Motif ID: HOXB13

Z-value: 0.592


Transcription factors associated with HOXB13:

Gene SymbolEntrez IDGene Name
HOXB13 ENSG00000159184.7 HOXB13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_46806558-0.891.4e-03Click!


Activity profile for motif HOXB13.

activity profile for motif HOXB13


Sorted Z-values histogram for motif HOXB13

Sorted Z-values for motif HOXB13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_69180083 2.928 ENST00000328895.4
 GKN2
gastrokine 2
chr2_-_69180012 2.421 ENST00000481498.1
 GKN2
gastrokine 2
chr17_-_39538550 1.494 ENST00000394001.1
 KRT34
keratin 34
chr1_+_66458072 0.451 ENST00000423207.2
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_-_50860565 0.213 ENST00000403097.1
 GRB10
growth factor receptor-bound protein 10
chr14_-_51027838 0.207 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr11_+_63606373 0.197 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
 MARK2




MAP/microtubule affinity-regulating kinase 2




chr9_-_14180778 0.175 ENST00000380924.1
ENST00000543693.1
 NFIB

nuclear factor I/B

chr21_+_30673091 0.166 ENST00000447177.1
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr1_+_23037323 0.161 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
 EPHB2



EPH receptor B2



chr3_-_195310802 0.156 ENST00000421243.1
ENST00000453131.1
 APOD

apolipoprotein D

chr22_-_38240316 0.144 ENST00000411961.2
ENST00000434930.1
 ANKRD54

ankyrin repeat domain 54

chr21_-_35899113 0.142 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
 RCAN1


regulator of calcineurin 1


chr12_-_94673956 0.141 ENST00000551941.1
 RP11-1105G2.3
Uncharacterized protein
chr9_+_125132803 0.135 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_210501589 0.135 ENST00000413764.2
ENST00000541565.1
 HHAT

hedgehog acyltransferase

chr9_+_125133315 0.133 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr16_+_30669720 0.130 ENST00000356166.6
 FBRS
fibrosin
chr19_+_56154913 0.128 ENST00000270451.5
ENST00000588537.1
 ZNF581

zinc finger protein 581

chr14_-_50583271 0.121 ENST00000395860.2
ENST00000395859.2
 VCPKMT

valosin containing protein lysine (K) methyltransferase

chr15_+_71839566 0.120 ENST00000357769.4
 THSD4
thrombospondin, type I, domain containing 4
chr22_-_38240412 0.119 ENST00000215941.4
 ANKRD54
ankyrin repeat domain 54
chr5_-_159766528 0.117 ENST00000505287.2
 CCNJL
cyclin J-like
chr18_+_3252206 0.112 ENST00000578562.2
 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr4_+_169575875 0.105 ENST00000503457.1
 PALLD
palladin, cytoskeletal associated protein
chr1_-_149783914 0.098 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
 HIST2H2BF


histone cluster 2, H2bf


chr18_+_3252265 0.091 ENST00000580887.1
ENST00000536605.1
 MYL12A

myosin, light chain 12A, regulatory, non-sarcomeric

chr12_-_52715179 0.090 ENST00000293670.3
 KRT83
keratin 83
chr11_-_13461790 0.082 ENST00000530907.1
 BTBD10
BTB (POZ) domain containing 10
chr1_+_84630574 0.073 ENST00000413538.1
ENST00000417530.1
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr9_+_125133467 0.073 ENST00000426608.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_136288113 0.073 ENST00000401392.1
 ZRANB3
zinc finger, RAN-binding domain containing 3
chr5_-_140053152 0.071 ENST00000542735.1
 DND1
DND microRNA-mediated repression inhibitor 1
chr13_+_28813645 0.068 ENST00000282391.5
 PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr21_+_30672433 0.063 ENST00000451655.1
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr7_+_128784712 0.059 ENST00000289407.4
 TSPAN33
tetraspanin 33
chr6_+_27782788 0.056 ENST00000359465.4
 HIST1H2BM
histone cluster 1, H2bm
chr5_+_135496675 0.056 ENST00000507637.1
 SMAD5
SMAD family member 5
chr19_-_5903714 0.055 ENST00000252675.5
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000586349.1
ENST00000585661.1
 FUT5
NDUFA11


AC024592.12

fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa


Uncharacterized protein

chr17_-_10560619 0.053 ENST00000583535.1
 MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr18_-_52989525 0.050 ENST00000457482.3
 TCF4
transcription factor 4
chr4_+_110749143 0.049 ENST00000317735.4
 RRH
retinal pigment epithelium-derived rhodopsin homolog
chr17_+_18086392 0.049 ENST00000541285.1
 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr1_+_84630645 0.048 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_139613269 0.047 ENST00000358430.3
 TXLNB
taxilin beta
chr1_+_84629976 0.047 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr5_-_145214848 0.042 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
 PRELID2



PRELI domain containing 2



chr3_-_150690786 0.040 ENST00000327047.1
 CLRN1
clarin 1
chr1_+_84630352 0.039 ENST00000450730.1
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_-_27782548 0.035 ENST00000333151.3
 HIST1H2AJ
histone cluster 1, H2aj
chr7_+_35756092 0.035 ENST00000458087.3
 AC018647.3
AC018647.3
chr10_-_94301107 0.033 ENST00000436178.1
 IDE
insulin-degrading enzyme
chr7_-_11871815 0.033 ENST00000423059.4
 THSD7A
thrombospondin, type I, domain containing 7A
chr9_+_125795788 0.032 ENST00000373643.5
 RABGAP1
RAB GTPase activating protein 1
chr10_+_104005272 0.031 ENST00000369983.3
 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr1_-_178838404 0.027 ENST00000444255.1
 ANGPTL1
angiopoietin-like 1
chr9_-_130829588 0.026 ENST00000373078.4
 NAIF1
nuclear apoptosis inducing factor 1
chr1_-_36863481 0.025 ENST00000315732.2
 LSM10
LSM10, U7 small nuclear RNA associated
chr8_+_35649365 0.022 ENST00000437887.1
 AC012215.1
Uncharacterized protein
chr8_+_77593474 0.021 ENST00000455469.2
ENST00000050961.6
 ZFHX4

zinc finger homeobox 4

chr1_+_84630367 0.018 ENST00000370680.1
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr15_+_48483736 0.018 ENST00000559641.1
ENST00000417307.2
 SLC12A1
CTXN2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
cortexin 2
chr1_-_151148492 0.018 ENST00000295314.4
 TMOD4
tropomodulin 4 (muscle)
chr12_-_16430619 0.018 ENST00000344941.3
 SLC15A5
solute carrier family 15, member 5
chr4_-_69111401 0.016 ENST00000332644.5
 TMPRSS11B
transmembrane protease, serine 11B
chr3_+_68053359 0.015 ENST00000478136.1
 FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr12_+_80838126 0.014 ENST00000266688.5
 PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr3_+_89156674 0.013 ENST00000336596.2
 EPHA3
EPH receptor A3
chr9_+_44868935 0.011 ENST00000448436.2
 RP11-160N1.10
RP11-160N1.10
chr5_-_145214893 0.010 ENST00000394450.2
 PRELID2
PRELI domain containing 2
chr16_-_71610985 0.009 ENST00000355962.4
 TAT
tyrosine aminotransferase
chr3_-_114790179 0.005 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr14_+_76776957 0.003 ENST00000512784.1
 ESRRB
estrogen-related receptor beta
chr7_-_130353553 0.002 ENST00000330992.7
ENST00000445977.2
 COPG2

coatomer protein complex, subunit gamma 2

chr3_+_89156799 0.002 ENST00000452448.2
ENST00000494014.1
 EPHA3

EPH receptor A3

chr16_-_24942273 0.002 ENST00000571406.1
 ARHGAP17
Rho GTPase activating protein 17
chr11_+_118401706 0.001 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
 TMEM25


transmembrane protein 25



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:2000097 negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.5 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 1.6 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.4 GO:0045178 basal part of cell(GO:0045178)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)