Motif ID: HOXD1

Z-value: 0.303


Transcription factors associated with HOXD1:

Gene SymbolEntrez IDGene Name
HOXD1 ENSG00000128645.11 HOXD1



Activity profile for motif HOXD1.

activity profile for motif HOXD1


Sorted Z-values histogram for motif HOXD1

Sorted Z-values for motif HOXD1



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXD1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_77154935 0.281 ENST00000481445.1
 COX7B
cytochrome c oxidase subunit VIIb
chr18_-_33709268 0.238 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr10_+_18549645 0.205 ENST00000396576.2
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_+_71900572 0.189 ENST00000312293.4
 FOLR1
folate receptor 1 (adult)
chr11_+_71900703 0.187 ENST00000393681.2
 FOLR1
folate receptor 1 (adult)
chr15_-_55562582 0.132 ENST00000396307.2
 RAB27A
RAB27A, member RAS oncogene family
chr15_-_55563072 0.123 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
 RAB27A


RAB27A, member RAS oncogene family


chr15_-_55562451 0.119 ENST00000568803.1
 RAB27A
RAB27A, member RAS oncogene family
chr14_+_74034310 0.106 ENST00000538782.1
 ACOT2
acyl-CoA thioesterase 2
chr5_+_148737562 0.099 ENST00000274569.4
 PCYOX1L
prenylcysteine oxidase 1 like
chr15_-_55562479 0.097 ENST00000564609.1
 RAB27A
RAB27A, member RAS oncogene family
chr2_+_135596180 0.096 ENST00000283054.4
ENST00000392928.1
 ACMSD

aminocarboxymuconate semialdehyde decarboxylase

chr12_-_10022735 0.093 ENST00000228438.2
 CLEC2B
C-type lectin domain family 2, member B
chr20_-_50419055 0.083 ENST00000217086.4
 SALL4
spalt-like transcription factor 4
chr14_+_57671888 0.078 ENST00000391612.1
 AL391152.1
AL391152.1
chr10_-_72142345 0.072 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
 LRRC20



leucine rich repeat containing 20



chr20_-_50418972 0.071 ENST00000395997.3
 SALL4
spalt-like transcription factor 4
chr14_+_32798547 0.070 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6


A kinase (PRKA) anchor protein 6


chr1_-_201140673 0.069 ENST00000367333.2
 TMEM9
transmembrane protein 9
chr7_+_99717230 0.067 ENST00000262932.3
 CNPY4
canopy FGF signaling regulator 4
chr3_-_126327398 0.066 ENST00000383572.2
 TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_-_190446759 0.065 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr19_-_3557570 0.064 ENST00000355415.2
 MFSD12
major facilitator superfamily domain containing 12
chr8_-_49834299 0.063 ENST00000396822.1
 SNAI2
snail family zinc finger 2
chr8_-_49833978 0.062 ENST00000020945.1
 SNAI2
snail family zinc finger 2
chr20_-_50418947 0.061 ENST00000371539.3
 SALL4
spalt-like transcription factor 4
chrX_-_19504642 0.060 ENST00000469203.2
 MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr2_+_135596106 0.060 ENST00000356140.5
 ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr17_+_57233087 0.054 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
 PRR11


proline rich 11


chr22_+_24951949 0.050 ENST00000402849.1
 SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr7_-_73256838 0.049 ENST00000297873.4
 WBSCR27
Williams Beuren syndrome chromosome region 27
chr7_+_37723450 0.048 ENST00000447769.1
 GPR141
G protein-coupled receptor 141
chr12_+_29376673 0.044 ENST00000547116.1
 FAR2
fatty acyl CoA reductase 2
chr15_+_58702742 0.043 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic

chr7_+_37723336 0.043 ENST00000450180.1
 GPR141
G protein-coupled receptor 141
chr2_+_54350316 0.041 ENST00000606865.1
 ACYP2
acylphosphatase 2, muscle type
chr12_+_29376592 0.038 ENST00000182377.4
 FAR2
fatty acyl CoA reductase 2
chr7_-_99717463 0.037 ENST00000437822.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_+_191221240 0.037 ENST00000409027.1
ENST00000458193.1
 INPP1

