0046983 | protein dimerization activity(GO:0046983) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 18.6 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 4.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 2.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.0 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.2 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 99.6 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 3.3 | 317.6 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.4 | 58.5 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.0 | 94.0 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.4 | 13.6 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.4 | 5.8 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 18.1 | REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.2 | 2.9 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.2 | 2.5 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 2.3 | REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.1 | 3.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 2.9 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.6 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 2.0 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.7 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.5 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 2.2 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 3.0 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
