Motif ID: FIGLA

Z-value: 1.284


Transcription factors associated with FIGLA:

Gene SymbolEntrez IDGene Name
FIGLA ENSG00000183733.6 FIGLA



Activity profile for motif FIGLA.

activity profile for motif FIGLA


Sorted Z-values histogram for motif FIGLA

Sorted Z-values for motif FIGLA



Network of associatons between targets according to the STRING database.



First level regulatory network of FIGLA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_89182178 3.033 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 2.810 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 2.764 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_-_39538550 2.055 ENST00000394001.1
KRT34
keratin 34
chr6_+_31783291 1.439 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A


heat shock 70kDa protein 1A


chr11_+_86511549 1.384 ENST00000533902.2
PRSS23
protease, serine, 23
chr17_+_48133330 1.255 ENST00000544892.1
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr6_+_31795506 1.203 ENST00000375650.3
HSPA1B
heat shock 70kDa protein 1B
chr17_+_48133459 1.202 ENST00000320031.8
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr5_-_150466692 1.171 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1


TNFAIP3 interacting protein 1


chr22_-_50970506 1.120 ENST00000428989.2
ENST00000403326.1
ODF3B

outer dense fiber of sperm tails 3B

chr3_+_105086056 1.093 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr3_+_105085734 1.083 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr5_-_150467221 1.034 ENST00000522226.1
TNIP1
TNFAIP3 interacting protein 1
chr7_-_148725733 0.978 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr1_+_55271736 0.944 ENST00000358193.3
ENST00000371273.3
C1orf177

chromosome 1 open reading frame 177

chr11_+_86511569 0.915 ENST00000441050.1
PRSS23
protease, serine, 23
chr2_-_42160486 0.902 ENST00000427054.1
AC104654.2
AC104654.2
chr16_-_74808710 0.870 ENST00000219368.3
ENST00000544337.1
FA2H

fatty acid 2-hydroxylase

chr1_-_230561475 0.842 ENST00000391860.1
PGBD5
piggyBac transposable element derived 5
chr7_-_148725544 0.809 ENST00000413966.1
PDIA4
protein disulfide isomerase family A, member 4
chr1_-_156675564 0.723 ENST00000368220.1
CRABP2
cellular retinoic acid binding protein 2
chr1_+_110754094 0.701 ENST00000369787.3
ENST00000413138.3
ENST00000438661.2
KCNC4


potassium voltage-gated channel, Shaw-related subfamily, member 4


chr8_-_145018905 0.689 ENST00000398774.2
PLEC
plectin
chr1_-_156675535 0.662 ENST00000368221.1
CRABP2
cellular retinoic acid binding protein 2
chr1_-_11120057 0.660 ENST00000376957.2
SRM
spermidine synthase
chr13_-_41635512 0.655 ENST00000405737.2
ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_+_30006615 0.632 ENST00000563197.1
INO80E
INO80 complex subunit E
chr6_+_18387570 0.624 ENST00000259939.3
RNF144B
ring finger protein 144B
chr19_-_56109119 0.612 ENST00000587678.1
FIZ1
FLT3-interacting zinc finger 1
chr7_+_2687173 0.609 ENST00000403167.1
TTYH3
tweety family member 3
chr3_-_49851313 0.609 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr16_+_30006997 0.592 ENST00000304516.7
INO80E
INO80 complex subunit E
chr6_-_39197226 0.585 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr7_+_20370746 0.584 ENST00000222573.4
ITGB8
integrin, beta 8
chr19_+_14017003 0.570 ENST00000318003.7
CC2D1A
coiled-coil and C2 domain containing 1A
chr1_-_156675368 0.569 ENST00000368222.3
CRABP2
cellular retinoic acid binding protein 2
chr1_-_150669604 0.555 ENST00000427665.1
ENST00000540514.1
GOLPH3L

golgi phosphoprotein 3-like

chr2_+_241375069 0.554 ENST00000264039.2
GPC1
glypican 1
chr2_-_75788038 0.545 ENST00000393913.3
ENST00000410113.1
EVA1A

eva-1 homolog A (C. elegans)

chr19_+_14017116 0.544 ENST00000589606.1
CC2D1A
coiled-coil and C2 domain containing 1A
chr17_-_79805146 0.542 ENST00000415593.1
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_+_76164639 0.529 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
SYNGR2




synaptogyrin 2




chr12_+_122150646 0.524 ENST00000449592.2
TMEM120B
transmembrane protein 120B
chr6_-_42016385 0.520 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3





cyclin D3





chr18_+_77439775 0.506 ENST00000299543.7
ENST00000075430.7
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr16_-_30006922 0.489 ENST00000564026.1
HIRIP3
HIRA interacting protein 3
chr15_-_34628951 0.469 ENST00000397707.2
ENST00000560611.1
SLC12A6

solute carrier family 12 (potassium/chloride transporter), member 6

chr3_-_69435224 0.466 ENST00000398540.3
FRMD4B
FERM domain containing 4B
chr1_-_153585539 0.457 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chr19_+_35739631 0.449 ENST00000602003.1
ENST00000360798.3
ENST00000354900.3
LSR


lipolysis stimulated lipoprotein receptor


chr17_+_76165213 0.440 ENST00000590201.1
SYNGR2
synaptogyrin 2
chr16_-_2162831 0.430 ENST00000483024.1
PKD1
polycystic kidney disease 1 (autosomal dominant)
chr5_+_34656529 0.430 ENST00000513974.1
ENST00000512629.1
RAI14

retinoic acid induced 14

chr12_+_79258547 0.422 ENST00000457153.2
SYT1
synaptotagmin I
chr9_+_140172200 0.418 ENST00000357503.2
TOR4A
torsin family 4, member A
chr4_+_6271558 0.412 ENST00000503569.1
ENST00000226760.1
WFS1

Wolfram syndrome 1 (wolframin)

chr6_-_33281979 0.411 ENST00000426633.2
ENST00000467025.1
TAPBP

TAP binding protein (tapasin)

chr12_-_52585765 0.407 ENST00000313234.5
ENST00000394815.2
KRT80

keratin 80

chr2_+_228029281 0.404 ENST00000396578.3
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr19_-_42721819 0.402 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2



death effector domain containing 2



chr2_+_137523086 0.392 ENST00000409968.1
THSD7B
thrombospondin, type I, domain containing 7B
chr13_+_76362974 0.392 ENST00000497947.2
LMO7
LIM domain 7
chr12_+_79258444 0.382 ENST00000261205.4
SYT1
synaptotagmin I
chr11_+_120110863 0.375 ENST00000543440.2
POU2F3
POU class 2 homeobox 3
chr17_-_4458616 0.375 ENST00000381556.2
MYBBP1A
MYB binding protein (P160) 1a
chr19_-_46272106 0.372 ENST00000560168.1
SIX5
SIX homeobox 5
chr19_+_35739597 0.369 ENST00000361790.3
LSR
lipolysis stimulated lipoprotein receptor
chr22_+_31090793 0.366 ENST00000332585.6
ENST00000382310.3
ENST00000446658.2
OSBP2


oxysterol binding protein 2


chr6_+_34204642 0.359 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr21_-_39870339 0.358 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG




v-ets avian erythroblastosis virus E26 oncogene homolog




chr9_-_22009241 0.351 ENST00000380142.4
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr17_+_73521763 0.350 ENST00000167462.5
ENST00000375227.4
ENST00000392550.3
ENST00000578363.1
ENST00000579392.1
LLGL2




lethal giant larvae homolog 2 (Drosophila)




chr5_+_56471592 0.349 ENST00000511209.1
GPBP1
GC-rich promoter binding protein 1
chr19_+_35739280 0.347 ENST00000602122.1
LSR
lipolysis stimulated lipoprotein receptor
chr12_-_49523896 0.346 ENST00000549870.1
TUBA1B
tubulin, alpha 1b
chr12_+_56325812 0.344 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
DGKA





diacylglycerol kinase, alpha 80kDa





chr5_-_141257954 0.340 ENST00000456271.1
ENST00000394536.3
ENST00000503492.1
ENST00000287008.3
PCDH1



protocadherin 1



chr16_-_69418649 0.332 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr17_+_27895609 0.332 ENST00000581411.2
ENST00000301057.7
TP53I13

tumor protein p53 inducible protein 13

chr16_-_2314222 0.330 ENST00000566397.1
RNPS1
RNA binding protein S1, serine-rich domain
chr14_-_55369525 0.329 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GCH1



GTP cyclohydrolase 1



chr6_-_42110342 0.328 ENST00000356542.5
C6orf132
chromosome 6 open reading frame 132
chr11_-_119991589 0.325 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr11_-_62689046 0.318 ENST00000306960.3
ENST00000543973.1
CHRM1

cholinergic receptor, muscarinic 1

chr15_-_75165651 0.315 ENST00000562363.1
ENST00000564529.1
ENST00000268099.9
SCAMP2


secretory carrier membrane protein 2


chr5_+_34656450 0.313 ENST00000514527.1
RAI14
retinoic acid induced 14
chr19_+_39881951 0.312 ENST00000315588.5
ENST00000594368.1
ENST00000599213.2
ENST00000596297.1
MED29



mediator complex subunit 29



chr9_-_35619539 0.312 ENST00000396757.1
CD72
CD72 molecule
chr12_-_56326402 0.310 ENST00000547925.1
WIBG
within bgcn homolog (Drosophila)
chr3_-_49967292 0.310 ENST00000455683.2
MON1A
MON1 secretory trafficking family member A
chr1_+_100316041 0.308 ENST00000370165.3
ENST00000370163.3
ENST00000294724.4
AGL


amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase


chr11_-_111749878 0.306 ENST00000260257.4
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr3_-_194991876 0.305 ENST00000310380.6
XXYLT1
xyloside xylosyltransferase 1
chr2_-_225811747 0.304 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr7_+_12727250 0.302 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr17_+_74732889 0.302 ENST00000591864.1
MFSD11
major facilitator superfamily domain containing 11
chr5_-_137071756 0.301 ENST00000394937.3
ENST00000309755.4
KLHL3

kelch-like family member 3

chr4_-_103749205 0.295 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_-_118972575 0.294 ENST00000432443.2
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr9_-_134406565 0.290 ENST00000372210.3
ENST00000372211.3
UCK1

uridine-cytidine kinase 1

chr19_+_36249044 0.285 ENST00000444637.2
ENST00000396908.4
ENST00000544099.1
C19orf55


chromosome 19 open reading frame 55


chr7_+_6629621 0.280 ENST00000344417.5
C7orf26
chromosome 7 open reading frame 26
chr6_+_7107830 0.280 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr9_+_133710453 0.278 ENST00000318560.5
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr15_+_90728145 0.275 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr8_-_121824374 0.269 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr1_-_42384343 0.269 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr6_+_41888926 0.269 ENST00000230340.4
BYSL
bystin-like
chr20_-_36152914 0.267 ENST00000397131.1
BLCAP
bladder cancer associated protein
chr5_-_159739532 0.265 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
CCNJL


cyclin J-like


chr19_+_35739782 0.264 ENST00000347609.4
LSR
lipolysis stimulated lipoprotein receptor
chr1_+_66258846 0.263 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_+_12726623 0.262 ENST00000439721.1
ARL4A
ADP-ribosylation factor-like 4A
chr1_-_2461684 0.261 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr2_+_42104692 0.258 ENST00000398796.2
ENST00000442214.1
AC104654.1

AC104654.1

chr1_-_150669500 0.255 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr17_+_7462103 0.254 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chrX_-_153714917 0.246 ENST00000369653.4
UBL4A
ubiquitin-like 4A
chr3_+_111393501 0.246 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_+_100315613 0.245 ENST00000361915.3
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr19_-_10230562 0.244 ENST00000587146.1
ENST00000588709.1
ENST00000253108.4
EIF3G


eukaryotic translation initiation factor 3, subunit G


chr16_-_57513657 0.243 ENST00000566936.1
ENST00000568617.1
ENST00000567276.1
ENST00000569548.1
ENST00000569250.1
ENST00000564378.1
DOK4





docking protein 4





chr10_+_24755416 0.242 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217


KIAA1217


chr10_-_33625154 0.235 ENST00000265371.4
NRP1
neuropilin 1
chr5_+_34656569 0.234 ENST00000428746.2
RAI14
retinoic acid induced 14
chr16_+_83932684 0.234 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr14_-_50999373 0.233 ENST00000554273.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr7_-_92855762 0.233 ENST00000453812.2
ENST00000394468.2
HEPACAM2

HEPACAM family member 2

chr12_+_56324933 0.229 ENST00000549629.1
ENST00000555218.1
DGKA

diacylglycerol kinase, alpha 80kDa

chr19_-_18391708 0.225 ENST00000600972.1
JUND
jun D proto-oncogene
chr12_+_56324756 0.220 ENST00000331886.5
ENST00000555090.1
DGKA

diacylglycerol kinase, alpha 80kDa

chr19_-_18632861 0.218 ENST00000262809.4
ELL
elongation factor RNA polymerase II
chr7_-_97881429 0.217 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1




tectonin beta-propeller repeat containing 1




chr17_+_7461849 0.215 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_-_50360165 0.214 ENST00000428028.1
HYAL2
hyaluronoglucosaminidase 2
chr8_-_103668114 0.211 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr21_-_36260980 0.211 ENST00000344691.4
ENST00000358356.5
RUNX1

runt-related transcription factor 1

chr8_+_145438870 0.211 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr1_+_10509971 0.211 ENST00000320498.4
CORT
cortistatin
chr6_+_96463840 0.209 ENST00000302103.5
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr6_+_7107999 0.209 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1


ras responsive element binding protein 1


chr7_-_99698338 0.206 ENST00000354230.3
ENST00000425308.1
MCM7

minichromosome maintenance complex component 7

chr6_+_7108210 0.204 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1


ras responsive element binding protein 1


chr7_-_84816122 0.203 ENST00000444867.1
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr5_-_140053152 0.201 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1
chr17_+_40985407 0.197 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
PSME3








proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)








chr11_+_111749942 0.197 ENST00000260276.3
C11orf1
chromosome 11 open reading frame 1
chr19_-_56056888 0.195 ENST00000592464.1
ENST00000420723.3
SBK3

SH3 domain binding kinase family, member 3

chr12_-_80084333 0.193 ENST00000552637.1
PAWR
PRKC, apoptosis, WT1, regulator
chr2_+_121493717 0.191 ENST00000418323.1
GLI2
GLI family zinc finger 2
chr9_-_139258159 0.191 ENST00000371739.3
DNLZ
DNL-type zinc finger
chr16_-_69418553 0.190 ENST00000569542.2
TERF2
telomeric repeat binding factor 2
chr5_+_150406527 0.188 ENST00000520059.1
GPX3
glutathione peroxidase 3 (plasma)
chr7_-_2883928 0.186 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr1_-_111991850 0.185 ENST00000411751.2
WDR77
WD repeat domain 77
chr16_-_69419473 0.184 ENST00000566750.1
TERF2
telomeric repeat binding factor 2
chr2_-_43823093 0.182 ENST00000405006.4
THADA
thyroid adenoma associated
chr11_+_22646739 0.180 ENST00000428556.2
AC103801.2
AC103801.2
chr2_+_220299547 0.179 ENST00000312358.7
SPEG
SPEG complex locus
chr3_-_128207349 0.176 ENST00000487848.1
GATA2
GATA binding protein 2
chr5_-_159739483 0.175 ENST00000519673.1
ENST00000541762.1
CCNJL

cyclin J-like

chr11_-_122931881 0.174 ENST00000526110.1
ENST00000227378.3
HSPA8

heat shock 70kDa protein 8

chr12_-_53242770 0.173 ENST00000304620.4
ENST00000547110.1
KRT78

keratin 78

chr3_+_111393659 0.170 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_-_43823119 0.170 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
THADA



thyroid adenoma associated



chr16_-_103572 0.168 ENST00000293860.5
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr1_+_155146318 0.166 ENST00000368385.4
ENST00000545012.1
ENST00000392451.2
ENST00000368383.3
ENST00000368382.1
ENST00000334634.4
TRIM46





tripartite motif containing 46





chr16_-_12009735 0.164 ENST00000439887.2
ENST00000434724.2
GSPT1

G1 to S phase transition 1

chr4_-_103749179 0.163 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_-_65629497 0.162 ENST00000532134.1
CFL1
cofilin 1 (non-muscle)
chr19_+_18794470 0.159 ENST00000321949.8
ENST00000338797.6
CRTC1

CREB regulated transcription coactivator 1

chr12_-_13248598 0.158 ENST00000337630.6
ENST00000545699.1
GSG1

germ cell associated 1

chr19_-_42916499 0.158 ENST00000601189.1
ENST00000599211.1
LIPE

lipase, hormone-sensitive

chr19_-_10230540 0.157 ENST00000589454.1
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr19_-_39881777 0.157 ENST00000595564.1
ENST00000221265.3
PAF1

Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

chr3_-_50360192 0.156 ENST00000442581.1
ENST00000447092.1
ENST00000357750.4
HYAL2


hyaluronoglucosaminidase 2


chr16_-_12009833 0.156 ENST00000420576.2
GSPT1
G1 to S phase transition 1
chr7_+_93535817 0.156 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_+_52450298 0.151 ENST00000550582.2
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr7_-_149194756 0.146 ENST00000461958.2
ZNF746
zinc finger protein 746
chr4_-_139163491 0.145 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr17_-_48133054 0.145 ENST00000499842.1
RP11-1094H24.4
RP11-1094H24.4
chr7_-_44122063 0.145 ENST00000335195.6
ENST00000395831.3
ENST00000414235.1
ENST00000452049.1
ENST00000242248.5
POLM




polymerase (DNA directed), mu




chr13_-_28194541 0.144 ENST00000316334.3
LNX2
ligand of numb-protein X 2
chr2_-_136288740 0.143 ENST00000264159.6
ENST00000536680.1
ZRANB3

zinc finger, RAN-binding domain containing 3

chr4_+_108815402 0.141 ENST00000503385.1
SGMS2
sphingomyelin synthase 2
chr8_-_99837856 0.139 ENST00000518165.1
ENST00000419617.2
STK3

serine/threonine kinase 3

chr2_-_50574856 0.134 ENST00000342183.5
NRXN1
neurexin 1
chr8_+_98881268 0.131 ENST00000254898.5
ENST00000524308.1
ENST00000522025.2
MATN2


matrilin 2


chr17_+_7462031 0.130 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr20_+_44044717 0.129 ENST00000279036.6
ENST00000279035.9
ENST00000372689.5
ENST00000545755.1
ENST00000341555.5
ENST00000535404.1
ENST00000543458.2
ENST00000432270.1
PIGT







phosphatidylinositol glycan anchor biosynthesis, class T







chr10_-_30637906 0.128 ENST00000417581.1
MTPAP
mitochondrial poly(A) polymerase
chr3_-_50374869 0.128 ENST00000327761.3
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr7_-_11871815 0.125 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr1_-_39339777 0.124 ENST00000397572.2
MYCBP
MYC binding protein
chr5_+_34656331 0.123 ENST00000265109.3
RAI14
retinoic acid induced 14
chrX_-_153714994 0.121 ENST00000369660.4
UBL4A
ubiquitin-like 4A
chr19_+_36249057 0.120 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55



chromosome 19 open reading frame 55



chr1_-_111991908 0.120 ENST00000235090.5
WDR77
WD repeat domain 77

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.7 2.6 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.4 2.2 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2 1.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 0.7 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.2 0.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.4 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.1 0.8 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 2.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.1 0.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.3 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.1 0.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 0.5 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.4 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 0.3 GO:1990051 activation of protein kinase C activity(GO:1990051)
0.1 0.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.1 0.3 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 2.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 0.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.3 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.1 0.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.9 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.2 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 2.4 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 0.3 GO:0036292 DNA rewinding(GO:0036292)
0.1 0.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.4 GO:0070295 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
0.1 0.3 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.5 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.2 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.6 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0019085 early viral transcription(GO:0019085)
0.0 0.2 GO:0036115 fatty-acyl-CoA catabolic process(GO:0036115)
0.0 0.2 GO:0006601 creatine biosynthetic process(GO:0006601)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) saliva secretion(GO:0046541)
0.0 0.2 GO:2000977 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854) regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 0.2 GO:0034486 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.4 GO:0006983 ER overload response(GO:0006983)
0.0 0.9 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.4 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.3 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.6 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 2.4 GO:0070268 cornification(GO:0070268)
0.0 0.4 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 1.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.0 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0035995 skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995)
0.0 0.2 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.0 0.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.1 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.2 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.2 GO:0060149 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.2 0.6 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 1.4 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.3 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.8 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 8.7 GO:0015030 Cajal body(GO:0015030)
0.1 2.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.4 GO:0002133 polycystin complex(GO:0002133)
0.1 0.4 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.6 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.0 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 2.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.7 GO:0004766 spermidine synthase activity(GO:0004766)
0.2 0.6 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 2.0 GO:0019841 retinol binding(GO:0019841)
0.1 2.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 2.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.2 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.1 0.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 2.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.5 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.3 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.5 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.0 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 2.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA