Motif ID: GATA6

Z-value: 0.624


Transcription factors associated with GATA6:

Gene SymbolEntrez IDGene Name
GATA6 ENSG00000141448.4 GATA6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19750894_197509800.983.1e-06Click!


Activity profile for motif GATA6.

activity profile for motif GATA6


Sorted Z-values histogram for motif GATA6

Sorted Z-values for motif GATA6



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_102928009 4.378 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr2_+_102927962 3.116 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
 IL1RL1

IL18R1
interleukin 1 receptor-like 1

interleukin 18 receptor 1
chr17_+_38673270 1.117 ENST00000578280.1
 RP5-1028K7.2
RP5-1028K7.2
chr6_+_12290586 0.917 ENST00000379375.5
 EDN1
endothelin 1
chr18_+_19749386 0.676 ENST00000269216.3
 GATA6
GATA binding protein 6
chr1_-_94050668 0.599 ENST00000539242.1
 BCAR3
breast cancer anti-estrogen resistance 3
chr12_+_111843749 0.547 ENST00000341259.2
 SH2B3
SH2B adaptor protein 3
chr17_+_74381343 0.457 ENST00000392496.3
 SPHK1
sphingosine kinase 1
chr8_+_70404996 0.449 ENST00000402687.4
ENST00000419716.3
 SULF1

sulfatase 1

chr6_-_86099898 0.443 ENST00000455071.1
 RP11-30P6.6
RP11-30P6.6
chr1_-_24469602 0.383 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr17_-_62084241 0.371 ENST00000449662.2
 ICAM2
intercellular adhesion molecule 2
chr1_-_226187013 0.353 ENST00000272091.7
 SDE2
SDE2 telomere maintenance homolog (S. pombe)
chr8_+_70378852 0.349 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
 SULF1


sulfatase 1


chr11_+_10326612 0.341 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
 ADM





adrenomedullin





chr14_-_38036271 0.308 ENST00000556024.1
 RP11-356O9.2
RP11-356O9.2
chr5_-_141703713 0.294 ENST00000511815.1
 SPRY4
sprouty homolog 4 (Drosophila)
chr20_-_30795511 0.293 ENST00000246229.4
 PLAGL2
pleiomorphic adenoma gene-like 2
chr11_+_10326918 0.291 ENST00000528544.1
 ADM
adrenomedullin
chr17_-_29645836 0.276 ENST00000578584.1
 CTD-2370N5.3
CTD-2370N5.3
chr7_-_100239132 0.256 ENST00000223051.3
ENST00000431692.1
 TFR2

transferrin receptor 2

chr3_+_69812701 0.252 ENST00000472437.1
 MITF
microphthalmia-associated transcription factor
chr21_-_39870339 0.237 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
 ERG




v-ets avian erythroblastosis virus E26 oncogene homolog




chr1_+_25599018 0.221 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
 RHD




Rh blood group, D antigen




chr2_-_202298268 0.215 ENST00000440597.1
 TRAK2
trafficking protein, kinesin binding 2
chr14_+_100204027 0.215 ENST00000554479.1
ENST00000555145.1
 EML1

echinoderm microtubule associated protein like 1

chr14_-_38028689 0.174 ENST00000553425.1
 RP11-356O9.2
RP11-356O9.2
chr3_+_69812877 0.163 ENST00000457080.1
ENST00000328528.6
 MITF

microphthalmia-associated transcription factor

chrX_+_37865804 0.160 ENST00000297875.2
ENST00000357972.5
 SYTL5

synaptotagmin-like 5

chr12_+_4430371 0.158 ENST00000179259.4
 C12orf5
chromosome 12 open reading frame 5
chr8_+_70379072 0.147 ENST00000529134.1
 SULF1
sulfatase 1
chr1_-_205912577 0.137 ENST00000367135.3
ENST00000367134.2
 SLC26A9

solute carrier family 26 (anion exchanger), member 9

chr12_+_122880045 0.137 ENST00000539034.1
ENST00000535976.1
 RP11-450K4.1

RP11-450K4.1

chr20_-_60294804 0.133 ENST00000317652.1
 RP11-429E11.3
Uncharacterized protein
chr1_+_206317450 0.132 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
 CTSE


cathepsin E


chr15_+_59279851 0.124 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111


ring finger protein 111


chr22_-_20231207 0.115 ENST00000425986.1
 RTN4R
reticulon 4 receptor
chrX_-_10851762 0.106 ENST00000380785.1
ENST00000380787.1
 MID1

midline 1 (Opitz/BBB syndrome)

chr1_+_66999799 0.098 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
 SGIP1


SH3-domain GRB2-like (endophilin) interacting protein 1


chr16_+_4475806 0.092 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
 DNAJA3



DnaJ (Hsp40) homolog, subfamily A, member 3



chr10_-_21186144 0.089 ENST00000377119.1
 NEBL
nebulette
chr1_+_50574585 0.086 ENST00000371824.1
ENST00000371823.4
 ELAVL4

ELAV like neuron-specific RNA binding protein 4

chr9_-_114937543 0.086 ENST00000374264.2
ENST00000374263.3
 SUSD1

sushi domain containing 1

chr17_+_75283973 0.080 ENST00000431235.2
ENST00000449803.2
 SEPT9

septin 9

chr4_-_48683188 0.077 ENST00000505759.1
 FRYL
FRY-like
chr3_+_137717571 0.075 ENST00000343735.4
 CLDN18
claudin 18
chr11_-_66206260 0.071 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
 MRPL11


mitochondrial ribosomal protein L11


chr13_-_46716969 0.067 ENST00000435666.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_69098566 0.066 ENST00000295379.1
 BMP10
bone morphogenetic protein 10
chr9_-_114937676 0.063 ENST00000374270.3
 SUSD1
sushi domain containing 1
chr1_+_206317591 0.060 ENST00000432969.2
 CTSE
cathepsin E
chr19_+_14138960 0.060 ENST00000431365.2
ENST00000585987.1
 RLN3

relaxin 3

chr5_-_135290705 0.057 ENST00000274507.1
 LECT2
leukocyte cell-derived chemotaxin 2
chr11_-_10920838 0.050 ENST00000503469.2
 CTD-2003C8.2
CTD-2003C8.2
chr11_-_116708302 0.050 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
 APOA1



apolipoprotein A-I



chr9_-_114937465 0.049 ENST00000355396.3
 SUSD1
sushi domain containing 1
chr12_-_6233828 0.047 ENST00000572068.1
ENST00000261405.5
 VWF

von Willebrand factor

chr11_-_26743546 0.043 ENST00000280467.6
ENST00000396005.3
 SLC5A12

solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

chr8_-_38008783 0.043 ENST00000276449.4
 STAR
steroidogenic acute regulatory protein
chr9_+_125796806 0.038 ENST00000373642.1
 GPR21
G protein-coupled receptor 21
chr11_-_59612969 0.036 ENST00000541311.1
ENST00000257248.2
 GIF

gastric intrinsic factor (vitamin B synthesis)

chr8_+_21823726 0.034 ENST00000433566.4
 XPO7
exportin 7
chr2_-_40739501 0.033 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
 SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr17_+_4675175 0.033 ENST00000270560.3
 TM4SF5
transmembrane 4 L six family member 5
chr10_+_24755416 0.032 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
 KIAA1217


KIAA1217


chr1_-_27240455 0.030 ENST00000254227.3
 NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_+_88188254 0.029 ENST00000309495.5
 ZNF654
zinc finger protein 654
chr13_+_24144509 0.029 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr19_+_36132631 0.026 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
 ETV2



ets variant 2



chr14_-_21945057 0.025 ENST00000397762.1
 RAB2B
RAB2B, member RAS oncogene family
chr7_-_107880508 0.024 ENST00000425651.2
 NRCAM
neuronal cell adhesion molecule
chr16_+_333152 0.022 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
 PDIA2


protein disulfide isomerase family A, member 2


chr11_+_73357614 0.022 ENST00000536527.1
 PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chrX_+_107288197 0.021 ENST00000415430.3
 VSIG1
V-set and immunoglobulin domain containing 1
chr12_+_72332618 0.020 ENST00000333850.3
 TPH2
tryptophan hydroxylase 2
chrX_+_107288239 0.018 ENST00000217957.5
 VSIG1
V-set and immunoglobulin domain containing 1
chr20_+_43935474 0.018 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
 RBPJL


recombination signal binding protein for immunoglobulin kappa J region-like


chr19_-_51522955 0.018 ENST00000358789.3
 KLK10
kallikrein-related peptidase 10
chr2_-_44065889 0.016 ENST00000543989.1
ENST00000405322.1
 ABCG5

ATP-binding cassette, sub-family G (WHITE), member 5

chr5_+_157602404 0.014 ENST00000522975.1
 CTC-436K13.1
CTC-436K13.1
chr12_+_70219052 0.013 ENST00000552032.2
ENST00000547771.2
 MYRFL

myelin regulatory factor-like

chr1_-_167487758 0.008 ENST00000362089.5
 CD247
CD247 molecule
chr5_+_135496675 0.007 ENST00000507637.1
 SMAD5
SMAD family member 5
chr19_-_55549624 0.007 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
 GP6


glycoprotein VI (platelet)


chr16_+_53920795 0.007 ENST00000431610.2
ENST00000460382.1
 FTO

fat mass and obesity associated

chr12_+_109785708 0.006 ENST00000310903.5
 MYO1H
myosin IH
chr14_+_53173890 0.005 ENST00000445930.2
 PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr12_-_52995179 0.004 ENST00000549979.1
 KRT72
keratin 72
chr4_-_103266355 0.003 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_+_75428857 0.003 ENST00000198801.5
 MOGAT2
monoacylglycerol O-acyltransferase 2
chr6_+_130339710 0.003 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr17_+_56833184 0.002 ENST00000308249.2
 PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr14_+_53173910 0.000 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
 PSMC6


proteasome (prosome, macropain) 26S subunit, ATPase, 6



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.3 0.9 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.7 GO:0051891 negative regulation of transforming growth factor beta1 production(GO:0032911) negative regulation of transforming growth factor beta2 production(GO:0032912) positive regulation of cardioblast differentiation(GO:0051891)
0.1 0.2 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.3 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.3 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963)
0.0 0.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 7.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.9 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.5 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling