Motif ID: FOSL1
Z-value: 3.531
Transcription factors associated with FOSL1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOSL1 | ENSG00000175592.4 | FOSL1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667997_65668044 | 0.99 | 7.3e-08 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 30.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 4.9 | 14.6 | GO:2000364 | regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 3.5 | 10.6 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 3.0 | 9.1 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 2.4 | 17.1 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 1.9 | 26.1 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 1.7 | 13.9 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.6 | 9.6 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 1.5 | 3.1 | GO:2001183 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 1.5 | 4.5 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 1.4 | 8.4 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 1.4 | 5.4 | GO:0002268 | follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) |
| 1.1 | 4.5 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 1.1 | 25.7 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 1.1 | 3.3 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 1.0 | 3.1 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 0.9 | 2.8 | GO:0060721 | spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723) |
| 0.8 | 2.3 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.8 | 3.8 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.8 | 3.8 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 0.7 | 5.9 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.7 | 12.4 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.7 | 2.2 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.7 | 5.8 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.7 | 2.0 | GO:0071288 | carbon dioxide transmembrane transport(GO:0035378) cellular response to mercury ion(GO:0071288) |
| 0.7 | 2.0 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.7 | 9.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.6 | 1.8 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.6 | 2.4 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 0.6 | 1.8 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.6 | 2.3 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.5 | 2.3 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.4 | 1.3 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.4 | 1.7 | GO:0052214 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.4 | 1.2 | GO:1901340 | negative regulation of store-operated calcium channel activity(GO:1901340) |
| 0.4 | 1.6 | GO:1903281 | positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 0.4 | 1.6 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.4 | 1.9 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 0.4 | 6.3 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.4 | 2.9 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.4 | 2.2 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.4 | 0.7 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.4 | 1.4 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.3 | 3.3 | GO:0001554 | luteolysis(GO:0001554) |
| 0.3 | 2.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.3 | 0.6 | GO:1903923 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
| 0.3 | 7.1 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.3 | 3.8 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.3 | 3.1 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.3 | 1.7 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.3 | 2.8 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.3 | 3.2 | GO:0042940 | D-amino acid transport(GO:0042940) |
| 0.3 | 0.8 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.3 | 4.0 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.3 | 2.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.2 | 1.2 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.2 | 3.7 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.2 | 2.2 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.2 | 0.7 | GO:1904404 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
| 0.2 | 4.7 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.2 | 0.9 | GO:1990535 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535) |
| 0.2 | 2.6 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.2 | 1.4 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.2 | 7.0 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
| 0.2 | 4.1 | GO:0034134 | activation of NF-kappaB-inducing kinase activity(GO:0007250) toll-like receptor 2 signaling pathway(GO:0034134) |
| 0.2 | 2.1 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.2 | 3.5 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.2 | 1.0 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.2 | 5.6 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 3.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.2 | 0.7 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168) |
| 0.2 | 2.5 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.2 | 5.7 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.2 | 1.1 | GO:0032962 | regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.1 | 1.6 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.1 | 0.7 | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) |
| 0.1 | 3.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.9 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.1 | 0.9 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.1 | 1.7 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 2.7 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.1 | 0.4 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.1 | 0.6 | GO:0033123 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 0.1 | 0.9 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 3.3 | GO:0002717 | positive regulation of natural killer cell mediated immunity(GO:0002717) |
| 0.1 | 1.7 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 3.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.3 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.1 | 1.2 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 0.3 | GO:0002740 | negative regulation of cytokine secretion involved in immune response(GO:0002740) |
| 0.1 | 1.4 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 3.0 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 3.6 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.1 | 5.0 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
| 0.1 | 0.6 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 0.5 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.1 | 5.0 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.1 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 0.4 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.1 | 1.2 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 1.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 2.8 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) |
| 0.1 | 1.3 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.1 | 2.3 | GO:0032402 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 0.1 | 0.7 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 0.7 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 0.8 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.1 | 0.3 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.1 | 1.1 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 1.3 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.1 | 0.9 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 3.0 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.1 | 0.5 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 2.9 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 2.6 | GO:0044380 | protein localization to cytoskeleton(GO:0044380) |
| 0.0 | 0.5 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 4.4 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.0 | 0.3 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.0 | 1.6 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.8 | GO:0044849 | estrous cycle(GO:0044849) |
| 0.0 | 5.4 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.0 | 1.9 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.0 | 6.5 | GO:0051781 | positive regulation of cell division(GO:0051781) |
| 0.0 | 2.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.9 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.0 | 2.3 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.2 | GO:1901090 | regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094) |
| 0.0 | 2.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 0.0 | GO:0060319 | primitive erythrocyte differentiation(GO:0060319) |
| 0.0 | 1.4 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 3.4 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.3 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.0 | 2.7 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.6 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 0.1 | GO:0098972 | dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972) |
| 0.0 | 0.6 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.0 | 2.9 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 0.0 | 1.6 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.0 | 0.4 | GO:0030207 | chondroitin sulfate catabolic process(GO:0030207) |
| 0.0 | 0.7 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.0 | 1.2 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.0 | 0.1 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.0 | 0.5 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 1.2 | GO:0046464 | neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464) |
| 0.0 | 1.6 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) |
| 0.0 | 0.1 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.0 | 0.4 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 0.7 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
| 0.0 | 0.4 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 0.4 | GO:0048745 | smooth muscle tissue development(GO:0048745) |
| 0.0 | 1.2 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.8 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 0.1 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.0 | 0.6 | GO:0021983 | pituitary gland development(GO:0021983) |
| 0.0 | 0.5 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.0 | 0.0 | GO:1904729 | regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729) |
| 0.0 | 1.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.5 | GO:0048146 | positive regulation of fibroblast proliferation(GO:0048146) |
| 0.0 | 0.2 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.0 | 0.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 1.2 | GO:0006306 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 0.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 0.8 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.9 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.4 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.6 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 1.7 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 1.4 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.8 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 0.1 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.0 | 0.2 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.2 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.0 | 0.2 | GO:0030202 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.0 | 0.1 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 14.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 1.4 | 5.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 1.0 | 3.1 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.8 | 2.3 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.7 | 5.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.7 | 2.9 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.7 | 2.8 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.7 | 4.1 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.6 | 2.5 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.5 | 1.6 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.4 | 1.3 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.4 | 4.4 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.4 | 1.7 | GO:0044753 | amphisome(GO:0044753) |
| 0.4 | 2.1 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.4 | 4.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.4 | 3.8 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 1.7 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.3 | 30.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 53.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 10.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.3 | 2.0 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) extracellular membrane-bounded organelle(GO:0065010) |
| 0.3 | 2.7 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.3 | 3.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.3 | 6.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 0.7 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.2 | 1.0 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.2 | 7.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 2.9 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.2 | 2.8 | GO:0097433 | dense body(GO:0097433) |
| 0.2 | 1.7 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 4.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 3.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 0.6 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 0.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 12.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.3 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.1 | 3.1 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 24.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 0.8 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 0.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 1.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 0.7 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 0.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 2.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 2.3 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 2.8 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 1.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 1.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 1.5 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 1.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.9 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 3.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 2.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 5.7 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 1.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 4.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 2.2 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 0.4 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 1.3 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 3.3 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 0.1 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 0.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.5 | GO:0019867 | mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968) |
| 0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.2 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 30.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 6.5 | 26.1 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 3.5 | 21.1 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 2.1 | 14.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 1.7 | 17.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.5 | 4.5 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 1.5 | 14.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 1.2 | 5.8 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 1.1 | 4.5 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.8 | 3.3 | GO:0002134 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 0.8 | 2.3 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.8 | 3.8 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.7 | 2.0 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.7 | 3.3 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.6 | 3.8 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.6 | 11.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.6 | 4.1 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.5 | 2.4 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.5 | 2.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.5 | 1.9 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.5 | 2.3 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.4 | 1.3 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.4 | 1.7 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.4 | 2.9 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.4 | 2.0 | GO:0050659 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756) N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.4 | 3.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.4 | 1.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 4.7 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.3 | 2.2 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.3 | 2.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.3 | 1.2 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.3 | 7.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 8.1 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.3 | 2.5 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.3 | 3.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.3 | 2.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 0.7 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.2 | 4.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 3.2 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.2 | 4.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 9.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.9 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 5.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 1.6 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.1 | 4.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.1 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 0.8 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 1.9 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.1 | 4.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 1.4 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 1.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 2.9 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 7.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.8 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 19.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 3.1 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 1.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 3.0 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 10.0 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 2.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 33.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 1.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 5.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.9 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 4.4 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 1.1 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 2.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.0 | 0.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.4 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 0.3 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.0 | 0.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 1.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.8 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 1.0 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.4 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.6 | GO:0055103 | ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.0 | 0.2 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 1.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.1 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.0 | 2.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 0.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.2 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.0 | 0.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.0 | 0.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.4 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.5 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 4.7 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 1.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.0 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.8 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.1 | GO:0070891 | peptidoglycan receptor activity(GO:0016019) lipoteichoic acid binding(GO:0070891) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.9 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 4.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 17.2 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.3 | 22.0 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 13.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 34.9 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 24.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 5.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 7.4 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 12.1 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 3.1 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 9.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.1 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 2.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 11.9 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.2 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.4 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.1 | 5.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 2.3 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.1 | 3.0 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.2 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 1.7 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 5.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.9 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 3.3 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 2.5 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 11.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.9 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.3 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.1 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.9 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.6 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.1 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.6 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.4 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 0.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.1 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.9 | 17.2 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.5 | 8.9 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.5 | 5.0 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.4 | 3.1 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.4 | 30.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 8.5 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.3 | 5.9 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 9.1 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 3.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 8.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 2.0 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 10.1 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 2.4 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 4.0 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 4.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.9 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.1 | 2.0 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 4.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 7.1 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 5.1 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 2.0 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 3.4 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 6.1 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 2.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.2 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 8.7 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 3.7 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 1.8 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.1 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.2 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 9.5 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 2.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 2.2 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.5 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 1.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.8 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.9 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 4.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.7 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.3 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.6 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.2 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
