Motif ID: BBX

Z-value: 0.537


Transcription factors associated with BBX:

Gene SymbolEntrez IDGene Name
BBX ENSG00000114439.14 BBX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.608.9e-02Click!


Activity profile for motif BBX.

activity profile for motif BBX


Sorted Z-values histogram for motif BBX

Sorted Z-values for motif BBX



Network of associatons between targets according to the STRING database.



First level regulatory network of BBX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_186696561 0.744 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
 SORBS2





sorbin and SH3 domain containing 2





chr4_-_186696425 0.708 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2


sorbin and SH3 domain containing 2


chr15_+_49715293 0.643 ENST00000267843.4
ENST00000560270.1
 FGF7

fibroblast growth factor 7

chr4_-_186733363 0.619 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
 SORBS2


sorbin and SH3 domain containing 2


chr4_-_186682716 0.600 ENST00000445343.1
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186697044 0.499 ENST00000437304.2
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186696515 0.466 ENST00000456596.1
ENST00000414724.1
 SORBS2

sorbin and SH3 domain containing 2

chr17_+_4853442 0.410 ENST00000522301.1
 ENO3
enolase 3 (beta, muscle)
chr4_-_186696636 0.382 ENST00000444771.1
 SORBS2
sorbin and SH3 domain containing 2
chr3_+_140981456 0.339 ENST00000504264.1
 ACPL2
acid phosphatase-like 2
chr6_+_72922590 0.313 ENST00000523963.1
 RIMS1
regulating synaptic membrane exocytosis 1
chr4_-_104021009 0.256 ENST00000509245.1
ENST00000296424.4
 BDH2

3-hydroxybutyrate dehydrogenase, type 2

chr9_-_5833027 0.240 ENST00000339450.5
 ERMP1
endoplasmic reticulum metallopeptidase 1
chr4_-_104020968 0.237 ENST00000504285.1
 BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr6_+_72922505 0.222 ENST00000401910.3
 RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_28527070 0.221 ENST00000596102.1
 AL353354.2
AL353354.2
chr10_+_111765562 0.212 ENST00000360162.3
 ADD3
adducin 3 (gamma)
chr14_+_94492674 0.212 ENST00000203664.5
ENST00000553723.1
 OTUB2

OTU domain, ubiquitin aldehyde binding 2

chr17_+_66255310 0.197 ENST00000448504.2
 ARSG
arylsulfatase G
chr4_-_186734275 0.184 ENST00000456060.1
 SORBS2
sorbin and SH3 domain containing 2
chr16_+_53483983 0.170 ENST00000544545.1
 RBL2
retinoblastoma-like 2 (p130)
chr17_-_30470154 0.164 ENST00000398832.2
 AC090616.2
Uncharacterized protein
chr6_+_106534192 0.161 ENST00000369091.2
ENST00000369096.4
 PRDM1

PR domain containing 1, with ZNF domain

chr1_-_161337662 0.160 ENST00000367974.1
 C1orf192
chromosome 1 open reading frame 192
chr11_-_14541872 0.156 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
 PSMA1



proteasome (prosome, macropain) subunit, alpha type, 1



chr1_+_229440129 0.153 ENST00000366688.3
 SPHAR
S-phase response (cyclin related)
chr7_-_16872932 0.152 ENST00000419572.2
ENST00000412973.1
 AGR2

anterior gradient 2

chr20_-_56286479 0.150 ENST00000265626.4
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_+_9361606 0.149 ENST00000456448.1
 OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr1_+_95616933 0.142 ENST00000604203.1
 RP11-57H12.6
TMEM56-RWDD3 readthrough
chr14_+_23235886 0.142 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
 OXA1L



oxidase (cytochrome c) assembly 1-like



chr12_-_100378006 0.133 ENST00000547776.2
ENST00000329257.7
ENST00000547010.1
 ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr2_+_63816295 0.130 ENST00000539945.1
ENST00000544381.1
 MDH1

malate dehydrogenase 1, NAD (soluble)

chrX_+_54834004 0.125 ENST00000375068.1
 MAGED2
melanoma antigen family D, 2
chr22_+_32871224 0.117 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
 FBXO7


F-box protein 7


chr17_-_59668550 0.113 ENST00000521764.1
 NACA2
nascent polypeptide-associated complex alpha subunit 2
chrX_+_100663243 0.109 ENST00000316594.5
 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr3_+_122399444 0.105 ENST00000474629.2
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr10_-_94003003 0.099 ENST00000412050.4
 CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_+_151358048 0.094 ENST00000450635.1
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr5_-_119669160 0.092 ENST00000514240.1
 CTC-552D5.1
CTC-552D5.1
chr4_+_108910870 0.092 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
 HADH


hydroxyacyl-CoA dehydrogenase


chr9_+_35161998 0.092 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
 UNC13B


unc-13 homolog B (C. elegans)


chr2_-_120124258 0.091 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
 C2orf76



chromosome 2 open reading frame 76



chrX_+_54834159 0.091 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
 MAGED2


melanoma antigen family D, 2


chr10_+_115674530 0.086 ENST00000451472.1
 AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr12_-_100656134 0.085 ENST00000548313.1
 DEPDC4
DEP domain containing 4
chr7_+_135611542 0.084 ENST00000416501.1
 AC015987.2
AC015987.2
chr19_+_47421933 0.083 ENST00000404338.3
 ARHGAP35
Rho GTPase activating protein 35
chr17_-_8263538 0.081 ENST00000535173.1
 AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr22_+_44319619 0.077 ENST00000216180.3
 PNPLA3
patatin-like phospholipase domain containing 3
chr7_-_38969150 0.074 ENST00000418457.2
 VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr6_-_107235378 0.072 ENST00000606430.1
 RP1-60O19.1
RP1-60O19.1
chr4_+_129349188 0.072 ENST00000511497.1
 RP11-420A23.1
RP11-420A23.1
chr5_+_140729649 0.066 ENST00000523390.1
 PCDHGB1
protocadherin gamma subfamily B, 1
chr4_-_113558014 0.059 ENST00000503172.1
ENST00000505019.1
ENST00000309071.5
 C4orf21


chromosome 4 open reading frame 21


chr5_+_140514782 0.055 ENST00000231134.5
 PCDHB5
protocadherin beta 5
chr3_-_133380731 0.050 ENST00000260810.5
 TOPBP1
topoisomerase (DNA) II binding protein 1
chr4_-_987164 0.046 ENST00000398520.2
 SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr8_-_28347737 0.045 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
 FBXO16



F-box protein 16



chr9_-_95166841 0.045 ENST00000262551.4
 OGN
osteoglycin
chr16_+_57139933 0.043 ENST00000566259.1
 CPNE2
copine II
chr9_-_95166884 0.043 ENST00000375561.5
 OGN
osteoglycin
chr17_+_40950900 0.041 ENST00000588527.1
 CNTD1
cyclin N-terminal domain containing 1
chr14_+_67656110 0.041 ENST00000524532.1
ENST00000530728.1
 FAM71D

family with sequence similarity 71, member D

chr5_+_179921344 0.037 ENST00000261951.4
 CNOT6
CCR4-NOT transcription complex, subunit 6
chr12_-_99548270 0.037 ENST00000546568.1
ENST00000332712.7
ENST00000546960.1
 ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr5_+_180794269 0.036 ENST00000456475.1
 OR4F3
olfactory receptor, family 4, subfamily F, member 3
chr2_-_231084617 0.036 ENST00000409815.2
 SP110
SP110 nuclear body protein
chr4_+_26578293 0.035 ENST00000512840.1
 TBC1D19
TBC1 domain family, member 19
chr5_+_74011328 0.035 ENST00000513336.1
 HEXB
hexosaminidase B (beta polypeptide)
chr13_+_33160553 0.035 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr9_-_95166976 0.035 ENST00000447356.1
 OGN
osteoglycin
chr17_+_44803922 0.035 ENST00000465370.1
 NSF
N-ethylmaleimide-sensitive factor
chr1_+_51567910 0.034 ENST00000467127.1
 C1orf185
chromosome 1 open reading frame 185
chr1_+_212475148 0.034 ENST00000537030.3
 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr16_-_28374829 0.032 ENST00000532254.1
 NPIPB6
nuclear pore complex interacting protein family, member B6
chr7_-_130080977 0.032 ENST00000223208.5
 CEP41
centrosomal protein 41kDa
chr13_+_77522632 0.032 ENST00000377462.1
 IRG1
immunoresponsive 1 homolog (mouse)
chr10_+_24497704 0.030 ENST00000376456.4
ENST00000458595.1
 KIAA1217

KIAA1217

chr18_-_21017817 0.030 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241





transmembrane protein 241





chr18_-_56985776 0.029 ENST00000587244.1
 CPLX4
complexin 4
chr14_+_57671888 0.028 ENST00000391612.1
 AL391152.1
AL391152.1
chr12_+_4382917 0.025 ENST00000261254.3
 CCND2
cyclin D2
chr6_-_29343068 0.024 ENST00000396806.3
 OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr1_-_59043166 0.024 ENST00000371225.2
 TACSTD2
tumor-associated calcium signal transducer 2
chr7_+_95171457 0.023 ENST00000601424.1
 AC002451.1
Protein LOC100996577
chr10_-_4285835 0.022 ENST00000454470.1
 LINC00702
long intergenic non-protein coding RNA 702
chr1_-_198509804 0.021 ENST00000489986.1
ENST00000367382.1
 ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr10_-_4285923 0.020 ENST00000418372.1
ENST00000608792.1
 LINC00702

long intergenic non-protein coding RNA 702

chr7_+_128349106 0.019 ENST00000485070.1
 FAM71F1
family with sequence similarity 71, member F1
chr3_+_111260954 0.019 ENST00000283285.5
 CD96
CD96 molecule
chr1_+_109265033 0.019 ENST00000445274.1
 FNDC7
fibronectin type III domain containing 7
chr6_-_135818368 0.019 ENST00000367798.2
 AHI1
Abelson helper integration site 1
chr18_-_56985873 0.018 ENST00000299721.3
 CPLX4
complexin 4
chr3_+_111260856 0.017 ENST00000352690.4
 CD96
CD96 molecule
chr12_-_39734783 0.017 ENST00000552961.1
 KIF21A
kinesin family member 21A
chr12_-_4754339 0.017 ENST00000228850.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr3_-_47950745 0.017 ENST00000429422.1
 MAP4
microtubule-associated protein 4
chr12_-_8765446 0.017 ENST00000537228.1
ENST00000229335.6
 AICDA

activation-induced cytidine deaminase

chr11_+_22689648 0.015 ENST00000278187.3
 GAS2
growth arrest-specific 2
chr3_+_51851612 0.015 ENST00000456080.1
 IQCF3
IQ motif containing F3
chr1_+_51567895 0.015 ENST00000371759.2
 C1orf185
chromosome 1 open reading frame 185
chr12_-_10978957 0.015 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr9_-_13175823 0.014 ENST00000545857.1
 MPDZ
multiple PDZ domain protein
chr12_-_4754318 0.013 ENST00000536414.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr1_-_206785789 0.013 ENST00000437518.1
ENST00000367114.3
 EIF2D

eukaryotic translation initiation factor 2D

chr1_-_36948879 0.012 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
 CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr5_+_140810132 0.012 ENST00000252085.3
 PCDHGA12
protocadherin gamma subfamily A, 12
chr4_-_70080449 0.012 ENST00000446444.1
 UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr14_-_23292596 0.012 ENST00000554741.1
 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_-_4754356 0.010 ENST00000540967.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr6_-_107235287 0.010 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
 RP1-60O19.1


RP1-60O19.1


chr6_+_31895254 0.009 ENST00000299367.5
ENST00000442278.2
 C2

complement component 2

chr4_+_187813673 0.008 ENST00000606881.1
 RP11-11N5.3
RP11-11N5.3
chr13_+_76445187 0.007 ENST00000318245.4
 C13orf45
chromosome 13 open reading frame 45
chr18_+_29769978 0.007 ENST00000269202.6
ENST00000581447.1
 MEP1B

meprin A, beta

chr9_-_116837249 0.007 ENST00000466610.2
 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_45331184 0.006 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
 ITGB3


integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)


chr2_-_62081148 0.006 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr1_-_216978709 0.004 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr1_+_52082751 0.003 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
 OSBPL9



oxysterol binding protein-like 9



chr6_+_29424958 0.003 ENST00000377136.1
ENST00000377133.1
 OR2H1

olfactory receptor, family 2, subfamily H, member 1

chr19_+_6887571 0.002 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
 EMR1




egf-like module containing, mucin-like, hormone receptor-like 1




chr4_-_987217 0.001 ENST00000361661.2
ENST00000398516.2
 SLC26A1

solute carrier family 26 (anion exchanger), member 1

chr21_+_19617140 0.000 ENST00000299295.2
ENST00000338326.3
 CHODL

chondrolectin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.6 GO:0060437 positive regulation of keratinocyte migration(GO:0051549) lung growth(GO:0060437) regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.6 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.5 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 3.8 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 4.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases