Motif ID: HOXB5

Z-value: 0.436


Transcription factors associated with HOXB5:

Gene SymbolEntrez IDGene Name
HOXB5 ENSG00000120075.5 HOXB5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_46671323-0.703.6e-02Click!


Activity profile for motif HOXB5.

activity profile for motif HOXB5


Sorted Z-values histogram for motif HOXB5

Sorted Z-values for motif HOXB5



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_38660185 0.438 ENST00000555655.1
 CTD-2142D14.1
CTD-2142D14.1
chr7_+_125557914 0.437 ENST00000411856.1
 AC005276.1
AC005276.1
chr11_+_72281681 0.436 ENST00000450804.3
 RP11-169D4.1
RP11-169D4.1
chr12_+_56915713 0.404 ENST00000262031.5
ENST00000552247.2
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr12_+_56915776 0.394 ENST00000550726.1
ENST00000542360.1
 RBMS2

RNA binding motif, single stranded interacting protein 2

chr1_+_157963391 0.333 ENST00000359209.6
ENST00000416935.2
 KIRREL

kin of IRRE like (Drosophila)

chr13_-_54706954 0.313 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
 LINC00458




long intergenic non-protein coding RNA 458




chr6_-_32820529 0.282 ENST00000425148.2
 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr14_-_102704783 0.278 ENST00000522534.1
 MOK
MOK protein kinase
chr15_-_75017711 0.241 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
 CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1





chr11_-_57089774 0.229 ENST00000527207.1
 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr16_-_28936007 0.194 ENST00000568703.1
ENST00000567483.1
 RABEP2

rabaptin, RAB GTPase binding effector protein 2

chr1_+_154975110 0.190 ENST00000535420.1
ENST00000368426.3
 ZBTB7B

zinc finger and BTB domain containing 7B

chr16_-_84651647 0.185 ENST00000564057.1
 COTL1
coactosin-like 1 (Dictyostelium)
chr4_-_114900831 0.183 ENST00000315366.7
 ARSJ
arylsulfatase family, member J
chr1_+_154229547 0.175 ENST00000428595.1
 UBAP2L
ubiquitin associated protein 2-like
chr11_-_57089671 0.173 ENST00000532437.1
 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr18_+_32558208 0.153 ENST00000436190.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_-_17140436 0.152 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
 FLCN


folliculin


chr18_+_32558380 0.135 ENST00000588349.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr12_+_57984943 0.130 ENST00000422156.3
 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr1_+_41157361 0.129 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
 NFYC




nuclear transcription factor Y, gamma




chr15_-_72523454 0.128 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
 PKM





pyruvate kinase, muscle





chr1_+_41157421 0.127 ENST00000372654.1
 NFYC
nuclear transcription factor Y, gamma
chr19_-_42724261 0.127 ENST00000595337.1
 DEDD2
death effector domain containing 2
chr1_+_162351503 0.121 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr18_-_33077556 0.121 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr1_+_41157671 0.115 ENST00000534399.1
ENST00000372653.1
 NFYC

nuclear transcription factor Y, gamma

chr16_-_30381580 0.111 ENST00000409939.3
 TBC1D10B
TBC1 domain family, member 10B
chr1_+_235492300 0.099 ENST00000476121.1
ENST00000497327.1
 GGPS1

geranylgeranyl diphosphate synthase 1

chr12_+_53693466 0.098 ENST00000267103.5
ENST00000548632.1
 C12orf10

chromosome 12 open reading frame 10

chr12_-_53614155 0.092 ENST00000543726.1
 RARG
retinoic acid receptor, gamma
chr12_-_53614043 0.091 ENST00000338561.5
 RARG
retinoic acid receptor, gamma
chr12_-_6798410 0.089 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
 ZNF384


zinc finger protein 384


chr1_+_146373546 0.084 ENST00000446760.2
 NBPF12
neuroblastoma breakpoint family, member 12
chr12_-_6798523 0.080 ENST00000319770.3
 ZNF384
zinc finger protein 384
chr12_-_6798616 0.077 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
 ZNF384



zinc finger protein 384



chrX_+_47077680 0.075 ENST00000522883.1
 CDK16
cyclin-dependent kinase 16
chr3_-_127541194 0.073 ENST00000453507.2
 MGLL
monoglyceride lipase
chr1_+_206317450 0.072 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
 CTSE


cathepsin E


chr5_+_67511524 0.070 ENST00000521381.1
ENST00000521657.1
 PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

chr2_-_47168850 0.070 ENST00000409207.1
 MCFD2
multiple coagulation factor deficiency 2
chr1_+_235491714 0.068 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
 GGPS1



geranylgeranyl diphosphate synthase 1



chr9_-_130700080 0.060 ENST00000373110.4
 DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr1_-_155658260 0.058 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
 YY1AP1







YY1 associated protein 1







chr1_-_235491462 0.058 ENST00000418304.1
ENST00000264183.3
ENST00000349213.3
 ARID4B


AT rich interactive domain 4B (RBP1-like)


chr15_+_74218787 0.051 ENST00000261921.7
 LOXL1
lysyl oxidase-like 1
chr16_-_1821496 0.048 ENST00000564628.1
ENST00000563498.1
 NME3

NME/NM23 nucleoside diphosphate kinase 3

chr6_-_31869769 0.047 ENST00000375527.2
 ZBTB12
zinc finger and BTB domain containing 12
chr2_-_70409953 0.046 ENST00000419381.1
 C2orf42
chromosome 2 open reading frame 42
chr12_-_52715179 0.042 ENST00000293670.3
 KRT83
keratin 83
chr15_+_41913690 0.038 ENST00000563576.1
 MGA
MGA, MAX dimerization protein
chr3_-_195538728 0.037 ENST00000349607.4
ENST00000346145.4
 MUC4

mucin 4, cell surface associated

chr1_-_155658085 0.036 ENST00000311573.5
ENST00000438245.2
 YY1AP1

YY1 associated protein 1

chr14_-_24020858 0.035 ENST00000419474.3
 ZFHX2
zinc finger homeobox 2
chr1_+_113263199 0.034 ENST00000361886.3
 FAM19A3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr1_+_145575227 0.034 ENST00000393046.2
ENST00000369299.3
ENST00000463514.2
 PIAS3


protein inhibitor of activated STAT, 3


chr16_-_1821721 0.033 ENST00000219302.3
 NME3
NME/NM23 nucleoside diphosphate kinase 3
chr1_-_155658518 0.032 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
 YY1AP1


YY1 associated protein 1


chr17_-_42143963 0.031 ENST00000585388.1
ENST00000293406.3
 LSM12

LSM12 homolog (S. cerevisiae)

chr1_-_155658766 0.029 ENST00000295566.4
ENST00000368330.2
 YY1AP1

YY1 associated protein 1

chr1_+_206317591 0.029 ENST00000432969.2
 CTSE
cathepsin E
chr2_+_219283815 0.028 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
 VIL1


villin 1


chr3_+_187420101 0.028 ENST00000449623.1
ENST00000437407.1
 RP11-211G3.3

Uncharacterized protein

chr2_-_47168906 0.027 ENST00000444761.2
ENST00000409147.1
 MCFD2

multiple coagulation factor deficiency 2

chr8_+_118147498 0.026 ENST00000519688.1
ENST00000456015.2
 SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr6_+_30749649 0.026 ENST00000422944.1
 HCG20
HLA complex group 20 (non-protein coding)
chr3_-_164914640 0.024 ENST00000241274.3
 SLITRK3
SLIT and NTRK-like family, member 3
chr1_+_155579979 0.023 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
 MSTO1



misato 1, mitochondrial distribution and morphology regulator



chr3_+_45986511 0.019 ENST00000458629.1
ENST00000457814.1
 CXCR6

chemokine (C-X-C motif) receptor 6

chr3_+_51422478 0.017 ENST00000528157.1
 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr5_+_149569520 0.016 ENST00000230671.2
ENST00000524041.1
 SLC6A7

solute carrier family 6 (neurotransmitter transporter), member 7

chr11_-_35440579 0.014 ENST00000606205.1
 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_6679528 0.009 ENST00000321535.4
 FBXO39
F-box protein 39
chr16_+_31539183 0.007 ENST00000302312.4
 AHSP
alpha hemoglobin stabilizing protein
chr11_-_125648690 0.007 ENST00000436890.2
ENST00000358524.3
 PATE2

prostate and testis expressed 2

chr9_-_112970436 0.006 ENST00000400613.4
 C9orf152
chromosome 9 open reading frame 152
chr16_+_31539197 0.006 ENST00000564707.1
 AHSP
alpha hemoglobin stabilizing protein
chr3_-_195538760 0.004 ENST00000475231.1
 MUC4
mucin 4, cell surface associated
chrX_+_100333709 0.004 ENST00000372930.4
 TMEM35
transmembrane protein 35
chr10_+_114135952 0.003 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
 ACSL5


acyl-CoA synthetase long-chain family member 5


chr6_-_97285336 0.002 ENST00000229955.3
ENST00000417980.1
 GPR63

G protein-coupled receptor 63

chr17_-_29233769 0.001 ENST00000581216.1
 TEFM
transcription elongation factor, mitochondrial
chr11_+_4664650 0.000 ENST00000396952.5
 OR51E1
olfactory receptor, family 51, subfamily E, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043449 insecticide metabolic process(GO:0017143) cellular alkene metabolic process(GO:0043449) olefin metabolic process(GO:1900673)
0.1 0.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.2 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.2 GO:2000506 negative regulation of energy homeostasis(GO:2000506)
0.0 0.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:1902912 pyruvate kinase complex(GO:1902912)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.3 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.2 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.0 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases