• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: BRCA1

Z-value: 0.612

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_+_196522032	1.064	ENST00000418005.1	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr10_-_69597810	0.820	ENST00000483798.2	DNAJC12	DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_-_69597828	0.743	ENST00000339758.7	DNAJC12	DnaJ (Hsp40) homolog, subfamily C, member 12
chr2_+_196521458	0.690	ENST00000409086.3	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr17_-_41738931	0.658	ENST00000329168.3 ENST00000549132.1	MEOX1	mesenchyme homeobox 1
chr20_+_52105495	0.639	ENST00000439873.2	AL354993.1	Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr17_-_41739283	0.628	ENST00000393661.2 ENST00000318579.4	MEOX1	mesenchyme homeobox 1
chr13_+_30002846	0.578	ENST00000542829.1	MTUS2	microtubule associated tumor suppressor candidate 2
chr13_+_30002741	0.572	ENST00000380808.2	MTUS2	microtubule associated tumor suppressor candidate 2
chr2_+_196521845	0.479	ENST00000359634.5 ENST00000412905.1	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr20_+_31749574	0.475	ENST00000253362.2	BPIFA2	BPI fold containing family A, member 2
chr2_+_196521903	0.432	ENST00000541054.1	SLC39A10	solute carrier family 39 (zinc transporter), member 10
chr5_-_68665084	0.339	ENST00000509462.1	TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr10_-_61900762	0.327	ENST00000355288.2	ANK3	ankyrin 3, node of Ranvier (ankyrin G)
chr8_-_116681221	0.291	ENST00000395715.3	TRPS1	trichorhinophalangeal syndrome I
chr2_-_152118276	0.286	ENST00000409092.1	RBM43	RNA binding motif protein 43
chr5_-_68665469	0.274	ENST00000217893.5	TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr13_+_27825706	0.263	ENST00000272274.4 ENST00000319826.4 ENST00000326092.4	RPL21	ribosomal protein L21
chr6_+_42981922	0.257	ENST00000326974.4 ENST00000244670.8	KLHDC3	kelch domain containing 3
chr5_-_68664989	0.243	ENST00000508954.1	TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr1_-_170043709	0.242	ENST00000367767.1 ENST00000361580.2 ENST00000538366.1	KIFAP3	kinesin-associated protein 3
chr3_-_176914238	0.229	ENST00000430069.1 ENST00000428970.1	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1
chr17_-_27230035	0.229	ENST00000378895.4 ENST00000394901.3	DHRS13	dehydrogenase/reductase (SDR family) member 13
chr10_+_122610853	0.228	ENST00000604585.1	WDR11	WD repeat domain 11
chr12_+_510795	0.227	ENST00000412006.2	CCDC77	coiled-coil domain containing 77
chr13_+_27825446	0.221	ENST00000311549.6	RPL21	ribosomal protein L21
chr12_+_510742	0.214	ENST00000239830.4	CCDC77	coiled-coil domain containing 77
chr10_-_102289611	0.214	ENST00000535773.1 ENST00000299166.4 ENST00000370320.4 ENST00000531258.1 ENST00000370322.1	SEC31B NDUFB8	SEC31 homolog B (S. cerevisiae) NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
chr10_+_122610687	0.212	ENST00000263461.6	WDR11	WD repeat domain 11
chr5_+_139027877	0.200	ENST00000302517.3	CXXC5	CXXC finger protein 5
chr1_+_10271674	0.187	ENST00000377086.1	KIF1B	kinesin family member 1B
chr6_+_33172407	0.180	ENST00000374662.3	HSD17B8	hydroxysteroid (17-beta) dehydrogenase 8
chr11_-_119234876	0.168	ENST00000525735.1	USP2	ubiquitin specific peptidase 2
chr7_+_99717230	0.164	ENST00000262932.3	CNPY4	canopy FGF signaling regulator 4
chr6_-_66417107	0.163	ENST00000370621.3 ENST00000370618.3 ENST00000503581.1 ENST00000393380.2	EYS	eyes shut homolog (Drosophila)
chr2_+_61404624	0.151	ENST00000394457.3	AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr8_+_22022653	0.141	ENST00000354870.5 ENST00000397816.3 ENST00000306349.8	BMP1	bone morphogenetic protein 1
chr3_+_187461442	0.140	ENST00000450760.1	RP11-211G3.2	RP11-211G3.2
chr8_+_22022800	0.134	ENST00000397814.3	BMP1	bone morphogenetic protein 1
chr2_+_203879568	0.133	ENST00000449802.1	NBEAL1	neurobeachin-like 1
chr6_-_170862322	0.129	ENST00000262193.6	PSMB1	proteasome (prosome, macropain) subunit, beta type, 1
chr9_+_35792151	0.124	ENST00000342694.2	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr14_+_32030582	0.109	ENST00000550649.1 ENST00000281081.7	NUBPL	nucleotide binding protein-like
chr6_+_16129308	0.105	ENST00000356840.3 ENST00000349606.4	MYLIP	myosin regulatory light chain interacting protein
chr19_+_46000479	0.105	ENST00000456399.2	PPM1N	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr17_+_21730180	0.104	ENST00000584398.1	UBBP4	ubiquitin B pseudogene 4
chr4_+_619386	0.092	ENST00000496514.1	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta
chr6_-_137314371	0.089	ENST00000432330.1 ENST00000418699.1	RP11-55K22.5	RP11-55K22.5
chr1_-_115301235	0.089	ENST00000525878.1	CSDE1	cold shock domain containing E1, RNA-binding
chr4_-_140005443	0.083	ENST00000510408.1 ENST00000420916.2 ENST00000358635.3	ELF2	E74-like factor 2 (ets domain transcription factor)
chr3_+_184056614	0.082	ENST00000453072.1	FAM131A	family with sequence similarity 131, member A
chr4_+_619347	0.079	ENST00000255622.6	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta
chr19_-_37663572	0.076	ENST00000588354.1 ENST00000292841.5 ENST00000355533.2 ENST00000356958.4	ZNF585A	zinc finger protein 585A
chr1_+_70687137	0.075	ENST00000436161.2	SRSF11	serine/arginine-rich splicing factor 11
chr1_+_70687079	0.075	ENST00000395136.2	SRSF11	serine/arginine-rich splicing factor 11
chr5_-_68665296	0.069	ENST00000512152.1 ENST00000503245.1 ENST00000512561.1 ENST00000380822.4	TAF9	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr4_+_185570767	0.064	ENST00000314970.6 ENST00000515774.1 ENST00000503752.1	PRIMPOL	primase and polymerase (DNA-directed)
chr1_-_160232291	0.062	ENST00000368074.1 ENST00000447377.1	DCAF8	DDB1 and CUL4 associated factor 8
chr14_+_103058948	0.060	ENST00000262241.6	RCOR1	REST corepressor 1
chr8_-_72459885	0.046	ENST00000523987.1	RP11-1102P16.1	Uncharacterized protein
chr7_-_23510086	0.044	ENST00000258729.3	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chrX_+_150565038	0.043	ENST00000370361.1	VMA21	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr9_-_124976154	0.043	ENST00000482062.1	LHX6	LIM homeobox 6
chr13_-_31038370	0.042	ENST00000399489.1 ENST00000339872.4	HMGB1	high mobility group box 1
chr1_-_160232197	0.042	ENST00000419626.1 ENST00000610139.1 ENST00000475733.1 ENST00000407642.2 ENST00000368073.3 ENST00000326837.2	DCAF8	DDB1 and CUL4 associated factor 8
chrX_-_70288234	0.039	ENST00000276105.3 ENST00000374274.3	SNX12	sorting nexin 12
chr12_-_117319236	0.039	ENST00000257572.5	HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)
chr11_+_117947782	0.035	ENST00000522307.1 ENST00000523251.1 ENST00000437212.3 ENST00000522824.1 ENST00000522151.1	TMPRSS4	transmembrane protease, serine 4
chr8_+_37553261	0.035	ENST00000331569.4	ZNF703	zinc finger protein 703
chr11_+_117947724	0.034	ENST00000534111.1	TMPRSS4	transmembrane protease, serine 4
chr1_-_173020056	0.034	ENST00000239468.2 ENST00000404377.3	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18
chr12_-_96336369	0.033	ENST00000546947.1 ENST00000546386.1	CCDC38	coiled-coil domain containing 38
chr2_-_134326009	0.032	ENST00000409261.1 ENST00000409213.1	NCKAP5	NCK-associated protein 5
chr10_+_93683519	0.032	ENST00000265990.6	BTAF1	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chr3_+_185303962	0.031	ENST00000296257.5	SENP2	SUMO1/sentrin/SMT3 specific peptidase 2
chr2_-_158182105	0.031	ENST00000409925.1	ERMN	ermin, ERM-like protein
chr5_-_142023766	0.030	ENST00000394496.2	FGF1	fibroblast growth factor 1 (acidic)
chr8_-_116681123	0.029	ENST00000519674.1	TRPS1	trichorhinophalangeal syndrome I
chr10_-_75385711	0.029	ENST00000433394.1	USP54	ubiquitin specific peptidase 54
chr9_-_43133544	0.027	ENST00000254835.2	ANKRD20A3	ankyrin repeat domain 20 family, member A3
chr19_+_45971246	0.027	ENST00000585836.1 ENST00000417353.2 ENST00000353609.3 ENST00000591858.1 ENST00000443841.2 ENST00000590335.1	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr17_+_36908984	0.026	ENST00000225426.4 ENST00000579088.1	PSMB3	proteasome (prosome, macropain) subunit, beta type, 3
chr2_-_152118352	0.025	ENST00000331426.5	RBM43	RNA binding motif protein 43
chr1_+_63063152	0.020	ENST00000371129.3	ANGPTL3	angiopoietin-like 3
chr1_-_160232312	0.020	ENST00000440682.1	DCAF8	DDB1 and CUL4 associated factor 8
chr12_-_122879969	0.016	ENST00000540304.1	CLIP1	CAP-GLY domain containing linker protein 1
chr19_-_37663332	0.016	ENST00000392157.2	ZNF585A	zinc finger protein 585A
chr13_-_103046837	0.016	ENST00000607251.1	FGF14-IT1	FGF14 intronic transcript 1 (non-protein coding)
chr19_-_48059113	0.015	ENST00000391901.3 ENST00000314121.4 ENST00000448976.1	ZNF541	zinc finger protein 541
chr7_+_73868439	0.012	ENST00000424337.2	GTF2IRD1	GTF2I repeat domain containing 1
chr11_-_110583912	0.011	ENST00000533353.1 ENST00000527598.1	ARHGAP20	Rho GTPase activating protein 20
chr14_-_60097524	0.008	ENST00000342503.4	RTN1	reticulon 1
chr6_+_123100620	0.008	ENST00000368444.3	FABP7	fatty acid binding protein 7, brain
chr11_-_6817128	0.008	ENST00000332601.3	OR6A2	olfactory receptor, family 6, subfamily A, member 2
chr7_-_6010263	0.006	ENST00000455618.2 ENST00000405415.1 ENST00000404406.1 ENST00000542644.1	RSPH10B	radial spoke head 10 homolog B (Chlamydomonas)
chr9_-_86593238	0.006	ENST00000351839.3	HNRNPK	heterogeneous nuclear ribonucleoprotein K
chr4_-_48782259	0.005	ENST00000507711.1 ENST00000358350.4 ENST00000537810.1 ENST00000264319.7	FRYL	FRY-like
chr2_-_179914760	0.005	ENST00000420890.2 ENST00000409284.1 ENST00000443758.1 ENST00000446116.1	CCDC141	coiled-coil domain containing 141
chr17_-_7082861	0.004	ENST00000269299.3	ASGR1	asialoglycoprotein receptor 1
chr8_-_81083341	0.003	ENST00000519303.2	TPD52	tumor protein D52
chr1_+_160147176	0.002	ENST00000470705.1	ATP1A4	ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr8_+_97773202	0.002	ENST00000519484.1	CPQ	carboxypeptidase Q
chrX_+_49644470	0.001	ENST00000508866.2	USP27X	ubiquitin specific peptidase 27, X-linked

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.7	GO:1903615	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.3	1.3	GO:0061056	sclerotome development(GO:0061056)
0.1	0.2	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1	0.9	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.1	0.3	GO:0072658	maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0	0.2	GO:1904647	response to rotenone(GO:1904647)
0.0	0.1	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0032072	plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0000125	PCAF complex(GO:0000125)
0.1	0.2	GO:1990075	kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0	0.3	GO:0043194	axon initial segment(GO:0043194)
0.0	1.0	GO:0005881	cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0047025	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1	0.9	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1	2.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	1.3	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.5	GO:0001530	lipopolysaccharide binding(GO:0001530)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	PID_MYC_PATHWAY	C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	REACTOME_ZINC_TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.3	REACTOME_HDL_MEDIATED_LIPID_TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.8	REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

---