Motif ID: AAGGUGC

Z-value: 0.239


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a-5p MIMAT0000072
hsa-miR-18b-5p MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_39873268 0.303 ENST00000397591.2
ENST00000260356.5
 THBS1

thrombospondin 1

chr6_-_132272504 0.179 ENST00000367976.3
 CTGF
connective tissue growth factor
chr6_+_138188551 0.163 ENST00000237289.4
ENST00000433680.1
 TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr1_-_38325256 0.105 ENST00000373036.4
 MTF1
metal-regulatory transcription factor 1
chr7_-_121036337 0.105 ENST00000426156.1
ENST00000359943.3
ENST00000412653.1
 FAM3C


family with sequence similarity 3, member C


chr5_+_56111361 0.092 ENST00000399503.3
 MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr4_-_125633876 0.092 ENST00000504087.1
ENST00000515641.1
 ANKRD50

ankyrin repeat domain 50

chr16_+_69599861 0.086 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr15_-_56209306 0.085 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
 NEDD4


neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase


chr3_+_171758344 0.080 ENST00000336824.4
ENST00000423424.1
 FNDC3B

fibronectin type III domain containing 3B

chr15_-_34628951 0.076 ENST00000397707.2
ENST00000560611.1
 SLC12A6

solute carrier family 12 (potassium/chloride transporter), member 6

chr2_-_153032484 0.076 ENST00000263904.4
 STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr11_+_109964087 0.073 ENST00000278590.3
 ZC3H12C
zinc finger CCCH-type containing 12C
chr9_-_74383799 0.072 ENST00000377044.4
 TMEM2
transmembrane protein 2
chr5_-_73937244 0.070 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
 ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr21_-_36260980 0.059 ENST00000344691.4
ENST00000358356.5
 RUNX1

runt-related transcription factor 1

chr12_+_69864129 0.058 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
 FRS2









fibroblast growth factor receptor substrate 2









chr1_+_162467595 0.058 ENST00000538489.1
ENST00000489294.1
 UHMK1

U2AF homology motif (UHM) kinase 1

chr5_-_43313574 0.056 ENST00000325110.6
ENST00000433297.2
 HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr3_+_152017181 0.056 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
 MBNL1



muscleblind-like splicing regulator 1



chr1_-_95007193 0.056 ENST00000370207.4
ENST00000334047.7
 F3

coagulation factor III (thromboplastin, tissue factor)

chr9_-_35563896 0.053 ENST00000399742.2
 FAM166B
family with sequence similarity 166, member B
chr10_-_119806085 0.052 ENST00000355624.3
 RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr19_+_48949030 0.051 ENST00000253237.5
 GRWD1
glutamate-rich WD repeat containing 1
chr10_-_71930222 0.049 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
 SAR1A



SAR1 homolog A (S. cerevisiae)



chr6_-_11232891 0.048 ENST00000379433.5
ENST00000379446.5
 NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr17_+_46985731 0.047 ENST00000360943.5
 UBE2Z
ubiquitin-conjugating enzyme E2Z
chr20_+_43104508 0.047 ENST00000262605.4
ENST00000372904.3
 TTPAL

tocopherol (alpha) transfer protein-like

chr1_-_204329013 0.046 ENST00000272203.3
ENST00000414478.1
 PLEKHA6

pleckstrin homology domain containing, family A member 6

chr1_-_120612240 0.045 ENST00000256646.2
 NOTCH2
notch 2
chr2_-_206950781 0.045 ENST00000403263.1
 INO80D
INO80 complex subunit D
chr2_-_26101374 0.043 ENST00000435504.4
 ASXL2
additional sex combs like 2 (Drosophila)
chr2_+_235860616 0.043 ENST00000392011.2
 SH3BP4
SH3-domain binding protein 4
chr12_+_104458235 0.042 ENST00000229330.4
 HCFC2
host cell factor C2
chr1_+_32573636 0.042 ENST00000373625.3
 KPNA6
karyopherin alpha 6 (importin alpha 7)
chr12_+_11802753 0.041 ENST00000396373.4
 ETV6
ets variant 6
chr5_-_142783175 0.041 ENST00000231509.3
ENST00000394464.2
 NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

chr2_+_24714729 0.040 ENST00000406961.1
ENST00000405141.1
 NCOA1

nuclear receptor coactivator 1

chr12_+_50690489 0.037 ENST00000598429.1
 AC140061.12
Uncharacterized protein
chr1_+_117452669 0.037 ENST00000393203.2
 PTGFRN
prostaglandin F2 receptor inhibitor
chr13_-_77601282 0.036 ENST00000355619.5
 FBXL3
F-box and leucine-rich repeat protein 3
chr3_-_123603137 0.035 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
 MYLK



myosin light chain kinase



chr1_+_173684047 0.035 ENST00000546011.1
ENST00000209884.4
 KLHL20

kelch-like family member 20

chrX_-_80065146 0.035 ENST00000373275.4
 BRWD3
bromodomain and WD repeat domain containing 3
chrX_-_19905703 0.034 ENST00000397821.3
 SH3KBP1
SH3-domain kinase binding protein 1
chr9_-_123639600 0.032 ENST00000373896.3
 PHF19
PHD finger protein 19
chr9_+_91003271 0.031 ENST00000375859.3
ENST00000541629.1
 SPIN1

spindlin 1

chr2_+_36582857 0.031 ENST00000280527.2
 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr5_-_142065612 0.031 ENST00000360966.5
ENST00000411960.1
 FGF1

fibroblast growth factor 1 (acidic)

chr4_+_25314388 0.030 ENST00000302874.4
 ZCCHC4
zinc finger, CCHC domain containing 4
chr3_-_169899504 0.028 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
 PHC3









polyhomeotic homolog 3 (Drosophila)









chr14_-_81687197 0.026 ENST00000553612.1
 GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr5_+_125935960 0.025 ENST00000297540.4
 PHAX
phosphorylated adaptor for RNA export
chr11_+_108093839 0.025 ENST00000452508.2
 ATM
ataxia telangiectasia mutated
chr9_+_15553055 0.025 ENST00000380701.3
 CCDC171
coiled-coil domain containing 171
chr17_+_27717415 0.023 ENST00000583121.1
ENST00000261716.3
 TAOK1

TAO kinase 1

chr3_+_43328004 0.022 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
 SNRK



SNF related kinase



chr21_+_38071430 0.021 ENST00000290399.6
 SIM2
single-minded family bHLH transcription factor 2
chr1_+_38259540 0.021 ENST00000397631.3
 MANEAL
mannosidase, endo-alpha-like
chr8_-_81787006 0.021 ENST00000327835.3
 ZNF704
zinc finger protein 704
chr8_+_8860314 0.021 ENST00000250263.7
ENST00000519292.1
 ERI1

exoribonuclease 1

chr1_-_55680762 0.020 ENST00000407756.1
ENST00000294383.6
 USP24

ubiquitin specific peptidase 24

chr12_+_49212514 0.019 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
 CACNB3


calcium channel, voltage-dependent, beta 3 subunit


chr4_+_79697495 0.019 ENST00000502871.1
ENST00000335016.5
 BMP2K

BMP2 inducible kinase

chr18_-_29522989 0.019 ENST00000582539.1
ENST00000283351.4
ENST00000582513.1
 TRAPPC8


trafficking protein particle complex 8


chr22_-_30642728 0.018 ENST00000403987.3
 LIF
leukemia inhibitory factor
chr1_-_20812690 0.018 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_+_173940442 0.017 ENST00000409176.2
ENST00000338983.3
ENST00000431503.2
 MLTK


Mitogen-activated protein kinase kinase kinase MLT


chr9_+_125703282 0.016 ENST00000373647.4
ENST00000402311.1
 RABGAP1

RAB GTPase activating protein 1

chr3_-_185542817 0.016 ENST00000382199.2
 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_96271141 0.016 ENST00000231368.5
 LNPEP
leucyl/cystinyl aminopeptidase
chr10_+_72575643 0.016 ENST00000373202.3
 SGPL1
sphingosine-1-phosphate lyase 1
chr7_-_111846435 0.016 ENST00000437633.1
ENST00000428084.1
 DOCK4

dedicator of cytokinesis 4

chr16_+_28996114 0.015 ENST00000395461.3
 LAT
linker for activation of T cells
chr14_+_52456327 0.015 ENST00000556760.1
 C14orf166
chromosome 14 open reading frame 166
chr6_-_86352642 0.015 ENST00000355238.6
 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr21_-_40685477 0.015 ENST00000342449.3
 BRWD1
bromodomain and WD repeat domain containing 1
chr19_+_13229126 0.014 ENST00000292431.4
 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr17_-_40306934 0.014 ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
ENST00000592574.1
 RAB5C



CTD-2132N18.3
RAB5C, member RAS oncogene family



Uncharacterized protein
chr12_-_56652111 0.014 ENST00000267116.7
 ANKRD52
ankyrin repeat domain 52
chr1_+_40862501 0.014 ENST00000539317.1
 SMAP2
small ArfGAP2
chr7_+_129074266 0.014 ENST00000249344.2
ENST00000435494.2
 STRIP2

striatin interacting protein 2

chr20_+_56884752 0.013 ENST00000244040.3
 RAB22A
RAB22A, member RAS oncogene family
chr20_+_49348081 0.013 ENST00000371610.2
 PARD6B
par-6 family cell polarity regulator beta
chr17_+_40834580 0.013 ENST00000264638.4
 CNTNAP1
contactin associated protein 1
chr1_+_78245303 0.013 ENST00000370791.3
ENST00000443751.2
 FAM73A

family with sequence similarity 73, member A

chr1_+_167190066 0.012 ENST00000367866.2
ENST00000429375.2
ENST00000452019.1
ENST00000420254.3
ENST00000541643.3
 POU2F1




POU class 2 homeobox 1




chr6_+_134274322 0.012 ENST00000367871.1
ENST00000237264.4
 TBPL1

TBP-like 1

chr20_+_30865429 0.012 ENST00000375712.3
 KIF3B
kinesin family member 3B
chr3_+_187930719 0.012 ENST00000312675.4
 LPP
LIM domain containing preferred translocation partner in lipoma
chr6_-_53409890 0.012 ENST00000229416.6
 GCLC
glutamate-cysteine ligase, catalytic subunit
chr10_-_735553 0.012 ENST00000280886.6
ENST00000423550.1
 DIP2C

DIP2 disco-interacting protein 2 homolog C (Drosophila)

chr9_+_116638562 0.011 ENST00000374126.5
ENST00000288466.7
 ZNF618

zinc finger protein 618

chr3_-_113465065 0.011 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
 NAA50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr4_+_6784401 0.010 ENST00000425103.1
ENST00000307659.5
 KIAA0232

KIAA0232

chr5_+_108083517 0.009 ENST00000281092.4
ENST00000536402.1
 FER

fer (fps/fes related) tyrosine kinase

chr3_+_141205852 0.009 ENST00000286364.3
ENST00000452898.1
 RASA2

RAS p21 protein activator 2

chr18_+_20513782 0.009 ENST00000399722.2
ENST00000399725.2
ENST00000399721.2
ENST00000583594.1
 RBBP8



retinoblastoma binding protein 8



chr5_-_78809950 0.009 ENST00000334082.6
 HOMER1
homer homolog 1 (Drosophila)
chr6_-_107436473 0.009 ENST00000369042.1
 BEND3
BEN domain containing 3
chr11_+_94822968 0.008 ENST00000278505.4
 ENDOD1
endonuclease domain containing 1
chr2_-_201828356 0.008 ENST00000234296.2
 ORC2
origin recognition complex, subunit 2
chr10_+_102295616 0.008 ENST00000299163.6
 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr17_-_27621125 0.007 ENST00000579665.1
ENST00000225388.4
 NUFIP2

nuclear fragile X mental retardation protein interacting protein 2

chr11_-_72853091 0.007 ENST00000311172.7
ENST00000409314.1
 FCHSD2

FCH and double SH3 domains 2

chr2_+_85198216 0.007 ENST00000456682.1
ENST00000409785.4
 KCMF1

potassium channel modulatory factor 1

chr15_+_73344791 0.006 ENST00000261908.6
 NEO1
neogenin 1
chr4_+_55524085 0.006 ENST00000412167.2
ENST00000288135.5
 KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr12_-_44200052 0.006 ENST00000548315.1
ENST00000552521.1
ENST00000546662.1
ENST00000548403.1
ENST00000546506.1
 TWF1




twinfilin actin-binding protein 1




chr14_+_103058948 0.006 ENST00000262241.6
 RCOR1
REST corepressor 1
chr11_-_108464321 0.006 ENST00000265843.4
 EXPH5
exophilin 5
chr1_+_42846443 0.005 ENST00000410070.2
ENST00000431473.3
 RIMKLA

ribosomal modification protein rimK-like family member A

chr20_+_43595115 0.005 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
 STK4



serine/threonine kinase 4



chr2_+_46926048 0.005 ENST00000306503.5
 SOCS5
suppressor of cytokine signaling 5
chr7_-_44924939 0.004 ENST00000395699.2
 PURB
purine-rich element binding protein B
chr5_-_180288248 0.004 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
 ZFP62



ZFP62 zinc finger protein



chr3_-_33481835 0.004 ENST00000283629.3
 UBP1
upstream binding protein 1 (LBP-1a)
chr20_+_60697480 0.004 ENST00000370915.1
ENST00000253001.4
ENST00000400318.2
ENST00000279068.6
ENST00000279069.7
 LSM14B




LSM14B, SCD6 homolog B (S. cerevisiae)




chr8_+_28747884 0.004 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
 HMBOX1







homeobox containing 1







chr1_+_100435315 0.003 ENST00000370155.3
ENST00000465289.1
 SLC35A3

solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

chr7_+_90225796 0.003 ENST00000380050.3
 CDK14
cyclin-dependent kinase 14
chr17_-_62340581 0.003 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
 TEX2


testis expressed 2


chr5_+_102594403 0.003 ENST00000319933.2
 C5orf30
chromosome 5 open reading frame 30
chr11_-_116968987 0.003 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
 SIK3






SIK family kinase 3






chr5_-_171711061 0.003 ENST00000393792.2
 UBTD2
ubiquitin domain containing 2
chr5_+_31193847 0.003 ENST00000514738.1
ENST00000265071.2
 CDH6

cadherin 6, type 2, K-cadherin (fetal kidney)

chr10_+_133918175 0.003 ENST00000298622.4
 JAKMIP3
Janus kinase and microtubule interacting protein 3
chr1_+_201617450 0.002 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
 NAV1


neuron navigator 1


chrX_+_108780062 0.002 ENST00000372106.1
 NXT2
nuclear transport factor 2-like export factor 2
chr14_+_55518349 0.002 ENST00000395468.4
 MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr9_+_140513438 0.002 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
 EHMT1


euchromatic histone-lysine N-methyltransferase 1


chr11_-_79151695 0.001 ENST00000278550.7
 TENM4
teneurin transmembrane protein 4
chr16_+_71879861 0.001 ENST00000568581.1
ENST00000427980.2
 IST1
ATXN1L
increased sodium tolerance 1 homolog (yeast)
ataxin 1-like
chr1_-_109506036 0.001 ENST00000369976.1
ENST00000356970.2
ENST00000369971.2
ENST00000415331.1
ENST00000357393.4
 CLCC1



AKNAD1
chloride channel CLIC-like 1



AKNA domain containing 1
chr4_-_157892498 0.001 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chrX_+_13707235 0.000 ENST00000464506.1
 RAB9A
RAB9A, member RAS oncogene family
chr1_+_84543734 0.000 ENST00000370689.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr19_-_36523709 0.000 ENST00000592017.1
ENST00000360535.4
 CLIP3

CAP-GLY domain containing linker protein 3

chr1_+_22379120 0.000 ENST00000400259.1
ENST00000344548.3
 CDC42

cell division cycle 42

chr16_-_74640986 0.000 ENST00000422840.2
ENST00000565260.1
ENST00000447066.2
ENST00000205061.5
 GLG1



golgi glycoprotein 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059)
0.1 0.2 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.0 0.1 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.0 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0033565 ESCRT-0 complex(GO:0033565)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070051 fibrinogen binding(GO:0070051) collagen V binding(GO:0070052)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.1 GO:0050816 phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)
0.0 0.0 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)