Motif ID: AIRE

Z-value: 0.335


Transcription factors associated with AIRE:

Gene SymbolEntrez IDGene Name
AIRE ENSG00000160224.12 AIRE

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.274.8e-01Click!


Activity profile for motif AIRE.

activity profile for motif AIRE


Sorted Z-values histogram for motif AIRE

Sorted Z-values for motif AIRE



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_36649170 0.440 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
 APOL1





apolipoprotein L, 1





chr4_-_186696425 0.318 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2


sorbin and SH3 domain containing 2


chr12_+_75874984 0.271 ENST00000550491.1
 GLIPR1
GLI pathogenesis-related 1
chr15_+_45938079 0.266 ENST00000561493.1
 SQRDL
sulfide quinone reductase-like (yeast)
chr12_+_75874580 0.249 ENST00000456650.3
 GLIPR1
GLI pathogenesis-related 1
chr22_+_36649056 0.249 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
 APOL1



apolipoprotein L, 1



chr1_+_79115503 0.214 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44


interferon-induced protein 44


chr9_-_95298254 0.151 ENST00000444490.2
 ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr16_+_3254247 0.142 ENST00000304646.2
 OR1F1
olfactory receptor, family 1, subfamily F, member 1
chr20_+_12989596 0.125 ENST00000434210.1
ENST00000399002.2
 SPTLC3

serine palmitoyltransferase, long chain base subunit 3

chr15_+_59910132 0.121 ENST00000559200.1
 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_-_113772835 0.117 ENST00000552014.1
ENST00000548186.1
ENST00000202831.3
ENST00000549181.1
 SLC8B1



solute carrier family 8 (sodium/lithium/calcium exchanger), member B1



chr3_-_49466686 0.103 ENST00000273598.3
ENST00000436744.2
 NICN1

nicolin 1

chr5_+_667759 0.101 ENST00000594226.1
 AC026740.1
Uncharacterized protein
chr3_+_107318157 0.095 ENST00000406780.1
 BBX
bobby sox homolog (Drosophila)
chr16_+_446713 0.088 ENST00000397722.1
ENST00000454619.1
 NME4

NME/NM23 nucleoside diphosphate kinase 4

chr17_-_70989072 0.081 ENST00000582769.1
 SLC39A11
solute carrier family 39, member 11
chr5_+_140625147 0.071 ENST00000231173.3
 PCDHB15
protocadherin beta 15
chr21_-_44495964 0.071 ENST00000398168.1
ENST00000398165.3
 CBS

cystathionine-beta-synthase

chr4_-_123843597 0.070 ENST00000510735.1
ENST00000304430.5
 NUDT6

nudix (nucleoside diphosphate linked moiety X)-type motif 6

chr21_-_44495919 0.070 ENST00000398158.1
 CBS
cystathionine-beta-synthase
chr5_+_118691008 0.070 ENST00000504642.1
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr13_-_30160925 0.068 ENST00000450494.1
 SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr11_+_64794991 0.065 ENST00000352068.5
ENST00000525648.1
 SNX15

sorting nexin 15

chr1_+_100810575 0.063 ENST00000542213.1
 CDC14A
cell division cycle 14A
chr7_-_149194843 0.063 ENST00000458143.2
ENST00000340622.3
 ZNF746

zinc finger protein 746

chr11_-_327537 0.058 ENST00000602735.1
 IFITM3
interferon induced transmembrane protein 3
chr6_+_36839616 0.055 ENST00000359359.2
ENST00000510325.2
 C6orf89

chromosome 6 open reading frame 89

chrX_-_49041242 0.051 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
 PRICKLE3



prickle homolog 3 (Drosophila)



chr17_+_77030267 0.050 ENST00000581774.1
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_-_13350447 0.047 ENST00000429930.1
 AL138764.1
Uncharacterized protein
chr19_-_59084922 0.044 ENST00000215057.2
ENST00000599369.1
 MZF1

myeloid zinc finger 1

chr16_-_28503327 0.043 ENST00000535392.1
ENST00000395653.4
 CLN3

ceroid-lipofuscinosis, neuronal 3

chr19_-_52552051 0.043 ENST00000221315.5
 ZNF432
zinc finger protein 432
chr7_-_87936195 0.043 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
 STEAP4


STEAP family member 4


chrM_+_8366 0.042 ENST00000361851.1
 MT-ATP8
mitochondrially encoded ATP synthase 8
chr20_+_44036900 0.041 ENST00000443296.1
 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_8954491 0.041 ENST00000526227.1
ENST00000525780.1
ENST00000326053.5
 C11orf16


chromosome 11 open reading frame 16


chr12_+_7282795 0.040 ENST00000266546.6
 CLSTN3
calsyntenin 3
chrM_+_5824 0.040 ENST00000361624.2
 MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr11_+_107650219 0.039 ENST00000398067.1
 AP001024.1
Uncharacterized protein
chr1_-_154600421 0.039 ENST00000368471.3
ENST00000292205.5
 ADAR

adenosine deaminase, RNA-specific

chr16_+_57126428 0.039 ENST00000290776.8
 CPNE2
copine II
chr1_+_198189921 0.038 ENST00000391974.3
 NEK7
NIMA-related kinase 7
chr5_-_36242119 0.038 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
 NADK2


NAD kinase 2, mitochondrial


chr10_+_127661942 0.036 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
 FANK1


fibronectin type III and ankyrin repeat domains 1


chr11_+_64794875 0.036 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
 SNX15


sorting nexin 15


chr9_+_71357171 0.036 ENST00000440050.1
 PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr15_-_81202118 0.035 ENST00000560560.1
 RP11-351M8.1
Uncharacterized protein
chr16_+_57126482 0.035 ENST00000537605.1
ENST00000535318.2
 CPNE2

copine II

chr20_-_33735070 0.033 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr5_-_38845812 0.033 ENST00000513480.1
ENST00000512519.1
 CTD-2127H9.1

CTD-2127H9.1

chr20_+_44036620 0.032 ENST00000372710.3
 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_-_225811747 0.032 ENST00000409592.3
 DOCK10
dedicator of cytokinesis 10
chr4_+_71588372 0.032 ENST00000536664.1
 RUFY3
RUN and FYVE domain containing 3
chr5_+_118690466 0.032 ENST00000503646.1
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_-_10491234 0.032 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
 TYK2


tyrosine kinase 2


chr16_-_31147020 0.030 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
 PRSS8


protease, serine, 8


chr19_-_47249679 0.028 ENST00000263280.6
 STRN4
striatin, calmodulin binding protein 4
chr15_-_99789736 0.028 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
 TTC23








tetratricopeptide repeat domain 23








chr15_-_22448819 0.027 ENST00000604066.1
 IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr1_-_167883327 0.027 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10


adenylate cyclase 10 (soluble)


chr3_-_121468513 0.026 ENST00000494517.1
ENST00000393667.3
 GOLGB1

golgin B1

chr3_-_121468602 0.026 ENST00000340645.5
 GOLGB1
golgin B1
chr7_-_86849836 0.025 ENST00000455575.1
 TMEM243
transmembrane protein 243, mitochondrial
chr6_+_42584847 0.025 ENST00000372883.3
 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr7_+_76101379 0.025 ENST00000429179.1
 DTX2
deltex homolog 2 (Drosophila)
chr14_-_106967788 0.025 ENST00000390622.2
 IGHV1-46
immunoglobulin heavy variable 1-46
chr16_+_11439286 0.025 ENST00000312499.5
ENST00000576027.1
 RMI2

RecQ mediated genome instability 2

chr4_-_120243545 0.024 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr19_-_52551814 0.024 ENST00000594154.1
ENST00000598745.1
ENST00000597273.1
 ZNF432


zinc finger protein 432


chr4_-_4544061 0.022 ENST00000507908.1
 STX18
syntaxin 18
chrM_+_7586 0.022 ENST00000361739.1
 MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr6_+_127898312 0.022 ENST00000329722.7
 C6orf58
chromosome 6 open reading frame 58
chr5_-_107703556 0.021 ENST00000496714.1
 FBXL17
F-box and leucine-rich repeat protein 17
chr6_+_116937636 0.021 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr14_-_24912047 0.021 ENST00000553930.1
 SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr13_+_50570019 0.020 ENST00000442421.1
 TRIM13
tripartite motif containing 13
chr16_+_50059125 0.020 ENST00000427478.2
 CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chrM_+_4431 0.020 ENST00000361453.3
 MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr14_-_106668095 0.020 ENST00000390606.2
 IGHV3-20
immunoglobulin heavy variable 3-20
chr14_-_24911971 0.019 ENST00000555365.1
ENST00000399395.3
 SDR39U1

short chain dehydrogenase/reductase family 39U, member 1

chr8_+_80209929 0.018 ENST00000519983.1
 RP11-1114I9.1
RP11-1114I9.1
chr3_+_189507460 0.018 ENST00000434928.1
 TP63
tumor protein p63
chr18_+_39766626 0.017 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
 LINC00907








long intergenic non-protein coding RNA 907








chr3_-_121264848 0.017 ENST00000264233.5
 POLQ
polymerase (DNA directed), theta
chr1_-_161207986 0.017 ENST00000506209.1
ENST00000367980.2
 NR1I3

nuclear receptor subfamily 1, group I, member 3

chr12_-_11139511 0.017 ENST00000506868.1
 TAS2R50
taste receptor, type 2, member 50
chr4_+_71587669 0.017 ENST00000381006.3
ENST00000226328.4
 RUFY3

RUN and FYVE domain containing 3

chr17_+_36452989 0.017 ENST00000312513.5
ENST00000582535.1
 MRPL45

mitochondrial ribosomal protein L45

chr19_-_10491130 0.016 ENST00000530829.1
ENST00000529370.1
 TYK2

tyrosine kinase 2

chr10_+_115511213 0.016 ENST00000361048.1
 PLEKHS1
pleckstrin homology domain containing, family S member 1
chr15_+_85523671 0.015 ENST00000310298.4
ENST00000557957.1
 PDE8A

phosphodiesterase 8A

chr16_-_31146961 0.015 ENST00000567531.1
 PRSS8
protease, serine, 8
chrX_-_153191674 0.014 ENST00000350060.5
ENST00000370016.1
 ARHGAP4

Rho GTPase activating protein 4

chr4_+_78829479 0.014 ENST00000504901.1
 MRPL1
mitochondrial ribosomal protein L1
chrX_-_153191708 0.013 ENST00000393721.1
ENST00000370028.3
 ARHGAP4

Rho GTPase activating protein 4

chr8_+_54764346 0.013 ENST00000297313.3
ENST00000344277.6
 RGS20

regulator of G-protein signaling 20

chr7_-_142162390 0.013 ENST00000390371.3
 TRBV6-6
T cell receptor beta variable 6-6
chrM_+_14741 0.013 ENST00000361789.2
 MT-CYB
mitochondrially encoded cytochrome b
chr6_-_10211841 0.012 ENST00000481704.1
 OFCC1
orofacial cleft 1 candidate 1
chr16_-_71518504 0.012 ENST00000565100.2
 ZNF19
zinc finger protein 19
chr5_+_122181279 0.011 ENST00000395451.4
ENST00000506996.1
 SNX24

sorting nexin 24

chr3_-_33686925 0.011 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
 CLASP2


cytoplasmic linker associated protein 2


chr2_+_62423242 0.011 ENST00000301998.4
 B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr3_-_176914191 0.011 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
 TBL1XR1


transducin (beta)-like 1 X-linked receptor 1


chr9_-_95298927 0.011 ENST00000395534.2
 ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_+_204732487 0.010 ENST00000302823.3
 CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr9_-_70429731 0.010 ENST00000377413.1
 FOXD4L4
forkhead box D4-like 4
chr10_-_46030841 0.010 ENST00000453424.2
 MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr1_+_36038971 0.010 ENST00000373235.3
 TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr19_-_2085323 0.010 ENST00000591638.1
 MOB3A
MOB kinase activator 3A
chr3_+_193965426 0.009 ENST00000455821.1
 RP11-513G11.3
RP11-513G11.3
chr1_+_174670143 0.009 ENST00000367687.1
ENST00000347255.2
 RABGAP1L

RAB GTPase activating protein 1-like

chr19_-_4902877 0.009 ENST00000381781.2
 ARRDC5
arrestin domain containing 5
chr8_-_145652336 0.009 ENST00000529182.1
ENST00000526054.1
 VPS28

vacuolar protein sorting 28 homolog (S. cerevisiae)

chr1_+_174843548 0.008 ENST00000478442.1
ENST00000465412.1
 RABGAP1L

RAB GTPase activating protein 1-like

chr10_-_106240032 0.008 ENST00000447860.1
 RP11-127O4.3
RP11-127O4.3
chr7_+_80255472 0.008 ENST00000428497.1
 CD36
CD36 molecule (thrombospondin receptor)
chr12_-_11287243 0.008 ENST00000539585.1
 TAS2R30
taste receptor, type 2, member 30
chr5_+_122181184 0.008 ENST00000513881.1
 SNX24
sorting nexin 24
chr11_+_35211511 0.007 ENST00000524922.1
 CD44
CD44 molecule (Indian blood group)
chr2_-_136633940 0.007 ENST00000264156.2
 MCM6
minichromosome maintenance complex component 6
chr19_+_56751773 0.007 ENST00000600684.1
 ZSCAN5D
zinc finger and SCAN domain containing 5D
chr9_+_42717234 0.007 ENST00000377590.1
 FOXD4L2
forkhead box D4-like 2
chr7_-_64023441 0.006 ENST00000309683.6
 ZNF680
zinc finger protein 680
chr7_-_142181009 0.006 ENST00000390368.2
 TRBV6-5
T cell receptor beta variable 6-5
chr2_-_202508169 0.006 ENST00000409883.2
 TMEM237
transmembrane protein 237
chr2_+_179316163 0.006 ENST00000409117.3
 DFNB59
deafness, autosomal recessive 59
chr12_-_6580094 0.006 ENST00000361716.3
 VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr1_-_145826450 0.006 ENST00000462900.2
 GPR89A
G protein-coupled receptor 89A
chr17_-_191188 0.005 ENST00000575634.1
 RPH3AL
rabphilin 3A-like (without C2 domains)
chr4_+_76649797 0.005 ENST00000538159.1
ENST00000514213.2
 USO1

USO1 vesicle transport factor

chr22_+_40322595 0.005 ENST00000420971.1
ENST00000544756.1
 GRAP2

GRB2-related adaptor protein 2

chr21_+_30673091 0.005 ENST00000447177.1
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr10_+_82300575 0.004 ENST00000313455.4
 SH2D4B
SH2 domain containing 4B
chr21_+_30672433 0.004 ENST00000451655.1
 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr16_+_50059182 0.004 ENST00000562576.1
 CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr1_-_35497506 0.004 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
 ZMYM6


zinc finger, MYM-type 6


chr19_+_56280507 0.004 ENST00000341750.4
 RFPL4AL1
ret finger protein-like 4A-like 1
chr19_+_16607122 0.004 ENST00000221671.3
ENST00000594035.1
ENST00000599550.1
ENST00000594813.1
 C19orf44



chromosome 19 open reading frame 44



chr22_+_40322623 0.003 ENST00000399090.2
 GRAP2
GRB2-related adaptor protein 2
chr19_-_48753028 0.003 ENST00000522431.1
 CARD8
caspase recruitment domain family, member 8
chr9_-_113761720 0.003 ENST00000541779.1
ENST00000374430.2
 LPAR1

lysophosphatidic acid receptor 1

chr1_+_207669573 0.002 ENST00000400960.2
ENST00000534202.1
 CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr10_-_46030787 0.002 ENST00000395769.2
 MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr17_-_38721711 0.002 ENST00000578085.1
ENST00000246657.2
 CCR7

chemokine (C-C motif) receptor 7

chr3_+_88199099 0.002 ENST00000486971.1
 C3orf38
chromosome 3 open reading frame 38
chr2_+_234686976 0.002 ENST00000389758.3
 MROH2A
maestro heat-like repeat family member 2A
chr20_+_58203664 0.002 ENST00000541461.1
 PHACTR3
phosphatase and actin regulator 3
chr2_+_38177575 0.001 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
 RMDN2



regulator of microtubule dynamics 2



chr9_-_70178815 0.001 ENST00000377420.1
 FOXD4L5
forkhead box D4-like 5
chr3_-_123710199 0.001 ENST00000184183.4
 ROPN1
rhophilin associated tail protein 1
chr10_-_101841588 0.001 ENST00000370418.3
 CPN1
carboxypeptidase N, polypeptide 1
chr13_-_46756351 0.001 ENST00000323076.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_-_75682535 0.001 ENST00000409178.1
 C10orf55
chromosome 10 open reading frame 55
chr14_+_39944025 0.000 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
 RP11-111A21.1


RP11-111A21.1


chr19_-_16606930 0.000 ENST00000600762.1
 CALR3
calreticulin 3
chr2_-_127977654 0.000 ENST00000409327.1
 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr9_+_71986182 0.000 ENST00000303068.7
 FAM189A2
family with sequence similarity 189, member A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.0 0.1 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.7 GO:0019835 cytolysis(GO:0019835)
0.0 0.0 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 0.0 GO:0035752 lysosomal lumen pH elevation(GO:0035752)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.0 0.1 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026) nitrite reductase activity(GO:0098809)
0.0 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)