Motif ID: IRF2_STAT2_IRF8_IRF1
Z-value: 12.456
Transcription factors associated with IRF2_STAT2_IRF8_IRF1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF1 | ENSG00000125347.9 | IRF1 |
| IRF2 | ENSG00000168310.6 | IRF2 |
| IRF8 | ENSG00000140968.6 | IRF8 |
| STAT2 | ENSG00000170581.9 | STAT2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 1.00 | 7.5e-11 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.88 | 1.7e-03 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.34 | 3.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 81.0 | 324.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 47.8 | 286.9 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 30.1 | 180.6 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 26.9 | 376.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 24.9 | 273.6 | GO:0018377 | protein myristoylation(GO:0018377) |
| 24.4 | 146.3 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 23.7 | 94.7 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 21.2 | 106.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 20.8 | 249.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 10.0 | 30.0 | GO:0050823 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 7.4 | 89.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 5.9 | 88.5 | GO:0010819 | regulation of T cell chemotaxis(GO:0010819) |
| 5.4 | 27.1 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 5.3 | 21.4 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 5.0 | 20.1 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 4.5 | 18.0 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 3.8 | 45.2 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 3.3 | 126.6 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 3.3 | 49.7 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 3.1 | 9.3 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 2.9 | 8.7 | GO:0002856 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318) |
| 2.7 | 94.6 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 2.5 | 12.5 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 2.4 | 46.4 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 2.4 | 7.1 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 2.3 | 55.3 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 2.3 | 11.4 | GO:1902728 | mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 2.2 | 95.4 | GO:0019835 | cytolysis(GO:0019835) |
| 2.2 | 51.8 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 2.1 | 10.7 | GO:1901545 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 2.1 | 12.8 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 2.1 | 8.3 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 2.0 | 8.1 | GO:2000697 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 2.0 | 21.5 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 1.9 | 5.6 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 1.8 | 51.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 1.8 | 166.0 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 1.7 | 5.2 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 1.5 | 27.4 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 1.3 | 2.7 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 1.3 | 3.9 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
| 1.3 | 6.3 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
| 1.2 | 6.2 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 1.2 | 1.2 | GO:0050787 | detoxification of mercury ion(GO:0050787) |
| 1.2 | 4.6 | GO:0051891 | positive regulation of cardioblast differentiation(GO:0051891) |
| 1.1 | 3.3 | GO:0032242 | regulation of nucleoside transport(GO:0032242) |
| 1.0 | 3.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 1.0 | 17.9 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.9 | 6.6 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.9 | 13.9 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.9 | 5.5 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.9 | 42.0 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.9 | 53.9 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.8 | 3.2 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
| 0.8 | 2.4 | GO:0070859 | lipid transport involved in lipid storage(GO:0010877) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.8 | 3.8 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.8 | 1.5 | GO:0045994 | positive regulation of translational initiation by iron(GO:0045994) |
| 0.7 | 5.0 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.7 | 4.1 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.7 | 2.6 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.6 | 8.5 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.6 | 1.8 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.6 | 12.7 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.6 | 2.4 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.6 | 17.9 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.6 | 3.0 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.6 | 4.6 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.6 | 3.9 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 0.5 | 2.2 | GO:2000729 | mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 0.5 | 4.9 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.5 | 9.6 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.5 | 5.7 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.5 | 4.6 | GO:0042246 | regeneration(GO:0031099) tissue regeneration(GO:0042246) |
| 0.5 | 4.0 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.5 | 25.2 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.5 | 1.9 | GO:0060264 | respiratory burst involved in inflammatory response(GO:0002536) regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.5 | 51.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.5 | 2.8 | GO:0002200 | somatic diversification of immune receptors(GO:0002200) |
| 0.5 | 0.9 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) |
| 0.4 | 3.1 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.4 | 0.9 | GO:0035669 | TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669) |
| 0.4 | 1.3 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 0.4 | 2.4 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.4 | 1.2 | GO:0006481 | C-terminal protein methylation(GO:0006481) |
| 0.4 | 1.5 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.4 | 2.7 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.4 | 2.3 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.4 | 7.9 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.4 | 2.3 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.4 | 1.5 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.4 | 1.9 | GO:1904764 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.4 | 0.4 | GO:0009988 | cell-cell recognition(GO:0009988) |
| 0.4 | 0.7 | GO:1902523 | positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.4 | 1.8 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.4 | 8.9 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.3 | 5.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.3 | 1.3 | GO:0021938 | ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) notochord regression(GO:0060032) |
| 0.3 | 3.6 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.3 | 1.3 | GO:1990668 | vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane(GO:1990668) |
| 0.3 | 1.3 | GO:0042335 | cuticle development(GO:0042335) |
| 0.3 | 1.0 | GO:0048075 | positive regulation of eye pigmentation(GO:0048075) |
| 0.3 | 2.5 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 15.1 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.3 | 4.8 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.3 | 2.1 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.3 | 3.5 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.3 | 1.5 | GO:0038155 | interleukin-23-mediated signaling pathway(GO:0038155) |
| 0.3 | 1.7 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.3 | 0.9 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.3 | 3.7 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.3 | 1.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.3 | 2.6 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.3 | 0.6 | GO:1901526 | positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
| 0.3 | 1.9 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.3 | 3.0 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.3 | 1.1 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.3 | 4.4 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.3 | 6.5 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.3 | 2.2 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.3 | 6.6 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.3 | 2.9 | GO:0071351 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
| 0.3 | 1.5 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 0.3 | 100.4 | GO:0009615 | response to virus(GO:0009615) |
| 0.3 | 1.0 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.3 | 68.0 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.3 | 1.8 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.3 | 1.0 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.2 | 1.2 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.2 | 6.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 1.9 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.2 | 1.4 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.2 | 0.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.2 | 0.5 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.2 | 5.7 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.2 | 1.3 | GO:0015886 | heme transport(GO:0015886) iron coordination entity transport(GO:1901678) |
| 0.2 | 3.2 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.2 | 1.8 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.2 | 0.6 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 0.2 | 0.6 | GO:0006429 | leucyl-tRNA aminoacylation(GO:0006429) |
| 0.2 | 2.6 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.2 | 0.8 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.2 | 1.3 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.2 | 0.9 | GO:0032474 | otolith morphogenesis(GO:0032474) otolith development(GO:0048840) |
| 0.2 | 1.1 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.2 | 0.7 | GO:0060336 | negative regulation of receptor biosynthetic process(GO:0010871) negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) cellular response to vitamin E(GO:0071306) negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.2 | 5.1 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.2 | 1.4 | GO:2000152 | regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 0.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.2 | 1.1 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 9.5 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.2 | 3.9 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.2 | 0.3 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 0.2 | 0.5 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.2 | 2.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 0.9 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.2 | 3.4 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.2 | 1.7 | GO:0001302 | replicative cell aging(GO:0001302) |
| 0.1 | 1.2 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
| 0.1 | 0.4 | GO:0016998 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 0.7 | GO:0003404 | optic vesicle morphogenesis(GO:0003404) optic cup structural organization(GO:0003409) |
| 0.1 | 0.3 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.1 | 0.3 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.1 | 1.0 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 0.4 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.1 | 1.0 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 1.0 | GO:0051106 | positive regulation of DNA ligation(GO:0051106) |
| 0.1 | 4.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.1 | 1.1 | GO:0001501 | skeletal system development(GO:0001501) |
| 0.1 | 0.8 | GO:0032439 | endosome localization(GO:0032439) |
| 0.1 | 0.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 3.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.7 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.1 | 1.1 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.1 | 0.7 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.1 | 0.5 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.1 | 1.0 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.1 | 3.1 | GO:0035994 | response to muscle stretch(GO:0035994) |
| 0.1 | 0.1 | GO:0051595 | response to methylglyoxal(GO:0051595) |
| 0.1 | 0.8 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 0.6 | GO:2000273 | positive regulation of receptor activity(GO:2000273) |
| 0.1 | 2.4 | GO:0033151 | V(D)J recombination(GO:0033151) |
| 0.1 | 3.1 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 18.5 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.1 | 0.5 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 2.3 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 0.5 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 3.5 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 0.6 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.1 | 0.6 | GO:0032960 | regulation of inositol trisphosphate biosynthetic process(GO:0032960) |
| 0.1 | 3.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.8 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.1 | 0.7 | GO:1904354 | negative regulation of telomere capping(GO:1904354) |
| 0.1 | 1.4 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.1 | 1.0 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.1 | 1.2 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 1.5 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.1 | 3.1 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 2.3 | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway(GO:0040036) |
| 0.1 | 3.8 | GO:0010506 | regulation of autophagy(GO:0010506) |
| 0.1 | 0.8 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) negative regulation of metallopeptidase activity(GO:1905049) |
| 0.1 | 0.3 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.1 | 0.3 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 0.1 | 1.5 | GO:0043586 | tongue development(GO:0043586) |
| 0.1 | 0.7 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) |
| 0.1 | 10.8 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 0.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 0.2 | GO:1903984 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.1 | 1.4 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.1 | 3.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.1 | 11.4 | GO:0031929 | TOR signaling(GO:0031929) |
| 0.1 | 0.7 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.1 | 1.2 | GO:0015866 | ADP transport(GO:0015866) |
| 0.1 | 0.6 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.1 | 0.3 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 0.2 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 0.3 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
| 0.1 | 1.9 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.1 | 0.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.1 | 0.5 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.1 | 0.6 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 14.6 | GO:0015992 | proton transport(GO:0015992) |
| 0.1 | 1.2 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 1.1 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.1 | 1.3 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.1 | 0.7 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.1 | 1.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.1 | 0.2 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.1 | 0.4 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.1 | 2.2 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 0.7 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 0.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 3.2 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.1 | 0.3 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.1 | 0.1 | GO:0008217 | regulation of blood pressure(GO:0008217) |
| 0.1 | 0.5 | GO:0010528 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
| 0.1 | 0.3 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.1 | 1.4 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 2.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 1.1 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161) |
| 0.1 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 1.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 1.0 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.0 | 0.4 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.0 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
| 0.0 | 0.4 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 1.6 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.6 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.0 | 0.9 | GO:0019076 | viral release from host cell(GO:0019076) |
| 0.0 | 1.2 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 1.1 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.9 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 1.8 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.0 | 1.4 | GO:0198738 | cell-cell signaling by wnt(GO:0198738) |
| 0.0 | 0.1 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.0 | 0.2 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.0 | 1.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.0 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.0 | 0.7 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
| 0.0 | 0.8 | GO:0010942 | positive regulation of cell death(GO:0010942) |
| 0.0 | 0.1 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.0 | 1.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.7 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.6 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.0 | 0.3 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.0 | 2.7 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.0 | 0.3 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.0 | 0.3 | GO:0090344 | negative regulation of cell aging(GO:0090344) |
| 0.0 | 0.3 | GO:1903573 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235) negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) negative regulation of response to endoplasmic reticulum stress(GO:1903573) |
| 0.0 | 0.6 | GO:0021794 | thalamus development(GO:0021794) |
| 0.0 | 3.4 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.0 | 0.2 | GO:1902172 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
| 0.0 | 1.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 2.4 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 2.9 | GO:0002456 | T cell mediated immunity(GO:0002456) |
| 0.0 | 1.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.3 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.0 | 0.4 | GO:1900364 | negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.1 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 0.6 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
| 0.0 | 1.0 | GO:0006839 | mitochondrial transport(GO:0006839) |
| 0.0 | 0.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.6 | GO:0001649 | osteoblast differentiation(GO:0001649) |
| 0.0 | 0.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.6 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 0.6 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 1.5 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.0 | 0.9 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 0.1 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.0 | 0.0 | GO:0045657 | positive regulation of monocyte differentiation(GO:0045657) |
| 0.0 | 0.2 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
| 0.0 | 0.2 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) |
| 0.0 | 0.9 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.0 | 0.2 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.0 | 0.0 | GO:0034137 | toll-like receptor 1 signaling pathway(GO:0034130) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
| 0.0 | 0.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.4 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.0 | 0.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.1 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.0 | 0.0 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.3 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.1 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
| 0.0 | 0.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.1 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.0 | 0.1 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.0 | 0.2 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.4 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
| 0.0 | 2.2 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.0 | 0.3 | GO:0001696 | gastric acid secretion(GO:0001696) oxalate transport(GO:0019532) |
| 0.0 | 1.1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.0 | 0.1 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 0.1 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.8 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 51.4 | GO:0042825 | TAP complex(GO:0042825) |
| 5.8 | 52.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 5.7 | 97.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 3.4 | 102.6 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 2.2 | 8.6 | GO:0031213 | RSF complex(GO:0031213) |
| 2.1 | 48.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 1.8 | 14.1 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 1.7 | 13.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 1.5 | 9.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 1.3 | 158.6 | GO:0005811 | lipid particle(GO:0005811) |
| 1.2 | 8.7 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 1.2 | 3.5 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 1.1 | 245.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.1 | 99.5 | GO:0015030 | Cajal body(GO:0015030) |
| 1.1 | 7.7 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.9 | 10.9 | GO:0032059 | bleb(GO:0032059) |
| 0.8 | 3.1 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.7 | 5.9 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.7 | 162.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.6 | 1.3 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.6 | 79.8 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.6 | 15.9 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.5 | 3.8 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.5 | 10.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.5 | 3.0 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.5 | 1.5 | GO:0042022 | interleukin-12 receptor complex(GO:0042022) |
| 0.5 | 1.4 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.4 | 2.6 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.4 | 42.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.4 | 2.4 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.4 | 0.4 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012) |
| 0.4 | 8.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.3 | 26.5 | GO:0012505 | endomembrane system(GO:0012505) |
| 0.3 | 5.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.3 | 3.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 3.9 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.3 | 2.4 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.3 | 2.7 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.3 | 1.7 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.3 | 0.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.3 | 1.9 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.3 | 2.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 22.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 0.8 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.3 | 0.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.3 | 3.6 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.3 | 1.0 | GO:0071547 | piP-body(GO:0071547) |
| 0.2 | 1.9 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 1.0 | GO:0031085 | BLOC-3 complex(GO:0031085) |
| 0.2 | 4.8 | GO:0071556 | integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.2 | 261.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.2 | 3.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.2 | 3.3 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.2 | 0.7 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.2 | 0.2 | GO:0032009 | early phagosome(GO:0032009) |
| 0.2 | 2.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.2 | 1.1 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.2 | 6.0 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.2 | 1.5 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 31.8 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 0.4 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 2.4 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 1.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 6.2 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 0.7 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.1 | 43.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 0.9 | GO:0042583 | chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584) |
| 0.1 | 0.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 2.4 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 5.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 842.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 5.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 2.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 0.9 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 1.4 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 2.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 37.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 1.8 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 1.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 0.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 2.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 38.7 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 1.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 1.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 3.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 2.8 | GO:0098793 | presynapse(GO:0098793) |
