ISMARA results: GRHL1

Motif ID: GRHL1

Z-value: 0.397

Transcription factors associated with GRHL1:

Gene Symbol	Entrez ID	Gene Name
GRHL1	ENSG00000134317.13	GRHL1

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
GRHL1	hg19_v2_chr2_+_10091815_10091864	-0.78	1.4e-02	Click!

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_-_138794081	0.953	ENST00000464606.1	ZC3HAV1	zinc finger CCCH-type, antiviral 1
chr3_+_101568349	0.901	ENST00000326151.5 ENST00000326172.5	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr11_+_76493294	0.399	ENST00000533752.1	TSKU	tsukushi, small leucine rich proteoglycan
chr1_+_35247859	0.398	ENST00000373362.3	GJB3	gap junction protein, beta 3, 31kDa
chr19_-_12405689	0.244	ENST00000355684.5	ZNF44	zinc finger protein 44
chr19_-_12405606	0.242	ENST00000356109.5	ZNF44	zinc finger protein 44
chr1_-_24469602	0.226	ENST00000270800.1	IL22RA1	interleukin 22 receptor, alpha 1
chr14_-_24732738	0.186	ENST00000558074.1 ENST00000560226.1	TGM1	transglutaminase 1
chr6_-_31107127	0.169	ENST00000259845.4	PSORS1C2	psoriasis susceptibility 1 candidate 2
chr7_-_80551671	0.165	ENST00000419255.2 ENST00000544525.1	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_206643806	0.160	ENST00000537984.1	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr19_-_11849697	0.158	ENST00000586121.1 ENST00000431998.1 ENST00000341191.6 ENST00000545749.1 ENST00000440527.1	ZNF823	zinc finger protein 823
chr1_+_206643787	0.155	ENST00000367120.3	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr5_+_125759140	0.145	ENST00000543198.1	GRAMD3	GRAM domain containing 3
chr14_-_80677613	0.130	ENST00000556811.1	DIO2	deiodinase, iodothyronine, type II
chr12_+_49687425	0.125	ENST00000257860.4	PRPH	peripherin
chr8_+_144821557	0.112	ENST00000534398.1	FAM83H-AS1	FAM83H antisense RNA 1 (head to head)
chr19_+_19496728	0.109	ENST00000537887.1 ENST00000417582.2	GATAD2A	GATA zinc finger domain containing 2A
chr7_-_102283238	0.109	ENST00000340457.8	UPK3BL	uroplakin 3B-like
chr5_+_125758813	0.107	ENST00000285689.3 ENST00000515200.1	GRAMD3	GRAM domain containing 3
chr5_+_125758865	0.105	ENST00000542322.1 ENST00000544396.1	GRAMD3	GRAM domain containing 3
chr14_-_80677815	0.104	ENST00000557125.1 ENST00000555750.1	DIO2	deiodinase, iodothyronine, type II
chr9_+_130565487	0.100	ENST00000373225.3 ENST00000431857.1	FPGS	folylpolyglutamate synthase
chr2_-_85641162	0.095	ENST00000447219.2 ENST00000409670.1 ENST00000409724.1	CAPG	capping protein (actin filament), gelsolin-like
chr1_-_16539094	0.085	ENST00000270747.3	ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19
chr19_-_17356697	0.085	ENST00000291442.3	NR2F6	nuclear receptor subfamily 2, group F, member 6
chr4_-_69083720	0.079	ENST00000432593.3	TMPRSS11BNL	TMPRSS11B N-terminal like
chr5_+_134303591	0.078	ENST00000282611.6	CATSPER3	cation channel, sperm associated 3
chr5_-_132299290	0.077	ENST00000378595.3	AFF4	AF4/FMR2 family, member 4
chr6_+_32121218	0.076	ENST00000414204.1 ENST00000361568.2 ENST00000395523.1	PPT2	palmitoyl-protein thioesterase 2
chr14_+_23938891	0.074	ENST00000408901.3 ENST00000397154.3 ENST00000555128.1	NGDN	neuroguidin, EIF4E binding protein
chr9_-_77703115	0.072	ENST00000361092.4 ENST00000376808.4	NMRK1	nicotinamide riboside kinase 1
chr14_-_23540747	0.069	ENST00000555566.1 ENST00000338631.6 ENST00000557515.1 ENST00000397341.3	ACIN1	apoptotic chromatin condensation inducer 1
chr14_-_23540826	0.068	ENST00000357481.2	ACIN1	apoptotic chromatin condensation inducer 1
chr9_+_130565568	0.067	ENST00000423577.1	FPGS	folylpolyglutamate synthase
chr7_-_102184083	0.061	ENST00000379357.5	POLR2J3	polymerase (RNA) II (DNA directed) polypeptide J3
chr11_+_119038897	0.058	ENST00000454811.1 ENST00000449394.1	NLRX1	NLR family member X1
chr11_+_119039414	0.057	ENST00000409991.1 ENST00000292199.2 ENST00000409265.4 ENST00000409109.1	NLRX1	NLR family member X1
chr11_+_119039069	0.052	ENST00000422249.1	NLRX1	NLR family member X1
chr6_-_43027105	0.051	ENST00000230413.5 ENST00000487429.1 ENST00000489623.1 ENST00000468957.1	MRPL2	mitochondrial ribosomal protein L2
chr1_+_44440575	0.048	ENST00000532642.1 ENST00000236067.4 ENST00000471859.2	ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_+_20494078	0.047	ENST00000579124.1 ENST00000577588.1 ENST00000582354.1 ENST00000581819.1	RBBP8	retinoblastoma binding protein 8
chr4_+_110736659	0.046	ENST00000394631.3 ENST00000226796.6	GAR1	GAR1 ribonucleoprotein
chr1_-_36863481	0.045	ENST00000315732.2	LSM10	LSM10, U7 small nuclear RNA associated
chr9_+_104161123	0.040	ENST00000374861.3 ENST00000339664.2 ENST00000259395.4	ZNF189	zinc finger protein 189
chr19_+_12035878	0.039	ENST00000254321.5 ENST00000538752.1 ENST00000590798.1	ZNF700 ZNF763 ZNF763	zinc finger protein 700 zinc finger protein 763 Uncharacterized protein; Zinc finger protein 763
chr19_-_40596767	0.039	ENST00000599972.1 ENST00000450241.2 ENST00000595687.2	ZNF780A	zinc finger protein 780A
chr21_+_33671264	0.036	ENST00000339944.4	MRAP	melanocortin 2 receptor accessory protein
chr1_-_52520828	0.036	ENST00000610127.1	TXNDC12	thioredoxin domain containing 12 (endoplasmic reticulum)
chr10_+_81838792	0.036	ENST00000372273.3	TMEM254	transmembrane protein 254
chr4_+_26859300	0.031	ENST00000494628.2	STIM2	stromal interaction molecule 2
chr11_+_706595	0.028	ENST00000531348.1 ENST00000530636.1	EPS8L2	EPS8-like 2
chr5_-_132299313	0.026	ENST00000265343.5	AFF4	AF4/FMR2 family, member 4
chr3_-_129513259	0.022	ENST00000329333.5	TMCC1	transmembrane and coiled-coil domain family 1
chr12_+_56498312	0.020	ENST00000552766.1	PA2G4	proliferation-associated 2G4, 38kDa
chr9_+_140122018	0.019	ENST00000445101.2	RNF224	ring finger protein 224
chr18_-_35145981	0.019	ENST00000420428.2 ENST00000412753.1	CELF4	CUGBP, Elav-like family member 4
chr10_-_94301107	0.018	ENST00000436178.1	IDE	insulin-degrading enzyme
chr12_-_10959892	0.018	ENST00000240615.2	TAS2R8	taste receptor, type 2, member 8
chr18_-_35145593	0.015	ENST00000334919.5 ENST00000591282.1 ENST00000588597.1	CELF4	CUGBP, Elav-like family member 4
chr7_-_29152509	0.014	ENST00000448959.1	CPVL	carboxypeptidase, vitellogenic-like
chr2_+_113816215	0.013	ENST00000346807.3	IL36RN	interleukin 36 receptor antagonist
chr19_+_19496624	0.010	ENST00000494516.2 ENST00000360315.3 ENST00000252577.5	GATAD2A	GATA zinc finger domain containing 2A
chr3_-_172241250	0.009	ENST00000420541.2 ENST00000241261.2	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10
chr16_+_2564254	0.009	ENST00000565223.1	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_+_12035913	0.009	ENST00000591944.1	ZNF763	Uncharacterized protein; Zinc finger protein 763
chr18_-_35145689	0.008	ENST00000591287.1 ENST00000601019.1 ENST00000601392.1	CELF4	CUGBP, Elav-like family member 4
chr1_-_28384598	0.006	ENST00000373864.1	EYA3	eyes absent homolog 3 (Drosophila)
chr1_+_40723779	0.006	ENST00000372759.3	ZMPSTE24	zinc metallopeptidase STE24
chr19_-_14945933	0.004	ENST00000322301.3	OR7A5	olfactory receptor, family 7, subfamily A, member 5
chr8_+_27950619	0.004	ENST00000542181.1 ENST00000524103.1 ENST00000537665.1 ENST00000380353.4 ENST00000520288.1	ELP3	elongator acetyltransferase complex subunit 3
chr10_+_81838411	0.004	ENST00000372281.3 ENST00000372277.3 ENST00000372275.1 ENST00000372274.1	TMEM254	transmembrane protein 254
chr1_+_155023757	0.003	ENST00000356955.2 ENST00000449910.2 ENST00000359280.4 ENST00000360674.4 ENST00000368412.3 ENST00000355956.2 ENST00000368410.2 ENST00000271836.6 ENST00000368413.1 ENST00000531455.1 ENST00000447332.3	ADAM15	ADAM metallopeptidase domain 15
chr8_+_22601	0.003	ENST00000522481.3 ENST00000518652.1	AC144568.2	Uncharacterized protein
chr18_+_44497455	0.002	ENST00000592005.1	KATNAL2	katanin p60 subunit A-like 2
chr3_-_3152031	0.001	ENST00000383846.1 ENST00000427088.1 ENST00000446632.2 ENST00000438560.1	IL5RA	interleukin 5 receptor, alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.1	1.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.1	0.2	GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0	0.2	GO:0003350	pulmonary myocardium development(GO:0003350)
0.0	0.2	GO:0043163	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0	0.0	GO:0000454	snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.2	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0035188	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0	0.3	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.2	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0061574	ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042015	interleukin-20 binding(GO:0042015)
0.1	0.3	GO:0036435	IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.1	0.2	GO:0008841	tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.0	1.0	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.2	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.4	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0071209	U7 snRNA binding(GO:0071209)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	REACTOME_GAP_JUNCTION_ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.3	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway