Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
| Enrichment Score (ES) | -0.62548906 |
| Normalized Enrichment Score (NES) | -2.019972 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.4222223E-4 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | AOX1 | NA | AOX1 Entrez, Source | aldehyde oxidase 1 | 449 | 1.409 | 0.0110 | No |
| 2 | IL4I1 | NA | IL4I1 Entrez, Source | interleukin 4 induced 1 | 2740 | 0.461 | -0.1408 | No |
| 3 | DBT | NA | DBT Entrez, Source | dihydrolipoamide branched chain transacylase E2 | 3316 | 0.380 | -0.1707 | No |
| 4 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 3649 | 0.338 | -0.1843 | No |
| 5 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 5084 | 0.183 | -0.2827 | No |
| 6 | HSD17B10 | NA | 6177 | 0.069 | -0.3597 | No | ||
| 7 | BCAT1 | NA | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 7455 | -0.062 | -0.4504 | No |
| 8 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8688 | -0.190 | -0.5338 | No |
| 9 | IVD | NA | IVD Entrez, Source | isovaleryl Coenzyme A dehydrogenase | 9412 | -0.281 | -0.5776 | No |
| 10 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9636 | -0.312 | -0.5841 | No |
| 11 | MCCC2 | NA | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 9698 | -0.321 | -0.5786 | No |
| 12 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 9719 | -0.325 | -0.5700 | No |
| 13 | HIBCH | NA | HIBCH Entrez, Source | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 9987 | -0.362 | -0.5782 | No |
| 14 | ACAA2 | NA | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 10640 | -0.466 | -0.6111 | Yes |
| 15 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 10749 | -0.483 | -0.6040 | Yes |
| 16 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.6028 | Yes |
| 17 | PCCB | NA | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 10973 | -0.522 | -0.5879 | Yes |
| 18 | OXCT2 | NA | OXCT2 Entrez, Source | 3-oxoacid CoA transferase 2 | 11125 | -0.550 | -0.5819 | Yes |
| 19 | ACADSB | NA | ACADSB Entrez, Source | acyl-Coenzyme A dehydrogenase, short/branched chain | 11149 | -0.553 | -0.5664 | Yes |
| 20 | HADHB | NA | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 11304 | -0.585 | -0.5595 | Yes |
| 21 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 11456 | -0.615 | -0.5515 | Yes |
| 22 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 11963 | -0.742 | -0.5652 | Yes |
| 23 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 12010 | -0.760 | -0.5451 | Yes |
| 24 | ACADM | NA | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 12101 | -0.786 | -0.5273 | Yes |
| 25 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 12220 | -0.825 | -0.5103 | Yes |
| 26 | MCCC1 | NA | MCCC1 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) | 12490 | -0.932 | -0.5010 | Yes |
| 27 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 12509 | -0.943 | -0.4732 | Yes |
| 28 | OXCT1 | NA | OXCT1 Entrez, Source | 3-oxoacid CoA transferase 1 | 12517 | -0.947 | -0.4444 | Yes |
| 29 | AUH | NA | AUH Entrez, Source | AU RNA binding protein/enoyl-Coenzyme A hydratase | 12524 | -0.949 | -0.4155 | Yes |
| 30 | BCAT2 | NA | BCAT2 Entrez, Source | branched chain aminotransferase 2, mitochondrial | 12548 | -0.960 | -0.3875 | Yes |
| 31 | BCKDHA | NA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 12554 | -0.963 | -0.3581 | Yes |
| 32 | ABAT | NA | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 12624 | -0.996 | -0.3324 | Yes |
| 33 | HIBADH | NA | HIBADH Entrez, Source | 3-hydroxyisobutyrate dehydrogenase | 12669 | -1.021 | -0.3040 | Yes |
| 34 | MCEE | NA | MCEE Entrez, Source | methylmalonyl CoA epimerase | 12681 | -1.026 | -0.2731 | Yes |
| 35 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.2490 | Yes |
| 36 | ACAD8 | NA | ACAD8 Entrez, Source | acyl-Coenzyme A dehydrogenase family, member 8 | 12826 | -1.104 | -0.2154 | Yes |
| 37 | MUT | NA | MUT Entrez, Source | methylmalonyl Coenzyme A mutase | 12830 | -1.107 | -0.1814 | Yes |
| 38 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 12961 | -1.190 | -0.1540 | Yes |
| 39 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 13109 | -1.302 | -0.1244 | Yes |
| 40 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 13135 | -1.324 | -0.0853 | Yes |
| 41 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 13202 | -1.396 | -0.0469 | Yes |
| 42 | ALDH6A1 | NA | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 13276 | -1.487 | -0.0063 | Yes |
| 43 | PCCA | NA | PCCA Entrez, Source | propionyl Coenzyme A carboxylase, alpha polypeptide | 13298 | -1.509 | 0.0389 | Yes |