| 0.1 | 1.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 2.3 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 1.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 3.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.1 | 9.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 0.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.3 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 3.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.0 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 1.0 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 2.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 10.0 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 40.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 11.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 4.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 2.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.2 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 1.9 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.2 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.5 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.1 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.6 | GO:0030427 | site of polarized growth(GO:0030427) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 35.9 | 431.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 35.3 | 106.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 30.1 | 180.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 17.0 | 67.9 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 14.9 | 193.8 | GO:0031386 | protein tag(GO:0031386) |
| 9.0 | 54.0 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 8.9 | 53.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 7.2 | 36.2 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 5.7 | 17.2 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 4.6 | 18.6 | GO:0046978 | TAP binding(GO:0046977) TAP1 binding(GO:0046978) |
| 4.6 | 612.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 4.3 | 25.6 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 4.2 | 42.4 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 4.0 | 20.1 | GO:0070052 | collagen V binding(GO:0070052) |
| 3.3 | 13.3 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 2.7 | 80.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 2.5 | 144.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 2.4 | 54.3 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 1.9 | 5.8 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) |
| 1.8 | 10.9 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 1.8 | 14.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 1.6 | 6.3 | GO:0005115 | receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379) |
| 1.6 | 4.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 1.5 | 13.9 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 1.5 | 1.5 | GO:1904713 | beta-catenin destruction complex binding(GO:1904713) |
| 1.5 | 48.4 | GO:0000339 | RNA cap binding(GO:0000339) |
| 1.4 | 13.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 1.3 | 41.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.3 | 14.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.2 | 9.6 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 1.2 | 9.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.1 | 11.4 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 1.1 | 12.3 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 1.1 | 10.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 1.1 | 57.2 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 1.0 | 42.9 | GO:0005521 | lamin binding(GO:0005521) |
| 1.0 | 3.1 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.9 | 4.5 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.9 | 2.7 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.8 | 3.9 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.8 | 6.2 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.8 | 6.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.8 | 13.7 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.7 | 4.5 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.7 | 92.6 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.7 | 15.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.7 | 3.5 | GO:0102008 | cytosolic dipeptidase activity(GO:0102008) |
| 0.7 | 6.6 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.6 | 15.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.6 | 2.6 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.6 | 2.4 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.6 | 4.2 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.6 | 5.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.5 | 10.8 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.5 | 1.5 | GO:0016517 | interleukin-12 receptor activity(GO:0016517) |
| 0.5 | 4.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 7.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.5 | 1.9 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.5 | 1.4 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.4 | 22.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.4 | 5.2 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.4 | 1.2 | GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) |
| 0.4 | 1.5 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.4 | 9.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.4 | 2.7 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.4 | 1.9 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.4 | 74.0 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.4 | 10.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.4 | 1.8 | GO:0050659 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756) N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.3 | 3.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.3 | 1.0 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.3 | 1.4 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 0.3 | 2.3 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.3 | 5.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.3 | 5.7 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 2.4 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.3 | 13.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.3 | 1.3 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.3 | 30.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 0.7 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.2 | 2.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 1.0 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.2 | 8.4 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.2 | 1.1 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.2 | 7.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 2.4 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.2 | 38.3 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.2 | 1.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 0.6 | GO:0004823 | leucine-tRNA ligase activity(GO:0004823) |
| 0.2 | 1.0 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.2 | 1.8 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.2 | 67.7 | GO:0016746 | transferase activity, transferring acyl groups(GO:0016746) |
| 0.2 | 3.3 | GO:0070513 | death domain binding(GO:0070513) |
| 0.2 | 8.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 1.2 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.2 | 1.3 | GO:0034618 | arginine binding(GO:0034618) |
| 0.2 | 1.2 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.2 | 1.0 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.2 | 0.8 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.2 | 11.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.2 | 2.0 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 3.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.5 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.2 | 5.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 2.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 2.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 2.3 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.1 | 0.3 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.1 | 1.5 | GO:0015288 | porin activity(GO:0015288) |
| 0.1 | 1.8 | GO:0004908 | interleukin-1 receptor activity(GO:0004908) |
| 0.1 | 1.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 2.2 | GO:0099604 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.1 | 0.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.9 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.1 | 0.7 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 3.2 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 2.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 26.3 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 1.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 3.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.3 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.1 | 0.5 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.1 | 68.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 0.9 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 21.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.0 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 0.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 0.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 1.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 4.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 211.9 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 21.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 2.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.5 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.1 | 1.0 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 0.6 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 2.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 1.0 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.3 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.1 | 1.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.2 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 1.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 2.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 2.4 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 2.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 1.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 135.7 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 1.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.4 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.1 | 0.7 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 2.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 1.1 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 0.5 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 0.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.4 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.3 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 0.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 0.4 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.6 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.6 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 1.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.0 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.0 | 0.4 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.3 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.0 | 0.9 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.2 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 0.0 | 0.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.0 | 1.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.0 | 1.6 | GO:0019212 | protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.0 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.0 | GO:0035663 | Toll-like receptor 2 binding(GO:0035663) |
| 0.0 | 0.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 7.2 | GO:0016887 | ATPase activity(GO:0016887) |
| 0.0 | 0.1 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.0 | 0.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 1.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 0.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.1 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.0 | 0.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 0.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 2.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 19.5 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 1.2 | 95.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.7 | 65.5 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.5 | 4.4 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.5 | 44.0 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 7.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.4 | 16.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.4 | 48.3 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.3 | 9.3 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.3 | 16.3 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.3 | 13.7 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 15.4 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 15.8 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.3 | 35.0 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.3 | 4.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 16.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 7.6 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 3.7 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 7.8 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 4.8 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 5.3 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 6.9 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.1 | 10.0 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 9.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 3.8 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.1 | 0.7 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.1 | 5.1 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 8.3 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.7 | PID_GMCSF_PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 5.0 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.1 | 2.9 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 4.1 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.1 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 0.9 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 1.1 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.0 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.2 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 0.9 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.5 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.6 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.2 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.7 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.2 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 4.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.3 | PID_TCR_PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.9 | 302.1 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 12.8 | 1213.6 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 3.8 | 158.6 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 2.5 | 256.2 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 2.1 | 47.0 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
| 1.8 | 7.1 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.6 | 16.1 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 1.2 | 34.8 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 1.0 | 15.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.9 | 10.2 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.9 | 11.4 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.8 | 63.8 | REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.6 | 29.5 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 32.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 2.1 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.5 | 11.0 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 10.7 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.4 | 32.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 11.0 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 3.0 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.3 | 5.8 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.2 | 3.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 15.6 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 4.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 5.2 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.7 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 15.1 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 0.9 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 4.9 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.3 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 6.7 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 4.7 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.0 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 3.5 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.1 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 7.1 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.2 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 2.4 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 14.7 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 0.6 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 1.8 | REACTOME_BOTULINUM_NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.0 | 1.0 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.0 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 2.1 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 2.6 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 0.9 | REACTOME_DAG_AND_IP3_SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.0 | 0.6 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 2.1 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 0.3 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 2.4 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.7 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.5 | REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS | Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| 0.0 | 1.2 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.6 | REACTOME_TRNA_AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.0 | 0.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.3 | REACTOME_S_PHASE | Genes involved in S Phase |
| 0.0 | 0.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.4 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 2.2 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.5 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.5 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.5 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.5 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
|
|
|