Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_TYPE_II_DIABETES_MELLITUS |
| Enrichment Score (ES) | -0.5167105 |
| Normalized Enrichment Score (NES) | -1.5809224 |
| Nominal p-value | 0.01438849 |
| FDR q-value | 0.093008615 |
| FWER p-Value | 0.737 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 384 | 1.526 | 0.0293 | No |
| 2 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 587 | 1.198 | 0.0595 | No |
| 3 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 1306 | 0.771 | 0.0363 | No |
| 4 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1699 | 0.658 | 0.0326 | No |
| 5 | HK2 | NA | HK2 Entrez, Source | hexokinase 2 | 1786 | 0.636 | 0.0502 | No |
| 6 | INSR | NA | INSR Entrez, Source | insulin receptor | 2342 | 0.526 | 0.0296 | No |
| 7 | SOCS2 | NA | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 2713 | 0.466 | 0.0203 | No |
| 8 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 2742 | 0.461 | 0.0355 | No |
| 9 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 5115 | 0.180 | -0.1296 | No |
| 10 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 5293 | 0.162 | -0.1364 | No |
| 11 | MTOR | NA | 6064 | 0.080 | -0.1892 | No | ||
| 12 | PRKCD | NA | PRKCD Entrez, Source | protein kinase C, delta | 8314 | -0.148 | -0.3466 | No |
| 13 | CACNA1E | NA | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 8340 | -0.151 | -0.3428 | No |
| 14 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | -0.3461 | No |
| 15 | KCNJ11 | NA | KCNJ11 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 11 | 8772 | -0.200 | -0.3603 | No |
| 16 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 8973 | -0.222 | -0.3664 | No |
| 17 | ADIPOQ | NA | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 9154 | -0.244 | -0.3703 | No |
| 18 | PDX1 | NA | 9320 | -0.267 | -0.3723 | No | ||
| 19 | SOCS4 | NA | SOCS4 Entrez, Source | suppressor of cytokine signaling 4 | 9421 | -0.282 | -0.3690 | No |
| 20 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9727 | -0.326 | -0.3789 | No |
| 21 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 9823 | -0.340 | -0.3731 | No |
| 22 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | -0.3617 | No |
| 23 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10142 | -0.384 | -0.3688 | No |
| 24 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 11136 | -0.552 | -0.4201 | No |
| 25 | IRS2 | NA | IRS2 Entrez, Source | insulin receptor substrate 2 | 12470 | -0.925 | -0.4821 | Yes |
| 26 | HK1 | NA | HK1 Entrez, Source | hexokinase 1 | 12755 | -1.065 | -0.4628 | Yes |
| 27 | PRKCZ | NA | PRKCZ Entrez, Source | protein kinase C, zeta | 12774 | -1.073 | -0.4239 | Yes |
| 28 | CACNA1D | NA | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 12921 | -1.162 | -0.3910 | Yes |
| 29 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 13175 | -1.371 | -0.3580 | Yes |
| 30 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 13226 | -1.426 | -0.3083 | Yes |
| 31 | CACNA1G | NA | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 13326 | -1.547 | -0.2575 | Yes |
| 32 | SLC2A4 | NA | SLC2A4 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 4 | 13651 | -2.263 | -0.1963 | Yes |
| 33 | MAFA | NA | MAFA Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) | 13706 | -2.562 | -0.1043 | Yes |
| 34 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | 0.0051 | Yes |
