Motif ID: FOSB
Z-value: 0.709
Transcription factors associated with FOSB:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOSB | ENSG00000125740.9 | FOSB |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg19_v2_chr19_+_45971246_45971265 | 0.64 | 6.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.3 | 2.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 1.8 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.2 | 0.6 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.1 | 0.6 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 1.1 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 0.4 | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) |
| 0.1 | 0.3 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.1 | 1.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 0.6 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.1 | 0.7 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 0.3 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 0.1 | 0.2 | GO:0032242 | negative regulation of glutamate secretion(GO:0014050) regulation of nucleoside transport(GO:0032242) |
| 0.1 | 0.3 | GO:0052214 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.1 | 0.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.1 | 0.2 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.2 | GO:0071288 | carbon dioxide transmembrane transport(GO:0035378) cellular response to mercury ion(GO:0071288) |
| 0.1 | 0.2 | GO:1905045 | Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045) |
| 0.1 | 0.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.1 | 0.3 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.1 | 1.0 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.1 | 1.2 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.7 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.0 | 0.2 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.0 | 0.7 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.4 | GO:0003383 | apical constriction(GO:0003383) |
| 0.0 | 0.2 | GO:0032796 | uropod organization(GO:0032796) |
| 0.0 | 0.5 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.2 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.0 | 0.2 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.0 | 0.1 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.0 | 0.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.2 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 0.0 | 0.3 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.0 | 0.1 | GO:0045994 | positive regulation of translational initiation by iron(GO:0045994) |
| 0.0 | 0.2 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.0 | 0.4 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.0 | 0.2 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.0 | 0.3 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.0 | 2.3 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.2 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.2 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.0 | 0.1 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.0 | 0.4 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.1 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.0 | 0.3 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.0 | 0.2 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 0.7 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.0 | 0.1 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.0 | 0.8 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 0.0 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.1 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.1 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.0 | 0.0 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.0 | 0.0 | GO:0002740 | negative regulation of cytokine secretion involved in immune response(GO:0002740) |
| 0.0 | 0.1 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.0 | 2.7 | GO:0051781 | positive regulation of cell division(GO:0051781) |
| 0.0 | 0.2 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.0 | 0.2 | GO:0036035 | osteoclast development(GO:0036035) |
| 0.0 | 0.2 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.2 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.1 | 1.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.4 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 0.3 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.1 | 0.3 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.7 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 1.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 0.2 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 0.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 0.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.1 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.0 | 0.4 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 3.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 2.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 2.1 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.8 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.2 | 2.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 1.1 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 0.2 | 0.6 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 0.7 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.7 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 0.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 0.8 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.2 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.1 | 0.3 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 0.2 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 1.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.7 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 0.3 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.0 | 0.7 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 0.2 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.4 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.0 | 0.2 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.0 | 0.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 0.2 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.0 | 1.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.4 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.0 | 0.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.2 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.3 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.2 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.0 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.0 | 0.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.0 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.0 | 0.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.0 | 0.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.1 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 0.0 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.0 | 0.2 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 0.1 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.0 | 0.1 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 0.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 2.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 2.3 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 3.4 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.0 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.7 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.6 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.9 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.0 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.2 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.6 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.1 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.4 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
