Motif ID: HMGA2

Z-value: 0.756


Transcription factors associated with HMGA2:

Gene SymbolEntrez IDGene Name
HMGA2 ENSG00000149948.9 HMGA2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_662186780.363.5e-01Click!


Activity profile for motif HMGA2.

activity profile for motif HMGA2


Sorted Z-values histogram for motif HMGA2

Sorted Z-values for motif HMGA2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_196621002 1.305 ENST00000367429.4
ENST00000439155.2
CFH

complement factor H

chr15_+_43885252 0.975 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B



creatine kinase, mitochondrial 1B



chr15_+_43985084 0.939 ENST00000434505.1
ENST00000411750.1
CKMT1A

creatine kinase, mitochondrial 1A

chr15_+_88120158 0.757 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr2_-_183387430 0.750 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr1_+_196621156 0.714 ENST00000359637.2
CFH
complement factor H
chr12_-_10573149 0.708 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3


killer cell lectin-like receptor subfamily C, member 3


chr2_-_183387064 0.664 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A



phosphodiesterase 1A, calmodulin-dependent



chr18_+_11851383 0.562 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr2_-_183387283 0.503 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_154801312 0.361 ENST00000497890.1
MME
membrane metallo-endopeptidase
chr3_-_157221128 0.332 ENST00000392833.2
ENST00000362010.2
VEPH1

ventricular zone expressed PH domain-containing 1

chr17_-_26220366 0.321 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9


RP1-66C13.4
LYR motif containing 9


Uncharacterized protein
chrX_+_117480036 0.304 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
WDR44


WD repeat domain 44


chr6_+_111580508 0.288 ENST00000368847.4
KIAA1919
KIAA1919
chr3_+_186501336 0.280 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2


eukaryotic translation initiation factor 4A2


chr6_+_123110302 0.272 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr15_+_84904525 0.261 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr6_+_106535455 0.253 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr22_+_22676808 0.251 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr18_-_14132422 0.250 ENST00000589498.1
ENST00000590202.1
ZNF519

zinc finger protein 519

chr6_-_32908765 0.248 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_-_102985035 0.226 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr4_+_184826418 0.215 ENST00000308497.4
ENST00000438269.1
STOX2

storkhead box 2

chr15_+_83098710 0.209 ENST00000561062.1
ENST00000358583.3
GOLGA6L9

golgin A6 family-like 20

chr15_+_82722225 0.202 ENST00000300515.8
GOLGA6L9
golgin A6 family-like 9
chr10_-_62332357 0.198 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_+_53483983 0.186 ENST00000544545.1
RBL2
retinoblastoma-like 2 (p130)
chr7_-_102985288 0.182 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr1_+_144989309 0.173 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr17_-_76220740 0.167 ENST00000600484.1
AC087645.1
Uncharacterized protein
chr19_+_44455368 0.161 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
ZNF221


zinc finger protein 221


chr6_-_127664736 0.160 ENST00000368291.2
ENST00000309620.9
ENST00000454859.3
ECHDC1


enoyl CoA hydratase domain containing 1


chr15_+_30375158 0.156 ENST00000341650.6
ENST00000567927.1
GOLGA8J

golgin A8 family, member J

chr1_+_104104379 0.144 ENST00000435302.1
AMY2B
amylase, alpha 2B (pancreatic)
chr1_-_223988426 0.141 ENST00000391879.2
TP53BP2
tumor protein p53 binding protein, 2
chr6_+_116892641 0.137 ENST00000487832.2
ENST00000518117.1
RWDD1

RWD domain containing 1

chr2_+_235887329 0.136 ENST00000409212.1
ENST00000344528.4
ENST00000444916.1
SH3BP4


SH3-domain binding protein 4


chr11_+_67250490 0.134 ENST00000528641.2
ENST00000279146.3
AIP

aryl hydrocarbon receptor interacting protein

chr14_+_37641012 0.134 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr9_-_34729457 0.134 ENST00000378788.3
FAM205A
family with sequence similarity 205, member A
chr3_-_123680246 0.132 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr7_+_80267973 0.128 ENST00000394788.3
ENST00000447544.2
CD36

CD36 molecule (thrombospondin receptor)

chr2_+_177134134 0.128 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2


metaxin 2


chr12_-_8765446 0.127 ENST00000537228.1
ENST00000229335.6
AICDA

activation-induced cytidine deaminase

chr15_+_58702742 0.124 ENST00000356113.6
ENST00000414170.3
LIPC

lipase, hepatic

chr14_+_45553296 0.124 ENST00000355765.6
ENST00000553605.1
PRPF39

pre-mRNA processing factor 39

chr20_+_46130619 0.119 ENST00000372004.3
NCOA3
nuclear receptor coactivator 3
chr17_-_30186328 0.119 ENST00000302362.6
COPRS
coordinator of PRMT5, differentiation stimulator
chr12_+_21207503 0.118 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr2_-_114461655 0.112 ENST00000424612.1
AC017074.2
AC017074.2
chr6_-_127664683 0.111 ENST00000528402.1
ENST00000454591.2
ECHDC1

enoyl CoA hydratase domain containing 1

chr15_-_82939157 0.110 ENST00000559949.1
RP13-996F3.5
golgin A6 family-like 18
chr20_+_46130601 0.103 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chrX_+_2670066 0.102 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG


Xg blood group


chr6_+_88106840 0.100 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr10_+_35456444 0.100 ENST00000361599.4
CREM
cAMP responsive element modulator
chrX_-_134186144 0.099 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr2_+_177134201 0.096 ENST00000452865.1
MTX2
metaxin 2
chr5_-_135290651 0.094 ENST00000522943.1
ENST00000514447.2
LECT2

leukocyte cell-derived chemotaxin 2

chr15_+_28623784 0.093 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
GOLGA8F


golgin A8 family, member F


chr20_+_46130671 0.092 ENST00000371998.3
ENST00000371997.3
NCOA3

nuclear receptor coactivator 3

chr7_+_80275953 0.083 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36


CD36 molecule (thrombospondin receptor)


chr2_+_172543967 0.080 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2




dynein, cytoplasmic 1, intermediate chain 2




chr17_+_73230799 0.079 ENST00000579838.1
NUP85
nucleoporin 85kDa
chr12_+_59194154 0.079 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr2_+_172544182 0.076 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
DYNC1I2





dynein, cytoplasmic 1, intermediate chain 2





chr20_+_9966728 0.075 ENST00000449270.1
RP5-839B4.8
RP5-839B4.8
chr5_+_150827143 0.074 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
SLC36A1


solute carrier family 36 (proton/amino acid symporter), member 1


chr5_-_102455801 0.073 ENST00000508629.1
ENST00000399004.2
GIN1

gypsy retrotransposon integrase 1

chr14_-_94759361 0.073 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr15_-_83018198 0.069 ENST00000557886.1
RP13-996F3.4
golgin A6 family-like 19
chr14_-_94759408 0.064 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chrX_-_23926004 0.061 ENST00000379226.4
ENST00000379220.3
APOO

apolipoprotein O

chr14_-_94759595 0.061 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_172544011 0.060 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr9_+_42704004 0.059 ENST00000457288.1
CBWD7
COBW domain containing 7
chr2_-_287299 0.058 ENST00000405290.1
FAM150B
family with sequence similarity 150, member B
chr3_-_157221357 0.054 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_-_32908792 0.054 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_-_128782722 0.053 ENST00000427399.1
APLN
apelin
chr2_+_120436760 0.052 ENST00000445518.1
ENST00000409951.1
TMEM177

transmembrane protein 177

chr2_-_287320 0.051 ENST00000401503.1
FAM150B
family with sequence similarity 150, member B
chr10_-_5046042 0.049 ENST00000421196.3
ENST00000455190.1
AKR1C2

aldo-keto reductase family 1, member C2

chr9_-_115480303 0.049 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
INIP



INTS3 and NABP interacting protein



chr2_+_220143989 0.049 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr3_-_157221380 0.047 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr10_-_101673782 0.044 ENST00000422692.1
DNMBP
dynamin binding protein
chr1_+_2487631 0.043 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chrX_-_71792477 0.043 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8








histone deacetylase 8








chr11_+_73661364 0.042 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_+_120436733 0.041 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177


transmembrane protein 177


chr19_+_11457175 0.041 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159


coiled-coil domain containing 159


chrY_+_22918021 0.039 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr2_+_220144052 0.037 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2


DnaJ (Hsp40) homolog, subfamily B, member 2


chr8_+_9911778 0.035 ENST00000317173.4
ENST00000441698.2
MSRA

methionine sulfoxide reductase A

chr12_+_65996599 0.033 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3

RP11-221N13.3

chr15_-_32747835 0.031 ENST00000509311.2
ENST00000414865.2
GOLGA8O

golgin A8 family, member O

chr12_+_69979113 0.029 ENST00000299300.6
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr17_-_295730 0.024 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr18_-_21017817 0.024 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
TMEM241





transmembrane protein 241





chr2_+_240499995 0.024 ENST00000358775.1
AC079612.1
Uncharacterized protein; cDNA FLJ45964 fis, clone PLACE7014396
chr19_-_12267524 0.023 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625



zinc finger protein 625



chr1_+_197886461 0.023 ENST00000367388.3
ENST00000337020.2
ENST00000367387.4
LHX9


LIM homeobox 9


chr1_+_55464600 0.021 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr2_-_180610767 0.020 ENST00000409343.1
ZNF385B
zinc finger protein 385B
chr12_+_8309630 0.019 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr19_-_11456935 0.019 ENST00000589655.1
ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
RAB3D
TMEM205







RAB3D, member RAS oncogene family
transmembrane protein 205







chr19_-_43099070 0.019 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr15_-_70994612 0.017 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA


uveal autoantigen with coiled-coil domains and ankyrin repeats


chr19_-_11456722 0.016 ENST00000354882.5
TMEM205
transmembrane protein 205
chr10_+_96305535 0.015 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS




helicase, lymphoid-specific




chr1_-_226374373 0.015 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr6_+_31887761 0.012 ENST00000413154.1
C2
complement component 2
chr21_-_31852663 0.012 ENST00000390689.2
KRTAP19-1
keratin associated protein 19-1
chrX_+_2670153 0.011 ENST00000509484.2
XG
Xg blood group
chr15_+_30427352 0.009 ENST00000569052.1
GOLGA8T
golgin A8 family, member T
chr12_+_69979210 0.009 ENST00000544368.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr19_+_41882466 0.007 ENST00000436170.2
TMEM91
transmembrane protein 91
chr2_+_1417228 0.006 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO







thyroid peroxidase







chr2_-_130031335 0.006 ENST00000375987.3
AC079586.1
AC079586.1
chr18_-_29340827 0.006 ENST00000269205.5
SLC25A52
solute carrier family 25, member 52
chr17_-_50236039 0.002 ENST00000451037.2
CA10
carbonic anhydrase X
chr9_-_34397800 0.001 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.3 GO:2001190 peptide antigen assembly with MHC class II protein complex(GO:0002503) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 1.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.3 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.1 0.9 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.3 GO:0035624 receptor transactivation(GO:0035624)
0.0 0.4 GO:0046449 creatinine metabolic process(GO:0046449)
0.0 0.6 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 0.2 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.0 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 2.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects