Motif ID: DMC1

Z-value: 0.309


Transcription factors associated with DMC1:

Gene SymbolEntrez IDGene Name
DMC1 ENSG00000100206.5 DMC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966123_38966163-0.324.0e-01Click!


Activity profile for motif DMC1.

activity profile for motif DMC1


Sorted Z-values histogram for motif DMC1

Sorted Z-values for motif DMC1



Network of associatons between targets according to the STRING database.



First level regulatory network of DMC1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_8803128 0.560 ENST00000543467.1
 MFAP5
microfibrillar associated protein 5
chr14_-_47351391 0.314 ENST00000399222.3
 MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr17_+_57297807 0.186 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
 GDPD1


glycerophosphodiester phosphodiesterase domain containing 1


chr3_+_9944492 0.139 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
 IL17RE


interleukin 17 receptor E


chr14_+_74318513 0.137 ENST00000555228.1
ENST00000555661.1
 PTGR2

prostaglandin reductase 2

chr14_+_74318611 0.133 ENST00000555976.1
ENST00000267568.4
 PTGR2

prostaglandin reductase 2

chr2_-_190044480 0.121 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr19_+_1041212 0.118 ENST00000433129.1
 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr3_+_9944303 0.116 ENST00000421412.1
ENST00000295980.3
 IL17RE

interleukin 17 receptor E

chr10_+_74870206 0.109 ENST00000357321.4
ENST00000349051.5
 NUDT13

nudix (nucleoside diphosphate linked moiety X)-type motif 13

chr2_+_120187465 0.104 ENST00000409826.1
ENST00000417645.1
 TMEM37

transmembrane protein 37

chr10_+_74870253 0.092 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13


nudix (nucleoside diphosphate linked moiety X)-type motif 13


chr2_-_61244550 0.086 ENST00000421319.1
 PUS10
pseudouridylate synthase 10
chr19_-_3600549 0.086 ENST00000589966.1
 TBXA2R
thromboxane A2 receptor
chr16_-_30122717 0.083 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_+_48667898 0.077 ENST00000281394.4
ENST00000294952.8
 PPP1R21

protein phosphatase 1, regulatory subunit 21

chr12_-_9268707 0.076 ENST00000318602.7
 A2M
alpha-2-macroglobulin
chr21_-_35281399 0.072 ENST00000418933.1
 ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr10_-_135187193 0.072 ENST00000368547.3
 ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr1_-_47131521 0.069 ENST00000542495.1
ENST00000532925.1
 ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

chr12_-_109025849 0.068 ENST00000228463.6
 SELPLG
selectin P ligand
chr3_-_141747459 0.068 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chr1_-_866445 0.068 ENST00000598827.1
 AL645608.1
Uncharacterized protein
chr2_-_85641162 0.067 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG


capping protein (actin filament), gelsolin-like


chr8_+_67104940 0.067 ENST00000517689.1
 LINC00967
long intergenic non-protein coding RNA 967
chr2_+_61244697 0.062 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
 PEX13


peroxisomal biogenesis factor 13


chr3_-_141747950 0.060 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_+_48667983 0.058 ENST00000449090.2
 PPP1R21
protein phosphatase 1, regulatory subunit 21
chr1_-_11863571 0.056 ENST00000376583.3
 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_71846764 0.051 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
 FOLR3


folate receptor 3 (gamma)


chr19_+_1041187 0.051 ENST00000531467.1
 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr10_-_104597286 0.047 ENST00000369887.3
 CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr18_+_11857439 0.041 ENST00000602628.1
 GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr12_-_71031185 0.040 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
 PTPRB


protein tyrosine phosphatase, receptor type, B


chr14_-_21491477 0.039 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
 NDRG2


NDRG family member 2


chr19_+_11466062 0.037 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
 DKFZP761J1410


Lipid phosphate phosphatase-related protein type 2


chr6_+_46661575 0.034 ENST00000450697.1
 TDRD6
tudor domain containing 6
chr15_-_44969022 0.034 ENST00000560110.1
 PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr1_+_12290121 0.032 ENST00000358136.3
ENST00000356315.4
 VPS13D

vacuolar protein sorting 13 homolog D (S. cerevisiae)

chr16_-_85969774 0.031 ENST00000598933.1
 RP11-542M13.3
RP11-542M13.3
chr1_+_1222489 0.027 ENST00000379099.3
 SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chrX_-_134305322 0.025 ENST00000276241.6
ENST00000344129.2
 CXorf48

cancer/testis antigen 55

chr10_-_74856608 0.025 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chrX_+_65382381 0.023 ENST00000519389.1
 HEPH
hephaestin
chr10_+_17851362 0.022 ENST00000331429.2
ENST00000457317.1
 MRC1L1

cDNA FLJ56855, highly similar to Macrophage mannose receptor 1

chr3_+_101546827 0.020 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
 NFKBIZ


nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta


chr6_+_80129989 0.019 ENST00000429444.1
 RP1-232L24.3
RP1-232L24.3
chr14_-_36536396 0.019 ENST00000546376.1
 RP11-116N8.4
RP11-116N8.4
chr11_-_73720276 0.018 ENST00000348534.4
 UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_-_62332357 0.017 ENST00000503366.1
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_+_65382433 0.016 ENST00000374727.3
 HEPH
hephaestin
chr19_-_42947121 0.016 ENST00000601181.1
 CXCL17
chemokine (C-X-C motif) ligand 17
chr9_-_34729457 0.015 ENST00000378788.3
 FAM205A
family with sequence similarity 205, member A
chr12_-_71031220 0.014 ENST00000334414.6
 PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_71846748 0.013 ENST00000445078.2
 FOLR3
folate receptor 3 (gamma)
chr4_+_106473768 0.011 ENST00000265154.2
ENST00000420470.2
 ARHGEF38

Rho guanine nucleotide exchange factor (GEF) 38

chr14_+_21492331 0.009 ENST00000533984.1
ENST00000532213.2
 AL161668.5

AL161668.5

chr1_+_18958008 0.009 ENST00000420770.2
ENST00000400661.3
 PAX7

paired box 7

chr3_-_156840776 0.008 ENST00000471357.1
 LINC00880
long intergenic non-protein coding RNA 880
chr19_+_44617511 0.007 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
 ZNF225


zinc finger protein 225


chr3_-_99569821 0.007 ENST00000487087.1
 FILIP1L
filamin A interacting protein 1-like
chr14_-_21492113 0.007 ENST00000554094.1
 NDRG2
NDRG family member 2
chr3_-_119276575 0.006 ENST00000383669.3
ENST00000383668.3
 CD80

CD80 molecule

chr7_+_107332334 0.006 ENST00000541474.1
ENST00000544569.1
 SLC26A4

solute carrier family 26 (anion exchanger), member 4

chr11_-_73720122 0.005 ENST00000426995.2
 UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr2_-_75426826 0.005 ENST00000305249.5
 TACR1
tachykinin receptor 1
chr2_+_233497931 0.005 ENST00000264059.3
 EFHD1
EF-hand domain family, member D1
chr2_-_61244308 0.005 ENST00000407787.1
ENST00000398658.2
 PUS10

pseudouridylate synthase 10

chrX_-_49965663 0.004 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
 AKAP4


A kinase (PRKA) anchor protein 4


chr1_-_9714644 0.004 ENST00000377320.3
 C1orf200
chromosome 1 open reading frame 200
chr17_-_60142609 0.004 ENST00000397786.2
 MED13
mediator complex subunit 13
chr2_-_31637560 0.003 ENST00000379416.3
 XDH
xanthine dehydrogenase
chr6_+_88054530 0.003 ENST00000388923.4
 C6orf163
chromosome 6 open reading frame 163
chr17_+_77019030 0.003 ENST00000580454.1
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_-_98031310 0.002 ENST00000427367.2
ENST00000413476.2
 BLNK

B-cell linker

chr6_-_31670723 0.001 ENST00000440843.2
ENST00000375842.4
 ABHD16A

abhydrolase domain containing 16A

chr6_+_26383318 0.001 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
 BTN2A2








butyrophilin, subfamily 2, member A2








chr18_-_5396271 0.001 ENST00000579951.1
 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_-_21022818 0.001 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
 C2orf43









chromosome 2 open reading frame 43









chrX_-_49965009 0.001 ENST00000437370.1
ENST00000376064.3
ENST00000448865.1
 AKAP4


A kinase (PRKA) anchor protein 4


chr14_-_21492251 0.000 ENST00000554398.1
 NDRG2
NDRG family member 2
chr11_+_71238313 0.000 ENST00000398536.4
 KRTAP5-7
keratin associated protein 5-7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1901076 positive regulation of engulfment of apoptotic cell(GO:1901076)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.1 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.6 GO:0060216 definitive hemopoiesis(GO:0060216)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.3 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0019959 interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)