Motif ID: BACH2
Z-value: 1.105
Transcription factors associated with BACH2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| BACH2 | ENSG00000112182.10 | BACH2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH2 | hg19_v2_chr6_-_91006627_91006641 | 0.26 | 5.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 12.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.0 | 3.0 | GO:2000364 | regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 0.8 | 2.5 | GO:0042660 | positive regulation of cell fate specification(GO:0042660) |
| 0.6 | 2.4 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.4 | 2.2 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 0.4 | 1.7 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.4 | 2.2 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.3 | 1.7 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.3 | 6.1 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.2 | 1.6 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.2 | 0.7 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.2 | 1.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 3.1 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.4 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.1 | 0.7 | GO:1903401 | L-lysine transmembrane transport(GO:1903401) |
| 0.1 | 0.6 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.1 | 2.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 0.8 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.1 | 0.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 0.3 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.1 | 0.2 | GO:0071288 | carbon dioxide transmembrane transport(GO:0035378) cellular response to mercury ion(GO:0071288) |
| 0.1 | 1.3 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 0.1 | 0.4 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.1 | 0.5 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.6 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.1 | 0.3 | GO:0015822 | mitochondrial ornithine transport(GO:0000066) ornithine transport(GO:0015822) |
| 0.1 | 0.2 | GO:0052214 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.1 | 0.2 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168) |
| 0.1 | 0.8 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 0.3 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 0.0 | 0.3 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.0 | 5.1 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.3 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.0 | 0.5 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.0 | 0.5 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.0 | 0.5 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.0 | 0.7 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 0.2 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) |
| 0.0 | 0.3 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.0 | 0.8 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 1.1 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 1.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.7 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 0.6 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.0 | 0.1 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.0 | 0.2 | GO:1905232 | cellular response to L-glutamate(GO:1905232) |
| 0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.1 | GO:0072720 | cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720) |
| 0.0 | 2.2 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.0 | 1.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.7 | GO:0035729 | cellular response to hepatocyte growth factor stimulus(GO:0035729) |
| 0.0 | 0.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.0 | 0.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 3.9 | GO:0051781 | positive regulation of cell division(GO:0051781) |
| 0.0 | 1.0 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 0.2 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.0 | 0.7 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 0.2 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 0.0 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.0 | 0.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.4 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 0.5 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.0 | 0.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.0 | 0.5 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.0 | 1.5 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.6 | GO:0071451 | cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) |
| 0.0 | 0.9 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 0.3 | GO:1903543 | positive regulation of exosomal secretion(GO:1903543) |
| 0.0 | 0.1 | GO:0040031 | snRNA modification(GO:0040031) |
| 0.0 | 0.1 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.4 | 1.7 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.2 | 1.3 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.2 | 0.8 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.2 | 1.7 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 0.7 | GO:0044753 | amphisome(GO:0044753) |
| 0.1 | 12.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 4.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.7 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 0.2 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.1 | 0.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 9.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.9 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.2 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 6.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.3 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.0 | 0.9 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 0.3 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 0.1 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 1.0 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.0 | GO:0031258 | lamellipodium membrane(GO:0031258) filopodium membrane(GO:0031527) |
| 0.0 | 1.3 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 0.3 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.8 | 2.4 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.3 | 1.0 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.2 | 2.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.2 | 0.6 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.2 | 0.7 | GO:0002134 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 0.2 | 2.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.2 | 1.6 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 1.2 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.1 | 0.8 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 2.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.7 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.1 | 2.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 0.2 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.1 | 0.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.9 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.3 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.1 | 0.2 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.1 | 1.3 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.1 | 1.2 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 1.0 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.9 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.2 | GO:0004347 | glucose-6-phosphate isomerase activity(GO:0004347) |
| 0.0 | 0.7 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 7.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 2.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 2.5 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.3 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.4 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.2 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.1 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 0.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.1 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.2 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.1 | 6.2 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.9 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 2.5 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 1.3 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.0 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.9 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 2.0 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 0.6 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.2 | 2.5 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.1 | 12.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 0.7 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 1.6 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 2.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.7 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.7 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.9 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.8 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 2.4 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.7 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 1.0 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.3 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.3 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