inositol polyphosphate-1-phosphatase

chr11_-_124190184 0.035 ENST00000357438.2
 OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr11_-_71823715 0.031 ENST00000545944.1
ENST00000502597.2
 ANAPC15

anaphase promoting complex subunit 15

chr4_+_86748898 0.026 ENST00000509300.1
 ARHGAP24
Rho GTPase activating protein 24
chr5_-_96478466 0.025 ENST00000274382.4
 LIX1
Lix1 homolog (chicken)
chr3_-_101039402 0.025 ENST00000193391.7
 IMPG2
interphotoreceptor matrix proteoglycan 2
chr11_+_73498898 0.023 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr4_+_144354644 0.023 ENST00000512843.1
 GAB1
GRB2-associated binding protein 1
chr10_-_99205607 0.022 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
 EXOSC1





exosome component 1





chr7_-_99716914 0.022 ENST00000431404.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_-_53171128 0.022 ENST00000332411.2
 KRT76
keratin 76
chr4_+_86525299 0.020 ENST00000512201.1
 ARHGAP24
Rho GTPase activating protein 24
chr3_-_164796269 0.020 ENST00000264382.3
 SI
sucrase-isomaltase (alpha-glucosidase)
chr11_+_118398178 0.019 ENST00000302783.4
ENST00000539546.1
 TTC36

tetratricopeptide repeat domain 36

chr11_+_65554493 0.017 ENST00000335987.3
 OVOL1
ovo-like zinc finger 1
chr4_+_144312659 0.016 ENST00000509992.1
 GAB1
GRB2-associated binding protein 1
chr17_-_57229155 0.016 ENST00000584089.1
 SKA2
spindle and kinetochore associated complex subunit 2
chr7_+_133812052 0.016 ENST00000285928.2
 LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr10_-_4285923 0.015 ENST00000418372.1
ENST00000608792.1
 LINC00702

long intergenic non-protein coding RNA 702

chr11_-_62521614 0.015 ENST00000527994.1
ENST00000394807.3
 ZBTB3

zinc finger and BTB domain containing 3

chr14_+_32798462 0.014 ENST00000280979.4
 AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_101918153 0.011 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr4_+_86749045 0.011 ENST00000514229.1
 ARHGAP24
Rho GTPase activating protein 24
chr14_+_56584414 0.011 ENST00000559044.1
 PELI2
pellino E3 ubiquitin protein ligase family member 2
chr4_-_146261573 0.011 ENST00000610239.1
 RP11-142A22.4
RP11-142A22.4
chr19_+_50016610 0.010 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_+_158493642 0.010 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
 RP11-364P22.1


RP11-364P22.1


chr4_-_139051839 0.009 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
 LINC00616


long intergenic non-protein coding RNA 616


chr4_-_69111401 0.009 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr7_-_99716952 0.009 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6










TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa










chr1_-_112032284 0.008 ENST00000414219.1
 ADORA3
adenosine A3 receptor
chr12_+_15699286 0.008 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O



chr12_-_52761262 0.007 ENST00000257901.3
 KRT85
keratin 85
chr11_-_102651343 0.007 ENST00000279441.4
ENST00000539681.1
 MMP10

matrix metallopeptidase 10 (stromelysin 2)

chr4_-_74486347 0.007 ENST00000342081.3
 RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr7_-_81399438 0.007 ENST00000222390.5
 HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_+_78400375 0.006 ENST00000602452.2
 MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr4_+_105828492 0.005 ENST00000506148.1
 RP11-556I14.1
RP11-556I14.1
chr19_-_36001113 0.005 ENST00000434389.1
 DMKN
dermokine
chr5_+_63802109 0.004 ENST00000334025.2
 RGS7BP
regulator of G-protein signaling 7 binding protein
chr6_+_130742231 0.003 ENST00000545622.1
 TMEM200A
transmembrane protein 200A
chr17_-_10372875 0.003 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chr19_+_11071546 0.002 ENST00000358026.2
 SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr17_-_27418537 0.002 ENST00000408971.2
 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr11_-_71823796 0.001 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15





anaphase promoting complex subunit 15





chr4_-_150736962 0.000 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
 RP11-526A4.1


RP11-526A4.1


chr9_-_5339873 0.000 ENST00000223862.1
ENST00000223858.4
 RLN1

relaxin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of high voltage-gated calcium channel activity(GO:1901843) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing