Motif ID: ARID3A
Z-value: 0.632
Transcription factors associated with ARID3A:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ARID3A | ENSG00000116017.6 | ARID3A |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID3A | hg19_v2_chr19_+_926000_926046 | 0.48 | 1.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.2 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.3 | 1.1 | GO:0002316 | follicular B cell differentiation(GO:0002316) |
| 0.2 | 1.2 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.7 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 1.0 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 1.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.1 | 0.3 | GO:1903979 | negative regulation of microglial cell activation(GO:1903979) |
| 0.1 | 0.3 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.1 | 0.3 | GO:0034699 | response to luteinizing hormone(GO:0034699) |
| 0.1 | 2.3 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 0.2 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 0.1 | 0.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.1 | 0.3 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 0.1 | 0.2 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
| 0.0 | 0.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 0.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.0 | 0.4 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 1.1 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.1 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) |
| 0.0 | 0.1 | GO:0072684 | mitochondrial tRNA 3'-trailer cleavage, endonucleolytic(GO:0072684) |
| 0.0 | 0.2 | GO:0016267 | O-glycan processing, core 1(GO:0016267) |
| 0.0 | 0.3 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.0 | 0.2 | GO:0018277 | protein deamination(GO:0018277) |
| 0.0 | 0.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.1 | GO:0006433 | prolyl-tRNA aminoacylation(GO:0006433) |
| 0.0 | 0.2 | GO:0015783 | GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079) |
| 0.0 | 1.0 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.1 | GO:1901545 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.0 | 0.0 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.0 | 0.1 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.0 | 0.1 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.1 | GO:0051389 | inactivation of MAPKK activity(GO:0051389) |
| 0.0 | 0.0 | GO:2000302 | positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423) positive regulation of synaptic vesicle exocytosis(GO:2000302) |
| 0.0 | 0.1 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.0 | 0.3 | GO:0001302 | replicative cell aging(GO:0001302) |
| 0.0 | 0.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.0 | 0.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.6 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.0 | 0.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.1 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.0 | 0.0 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.0 | 0.2 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.0 | 0.2 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 0.2 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.2 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.0 | 0.1 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.0 | 0.1 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA(GO:0090625) |
| 0.0 | 0.2 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.0 | 0.1 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 0.2 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.3 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 0.3 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.1 | 0.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 0.1 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 0.0 | 0.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.2 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.6 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.1 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 0.1 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 0.1 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.3 | 1.0 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.2 | 0.6 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) |
| 0.1 | 2.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 1.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.3 | GO:0070123 | transforming growth factor beta receptor activity, type III(GO:0070123) |
| 0.1 | 0.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.2 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.1 | 0.3 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.0 | 0.2 | GO:0016263 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) |
| 0.0 | 0.3 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 0.1 | GO:0010309 | acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309) |
| 0.0 | 0.3 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.2 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 0.1 | GO:0042781 | 3'-tRNA processing endoribonuclease activity(GO:0042781) |
| 0.0 | 0.2 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 0.1 | GO:0004827 | proline-tRNA ligase activity(GO:0004827) |
| 0.0 | 0.1 | GO:0010348 | lithium:proton antiporter activity(GO:0010348) |
| 0.0 | 0.2 | GO:0005457 | GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080) |
| 0.0 | 1.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.1 | GO:0070996 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.1 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 0.1 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.0 | 0.1 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) |
| 0.0 | 0.2 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 0.1 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.0 | 0.1 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.0 | 0.1 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.0 | 0.1 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 0.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.1 | GO:1902444 | riboflavin binding(GO:1902444) |
| 0.0 | 0.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.2 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.1 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 2.3 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.0 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 0.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.3 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.6 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 2.5 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.9 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.2 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.3 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
