Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.41239452 |
| Normalized Enrichment Score (NES) | 1.5328038 |
| Nominal p-value | 0.010526316 |
| FDR q-value | 0.119781196 |
| FWER p-Value | 0.771 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1 | 4.764 | 0.0820 | Yes |
| 2 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 10 | 4.462 | 0.1582 | Yes |
| 3 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.2334 | Yes |
| 4 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.314 | 0.3077 | Yes |
| 5 | JUN | NA | JUN Entrez, Source | jun oncogene | 236 | 1.996 | 0.3261 | Yes |
| 6 | TLR3 | NA | TLR3 Entrez, Source | toll-like receptor 3 | 284 | 1.798 | 0.3537 | Yes |
| 7 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.3748 | Yes |
| 8 | MAP2K3 | NA | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 572 | 1.213 | 0.3808 | Yes |
| 9 | TLR4 | NA | TLR4 Entrez, Source | toll-like receptor 4 | 729 | 1.068 | 0.3879 | Yes |
| 10 | IRAK1 | NA | IRAK1 Entrez, Source | interleukin-1 receptor-associated kinase 1 | 918 | 0.934 | 0.3903 | Yes |
| 11 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 1072 | 0.861 | 0.3940 | Yes |
| 12 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 1384 | 0.748 | 0.3843 | Yes |
| 13 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1484 | 0.721 | 0.3895 | Yes |
| 14 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1570 | 0.698 | 0.3953 | Yes |
| 15 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1699 | 0.658 | 0.3974 | Yes |
| 16 | FADD | NA | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1727 | 0.651 | 0.4066 | Yes |
| 17 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1819 | 0.628 | 0.4108 | Yes |
| 18 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2004 | 0.585 | 0.4075 | Yes |
| 19 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2074 | 0.574 | 0.4124 | Yes |
| 20 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2374 | 0.520 | 0.3996 | No |
| 21 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 2396 | 0.517 | 0.4070 | No |
| 22 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.4020 | No |
| 23 | TOLLIP | NA | TOLLIP Entrez, Source | toll interacting protein | 2726 | 0.463 | 0.3995 | No |
| 24 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 2742 | 0.461 | 0.4064 | No |
| 25 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 2997 | 0.421 | 0.3952 | No |
| 26 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 3193 | 0.394 | 0.3878 | No |
| 27 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3310 | 0.381 | 0.3859 | No |
| 28 | TRAF3 | NA | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 3421 | 0.364 | 0.3842 | No |
| 29 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 3444 | 0.361 | 0.3888 | No |
| 30 | TICAM1 | NA | TICAM1 Entrez, Source | toll-like receptor adaptor molecule 1 | 3602 | 0.344 | 0.3833 | No |
| 31 | TLR8 | NA | TLR8 Entrez, Source | toll-like receptor 8 | 3919 | 0.307 | 0.3657 | No |
| 32 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 4423 | 0.251 | 0.3335 | No |
| 33 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 4894 | 0.202 | 0.3028 | No |
| 34 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5043 | 0.187 | 0.2953 | No |
| 35 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 5293 | 0.162 | 0.2800 | No |
| 36 | MAP2K4 | NA | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 5370 | 0.154 | 0.2771 | No |
| 37 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 5556 | 0.134 | 0.2660 | No |
| 38 | IRAK4 | NA | IRAK4 Entrez, Source | interleukin-1 receptor-associated kinase 4 | 5776 | 0.109 | 0.2519 | No |
| 39 | TAB2 | NA | 6033 | 0.083 | 0.2348 | No | ||
| 40 | MAP2K7 | NA | MAP2K7 Entrez, Source | mitogen-activated protein kinase kinase 7 | 6049 | 0.082 | 0.2351 | No |
| 41 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 6608 | 0.027 | 0.1950 | No |
| 42 | TLR6 | NA | TLR6 Entrez, Source | toll-like receptor 6 | 7027 | -0.016 | 0.1649 | No |
| 43 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 7031 | -0.017 | 0.1650 | No |
| 44 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 7140 | -0.027 | 0.1576 | No |
| 45 | TAB1 | NA | 7323 | -0.047 | 0.1452 | No | ||
| 46 | TIRAP | NA | TIRAP Entrez, Source | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 7382 | -0.054 | 0.1419 | No |
| 47 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 7577 | -0.073 | 0.1291 | No |
| 48 | TLR7 | NA | TLR7 Entrez, Source | toll-like receptor 7 | 7976 | -0.111 | 0.1021 | No |
| 49 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 8472 | -0.166 | 0.0690 | No |
| 50 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 8839 | -0.207 | 0.0459 | No |
| 51 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 8905 | -0.215 | 0.0449 | No |
| 52 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 8973 | -0.222 | 0.0439 | No |
| 53 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 9483 | -0.292 | 0.0119 | No |
| 54 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9727 | -0.326 | -0.0001 | No |
| 55 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 9823 | -0.340 | -0.0012 | No |
| 56 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | 0.0033 | No |
| 57 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10063 | -0.374 | -0.0061 | No |
| 58 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10142 | -0.384 | -0.0052 | No |
| 59 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 10697 | -0.475 | -0.0372 | No |
| 60 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 10850 | -0.502 | -0.0396 | No |
| 61 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 11136 | -0.552 | -0.0509 | No |
| 62 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 11218 | -0.567 | -0.0470 | No |
| 63 | TLR1 | NA | TLR1 Entrez, Source | toll-like receptor 1 | 11940 | -0.736 | -0.0867 | No |
| 64 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 12189 | -0.816 | -0.0907 | No |
| 65 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 13175 | -1.371 | -0.1386 | No |
| 66 | MAP2K6 | NA | MAP2K6 Entrez, Source | mitogen-activated protein kinase kinase 6 | 13186 | -1.378 | -0.1156 | No |
| 67 | TLR5 | NA | TLR5 Entrez, Source | toll-like receptor 5 | 13197 | -1.389 | -0.0924 | No |
| 68 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 13226 | -1.426 | -0.0699 | No |
| 69 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 13407 | -1.667 | -0.0543 | No |
| 70 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 13543 | -1.911 | -0.0312 | No |
| 71 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 13763 | -3.033 | 0.0052 | No |
